ES2161703T3 - Procedimiento para preparar compuestos heterociclicos de aril-piperazinilo. - Google Patents
Procedimiento para preparar compuestos heterociclicos de aril-piperazinilo.Info
- Publication number
- ES2161703T3 ES2161703T3 ES93303576T ES93303576T ES2161703T3 ES 2161703 T3 ES2161703 T3 ES 2161703T3 ES 93303576 T ES93303576 T ES 93303576T ES 93303576 T ES93303576 T ES 93303576T ES 2161703 T3 ES2161703 T3 ES 2161703T3
- Authority
- ES
- Spain
- Prior art keywords
- ary
- piperazinyl
- prepare
- procedure
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Lubricants (AREA)
- Eye Examination Apparatus (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Abstract
UN PROCESO PARA PREPARAR COMPUESTOS DE LA FORMULA, O UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE, QUE COMPRENDE LA REACCION DE UNA PIPERACINA DE LA FORMULA, CON UN HALURO DE ALQUILO, CONTENIENDO COMPUESTO DE LA FORMULA, EN AGUA CON UN REACTIVO PARA NEUTRALIZAR EL ACIDO HIDROHALICO Y CALENTAR LA MEZCLA EN CONDICIONES QUE SON ADECUADAS PARA EJECUTAR EL ACOPLAMIENTO DE LA CITADA PIPERACINA CON EL CITADO COMPUESTO QUE CONTIENE HALURO DE ALQUILO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/936,179 US5206366A (en) | 1992-08-26 | 1992-08-26 | Process for preparing aryl piperazinyl-heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2161703T3 true ES2161703T3 (es) | 2001-12-16 |
Family
ID=25468285
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93303576T Expired - Lifetime ES2161703T3 (es) | 1992-08-26 | 1993-05-07 | Procedimiento para preparar compuestos heterociclicos de aril-piperazinilo. |
ES00201940T Expired - Lifetime ES2225015T3 (es) | 1992-08-26 | 1993-05-07 | Derivado de benzisotiazol-piperazinil y su uso como neuroleptico. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00201940T Expired - Lifetime ES2225015T3 (es) | 1992-08-26 | 1993-05-07 | Derivado de benzisotiazol-piperazinil y su uso como neuroleptico. |
Country Status (27)
Country | Link |
---|---|
US (1) | US5206366A (es) |
EP (2) | EP1029861B1 (es) |
JP (1) | JP2742370B2 (es) |
KR (1) | KR0123441B1 (es) |
CN (1) | CN1033089C (es) |
AT (2) | ATE273976T1 (es) |
AU (1) | AU642836B1 (es) |
BR (1) | BR9302065A (es) |
CZ (1) | CZ281893B6 (es) |
DE (2) | DE69333597T2 (es) |
DK (2) | DK1029861T3 (es) |
EG (1) | EG20214A (es) |
ES (2) | ES2161703T3 (es) |
FI (1) | FI111641B (es) |
HU (1) | HU223312B1 (es) |
IL (1) | IL105622A (es) |
MX (1) | MX9302813A (es) |
MY (1) | MY109731A (es) |
NO (1) | NO300685B1 (es) |
NZ (1) | NZ247539A (es) |
PL (1) | PL173840B1 (es) |
PT (2) | PT584903E (es) |
RU (1) | RU2061695C1 (es) |
SI (1) | SI9300287A (es) |
SK (1) | SK280584B6 (es) |
YU (1) | YU48964B (es) |
ZA (1) | ZA936225B (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206366A (en) * | 1992-08-26 | 1993-04-27 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds |
US5338846A (en) * | 1992-08-26 | 1994-08-16 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt |
US5359068A (en) * | 1993-06-28 | 1994-10-25 | Pfizer Inc. | Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one |
MX9709451A (es) * | 1995-06-06 | 1998-02-28 | Hoechst Marion Roussel Inc | Derivados de benzisoxazol e indazol como agentes antipsicoticos. |
IL126590A (en) * | 1996-05-07 | 2001-11-25 | Pfizer | Trihydrate salt of -5 (-2 (-4 (1 (2, 2-benzothiazole - 3yl) -1-piperazinyl) ethyl) - 6-chloro-1, 3-dihydro-2 (1H) - indole - 2On (= Ziprasidone) and pharmaceutical preparations containing it |
TW491847B (en) | 1996-05-07 | 2002-06-21 | Pfizer | Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one |
US5945421A (en) * | 1997-08-11 | 1999-08-31 | Warner-Lambert Company | Dopamine D4 receptor antagonists |
US6040448A (en) * | 1997-10-24 | 2000-03-21 | Neurogen Corporation | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands |
IL127497A (en) * | 1997-12-18 | 2002-07-25 | Pfizer Prod Inc | Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders |
CN100391455C (zh) * | 1998-03-06 | 2008-06-04 | 阿斯特拉曾尼卡有限公司 | 靛红和羟吲哚衍生物的制药用途 |
