SE521084C2 - Förfarande för framställning av paroxetin-hydroklorid- anhydrat från ett paroxetin-hydroklorid-solvat - Google Patents

Förfarande för framställning av paroxetin-hydroklorid- anhydrat från ett paroxetin-hydroklorid-solvat

Info

Publication number
SE521084C2
SE521084C2 SE9600406A SE9600406A SE521084C2 SE 521084 C2 SE521084 C2 SE 521084C2 SE 9600406 A SE9600406 A SE 9600406A SE 9600406 A SE9600406 A SE 9600406A SE 521084 C2 SE521084 C2 SE 521084C2
Authority
SE
Sweden
Prior art keywords
paroxetine hydrochloride
solvate
propan
hydrochloride anhydrate
anhydrate
Prior art date
Application number
SE9600406A
Other languages
English (en)
Swedish (sv)
Other versions
SE9600406D0 (sv
SE9600406L (sv
Inventor
Victor Witold Jacewicz
Neal Ward
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267578&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE521084(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9502297.6A external-priority patent/GB9502297D0/en
Priority claimed from GBGB9503112.6A external-priority patent/GB9503112D0/en
Priority claimed from GBGB9509807.5A external-priority patent/GB9509807D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SE9600406D0 publication Critical patent/SE9600406D0/xx
Publication of SE9600406L publication Critical patent/SE9600406L/xx
Publication of SE521084C2 publication Critical patent/SE521084C2/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE9600406A 1995-02-06 1996-02-05 Förfarande för framställning av paroxetin-hydroklorid- anhydrat från ett paroxetin-hydroklorid-solvat SE521084C2 (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9502297.6A GB9502297D0 (en) 1995-02-06 1995-02-06 Novel compound
GBGB9503112.6A GB9503112D0 (en) 1995-02-17 1995-02-17 Novel compound
GBGB9509807.5A GB9509807D0 (en) 1995-05-15 1995-05-15 Novel compounds

Publications (3)

Publication Number Publication Date
SE9600406D0 SE9600406D0 (sv) 1996-02-05
SE9600406L SE9600406L (sv) 1996-08-07
SE521084C2 true SE521084C2 (sv) 2003-09-30

Family

ID=27267578

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9600406A SE521084C2 (sv) 1995-02-06 1996-02-05 Förfarande för framställning av paroxetin-hydroklorid- anhydrat från ett paroxetin-hydroklorid-solvat

Country Status (47)

