RU93028444A - Способ получения алкилпиперазинил-гетероциклических соединений - Google Patents

Способ получения алкилпиперазинил-гетероциклических соединений

Info

Publication number
RU93028444A
RU93028444A RU93028444/04A RU93028444A RU93028444A RU 93028444 A RU93028444 A RU 93028444A RU 93028444/04 A RU93028444/04 A RU 93028444/04A RU 93028444 A RU93028444 A RU 93028444A RU 93028444 A RU93028444 A RU 93028444A
Authority
RU
Russia
Prior art keywords
obtaining
alkylpiperasinyl
heterocyclic compounds
formula
containing compound
Prior art date
Application number
RU93028444/04A
Other languages
English (en)
Other versions
RU2061695C1 (ru
Inventor
Боулс Поль
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/936,179 external-priority patent/US5206366A/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of RU93028444A publication Critical patent/RU93028444A/ru
Application granted granted Critical
Publication of RU2061695C1 publication Critical patent/RU2061695C1/ru

Links

Claims (1)

  1. Способ получения соединения формулы
    Figure 00000001

    или его фармацевтически приемлемой кислотно-аддитивной соли, включающей взаимодействие пиперазина формулы
    Figure 00000002

    с алкилгалогенид-содержащим соединением формулы
    Figure 00000003

    в воде с реагентом нейтрализации галоидводородной кислоты и нагревание смеси в условиях, подходящих для реакции сочетания указанного пиперазина с алкилгалогенид-содержащим соединением.
RU9393028444A 1992-08-26 1993-05-28 Способ получения арилпиперазинил-гетероциклических соединений или их фармацевтически приемлемой кислотно-аддитивной соли RU2061695C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US936,179 1992-08-26
US07/936,179 US5206366A (en) 1992-08-26 1992-08-26 Process for preparing aryl piperazinyl-heterocyclic compounds
US936179 1992-08-26

Publications (2)

Publication Number Publication Date
RU93028444A true RU93028444A (ru) 1996-01-27
RU2061695C1 RU2061695C1 (ru) 1996-06-10

Family

ID=25468285

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9393028444A RU2061695C1 (ru) 1992-08-26 1993-05-28 Способ получения арилпиперазинил-гетероциклических соединений или их фармацевтически приемлемой кислотно-аддитивной соли

Country Status (27)

