BR112018012343A2 - composições de benzofenonas poli-hidroxiladas e métodos de tratamento de distúrbios neurodegenerativos - Google Patents
composições de benzofenonas poli-hidroxiladas e métodos de tratamento de distúrbios neurodegenerativosInfo
- Publication number
- BR112018012343A2 BR112018012343A2 BR112018012343A BR112018012343A BR112018012343A2 BR 112018012343 A2 BR112018012343 A2 BR 112018012343A2 BR 112018012343 A BR112018012343 A BR 112018012343A BR 112018012343 A BR112018012343 A BR 112018012343A BR 112018012343 A2 BR112018012343 A2 BR 112018012343A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- neurodegenerative disorders
- treating neurodegenerative
- polyhydroxylated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
a presente invenção se refere a compostos de benzofenona poli-hidroxilada úteis no tratamento de doenças neurodegenerativas, neurológicas, psiquiátricas e cognitivas, em particular aquelas associadas a uma deficiência em atividade de hdac1 deacetilase.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562268899P | 2015-12-17 | 2015-12-17 | |
PCT/US2016/067592 WO2017106861A1 (en) | 2015-12-17 | 2016-12-19 | Compositions of polyhydroxylated benzophenones and methods of treatment of neurodegenerative disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018012343A2 true BR112018012343A2 (pt) | 2018-12-04 |
Family
ID=59057697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018012343A BR112018012343A2 (pt) | 2015-12-17 | 2016-12-19 | composições de benzofenonas poli-hidroxiladas e métodos de tratamento de distúrbios neurodegenerativos |
Country Status (13)
Country | Link |
---|---|
US (2) | US11180438B2 (pt) |
EP (1) | EP3390347A4 (pt) |
JP (1) | JP2019504827A (pt) |
KR (1) | KR20180101404A (pt) |
CN (1) | CN109071417A (pt) |
AU (1) | AU2016369642A1 (pt) |
BR (1) | BR112018012343A2 (pt) |
CA (1) | CA3008854A1 (pt) |
CL (1) | CL2018001633A1 (pt) |
IL (1) | IL260046A (pt) |
MX (1) | MX2018007458A (pt) |
RU (1) | RU2018126187A (pt) |
WO (1) | WO2017106861A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111393277B (zh) * | 2020-03-15 | 2023-01-03 | 山西医科大学 | 4-丁基多羟基二苯甲酮类化合物衍生物及其应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2257272B1 (pt) * | 1974-01-15 | 1978-08-25 | Pharmascience Labo | |
JPH02206A (ja) * | 1987-11-11 | 1990-01-05 | Fujisawa Pharmaceut Co Ltd | エキシホンと水溶性高分子化合物とを含有することを特徴とする新規製剤 |
ES2043766T3 (es) * | 1987-11-11 | 1994-01-01 | Pharmascience Lab | Una nueva composicion farmaceutica que comprende exifona y un polimero soluble en agua. |
US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
US20010047032A1 (en) * | 1999-12-30 | 2001-11-29 | Castillo Gerardo M. | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases |
US6777578B2 (en) | 2000-04-27 | 2004-08-17 | Arizona Board Of Regents | Hydroxyphenstatin and the prodrugs thereof |
GB0724989D0 (en) * | 2007-12-21 | 2008-01-30 | Univ Sheffield | Novel compounds |
CN102159203A (zh) * | 2008-07-23 | 2011-08-17 | 麻省理工学院 | 组蛋白脱乙酰酶1(hdac1)的活化防范dna损伤和增加神经元存活 |
JP6240063B2 (ja) * | 2011-04-28 | 2017-11-29 | ザ ブロード インスティテュート, インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
HUE042006T2 (hu) * | 2011-07-22 | 2019-06-28 | Massachusetts Inst Technology | Hiszton-dezacetilázok (HDACS) I osztályának aktivátorai és ezek alkalmazása |
WO2014127191A1 (en) * | 2013-02-15 | 2014-08-21 | The Regents Of The University Of Michigan | Compositions and methods relating to hindering dot1l recruitment by mll-fusion proteins |
ES2862126T3 (es) * | 2013-10-10 | 2021-10-07 | Acetylon Pharmaceuticals Inc | Compuestos de pirimidín-hidroxiamida como inhibidores de histona desacetilasa |
-
2016
- 2016-12-19 BR BR112018012343A patent/BR112018012343A2/pt not_active Application Discontinuation
- 2016-12-19 CA CA3008854A patent/CA3008854A1/en not_active Abandoned
- 2016-12-19 CN CN201680081835.1A patent/CN109071417A/zh active Pending
- 2016-12-19 JP JP2018532151A patent/JP2019504827A/ja active Pending
- 2016-12-19 EP EP16876929.7A patent/EP3390347A4/en not_active Withdrawn
- 2016-12-19 RU RU2018126187A patent/RU2018126187A/ru not_active Application Discontinuation
- 2016-12-19 WO PCT/US2016/067592 patent/WO2017106861A1/en active Application Filing
- 2016-12-19 MX MX2018007458A patent/MX2018007458A/es unknown
- 2016-12-19 KR KR1020187020548A patent/KR20180101404A/ko unknown
- 2016-12-19 AU AU2016369642A patent/AU2016369642A1/en not_active Abandoned
-
2018
- 2018-06-14 IL IL260046A patent/IL260046A/en unknown
- 2018-06-15 CL CL2018001633A patent/CL2018001633A1/es unknown
- 2018-06-15 US US16/010,030 patent/US11180438B2/en active Active
-
2020
- 2020-12-09 US US17/116,427 patent/US11639325B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20210171429A1 (en) | 2021-06-10 |
US11180438B2 (en) | 2021-11-23 |
EP3390347A1 (en) | 2018-10-24 |
CL2018001633A1 (es) | 2019-01-18 |
IL260046A (en) | 2018-07-31 |
RU2018126187A (ru) | 2020-01-20 |
WO2017106861A1 (en) | 2017-06-22 |
EP3390347A4 (en) | 2019-07-24 |
CN109071417A (zh) | 2018-12-21 |
JP2019504827A (ja) | 2019-02-21 |
AU2016369642A1 (en) | 2018-08-02 |
MX2018007458A (es) | 2018-11-29 |
US20200087236A9 (en) | 2020-03-19 |
US11639325B2 (en) | 2023-05-02 |
KR20180101404A (ko) | 2018-09-12 |
US20180290960A1 (en) | 2018-10-11 |
CA3008854A1 (en) | 2017-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |