RU97100948A - Способ расщепления рацематов трамадола - Google Patents
Способ расщепления рацематов трамадолаInfo
- Publication number
- RU97100948A RU97100948A RU97100948/04A RU97100948A RU97100948A RU 97100948 A RU97100948 A RU 97100948A RU 97100948/04 A RU97100948/04 A RU 97100948/04A RU 97100948 A RU97100948 A RU 97100948A RU 97100948 A RU97100948 A RU 97100948A
- Authority
- RU
- Russia
- Prior art keywords
- tramadol
- racemates
- splitting
- enantiomer
- paragraphs
- Prior art date
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N Tramadol Chemical class COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title claims 8
- 229960004380 Tramadol Drugs 0.000 claims 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N (+)-tartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 3
- 235000011002 L(+)-tartaric acid Nutrition 0.000 claims 2
- 239000001358 L(+)-tartaric acid Substances 0.000 claims 2
- FEWJPZIEWOKRBE-LWMBPPNESA-N L-(+)-Tartaric acid Natural products OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000005712 crystallization Effects 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000012452 mother liquor Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 229960001367 tartaric acid Drugs 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
Claims (5)
1. Способ расщепления рацематов трамадола, отличающийся тем, что рацемическую соль трамадола переводят в основание, с помощью L-(+)-винной кислоты осаждением отделяют (-)-энантиомер трамадола и из маточного раствора осадка, полученного осаждением винной кислотой, высвобождением основания и последующим переводом в отличную от тартрата соль выделяют (+)-энантиомер трамадола.
2. Способ по п. 1, отличающийся тем, что применяют рацемический гидрохлорид трамадола.
3. Способ по одному или обоим пп. 1 - 2, отличающийся тем, что L-(+)-винную кислоту применяют в присутствии органического растворителя, предпочтительно в присутствии алифатического C1-C5-спирта.
4. Способ по одному или нескольким пп. 1 - 3, отличающийся тем, что (-)-энантиомер трамадола отделяют путем кристаллизации.
5. Способ по одному или нескольким пп. 1 - 4, отличающийся тем, что (-)- и (+)-энантиомеры трамадола выделяют в виде гидрохлорида.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19601745A DE19601745C1 (de) | 1996-01-19 | 1996-01-19 | Verfahren zur Racematspaltung von Tramadol |
| DE19601745.9 | 1996-01-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97100948A true RU97100948A (ru) | 1999-05-20 |
| RU2192407C2 RU2192407C2 (ru) | 2002-11-10 |
Family
ID=7783112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97100948/04A RU2192407C2 (ru) | 1996-01-19 | 1997-01-17 | Способ расщепления рацематов трамадола |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5723668A (ru) |
| EP (1) | EP0787715B1 (ru) |
| JP (1) | JPH09216858A (ru) |
| KR (1) | KR100505527B1 (ru) |
| CN (1) | CN1131203C (ru) |
| AR (1) | AR005391A1 (ru) |
| AT (1) | ATE189205T1 (ru) |
| AU (1) | AU711750B2 (ru) |
| BR (1) | BR9700094A (ru) |
| CA (1) | CA2195370C (ru) |
| CO (1) | CO4520185A1 (ru) |
| CZ (1) | CZ291775B6 (ru) |
| DE (2) | DE19601745C1 (ru) |
| DK (1) | DK0787715T3 (ru) |
| ES (1) | ES2145373T3 (ru) |
| GR (1) | GR3032489T3 (ru) |
| HU (1) | HU223067B1 (ru) |
| IL (1) | IL120028A (ru) |
| IN (1) | IN182218B (ru) |
| MY (1) | MY116583A (ru) |
| NO (1) | NO306059B1 (ru) |
| NZ (1) | NZ299999A (ru) |
| PE (1) | PE29898A1 (ru) |
| PL (1) | PL187403B1 (ru) |
| PT (1) | PT787715E (ru) |
| RU (1) | RU2192407C2 (ru) |
| SI (1) | SI0787715T1 (ru) |
| SK (1) | SK281612B6 (ru) |
| UA (1) | UA45343C2 (ru) |
| UY (1) | UY24439A1 (ru) |
| ZA (1) | ZA97369B (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2130079B1 (es) | 1997-07-10 | 2000-01-16 | Esteve Labor Dr | Resolucion de aminas |
| EP0996613B1 (en) * | 1997-07-15 | 2002-10-30 | Russinsky Limited | Pure cis-tramadol hydrochloride production |
| DE19821039A1 (de) | 1998-05-11 | 1999-11-18 | Bayer Ag | Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan |
| GB9826540D0 (en) | 1998-12-02 | 1999-01-27 | Darwin Discovery Ltd | Process |