Country Link
US (1) US5206366A (ru)
EP (2) EP1029861B1 (ru)
JP (1) JP2742370B2 (ru)
KR (1) KR0123441B1 (ru)
CN (1) CN1033089C (ru)
AT (2) ATE206422T1 (ru)
AU (1) AU642836B1 (ru)
BR (1) BR9302065A (ru)
CZ (1) CZ281893B6 (ru)
DE (2) DE69333597T2 (ru)
DK (2) DK1029861T3 (ru)
EG (1) EG20214A (ru)
ES (2) ES2225015T3 (ru)
FI (1) FI111641B (ru)
HU (1) HU223312B1 (ru)
IL (1) IL105622A (ru)
MX (1) MX9302813A (ru)
MY (1) MY109731A (ru)
NO (1) NO300685B1 (ru)
NZ (1) NZ247539A (ru)
PL (1) PL173840B1 (ru)
PT (2) PT1029861E (ru)
RU (1) RU2061695C1 (ru)
SI (1) SI9300287A (ru)
SK (1) SK280584B6 (ru)
YU (1) YU48964B (ru)
ZA (1) ZA936225B (ru)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338846A (en) * 1992-08-26 1994-08-16 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5359068A (en) * 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one
HUP9802492A3 (en) * 1995-06-06 1999-10-28 Hoechst Marion Roussel Inc Cin Benzisoxazole and indazole derivatives as antipsychotic agents, process for their preparation and pharmaceutical compositions containing the same
TW491847B (en) * 1996-05-07 2002-06-21 Pfizer Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
KR100333214B1 (ko) * 1996-05-07 2002-06-20 디. 제이. 우드, 스피겔 알렌 제이 5-(2-(4-(1,2-벤즈이소티아졸-3-일)-1-피페라지닐)에틸)-6-클로로-1,3-디하이드로-2(1에이치)인돌-2-온(지프라시돈)의메실레이트트리하이드레이트염,이의제조방법및도파민디2길항물질로서의이의용도
US5945421A (en) * 1997-08-11 1999-08-31 Warner-Lambert Company Dopamine D4 receptor antagonists
US6040448A (en) * 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
KR20010041625A (ko) * 1998-03-06 2001-05-25 아스트라제네카 악티에볼라그 신규 용도
US6150366A (en) * 1998-06-15 2000-11-21 Pfizer Inc. Ziprasidone formulations
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
UY27668A1 (es) 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
KR20050057404A (ko) * 2002-09-17 2005-06-16 워너-램버트 캄파니 엘엘씨 정신분열증 치료용 헤테로환 치환된 피페라진
ES2297200T3 (es) * 2002-10-24 2008-05-01 Pfizer Products Inc. Derivados de acilo de 5-(2-(4-(1,2 bencisotiazol-3-il)-1-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-ona que presentan actividad neuroleptica.
BR0316108A (pt) * 2002-11-08 2005-09-27 Warner Lambert Co Derivados de fenilalquil e piridilalquil piperazina e composição farmacêutica compreendendo os mesmos
WO2004050655A1 (en) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride
US7488729B2 (en) 2002-12-04 2009-02-10 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
CN1255105C (zh) * 2002-12-17 2006-05-10 上海医药工业研究院 齐拉西酮及其盐的水溶性包合物及其制备方法
US20050143396A1 (en) * 2003-04-11 2005-06-30 Hertero Drugs Limited Novel crystalline forms of ziprasidone hydrochloride
EP1530570A2 (en) * 2003-06-03 2005-05-18 Teva Pharmaceutical Industries Limited CRISTALLINE ZIPRASIDONE HCl AND PROCESSES FOR PREPARATION THEREOF
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
US7667037B2 (en) 2003-10-24 2010-02-23 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
CA2550485A1 (en) * 2003-12-18 2005-07-07 Teva Pharmaceutical Industries Ltd. Polymorphic form b2 of ziprasidone base
WO2005085240A2 (en) * 2004-02-27 2005-09-15 Ranbaxy Laboratories Limited Process for the preparation of ziprasidone
ITMI20040944A1 (it) * 2004-05-11 2004-08-11 Dinamite Dipharma S P A In For Polimorfo di ziprasidone cloridrato e procedimento per la sua preparazione
CA2467538C (en) * 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
CA2471219A1 (en) * 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
US7728136B2 (en) 2004-06-18 2010-06-01 Lupin Limited Method for the preparation of aryl piperazinyl-heterocyclic compounds
WO2006026426A2 (en) * 2004-08-27 2006-03-09 University Of Kentucky Research Foundation Amyloid peptide inactivating enzyme to treat alzheimer’s disease peripherally
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
ES2250000B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Procedimiento para la preparacion de ziprasidona.
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
WO2006086779A1 (en) * 2005-02-11 2006-08-17 Teva Pharmaceutical Industries Ltd. Amorphous ziprasidone mesylate
WO2006099452A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Anhydrous ziprasidone mesylate and a process for its preparation
CA2599391A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
EA200701856A1 (ru) * 2005-04-01 2008-02-28 Уорнер-Ламберт Компани Ллс Тетрагидропиридоазепин-8-оны и родственные соединения для лечения шизофрении
HU230479B1 (hu) * 2006-05-02 2016-07-28 Richter Gedeon Nyrt. Eljárás 5-{2-[4-(1,2-benzizotiazol-3-il)-1-piperazinil]-etil}-6-klór-1,3-dihidro-2H-indol-2-on (Ziprasidon) előállítására
HUP0600868A3 (en) * 2006-11-24 2009-03-30 Richter Gedeon Nyrt 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation
WO2009116085A2 (en) * 2008-03-11 2009-09-24 Alkem Laboratories Ltd. An improved process for the preparation of ziprasidone
WO2011143430A1 (en) 2010-05-12 2011-11-17 Abbott Laboratories Indazole inhibitors of kinase
PL391810A1 (pl) 2010-07-14 2012-01-16 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Nowe sole ziprasidonu oraz sposoby ich otrzymywania
WO2012020424A1 (en) 2010-08-12 2012-02-16 Arch Pharmalabs Limited A short process for the preparation of ziprasidone and intermediates thereof
SI23610A (sl) 2011-01-13 2012-07-31 Diagen@d@o@o Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610988A (en) * 1982-04-09 1986-09-09 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted)piperazines useful for alleviating pain
FR2536749A1 (fr) * 1982-11-25 1984-06-01 Cerm Cent Europ Rech Mauvernay (amino-2 ethyl)-6 benzoxazolinones substituees, leur preparation et leurs applications en therapeutique
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5312925A (en) * 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride

Similar Documents

Publication Publication Date Title
RU93028444A (ru) Способ получения алкилпиперазинил-гетероциклических соединений
ES2161703T3 (es) Procedimiento para preparar compuestos heterociclicos de aril-piperazinilo.
ATE15362T1 (de) Neue dibenzoyl-methan-derivate, verfahren zu ihrer herstellung und ihre verwendung.
RU93005057A (ru) Фармацевтические соединения, производные тиенобензодиазепина, способ их получения, фармкомпозиция и их использование
RU93041055A (ru) Новые 4-арилпиперазины и 4-арилпиперидины
ATE110354T1 (de) Colloidale dispersionen einer cärium-iv- verbindung in wässrigem medium und verfahren zu deren gewinnung.
RU93005256A (ru) ПРОИЗВОДНЫЕ ЦИКЛОПЕПТАН-И ПЕНТЕН- β -АМИНОКИСЛОТ И ИХ СОЛИ, СПОСОБ ИХ ПОЛУЧЕНИЯ И АНТИБАКТЕРИАЛЬНОЕ СРЕДСТВО
FR2424904A1 (fr) Procede de preparation d'amides a, b-insatures, n-substitues
ZA836450B (en) 2-nitro-1,1-ethenediamines and processes for their preparation
RU97117101A (ru) Способ получения 1,2-бензизотиазолин-3-онов
DE59707004D1 (de) Verfahren zur Herstellung von 2-substituierten 5-Chlorimidazol-4-carbaldehyden
JPS57179146A (en) Amidine compound
DE3360063D1 (en) Para-sulpho-phenyl amides of cinnamic acid, or salts thereof, process for their preparation and their use as sun-screening agents
GR79822B (ru)
DE3469527D1 (en) Nortropine derivative, process for its preparation and its use
RU92014575A (ru) Замещенные фенилсульфенилтриазинилмочевины и их соли
RU93047054A (ru) Замещенные (гетеро)-арильные соединения, способ их получения, содержащие их средства и их применение в качестве антидотов
JPS57126482A (en) Sulfonyl piperazine derivative
RU95113184A (ru) Производные замещенных 1-(7-хлорхиноин-4 -ил)пиразол-3- карбоксамид-n-оксидов, способ их получения и фармацевтическая композиция на их основе
RU93016350A (ru) Способ получения урендопроизводных пенициллина или цефалоспорина
JPS56127367A (en) 1,5-benzothiazepine derivative and its salts
RU97100074A (ru) Способ получения 2-замещенных-5-хлоримидазол-4-карбальдегидов
IT8420625A0 (it) Procedimento migliorato per lapreparazione di composti di coordinazione fra bis-etiliden-ditiocarbammato di manganese e sali di zinco.
RU96100879A (ru) 7-алкокси-8,9-дигидроксантилиевые соли и способ их получения
RU97115645A (ru) Способ получения несимметричных порфиразинов