US6150366A (en) * | 1998-06-15 | 2000-11-21 | Pfizer Inc. | Ziprasidone formulations |
US6660858B2 (en) | 2001-03-28 | 2003-12-09 | Lion Bioscience Ag | 2-aminobenzoxazole derivatives and combinatorial libraries thereof |
UY27668A1 (es) * | 2002-02-20 | 2003-10-31 | Pfizer Prod Inc | Composición de ziprasidona y controles sintéticos |
US20040048876A1 (en) * | 2002-02-20 | 2004-03-11 | Pfizer Inc. | Ziprasidone composition and synthetic controls |
BR0314393A (pt) * | 2002-09-17 | 2005-07-19 | Warner Lambert Co | Piperazinas heterocìclicas substituìdas para o tratamento de esquizofrenia |
ES2297200T3 (es) * | 2002-10-24 | 2008-05-01 | Pfizer Products Inc. | Derivados de acilo de 5-(2-(4-(1,2 bencisotiazol-3-il)-1-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-ona que presentan actividad neuroleptica. |
WO2004041793A1 (en) * | 2002-11-08 | 2004-05-21 | Warner-Lambert Company Llc | Phenylalkyl and pyridylalkyl piperazine derivatives |
US7488729B2 (en) | 2002-12-04 | 2009-02-10 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof |
WO2004050655A1 (en) * | 2002-12-04 | 2004-06-17 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride |
CN1255105C (zh) * | 2002-12-17 | 2006-05-10 | 上海医药工业研究院 | 齐拉西酮及其盐的水溶性包合物及其制备方法 |
US20050143396A1 (en) * | 2003-04-11 | 2005-06-30 | Hertero Drugs Limited | Novel crystalline forms of ziprasidone hydrochloride |
CA2528192A1 (en) * | 2003-06-03 | 2005-02-24 | Teva Pharmaceutical Industries Ltd | Cristalline ziprasidone hcl and processes for preparation thereof |
US20050049295A1 (en) * | 2003-06-12 | 2005-03-03 | Dr. Reddy's Laboratories Limited | Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate |
US7160888B2 (en) * | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
US7667037B2 (en) | 2003-10-24 | 2010-02-23 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of ziprasidone |
EP1592688A2 (en) * | 2003-12-18 | 2005-11-09 | Teva Pharmaceutical Industries Ltd. | Polymorphic form b2 of ziprasidone base |
ES2334800T3 (es) * | 2004-02-27 | 2010-03-16 | Ranbaxy Laboratories Limited | Proceso para la preparacion de ziprasidona. |
ITMI20040944A1 (it) * | 2004-05-11 | 2004-08-11 | Dinamite Dipharma S P A In For | Polimorfo di ziprasidone cloridrato e procedimento per la sua preparazione |
CA2467538C (en) * | 2004-05-14 | 2010-08-24 | Apotex Pharmachem Inc. | New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same |
CA2471219A1 (en) * | 2004-06-14 | 2005-12-14 | Apotex Pharmachem Inc. | Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) |
US7728136B2 (en) | 2004-06-18 | 2010-06-01 | Lupin Limited | Method for the preparation of aryl piperazinyl-heterocyclic compounds |
US9044503B2 (en) * | 2004-08-27 | 2015-06-02 | University Of Kentucky Research Foundation | Amyloid peptide inactivating enzyme to treat alzheimer's disease peripherally |
ES2250000B1 (es) * | 2004-09-29 | 2007-06-01 | Medichem, S.A. | Procedimiento para la preparacion de ziprasidona. |
ES2250001B1 (es) * | 2004-09-29 | 2007-06-01 | Medichem, S.A. | Proceso para la purificacion de ziprasidona. |
US7777037B2 (en) * | 2004-10-27 | 2010-08-17 | Dr. Reddy's Laboratories Limited | Ziprasidone process |
CA2593497A1 (en) * | 2005-02-11 | 2006-08-17 | Judith Aronhime | Amorphous ziprasidone mesylate |
EP1858891A2 (en) * | 2005-03-14 | 2007-11-28 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of ziprasidone mesylate |
EP1858892A1 (en) * | 2005-03-14 | 2007-11-28 | Teva Pharmaceutical Industries Ltd | Anhydrous ziprasidone mesylate and a process for its preparation |
JP4109709B1 (ja) * | 2005-04-01 | 2008-07-02 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 統合失調症の治療のためのテトラヒドロ−ピリドアゼピン−8−オン及び関連化合物 |
HU230479B1 (hu) * | 2006-05-02 | 2016-07-28 | Richter Gedeon Nyrt. | Eljárás 5-{2-[4-(1,2-benzizotiazol-3-il)-1-piperazinil]-etil}-6-klór-1,3-dihidro-2H-indol-2-on (Ziprasidon) előállítására |