Country Link
EP (3) EP1378508A1 (no)
JP (2) JP2915338B2 (no)
KR (1) KR100289885B1 (no)
CN (3) CN1289496C (no)
AR (2) AR001982A1 (no)
AT (1) AT407528B (no)
AU (2) AU701518C (no)
BE (1) BE1009112A3 (no)
BG (1) BG62967B1 (no)
BR (1) BR9600534A (no)
CA (4) CA2210022C (no)
CH (3) CH688353A5 (no)
CZ (1) CZ297171B6 (no)
DE (3) DE69631298T2 (no)
DK (2) DK11996A (no)
DZ (1) DZ1989A1 (no)
ES (1) ES2114471B1 (no)
FI (3) FI111544B (no)
FR (1) FR2730232B1 (no)
GR (1) GR1002466B (no)
HK (1) HK59397A (no)
HU (1) HUP9600255A1 (no)
IE (1) IE80500B1 (no)
IL (1) IL117035A (no)
IT (1) IT1289532B1 (no)
LU (1) LU88711A1 (no)
LV (1) LV11618B (no)
MA (1) MA23802A1 (no)
MC (1) MC2411A1 (no)
MX (1) MX9600484A (no)
MY (1) MY132529A (no)
NL (1) NL1002248C2 (no)
NO (3) NO301009B1 (no)
NZ (1) NZ280943A (no)
OA (1) OA10261A (no)
PL (1) PL189247B1 (no)
PT (1) PT101827B (no)
RO (1) RO112426B1 (no)
RU (1) RU2125052C1 (no)
SE (1) SE521084C2 (no)
SG (1) SG43787A1 (no)
SI (2) SI9600036B (no)
SK (1) SK283608B6 (no)
TR (1) TR199600096A2 (no)
TW (1) TW503238B (no)
UA (1) UA49796C2 (no)
WO (1) WO1996024595A1 (no)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3882224B2 (ja) 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
EP0812827B1 (en) 1996-06-13 2009-09-02 Sumitomo Chemical Company, Limited Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation
WO1998002556A2 (en) * 1996-07-15 1998-01-22 Smithkline Beecham Plc Screening for and use of an esterase for a stereospecific resolution
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
US5672612A (en) * 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
CA2193939C (en) * 1996-12-24 2002-02-12 K.S. Keshava Murthy Useful form of anhydrous paroxetine hydrochloride
DE29724281U1 (de) * 1997-06-10 2000-08-10 Synthon Bv 4-Phenylpiperidin-Verbindungen
DE59801792D1 (de) * 1997-08-08 2001-11-22 Aventis Pharma Gmbh Kristallform von N-(4-Trifluormethylphenyl)-5-methylisoxazol-4-carbonsäureamid
GB9726907D0 (en) * 1997-12-19 1998-02-18 Smithkline Beecham Plc Novel compounds
CA2323896A1 (en) * 1998-03-16 1999-09-23 Andrew Simon Craig Crystalline form of paroxetine
GB9806312D0 (en) * 1998-03-24 1998-05-20 Smithkline Beecham Plc Novel formulations
US6699882B2 (en) 1998-03-24 2004-03-02 Smithkline Beecham P.L.C. Paroxetine compositions
AU2003200534B2 (en) * 1998-03-24 2004-12-02 Smithkline Beecham Plc Paroxetine compositions
JP3796351B2 (ja) * 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法
GB9812941D0 (en) * 1998-06-16 1998-08-12 Smithkline Beecham Plc Method of treatment
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
ES2138937B1 (es) 1998-07-07 2000-10-01 Medichem Sa Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen.
EP1100796B1 (en) * 1998-08-07 2003-05-02 SmithKline Beecham plc Process for the preparation of a non-crystalline anhydrate form of paroxetine hydrochloride
GB9824298D0 (en) * 1998-11-05 1998-12-30 Smithkline Beecham Plc Novel process
GB9826175D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826176D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826180D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826171D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel compounds
EP1135383B1 (en) * 1998-11-30 2003-12-03 SmithKline Beecham plc Mixed paroxetine propan-2-ol solvates
GB9826242D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826178D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9828767D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
ATE311883T1 (de) * 1999-03-12 2005-12-15 Aesica Pharmaceuticals Ltd Stabile pharmazeutische anwendungsform für paroxetin-anhydrat
GB9914583D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9914585D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9919001D0 (en) * 1999-08-12 1999-10-13 Smithkline Beecham Plc Novel process
GB9923446D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923439D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923445D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
HU226912B1 (en) * 2000-04-07 2010-03-01 Richter Gedeon Nyrt New paroxetin salt and medicament containing it
WO2002022609A1 (fr) * 2000-09-14 2002-03-21 Asahi Glass Company, Limited Procede de production de sel de paroxetine sensiblement exempt de solvant organique
JP2005524656A (ja) * 2002-02-22 2005-08-18 テバ ファーマシューティカル インダストリーズ リミティド 新規中間物質を用いるパロキセチンの調製
KR20080055990A (ko) * 2005-11-22 2008-06-19 테바 파마슈티컬 인더스트리즈 리미티드 시나칼셋 ＨＣｌ의 결정형 및 이의 제조 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
GB8430581D0 (en) * 1984-12-04 1985-01-09 Ferrosan As Treatment
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
GB8626936D0 (en) * 1986-11-11 1986-12-10 Ferrosan As Treatment
DK716088D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Reduktion af piperidin-dion-derivater samt intermediat
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
KR930702000A (ko) * 1990-11-24 1993-09-08 데이빗 로버츠 노년기 치매, 식용항진, 편두통, 또는 식용불량의 치료를 위한 파로세틴의 사용
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation

Also Published As

Publication number Publication date
SI21923B (sl) 2006-12-31
JPH11228571A (ja) 1999-08-24
AR036856A2 (es) 2004-10-06
PL189247B1 (pl) 2005-07-29
CA2210022A1 (en) 1996-08-07
EP1378508A1 (en) 2004-01-07
LV11618B (en) 1997-04-20
DE19603797C2 (de) 1998-11-12
NO20015070L (no) 1996-08-07
FR2730232A1 (fr) 1996-08-09
OA10261A (en) 1997-09-19
CN1216055C (zh) 2005-08-24
SK283608B6 (sk) 2003-10-07
TW503238B (en) 2002-09-21
CH688353A5 (de) 1997-08-15
FI20030162A (fi) 2003-02-03
DE69631298T2 (de) 2004-11-18
RU2125052C1 (ru) 1999-01-20
CA2210022C (en) 2005-09-13
PT101827B (pt) 1997-08-29
CA2168829A1 (en) 1996-08-07
WO1996024595A1 (en) 1996-08-15
AU4786496A (en) 1996-08-27
NO20015070D0 (no) 2001-10-18
CA2211522C (en) 1999-12-07
NL1002248C2 (nl) 1996-09-11
MY132529A (en) 2007-10-31
PL312646A1 (en) 1996-08-19
NO970939L (no) 1996-08-07
SI9600036B (sl) 2006-12-31
EP1136490A1 (en) 2001-09-26
MX198371B (no) 2000-08-29
CZ32096A3 (en) 1996-08-14
MX9600484A (es) 1997-01-31
NO970939D0 (no) 1997-02-28
BR9600534A (pt) 1997-05-13
SG43787A1 (en) 1997-11-14
CN1310180A (zh) 2001-08-29
ITMI960203A1 (it) 1997-08-05
EP0808314A1 (en) 1997-11-26
SE9600406D0 (sv) 1996-02-05
SK14396A3 (en) 1996-11-06
JPH08245620A (ja) 1996-09-24
SE9600406L (sv) 1996-08-07
NO960472D0 (no) 1996-02-05
AU4332896A (en) 1996-08-15
AU701518B2 (en) 1999-01-28
NO301009B1 (no) 1997-09-01
FI20030370A (fi) 2003-03-12
NZ280943A (en) 1997-01-29
BG62967B1 (bg) 2000-12-29
CA2210023A1 (en) 1996-08-07
GR1002466B (el) 1996-11-06
CH689229A5 (de) 1998-12-31
DK11996A (da) 1996-08-07
DZ1989A1 (fr) 2002-10-15
AU701518C (en) 2006-12-07
IT1289532B1 (it) 1998-10-15
SI9600036A (en) 1996-10-31
NO301009B3 (no) 2003-01-06
AR001982A1 (es) 1998-01-07
HK59397A (en) 1997-05-16
DE19603797A1 (de) 1996-08-14
FR2730232B1 (fr) 1997-08-01
MC2411A1 (fr) 1996-12-02
CN1090187C (zh) 2002-09-04
HU9600255D0 (en) 1996-03-28
LU88711A1 (fr) 1996-08-23
CN1143643A (zh) 1997-02-26
FI960519A0 (fi) 1996-02-05
CA2168829C (en) 1997-12-16
CA2211522A1 (en) 1996-08-07
FI960519A (fi) 1996-08-07
ES2114471A1 (es) 1998-05-16
DE69621777T2 (de) 2003-01-02
MA23802A1 (fr) 1996-10-01
BE1009112A3 (fr) 1996-11-05
DK200100223A (no) 2001-02-12
HUP9600255A1 (en) 1997-03-28
CA2210023C (en) 1999-02-09
ITMI960203A0 (no) 1996-02-05
JP2915338B2 (ja) 1999-07-05
EP1136490B1 (en) 2004-01-07
DE69631298D1 (de) 2004-02-12
KR100289885B1 (ko) 2001-05-15
IE960104A1 (en) 1996-08-07
ATA21096A (de) 2000-08-15
IE80500B1 (en) 1998-08-12
AT407528B (de) 2001-04-25
IL117035A (en) 2000-02-29
NO311519B1 (no) 2001-12-03
SI21923A (sl) 2006-06-30
PT101827A (pt) 1996-09-30
TR199600096A2 (tr) 1996-08-21
LV11618A (lv) 1996-12-20
KR960031409A (ko) 1996-09-17
RO112426B1 (ro) 1997-09-30
DE69621777D1 (de) 2002-07-18
CN1636993A (zh) 2005-07-13
ES2114471B1 (es) 1999-08-16
BG100333A (bg) 1996-08-30
IL117035A0 (en) 1996-09-12
UA49796C2 (uk) 2002-10-15
EP0808314B1 (en) 2002-06-12
CZ297171B6 (cs) 2006-09-13
NO960472L (no) 1996-08-07
FI111544B (fi) 2003-08-15
NL1002248A1 (nl) 1996-08-06
CH689804A5 (de) 1999-11-30
CN1289496C (zh) 2006-12-13

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Legal Events

Date Code Title Description
CANC Patent cancelled, revoked after opposition
NUG Patent has lapsed