SE430062B - Kopplings- eller tioleringsreagens - Google Patents
Kopplings- eller tioleringsreagensInfo
- Publication number
- SE430062B SE430062B SE7702462A SE7702462A SE430062B SE 430062 B SE430062 B SE 430062B SE 7702462 A SE7702462 A SE 7702462A SE 7702462 A SE7702462 A SE 7702462A SE 430062 B SE430062 B SE 430062B
- Authority
- SE
- Sweden
- Prior art keywords
- tiolation
- reagents
- coupling
- tiolation reagents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7702462A SE430062B (sv) | 1977-03-04 | 1977-03-04 | Kopplings- eller tioleringsreagens |
DE19782808523 DE2808523A1 (de) | 1977-03-04 | 1978-02-28 | Neue pyridinverbindungen sowie deren verwendung |
US05/882,546 US4149003A (en) | 1977-03-04 | 1978-03-02 | Pyridine disulfide compounds |
FR7806161A FR2382450A1 (fr) | 1977-03-04 | 1978-03-03 | Produits composes de la pyridine et leur application comme agents de liaison bifonctionnels et comme agents de formation de thiols |
GB8456/78A GB1597756A (en) | 1977-03-04 | 1978-03-03 | Pyridine disulphide derivatives and their use as bifunctional coupling agents and as thiolating agents |
JP2406678A JPS53130674A (en) | 1977-03-04 | 1978-03-04 | Novel pyridine compound |
JP60290918A JPS61191675A (ja) | 1977-03-04 | 1985-12-25 | 巨大分子物質 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7702462A SE430062B (sv) | 1977-03-04 | 1977-03-04 | Kopplings- eller tioleringsreagens |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7702462L SE7702462L (sv) | 1978-09-05 |
SE430062B true SE430062B (sv) | 1983-10-17 |
Family
ID=20330623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7702462A SE430062B (sv) | 1977-03-04 | 1977-03-04 | Kopplings- eller tioleringsreagens |
Country Status (6)
Country | Link |
---|---|
US (1) | US4149003A (xx) |
JP (2) | JPS53130674A (xx) |
DE (1) | DE2808523A1 (xx) |
FR (1) | FR2382450A1 (xx) |
GB (1) | GB1597756A (xx) |
SE (1) | SE430062B (xx) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2430943A1 (fr) * | 1978-07-13 | 1980-02-08 | Toyo Jozo Kk | Nouveaux derives disulfures |
SE446184B (sv) * | 1979-01-12 | 1986-08-18 | Toyo Jozo Kk | Polyfunktionell disulfidforening anvendbar som tverbindande medel |
SE8003732L (sv) * | 1980-05-19 | 1981-11-20 | Pharmacia Diagnostics Ab | Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner |
US4563304A (en) * | 1981-02-27 | 1986-01-07 | Pharmacia Fine Chemicals Ab | Pyridine compounds modifying proteins, polypeptides or polysaccharides |
SE8102194L (sv) * | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna |
SE8102193L (sv) * | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och dess anvendning |
US4433059A (en) * | 1981-09-08 | 1984-02-21 | Ortho Diagnostic Systems Inc. | Double antibody conjugate |
FR2522269A1 (fr) * | 1982-02-26 | 1983-09-02 | Pasteur Institut | Agents antitumoraux, tels que la daunorubicine, a efficacite amelioree, leur obtention et procede pour augmenter l'efficacite des agents antitumoraux |
FR2523445A1 (fr) * | 1982-03-17 | 1983-09-23 | Sanofi Sa | Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues |
US4614712A (en) * | 1983-02-25 | 1986-09-30 | The Upjohn Company | Immunoassays with luciferase labeled ligands or receptors |
SE8302758L (sv) * | 1983-05-17 | 1984-11-18 | Pharmacia Ab | Sett for uppspjelkning av disulfidbindningar och derigenom erhallen forening |
GB8334499D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Derivatives |
ATE107031T1 (de) * | 1984-12-03 | 1994-06-15 | Hoechst Celanese Corp | Verfahren zur bestimmung eines liganden. |
US4797491A (en) * | 1986-03-17 | 1989-01-10 | Cetus Corporation | Compound 1-(3-(2-pyridyldithio)propionamido)-12-(5-hydrazidoglutaramido)-4,9-dioxadodecane |
US4880935A (en) * | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
JPS6391563A (ja) * | 1986-10-07 | 1988-04-22 | Nitsusui Seiyaku Kk | 細菌由来蛋白特異抗原の検査法 |
US4798795A (en) * | 1987-02-17 | 1989-01-17 | Hoechst Celanese Corporation | Biotinylating agents |
US4794082A (en) * | 1987-02-17 | 1988-12-27 | Hoechst Celanese Corporation | Biotinylating agents |
US4709037A (en) * | 1987-02-17 | 1987-11-24 | Hoechst Celanese Corporation | Biotinylating agents |
JPS63189278U (xx) * | 1987-05-28 | 1988-12-05 | ||
DE3809986A1 (de) * | 1988-03-24 | 1989-10-05 | Boehringer Mannheim Gmbh | Verbindungen zur einfuehrung einer sh-gruppe in tyrosin |
