RU94039542A - Производные пиперазина как антагонисты 5-нт-рецепторов, способ получения, фармацевтическая композиция - Google Patents

Производные пиперазина как антагонисты 5-нт-рецепторов, способ получения, фармацевтическая композиция

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Publication number
RU94039542A
RU94039542A RU94039542/04A RU94039542A RU94039542A RU 94039542 A RU94039542 A RU 94039542A RU 94039542/04 A RU94039542/04 A RU 94039542/04A RU 94039542 A RU94039542 A RU 94039542A RU 94039542 A RU94039542 A RU 94039542A
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RU
Russia
Prior art keywords
synthesis
piperazine
derivatives
pharmaceutical composition
receptor antagonists
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Application number
RU94039542/04A
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English (en)
Other versions
RU2128653C1 (ru
Inventor
Энтони Клифф Ян
Gb]
Original Assignee
Джон Вайс Энд Бразер Лимитед (Gb)
Джон Вайс энд Бразер Лимитед
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Application filed by Джон Вайс Энд Бразер Лимитед (Gb), Джон Вайс энд Бразер Лимитед filed Critical Джон Вайс Энд Бразер Лимитед (Gb)
Publication of RU94039542A publication Critical patent/RU94039542A/ru
Application granted granted Critical
Publication of RU2128653C1 publication Critical patent/RU2128653C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Они являются антагонистами 5-HT, которые могут быть использованы, например, для лечения страха.

Claims (1)

  1. Они являются антагонистами 5-HTIA, которые могут быть использованы, например, для лечения страха.
RU94039542A 1992-01-08 1992-12-24 Производные пиперазина, способ их получения и фармацевтическая композиция RU2128653C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9200293.0 1992-01-08
GB929200293A GB9200293D0 (en) 1992-01-08 1992-01-08 Piperazine derivatives
PCT/GB1992/002399 WO1993014076A1 (en) 1992-01-08 1992-12-24 Piperazine derivatives as 5-ht receptors antagonists

Publications (2)

Publication Number Publication Date
RU94039542A true RU94039542A (ru) 1996-08-10
RU2128653C1 RU2128653C1 (ru) 1999-04-10

Family

ID=10708249

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94039542A RU2128653C1 (ru) 1992-01-08 1992-12-24 Производные пиперазина, способ их получения и фармацевтическая композиция

Country Status (21)

Country Link
US (1) US5532242A (ru)
EP (1) EP0620817B1 (ru)
JP (1) JP3274865B2 (ru)
KR (1) KR100283345B1 (ru)
AT (1) ATE183504T1 (ru)
AU (1) AU668901B2 (ru)
BR (1) BR9207030A (ru)
CA (1) CA2125182A1 (ru)
DE (1) DE69229834T2 (ru)
ES (1) ES2134835T3 (ru)
FI (1) FI106200B (ru)
GB (2) GB9200293D0 (ru)
HU (1) HUT70513A (ru)
IL (1) IL104305A (ru)
MX (1) MX9300031A (ru)
NZ (1) NZ246205A (ru)
PH (1) PH30268A (ru)
RU (1) RU2128653C1 (ru)
TW (1) TW265337B (ru)
WO (1) WO1993014076A1 (ru)
ZA (1) ZA93141B (ru)

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US7731940B2 (en) 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors
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CN101861316B (zh) * 2007-11-14 2013-08-21 奥梅-杨森制药有限公司 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
RU2517181C2 (ru) 2008-10-16 2014-05-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
BRPI0921333A2 (pt) 2008-11-28 2015-12-29 Addex Pharmaceuticals Sa derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
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Also Published As

Publication number Publication date
AU3169793A (en) 1993-08-03
RU2128653C1 (ru) 1999-04-10
IL104305A (en) 1998-04-05
GB2263110A (en) 1993-07-14
FI943247A0 (fi) 1994-07-07
DE69229834D1 (de) 1999-09-23
DE69229834T2 (de) 2000-01-13
JPH07502739A (ja) 1995-03-23
GB2263110B (en) 1995-08-09
US5532242A (en) 1996-07-02
ZA93141B (en) 1994-07-08
MX9300031A (es) 1993-07-01
KR100283345B1 (ko) 2001-03-02
ATE183504T1 (de) 1999-09-15
JP3274865B2 (ja) 2002-04-15
EP0620817A1 (en) 1994-10-26
CA2125182A1 (en) 1993-07-22
HU9402042D0 (en) 1994-09-28
NZ246205A (en) 1996-12-20
FI106200B (fi) 2000-12-15
BR9207030A (pt) 1995-12-05
GB9227001D0 (en) 1993-02-17
PH30268A (en) 1997-02-20
WO1993014076A1 (en) 1993-07-22
GB9200293D0 (en) 1992-02-26
ES2134835T3 (es) 1999-10-16
TW265337B (ru) 1995-12-11
IL104305A0 (en) 1993-05-13
FI943247A (fi) 1994-07-07
AU668901B2 (en) 1996-05-23
EP0620817B1 (en) 1999-08-18
HUT70513A (en) 1995-10-30

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