SA517381713B1 - تركيبة أطلاق معدلة من الأورليستات والأكارابوز لعلاج السمنة واضطرابات التمثيل الغذائي ذات الصلة - Google Patents
تركيبة أطلاق معدلة من الأورليستات والأكارابوز لعلاج السمنة واضطرابات التمثيل الغذائي ذات الصلةInfo
- Publication number
- SA517381713B1 SA517381713B1 SA517381713A SA517381713A SA517381713B1 SA 517381713 B1 SA517381713 B1 SA 517381713B1 SA 517381713 A SA517381713 A SA 517381713A SA 517381713 A SA517381713 A SA 517381713A SA 517381713 B1 SA517381713 B1 SA 517381713B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- orlistat
- acarbose
- obesity
- treatment
- release composition
- Prior art date
Links
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 title abstract 6
- 229960002632 acarbose Drugs 0.000 title abstract 6
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 title abstract 6
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical group CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 title abstract 6
- 229960001243 orlistat Drugs 0.000 title abstract 6
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 208000030159 metabolic disease Diseases 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- -1 b) a second part Chemical compound 0.000 abstract 1
Classifications
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
تركيبة أطلاق معدلة من الأورليستات والأكارابوز لعلاج السمنة واضطرابات التمثيل الغذائي ذات الصلة A MODIFIED RELEASE COMPOSITION OF ORLISTAT AND ACARBOSE FOR THE TREATMENT OF OBESITY AND RELATED METABOLIC DISORDERS الملخـــص يتعلق هذا الاختراع بتركيبة الاطلاق مُعدلة modified-release composition تتضمن الأورليستات orlistat والأكارابوز acarbose، بما في ذلك أجزاء منفصلة على حدة مع نماذج اطلاق مختلفة different release patterns. أ) الجزء الأول، G1، يتضمن حوالي 5 إلى حوالي 70% وزن/وزن من الجرعة الكلية total dose للأكارابوز acarbose، ب) الجزء الثاني، G2A، يتضمن حوالي 30 إلى حوالي 95% وزن/وزن من الجرعة الكلية للأكارابوز acarbose، ج) الجزء الثالث، G2B، يتضمن حوالي 10 إلى حوالي 90% وزن/وزن من الجرعة الكلية للأوليستات orlistat ، و د) الجزء الرابع، G3، يتضمن حوالي 10 إلى حوالي 80% وزن/وزن من الجرعة الكلية للأورليستات orlistat ، ويكون التركيز الكلي للأكارابوز acarbose والأورليستات orlistat ، على التوالي، في التركيبة 100% وزن/وزن. الشكل 2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14198468 | 2014-12-17 |
Publications (1)
Publication Number | Publication Date |
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SA517381713B1 true SA517381713B1 (ar) | 2022-03-17 |
Family
ID=52146175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA517381713A SA517381713B1 (ar) | 2014-12-17 | 2017-06-12 | تركيبة أطلاق معدلة من الأورليستات والأكارابوز لعلاج السمنة واضطرابات التمثيل الغذائي ذات الصلة |
Country Status (28)
Country | Link |
---|---|
US (2) | US10561617B2 (ar) |
EP (3) | EP4364743A2 (ar) |
JP (1) | JP6607955B2 (ar) |
KR (2) | KR102094631B1 (ar) |
CN (1) | CN107405309B (ar) |
AU (1) | AU2015367422B2 (ar) |
BR (1) | BR112017012714B1 (ar) |
CA (1) | CA2970991C (ar) |
CL (1) | CL2017001574A1 (ar) |
CO (1) | CO2017005834A2 (ar) |
DK (1) | DK3233066T3 (ar) |
EA (1) | EA033448B1 (ar) |
EC (1) | ECSP17035750A (ar) |
ES (1) | ES2901122T3 (ar) |
HU (1) | HUE057093T2 (ar) |
IL (1) | IL252865B2 (ar) |
MX (3) | MX2017007493A (ar) |
MY (1) | MY195038A (ar) |
NZ (1) | NZ732241A (ar) |
PE (1) | PE20171243A1 (ar) |
PH (1) | PH12017550023A1 (ar) |
PL (1) | PL3233066T3 (ar) |
SA (1) | SA517381713B1 (ar) |
SG (1) | SG11201704470PA (ar) |
SI (1) | SI3233066T1 (ar) |
UA (1) | UA122403C2 (ar) |
WO (1) | WO2016097170A1 (ar) |
ZA (1) | ZA201704590B (ar) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016097170A1 (en) | 2014-12-17 | 2016-06-23 | Empros Pharma Ab | A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
JP6359234B2 (ja) * | 2016-06-09 | 2018-07-18 | Dsファーマアニマルヘルス株式会社 | 動物用徐放性製剤組成物 |
WO2020227437A1 (en) | 2019-05-06 | 2020-11-12 | Axial Biotherapeutics, Inc. | Sustained release solid dosage forms for modulating the colonic microbiome |
KR102508141B1 (ko) * | 2019-07-01 | 2023-03-10 | 주식회사 연세대학교 바이오헬스기술지주회사 | 하이드로겔 및 egfr 리간드를 유효성분으로 포함하는 당 배출용 조성물 |
ES2975442T3 (es) * | 2019-12-11 | 2024-07-05 | Evonik Operations Gmbh | Forma farmacéutica para su uso en el tratamiento o la prevención de una enfermedad |
CN111297826B (zh) * | 2020-04-20 | 2021-08-03 | 鲁南制药集团股份有限公司 | 一种稳定的奥利司他胶囊及其制备方法 |
WO2022154687A1 (ru) * | 2021-01-14 | 2022-07-21 | Общество C Ограниченной Ответственностью "Новамедика" | Фармацевтическая композиция, включающая эзомепразол |
WO2022243528A1 (en) | 2021-05-21 | 2022-11-24 | Empros Pharma Ab | Use of a composition comprising orlistat and acarbose to obtain a sustained weight loss |
EP4340811A1 (en) | 2021-05-21 | 2024-03-27 | Empros Pharma AB | Synergistic effects on weight loss, improved quality of life and gastro-intestinal side effects with a composition of orlistat and acarbose |
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DE19802700A1 (de) * | 1998-01-24 | 1999-07-29 | Bayer Ag | Verfahren zur Herstellung einer im Mund schnell zerfallenden Arzneiform, die als Wirkstoff Acarbose enthält |
US20060240105A1 (en) * | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
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