| KR100342919B1 (ko) * | 1999-10-21 | 2002-07-04 | 박노중 | 트랜스체 염산 트라마돌의 분리 제조방법 |
| BR0114395A (pt) * | 2000-10-03 | 2005-08-16 | Penwest Pharmaceuticals Compan | Composição farmacêutica para administração por suprimento via oral |
| DE10108122A1 (de) | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Arzneimittel auf Basis von Tramadol |
| PT1397126E (pt) * | 2001-03-16 | 2006-10-31 | Dmi Biosciences Inc | Utilizacao de tramadol para retardar a ejaculacao |
| US6649783B2 (en) * | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
| WO2003048113A1 (en) | 2001-11-30 | 2003-06-12 | Sepracor Inc. | Tramadol analogs and uses thereof |
| US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| CN102718748B (zh) | 2005-01-26 | 2016-06-22 | 阿勒根公司 | 具有镇痛活性和/或免疫刺激物活性的化合物 |
| EP1785412A1 (en) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Tramadol recovery process |
| ES2384481T3 (es) * | 2007-02-12 | 2012-07-05 | Dmi Biosciences, Inc. | Tratamiento de la eyaculación precoz y la disfunción eréctil co-morbidas |
| CN101674728A (zh) | 2007-02-12 | 2010-03-17 | Dmi生物科学公司 | 降低曲马多的副作用 |
| DE102013009114A1 (de) | 2013-05-29 | 2014-12-04 | Franz Gerstheimer | Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen |
| KR102136004B1 (ko) | 2018-06-18 | 2020-07-22 | (주)센텍코리아 | 감지부의 잔존 수명을 추정할 수 있는 음주측정기 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2528267A (en) * | 1950-10-31 | Eobeet j | ||
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| IL50080A (en) * | 1975-07-29 | 1979-07-25 | Beecham Group Ltd | 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation |
| JPH06122686A (ja) * | 1992-10-12 | 1994-05-06 | Fujisawa Pharmaceut Co Ltd | ラセミ体の光学分割法 |
-
1996
- 1996-01-19 DE DE19601745A patent/DE19601745C1/de not_active Expired - Fee Related
- 1996-11-22 MY MYPI96004865A patent/MY116583A/en unknown
- 1996-12-18 PE PE1996000930A patent/PE29898A1/es not_active Application Discontinuation
- 1996-12-21 DE DE59604295T patent/DE59604295D1/de not_active Expired - Lifetime
- 1996-12-21 PT PT96120726T patent/PT787715E/pt unknown
- 1996-12-21 AT AT96120726T patent/ATE189205T1/de active
- 1996-12-21 SI SI9630150T patent/SI0787715T1/xx unknown
- 1996-12-21 ES ES96120726T patent/ES2145373T3/es not_active Expired - Lifetime
- 1996-12-21 DK DK96120726T patent/DK0787715T3/da active
- 1996-12-21 EP EP96120726A patent/EP0787715B1/de not_active Expired - Lifetime
- 1996-12-23 NZ NZ299999A patent/NZ299999A/en not_active IP Right Cessation
- 1996-12-30 CO CO96068520A patent/CO4520185A1/es unknown
- 1996-12-31 US US08/775,396 patent/US5723668A/en not_active Expired - Lifetime
-
1997
- 1997-01-07 AR ARP970100069A patent/AR005391A1/es active IP Right Grant
- 1997-01-09 IN IN45CA1997 patent/IN182218B/en unknown
- 1997-01-10 UY UY24439A patent/UY24439A1/es not_active IP Right Cessation
- 1997-01-14 BR BR9700094A patent/BR9700094A/pt not_active Application Discontinuation
- 1997-01-16 HU HU9700141A patent/HU223067B1/hu not_active IP Right Cessation
- 1997-01-16 ZA ZA9700369A patent/ZA97369B/xx unknown
- 1997-01-17 UA UA97010175A patent/UA45343C2/uk unknown
- 1997-01-17 IL IL12002897A patent/IL120028A/xx not_active IP Right Cessation
- 1997-01-17 RU RU97100948/04A patent/RU2192407C2/ru not_active IP Right Cessation
- 1997-01-17 PL PL97318003A patent/PL187403B1/pl not_active IP Right Cessation
- 1997-01-17 CN CN97102069A patent/CN1131203C/zh not_active Expired - Fee Related
- 1997-01-17 CA CA002195370A patent/CA2195370C/en not_active Expired - Fee Related
- 1997-01-17 SK SK68-97A patent/SK281612B6/sk not_active IP Right Cessation
- 1997-01-17 KR KR1019970001203A patent/KR100505527B1/ko not_active IP Right Cessation
- 1997-01-17 NO NO970211A patent/NO306059B1/no not_active IP Right Cessation
- 1997-01-17 JP JP9006903A patent/JPH09216858A/ja active Pending
- 1997-01-17 AU AU12232/97A patent/AU711750B2/en not_active Ceased
- 1997-01-17 CZ CZ1997156A patent/CZ291775B6/cs not_active IP Right Cessation
-
2000
- 2000-01-27 GR GR20000400183T patent/GR3032489T3/el unknown
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