RU97115880A - KALVULAN ACID SALTS - Google Patents
KALVULAN ACID SALTSInfo
- Publication number
- RU97115880A RU97115880A RU97115880/04A RU97115880A RU97115880A RU 97115880 A RU97115880 A RU 97115880A RU 97115880/04 A RU97115880/04 A RU 97115880/04A RU 97115880 A RU97115880 A RU 97115880A RU 97115880 A RU97115880 A RU 97115880A
- Authority
- RU
- Russia
- Prior art keywords
- salt
- clavulanic acid
- pharmaceutically acceptable
- benzhydrylamine
- organic solvent
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims 24
- 239000011780 sodium chloride Substances 0.000 title claims 24
- 239000002253 acid Substances 0.000 title 1
- HZZVJAQRINQKSD-PBFISZAISA-N Clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 claims 16
- 229960003324 Clavulanic Acid Drugs 0.000 claims 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical compound C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 claims 5
- 239000003960 organic solvent Substances 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 2
- -1 clavulanic acid ester Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002798 polar solvent Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N Dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 229940049954 Penicillin Drugs 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229960000626 benzylpenicillin Drugs 0.000 claims 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims 1
- 150000001780 cephalosporins Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000002132 β-lactam antibiotic Substances 0.000 claims 1
Claims (14)
где R1 и R2 независимо представляют собой атом водорода или фармацевтически приемлемый заместитель.1. Salt of clavulanic acid and benzhydrylamine of formula I
where R 1 and R 2 independently represent a hydrogen atom or a pharmaceutically acceptable substituent.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9503839.4 | 1995-02-25 | ||
GB9520915.1 | 1995-10-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU97115880A true RU97115880A (en) | 1999-07-20 |
Family
ID=
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