SA519402462B1 - مشتقات بيرولو[1، 2-b]بيريدازين - Google Patents

مشتقات بيرولو[1، 2-b]بيريدازين

Info

Publication number
SA519402462B1
SA519402462B1 SA519402462A SA519402462A SA519402462B1 SA 519402462 B1 SA519402462 B1 SA 519402462B1 SA 519402462 A SA519402462 A SA 519402462A SA 519402462 A SA519402462 A SA 519402462A SA 519402462 B1 SA519402462 B1 SA 519402462B1
Authority
SA
Saudi Arabia
Prior art keywords
pyrrolo
pyridazine derivatives
pyridazine
derivatives
irak4
Prior art date
Application number
SA519402462A
Other languages
English (en)
Inventor
ايلزابيث ام باكون
جيديميناس بريزجيس
جيمس جا تايلور
وينستون سى تس
جينيفير ار زهانج
شيلا ام زيبفيل
شينهونج شو
البيرت شين
جيرومى جا كوتيل
جون او لينك
ناثان اى وريت
زينج- يو يانج
Original Assignee
.جيليد سينسيس، إنك
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by .جيليد سينسيس، إنك filed Critical .جيليد سينسيس، إنك
Publication of SA519402462B1 publication Critical patent/SA519402462B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

تم توفير مركب له الصيغة (I) ؛ حيث تم تعريف المجموعات المتغيرة هنا، للاستخدام في علاج الاضطرابات الالتهابية المعدلة بواسطة مثبطات IRAK4
SA519402462A 2017-02-16 2019-08-18 مشتقات بيرولو[1، 2-b]بيريدازين SA519402462B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762460013P 2017-02-16 2017-02-16
PCT/US2018/018431 WO2018152368A1 (en) 2017-02-16 2018-02-15 Pyrrolo [1,2-b] pyridazine derivatives

Publications (1)

Publication Number Publication Date
SA519402462B1 true SA519402462B1 (ar) 2022-08-28

Family

ID=61563476

Family Applications (1)

Application Number Title Priority Date Filing Date
SA519402462A SA519402462B1 (ar) 2017-02-16 2019-08-18 مشتقات بيرولو[1، 2-b]بيريدازين

Country Status (32)

Country Link
US (1) US10336762B2 (ar)
EP (1) EP3583105B1 (ar)
JP (3) JP6924267B2 (ar)
KR (1) KR102337055B1 (ar)
CN (1) CN110300754A (ar)
AR (1) AR110935A1 (ar)
AU (2) AU2018221812B2 (ar)
BR (1) BR102018002879A2 (ar)
CA (1) CA3050148A1 (ar)
CL (1) CL2019002306A1 (ar)
CO (1) CO2019008868A2 (ar)
CR (1) CR20190373A (ar)
DK (1) DK3583105T3 (ar)
DO (1) DOP2019000214A (ar)
EA (1) EA201991544A1 (ar)
FI (1) FI3583105T3 (ar)
IL (1) IL267979B (ar)
JO (1) JOP20180011A1 (ar)
LT (1) LT3583105T (ar)
MA (1) MA47500B1 (ar)
MX (2) MX2019009840A (ar)
PE (1) PE20191540A1 (ar)
PH (1) PH12019550128A1 (ar)
PT (1) PT3583105T (ar)
RS (1) RS65397B1 (ar)
SA (1) SA519402462B1 (ar)
SG (1) SG11201906763RA (ar)
TW (3) TWI733982B (ar)
UA (1) UA124548C2 (ar)
UY (1) UY37608A (ar)
WO (1) WO2018152368A1 (ar)
ZA (1) ZA201905456B (ar)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
IL273432B (en) 2017-09-22 2022-09-01 Kymera Therapeutics Inc Protein compounds and their uses
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
WO2019133531A1 (en) 2017-12-26 2019-07-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
EP3737675A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. CRBN LIGANDS AND THEIR USES
EP3737666A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. PROTEIN DEGRADANTS AND USES THEREOF
EP3817748A4 (en) 2018-07-06 2022-08-24 Kymera Therapeutics, Inc. TRICYCLIC CRBN LIGANDS AND USES THEREOF
TWI721483B (zh) * 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
AU2019321267B2 (en) * 2018-08-13 2022-07-14 Gilead Sciences, Inc. Pyrrolo[1,2-b]pyridazine derivatives as IRAK4 inhibitors
TWI797366B (zh) * 2018-08-13 2023-04-01 美商基利科學股份有限公司 吡咯并[1,2-b]嗒衍生物
JP2022516401A (ja) 2018-11-30 2022-02-28 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ分解剤およびそれらの使用
CN113825543A (zh) 2019-03-19 2021-12-21 勃林格殷格翰动物保健美国公司 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物
CN111821308B (zh) * 2019-04-15 2021-10-08 中国科学院上海药物研究所 雷藤舒在制备用于治疗非酒精性脂肪性肝病的药物中的应用
CN110755452B (zh) * 2019-11-23 2021-07-06 博雅干细胞科技有限公司 干细胞治疗骨关节炎的用途
CN110755451B (zh) * 2019-11-23 2021-07-06 博雅干细胞科技有限公司 用于治疗骨关节炎的间充质干细胞组合物及其用途
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
BR112022011651A2 (pt) 2019-12-17 2022-08-23 Kymera Therapeutics Inc Degradadores de irak e usos dos mesmos
MX2022015038A (es) 2020-05-29 2023-01-04 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos como anthelminticos.
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
CA3226118A1 (en) 2021-08-18 2023-02-23 Nurix Therapeutics, Inc. Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof
AR127495A1 (es) 2021-11-01 2024-01-31 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelmínticos
TW202408362A (zh) 2022-06-21 2024-03-01 瑞士商先正達農作物保護公司 殺微生物的雙環雜環甲醯胺衍生物
WO2024089191A1 (en) 2022-10-27 2024-05-02 Syngenta Crop Protection Ag Microbiocidal heterobicyclic dihydrooxadiazine derivatives
CN117849327A (zh) * 2024-03-06 2024-04-09 军科正源（北京）药物研究有限责任公司 用于检测苏金单抗抗药性抗体的方法