JPH0253770U (xx) * | 1988-10-12 | 1990-04-18 | ||
JP2619549B2 (ja) * | 1989-06-29 | 1997-06-11 | 日本商事株式会社 | 抗原の定量法およびそれに用いる固相 |
US5137877B1 (en) * | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
WO1992001938A1 (en) * | 1990-07-20 | 1992-02-06 | City Of Hope | Derivatization of c-terminal proline |
US5516703A (en) * | 1993-08-20 | 1996-05-14 | The University Of Utah | Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands |
US6284503B1 (en) | 1993-08-20 | 2001-09-04 | University Of Utah Research Foundation | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces |
US20030176512A1 (en) * | 1998-08-11 | 2003-09-18 | Kirkpatrick D. Lynn | Asymmetric disulfides and methods of using same |
US6552060B1 (en) | 1997-08-11 | 2003-04-22 | Prolx Pharmaceuticals, Inc. | Asymmetric disulfides and methods of using same |
AR030612A1 (es) * | 2000-09-12 | 2003-08-27 | Smithkline Beecham Corp | Procedimiento e intermedios |
AU2003259163B2 (en) * | 2002-08-16 | 2008-07-03 | Immunogen, Inc. | Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs |
CA2503490C (en) | 2002-10-21 | 2012-04-03 | Allvivo, Inc. | Medical device surface coating comprising bioactive compound |
US7858108B2 (en) | 2003-10-21 | 2010-12-28 | Richard Nagler | Elutable surface coating |
ES2524449T3 (es) * | 2004-07-02 | 2014-12-09 | Genentech, Inc. | Inhibidores de IAP |
PT1819359E (pt) | 2004-12-09 | 2015-05-28 | Janssen Biotech Inc | Imunoconjugados anti-integrina, métodos para a sua produção e sua utilização |
CN101146803A (zh) | 2004-12-20 | 2008-03-19 | 健泰科生物技术公司 | Iap的吡咯烷抑制剂 |
US7811572B2 (en) | 2005-08-24 | 2010-10-12 | Immunogen, Inc. | Process for preparing purified drug conjugates |
CA2597407C (en) * | 2005-02-11 | 2013-09-10 | Immunogen, Inc. | Process for preparing stable drug conjugates |
US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
EP1973899A4 (en) * | 2005-12-19 | 2010-10-20 | Genentech Inc | HEMMER OF IAP |
US20070260041A1 (en) * | 2006-05-03 | 2007-11-08 | David Crich | Allylic disulfide rearrangement and desulfurization method for the preparation of allylic sulfides |
JP2010513561A (ja) * | 2006-12-19 | 2010-04-30 | ジェネンテック, インコーポレイテッド | Iapのイミダゾピリジンインヒビター |
TWI432212B (zh) * | 2007-04-30 | 2014-04-01 | Genentech Inc | Iap抑制劑 |
JP2011509938A (ja) * | 2008-01-11 | 2011-03-31 | ジェネンテック, インコーポレイテッド | Iapのインヒビター |
CA2730448A1 (en) | 2008-08-02 | 2010-02-11 | Genentech, Inc. | Inhibitors of iap |
SI2437790T1 (sl) | 2009-06-03 | 2019-07-31 | Immunogen, Inc. | Konjugacijske metode |
EA201991268A3 (ru) | 2011-03-29 | 2020-01-31 | Иммуноджен, Инк. | Получение конъюгатов "майтансиноид-антитело" одностадийным способом |
RU2661083C2 (ru) | 2012-10-04 | 2018-07-11 | Иммуноджен, Инк. | Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент |
US9518017B2 (en) | 2013-06-28 | 2016-12-13 | Immunogen, Inc. | Purification of intermediates used in the preparation of heterobifunctional linkers |
KR102325753B1 (ko) | 2019-12-20 | 2021-11-11 | 주식회사 포스코 | 흑색 도금 강판 및 그 제조방법 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2872450A (en) * | 1955-12-06 | 1959-02-03 | Bayer Ag | Thio- and dithio-carboxylic acid esters and a process for their manufacture |
US3950348A (en) * | 1971-12-30 | 1976-04-13 | Merck & Co., Inc. | Process for preparing e-pyridyl-4-methyloxycarbonyllysine |
-
1977
- 1977-03-04 SE SE7702462A patent/SE430062B/xx not_active IP Right Cessation
-
1978
- 1978-02-28 DE DE19782808523 patent/DE2808523A1/de active Granted
- 1978-03-02 US US05/882,546 patent/US4149003A/en not_active Expired - Lifetime
- 1978-03-03 GB GB8456/78A patent/GB1597756A/en not_active Expired
- 1978-03-03 FR FR7806161A patent/FR2382450A1/fr active Granted
- 1978-03-04 JP JP2406678A patent/JPS53130674A/ja active Granted
-
1985
- 1985-12-25 JP JP60290918A patent/JPS61191675A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2382450A1 (fr) | 1978-09-29 |
GB1597756A (en) | 1981-09-09 |
FR2382450B1 (xx) | 1982-11-05 |
SE7702462L (sv) | 1978-09-05 |
JPS53130674A (en) | 1978-11-14 |
JPS6121227B2 (xx) | 1986-05-26 |
JPS624368B2 (xx) | 1987-01-30 |
JPS61191675A (ja) | 1986-08-26 |
US4149003A (en) | 1979-04-10 |
DE2808523A1 (de) | 1978-09-07 |
DE2808523C2 (xx) | 1987-11-19 |
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Legal Events
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