HUP0600868A3 (en) * | 2006-11-24 | 2009-03-30 | Richter Gedeon Nyrt | 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-6-chloro-1,3-dihydro-2h-indol-2-one hydrogen bromide polimorphs and process for their preparation |
US8410268B2 (en) * | 2008-03-11 | 2013-04-02 | Alkem Laboratories Limited | Process for the preparation of ziprasidone |
CA2799154A1 (en) | 2010-05-12 | 2011-11-17 | Abbvie Inc. | Indazole inhibitors of kinase |
PL391810A1 (pl) | 2010-07-14 | 2012-01-16 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Nowe sole ziprasidonu oraz sposoby ich otrzymywania |
WO2012020424A1 (en) | 2010-08-12 | 2012-02-16 | Arch Pharmalabs Limited | A short process for the preparation of ziprasidone and intermediates thereof |
SI23610A (sl) | 2011-01-13 | 2012-07-31 | Diagen@d@o@o | Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4610988A (en) * | 1982-04-09 | 1986-09-09 | Hoechst-Roussel Pharmaceuticals Inc. | 1-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(substituted)piperazines useful for alleviating pain |
FR2536749A1 (fr) * | 1982-11-25 | 1984-06-01 | Cerm Cent Europ Rech Mauvernay | (amino-2 ethyl)-6 benzoxazolinones substituees, leur preparation et leurs applications en therapeutique |
MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
US4883795A (en) * | 1988-01-22 | 1989-11-28 | Pfizer Inc. | Piperazinyl-heterocyclic compounds |
US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
US5206366A (en) * | 1992-08-26 | 1993-04-27 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds |
US5312925A (en) * | 1992-09-01 | 1994-05-17 | Pfizer Inc. | Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride |
-
1992
- 1992-08-26 US US07/936,179 patent/US5206366A/en not_active Expired - Lifetime
-
1993
- 1993-05-03 NZ NZ247539A patent/NZ247539A/xx not_active IP Right Cessation
- 1993-05-04 HU HU9301291A patent/HU223312B1/hu not_active IP Right Cessation
- 1993-05-04 FI FI932012A patent/FI111641B/fi active Protection Beyond IP Right Term
- 1993-05-05 AU AU38403/93A patent/AU642836B1/en not_active Ceased
- 1993-05-06 IL IL105622A patent/IL105622A/en not_active IP Right Cessation
- 1993-05-06 NO NO931656A patent/NO300685B1/no unknown
- 1993-05-07 DK DK00201940T patent/DK1029861T3/da active
- 1993-05-07 DK DK93303576T patent/DK0584903T3/da active
- 1993-05-07 PT PT93303576T patent/PT584903E/pt unknown
- 1993-05-07 AT AT00201940T patent/ATE273976T1/de active
- 1993-05-07 DE DE69333597T patent/DE69333597T2/de not_active Expired - Lifetime
- 1993-05-07 DE DE69330853T patent/DE69330853T2/de not_active Expired - Fee Related
- 1993-05-07 ES ES93303576T patent/ES2161703T3/es not_active Expired - Lifetime
- 1993-05-07 AT AT93303576T patent/ATE206422T1/de not_active IP Right Cessation
- 1993-05-07 EP EP00201940A patent/EP1029861B1/en not_active Expired - Lifetime
- 1993-05-07 ES ES00201940T patent/ES2225015T3/es not_active Expired - Lifetime
- 1993-05-07 MY MYPI93000857A patent/MY109731A/en unknown
- 1993-05-07 EP EP93303576A patent/EP0584903B1/en not_active Expired - Lifetime
- 1993-05-07 PT PT00201940T patent/PT1029861E/pt unknown
- 1993-05-12 CZ CZ93877A patent/CZ281893B6/cs not_active IP Right Cessation
- 1993-05-13 MX MX9302813A patent/MX9302813A/es not_active IP Right Cessation
- 1993-05-13 EG EG27793A patent/EG20214A/xx active
- 1993-05-14 SK SK485-93A patent/SK280584B6/sk not_active IP Right Cessation
- 1993-05-19 PL PL93299002A patent/PL173840B1/pl not_active IP Right Cessation
- 1993-05-26 BR BR9302065A patent/BR9302065A/pt not_active Application Discontinuation
- 1993-05-28 SI SI9300287A patent/SI9300287A/sl not_active IP Right Cessation
- 1993-05-28 RU RU9393028444A patent/RU2061695C1/ru not_active IP Right Cessation
- 1993-06-04 CN CN93106669A patent/CN1033089C/zh not_active Expired - Fee Related
- 1993-07-20 KR KR1019930013678A patent/KR0123441B1/ko not_active IP Right Cessation
- 1993-08-13 JP JP5201542A patent/JP2742370B2/ja not_active Expired - Lifetime
- 1993-08-25 YU YU56593A patent/YU48964B/sh unknown
- 1993-08-25 ZA ZA936225A patent/ZA936225B/xx unknown
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