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2458533C (en) 2001-10-09 2011-01-04 Tularik Inc. Imidazole derivates as anti-inflammatory agents
WO2008016643A2 (en) 2006-08-01 2008-02-07 Cytokinetics, Incorporated Certain chemical entities, compositions, and methods
CA2663100A1 (en) 2006-09-07 2008-03-13 Biogen Idec Ma Inc. Indazole derivatives as modulators of interleukin-1 receptor-associated kinase
DE102009033208A1 (de) 2009-07-15 2011-01-20 Merck Patent Gmbh Aminopyridinderivate
JP2012254939A (ja) 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
EP3252054A1 (en) 2010-07-13 2017-12-06 F. Hoffmann-La Roche AG Pyrazolo[1,5a]pyrimidine derivatives as irak4 modulators
RU2632900C2 (ru) 2010-11-19 2017-10-11 Лиганд Фармасьютикалс Инкорпорейтед Гетероциклические амины и их применение
PL2655357T3 (pl) 2010-12-20 2016-12-30 Pochodne triazolowe indazolilowe jako inhibitory irak
EP3239154A1 (en) 2011-01-10 2017-11-01 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US9169260B2 (en) 2011-03-22 2015-10-27 Merck Sharp & Dohme Corp. Amidopyrazole inhibitors of interleukin receptor-associated kinases
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
WO2013066729A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
CA2849566C (en) 2011-11-09 2021-02-09 Cancer Research Technology Limited 5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use
TWI589579B (zh) 2012-01-10 2017-07-01 林伯士艾瑞斯公司 Ｉｒａｋ抑制劑及其用途
EP2802579B1 (en) 2012-01-13 2016-04-13 Bristol-Myers Squibb Company Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors
CN104169275B (zh) 2012-01-13 2017-06-09 百时美施贵宝公司 用作激酶抑制剂的***取代的吡啶化合物
CN104159896B (zh) 2012-01-13 2017-05-24 百时美施贵宝公司 用作激酶抑制剂的杂环取代的吡啶基化合物
SG11201500005SA (en) 2012-07-10 2015-01-29 Ares Trading Sa Pyrimidine pyrazolyl derivatives
WO2014011902A1 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2014011911A2 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
EP2872518A4 (en) 2012-07-11 2016-05-18 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
US9586948B2 (en) 2012-10-08 2017-03-07 Merck Sharp & Dohme Corp. Inhibitors of IRAK4 activity
EP2903617B1 (en) 2012-10-08 2019-01-30 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
JP6204484B2 (ja) 2012-11-08 2017-09-27 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ キナーゼモジュレーターとして有用なヘテロアリール置換ピリジル化合物
US9540333B2 (en) 2012-11-08 2017-01-10 Bristol-Myers Squibb Company Alkyl amide-substituted pyrimidine compounds useful in the modulation of IL-12, IL-23 and/or IFNα
EP2922846B1 (en) 2012-11-08 2018-10-03 Bristol-Myers Squibb Company Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn-alpha
WO2014074657A1 (en) 2012-11-08 2014-05-15 Bristol-Myers Squibb Company Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators
KR20150087850A (ko) 2012-11-20 2015-07-30 제넨테크, 인크. Egfr 돌연변이체를 함유하는 t790m의 억제제로서의 아미노피리미딘 화합물
BR112015014034A2 (pt) 2013-01-10 2017-07-11 Nimbus Iris Inc inibidores de irak e usos dos mesmos
JP6483624B2 (ja) 2013-02-07 2019-03-13 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリダジノン−アミド誘導体
JP6267729B2 (ja) 2013-02-07 2018-01-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 大環状ピリダジノン誘導体
EP2970334B1 (en) 2013-03-15 2018-05-23 Biogen MA Inc. Macrocyclic compounds as irak4 inhibitors for the treatment of inflammatory diseases
WO2014210354A1 (en) 2013-06-28 2014-12-31 Genentech, Inc. Azaindazole compounds as inhibitors of t790m containing egfr mutants
WO2015006181A1 (en) 2013-07-11 2015-01-15 Merck Sharp & Dohme Corp. Substituted amidopyrazole inhibitors of interleukin receptor-associated kinases (irak-4)
BR112016006319A2 (pt) 2013-09-27 2017-08-01 Nimbus Iris Inc inibidores de irak e usos dos mesmos
EP3066094B1 (en) 2013-11-08 2020-01-08 Takeda Pharmaceutical Company Limited Pyrazole for the treatment autoimmune disorders
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
TW201609693A (zh) * 2014-01-03 2016-03-16 必治妥美雅史谷比公司 雜芳基取代之菸鹼醯胺化合物
WO2015106058A1 (en) 2014-01-09 2015-07-16 Merck Patent Gmbh Pyrimidine pyrazolyl derivatives and their use as irak inhibitors
KR20160115933A (ko) 2014-01-10 2016-10-06 오리진 디스커버리 테크놀로지스 리미티드 Irak4 억제제로서의 인다졸 화합물
IL294895B2 (en) 2014-01-13 2023-10-01 Aurigene Oncology Ltd History of bicyclic heterocyclyls as IRAK4 inhibitors
SG11201608110WA (en) 2014-04-04 2016-10-28 Pfizer Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors
CA2945819A1 (en) 2014-04-22 2015-10-29 Nimbus Iris, Inc. Irak inhibitors and uses thereof
CA2952188A1 (en) 2014-06-20 2015-12-23 Aurigene Discovery Technologies Limited Substituted indazole compounds as irak4 inhibitors
WO2016011390A1 (en) 2014-07-18 2016-01-21 Biogen Ma Inc. Irak4 inhibiting agents
US9926330B2 (en) 2014-09-30 2018-03-27 Merck Sharp & Dohme Corp. Inhibitors of IRAK4 activity
WO2016053772A1 (en) 2014-09-30 2016-04-07 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
EP3200787B1 (en) 2014-09-30 2019-09-04 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
WO2016053770A1 (en) 2014-09-30 2016-04-07 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
RU2743718C2 (ru) 2014-11-20 2021-02-24 Мерк Патент Гмбх Гетероарильные соединения в качестве ингибиторов irak и их применения
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
KR20170109546A (ko) 2015-02-05 2017-09-29 메르크 파텐트 게엠베하 Irak1/4 억제제로서의 매크로시클릭 화합물 및 이들의 용도
CA2970550C (en) 2015-02-06 2023-09-19 Merck Patent Gmbh Pyridazinone macrocycles as irak inhibitors and uses thereof
EP3267996B1 (en) 2015-03-12 2020-11-11 Merck Sharp & Dohme Corp. Pyrazolopyrimidine inhibitors of irak4 activity
WO2016144847A1 (en) 2015-03-12 2016-09-15 Merck Sharp & Dohme Corp. Pyrrolopyridazine inhibitors of irak4 activity
WO2016144849A1 (en) 2015-03-12 2016-09-15 Merck Sharp & Dohme Corp. Thienopyrazine inhibitors of irak4 activity
EP3268006B1 (en) 2015-03-12 2020-01-08 Merck Sharp & Dohme Corp. Pyrrolotriazine inhibitors of irak4 activity
EP3268367B8 (en) 2015-03-12 2022-11-16 Merck Sharp & Dohme LLC Carboxamide inhibitors of irak4 activity
LT3286181T (lt) 2015-04-22 2021-04-26 Rigel Pharmaceuticals, Inc. Pirazolo junginiai ir junginių gamybos bei naudojimo būdas
WO2016174183A1 (en) 2015-04-30 2016-11-03 Bayer Pharma Aktiengesellschaft Combinations of inhibitors of irak4 with inhibitors of btk
WO2016210036A1 (en) * 2015-06-24 2016-12-29 Bristol-Myers Squibb Company Heteroaryl substituted aminopyridine compounds
AR105113A1 (es) 2015-06-24 2017-09-06 Bristol Myers Squibb Co Compuestos de aminopiridina sustituida con heteroarilo
ES2822956T3 (es) 2015-06-24 2021-05-05 Bristol Myers Squibb Co Compuestos de aminopiridina sustituidos con heteroarilo
WO2017004134A1 (en) 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2017004133A1 (en) 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
BR112018000635A2 (pt) 2015-07-15 2018-09-18 Aurigene Discovery Tech Ltd compostos aza substituídos como inibidores irak-4
EA201890307A1 (ru) 2015-07-15 2018-10-31 Ориджин Дискавери Текнолоджиз Лимитед Индазольные и азаиндазольные соединения как ингибиторы irak-4
EP3331879B1 (en) 2015-08-04 2020-05-20 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
ES2901349T3 (es) 2015-08-04 2022-03-22 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Derivado de pirazol pirimidina y usos del mismo
KR102048719B1 (ko) 2015-08-13 2019-11-26 베이징 한미 파마슈티컬 컴퍼니 리미티드 Irak4억제제 및 이의 용도
BR112018002071A2 (pt) 2015-08-13 2018-09-18 Pfizer compostos heteroarílicos ou arílicos fundidos bicíclicos
WO2017024589A1 (zh) 2015-08-13 2017-02-16 北京韩美药品有限公司 Irak4抑制剂及其应用
LT3341367T (lt) 2015-08-27 2021-04-26 Pfizer Inc. Biciklinis sulietas heteroarilas arba arilo junginiai kaip irak4 moduliatoriai
AU2016323612B2 (en) 2015-09-18 2021-04-08 Merck Patent Gmbh Heteroaryl compounds as IRAK inhibitors and uses thereof
CA2996318C (en) 2015-09-18 2023-10-10 Merck Patent Gmbh Heteroaryl compounds as irak inhibitors and uses thereof
GB201518456D0 (en) 2015-10-19 2015-12-02 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases
JP6895439B2 (ja) 2015-12-22 2021-06-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ＩＲＡＫ４調節因子としてのピラゾロ［１，５ａ］ピリミジン誘導体
WO2017108744A1 (de) 2015-12-22 2017-06-29 Bayer Pharma Aktiengesellschaft Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
EP3405465B1 (en) 2016-01-20 2021-10-13 Biogen MA Inc. Irak4 inhibiting agents
AU2017257211B2 (en) 2016-04-29 2021-05-27 Bayer Pharma Aktiengesellschaft Polymorphic form of N-{6-(2-Hydroxypropan-2-yl)-2-[2-(methylsulphonyl)ethyl]-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide
WO2017205762A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205769A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205766A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017207385A1 (de) 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Substituierte 3-methylindazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
CA3028997A1 (en) 2016-06-27 2018-01-04 Rigel Pharmaceuticals, Inc. 2,4-diamino-pyrimidine compounds and method for making and using the compounds
ES2946001T3 (es) 2016-10-26 2023-07-11 Rigel Pharmaceuticals Inc Compuestos de pirazol amida como inhibidores de IRAK
EP3535273A1 (en) 2016-11-02 2019-09-11 H. Hoffnabb-La Roche Ag PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Also Published As

Publication number Publication date
BR102018002879A2 (pt) 2018-10-30
SG11201906763RA (en) 2019-08-27
UA124548C2 (uk) 2021-10-05
DK3583105T3 (da) 2024-03-04
MX2023010197A (es) 2023-09-11
MX2019009840A (es) 2019-10-22
WO2018152368A1 (en) 2018-08-23
EP3583105B1 (en) 2024-02-07
IL267979B (en) 2022-07-01
KR20190115067A (ko) 2019-10-10
JP2023100791A (ja) 2023-07-19
TW202340194A (zh) 2023-10-16
UY37608A (es) 2018-09-28
MA47500B1 (fr) 2024-02-29
TW201840567A (zh) 2018-11-16
CR20190373A (es) 2019-10-17
CN110300754A (zh) 2019-10-01
IL267979A (en) 2019-09-26
EP3583105A1 (en) 2019-12-25
US10336762B2 (en) 2019-07-02
TW202140491A (zh) 2021-11-01
PT3583105T (pt) 2024-04-15
JP2021176902A (ja) 2021-11-11
AU2022228165A1 (en) 2022-09-29
AR110935A1 (es) 2019-05-15
AU2018221812B2 (en) 2022-06-16
JP2020507601A (ja) 2020-03-12
US20180230157A1 (en) 2018-08-16
AU2018221812A1 (en) 2019-08-08
KR102337055B1 (ko) 2021-12-07
ZA201905456B (en) 2021-09-29
MA47500A (fr) 2019-12-25
CA3050148A1 (en) 2018-08-23
TWI790674B (zh) 2023-01-21
CO2019008868A2 (es) 2019-08-20
JP6924267B2 (ja) 2021-08-25
TWI733982B (zh) 2021-07-21
FI3583105T3 (fi) 2024-02-16
JOP20180011A1 (ar) 2019-01-30
PH12019550128A1 (en) 2020-06-01
EA201991544A1 (ru) 2020-05-08
LT3583105T (lt) 2024-03-25
CL2019002306A1 (es) 2020-01-17
PE20191540A1 (es) 2019-10-23
DOP2019000214A (es) 2019-09-15
RS65397B1 (sr) 2024-04-30

Similar Documents

Publication Publication Date Title
SA519402462B1 (ar) مشتقات بيرولو[1، 2-b]بيريدازين
MX2022005827A (es) Derivados de pirazol como inhibidores de malt1.
PH12017501340A1 (en) 4h-pyrrolo[3,2-c]pyridin-4-one derivatives
PH12015501934B1 (en) New octahydro - pyrrolo [3,4-c] - pyrrole derivatives and analogs thereof as autotaxin inhibitors
AU2018258581A8 (en) RAF-degrading conjugate compounds
DK3880676T3 (da) 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-on-derivater som hpk1-inhibitorer til behandling af cancer
MY198004A (en) Antitumoral compounds
AU2017319080A1 (en) Pyrazolo[1,5-a]pyrimidine compound
MX2018001725A (es) Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3 -ona sustituida.
MY197244A (en) [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
EP3781142A4 (en) NEW [1.1.1] BICYCLO COMPOUNDS AS INDOLAMINE-2,3-DIOXYGENASE INHIBITORS
AU2015221431A8 (en) Novel 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione derivative compounds
WO2019088574A3 (ko) 알룰로스를 활용한 유통 중 미생물 안정성이 향상된 생면
UA99983U (ru) 2-амино-4-метил-7-оксо-9-фенил-3-циано-6,7,8,9-тетрагидропиридо[3',2'4,5]тиено[3,2-b]пиридин