RU2019139817A3 - - Google Patents

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RU2019139817A3
RU2019139817A3 RU2019139817A RU2019139817A RU2019139817A3 RU 2019139817 A3 RU2019139817 A3 RU 2019139817A3 RU 2019139817 A RU2019139817 A RU 2019139817A RU 2019139817 A RU2019139817 A RU 2019139817A RU 2019139817 A3 RU2019139817 A3 RU 2019139817A3
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Russia
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RU2019139817A
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
RU2019139817A 2017-05-10 2018-05-10 Микрочастицы с замедленным высвобождением и их суспензии для лекарственной терапии RU2019139817A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762504366P 2017-05-10 2017-05-10
US62/504,366 2017-05-10
US201762508355P 2017-05-18 2017-05-18
US62/508,355 2017-05-18
PCT/US2018/032167 WO2018209155A1 (en) 2017-05-10 2018-05-10 Extended release microparticles and suspensions thereof for medical therapy

Publications (2)

Publication Number Publication Date
RU2019139817A RU2019139817A (ru) 2021-06-10
RU2019139817A3 true RU2019139817A3 (ru) 2021-09-20

Family

ID=64095930

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019139817A RU2019139817A (ru) 2017-05-10 2018-05-10 Микрочастицы с замедленным высвобождением и их суспензии для лекарственной терапии

Country Status (10)

Country Link
US (4) US11160870B2 (ru)
EP (1) EP3621654A4 (ru)
JP (1) JP2020519585A (ru)
CN (1) CN111201040A (ru)
AU (1) AU2018265415A1 (ru)
BR (1) BR112019022908A2 (ru)
CA (1) CA3057875A1 (ru)
MX (1) MX2019013363A (ru)
RU (1) RU2019139817A (ru)
WO (1) WO2018209155A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3600324A4 (en) * 2017-03-23 2020-12-09 Graybug Vision, Inc. COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISORDERS
EP3806858A4 (en) 2018-06-15 2022-03-09 Handa Pharmaceuticals, Inc. SALTS OF KINASE INHIBITORS AND ASSOCIATED COMPOSITIONS
EP3880182A4 (en) * 2018-11-15 2022-08-10 Graybug Vision, Inc. ENHANCED AGGREGATED MICROPARTICLES
US11883525B2 (en) 2019-05-31 2024-01-30 Dose Medical Corporation Bioerodible polyester polymer axitinib ocular implants and related methods of use
CN111548482B (zh) * 2020-04-02 2022-09-13 复旦大学 一氧化氮供体修饰的共聚物、包含其的缓释制剂及其制备方法与应用
WO2022111379A1 (zh) * 2020-11-26 2022-06-02 成都康弘药业集团股份有限公司 一种阿西替尼眼内植入剂
CN113546058A (zh) * 2021-07-06 2021-10-26 吕梁学院 一种抑制tert出核的纳米粒子、制备方法及应用
WO2024074585A2 (en) 2022-10-05 2024-04-11 Mireca Medicines Gmbh MICROPARTICLE AND IMPLANT FORMULATIONS FOR cGMP ANALOG THERAPY

Family Cites Families (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB929405A (en) 1958-12-22 1963-06-19 Upjohn Co Processes for the encapsulation of particles
GB929401A (en) 1958-12-22 1963-06-19 Upjohn Co Encapsulated emulsions and processes for their preparation
IT1148784B (it) 1980-04-09 1986-12-03 Eurand Spa Procedimento per la preparazione di microcapsule in un veicolo liquido
US4760057A (en) * 1983-06-23 1988-07-26 Merck & Co., Inc. (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs
US4794000A (en) 1987-01-08 1988-12-27 Synthetic Blood Corporation Coacervate-based oral delivery system for medically useful compositions
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
US4997443A (en) 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
WO1988007044A1 (en) 1987-03-17 1988-09-22 Insite Vision, Inc. Timolol derivatives
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5681964A (en) 1990-10-23 1997-10-28 University Of Kentucky Research Foundation Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents
US5286495A (en) 1992-05-11 1994-02-15 University Of Florida Process for microencapsulating cells
US5344701A (en) 1992-06-09 1994-09-06 Minnesota Mining And Manufacturing Company Porous supports having azlactone-functional surfaces
US5506226A (en) 1993-04-19 1996-04-09 Alcon Laboratories, Inc. Ethacrynic acid-like compounds and use thereof to treat glaucoma
US5565215A (en) 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US6051576A (en) 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
US5502092A (en) 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
US5441722A (en) 1994-02-18 1995-08-15 Merck & Co., Inc. Short synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-[C3 H3 ]-4[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related non radioactive compounds
GB9412273D0 (en) 1994-06-18 1994-08-10 Univ Nottingham Administration means
US6007845A (en) 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
WO1996020698A2 (en) 1995-01-05 1996-07-11 The Board Of Regents Acting For And On Behalf Of The University Of Michigan Surface-modified nanoparticles and method of making and using same
US5612053A (en) 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
US5612052A (en) 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6413539B1 (en) 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
US5916586A (en) 1995-08-24 1999-06-29 Lever Brothers Company, Inc. Personal cleansing system comprising polymeric diamond-mesh bath sponge and liquid cleanser with deodorant composition
US5855615A (en) 1996-06-07 1999-01-05 Menlo Care, Inc. Controller expansion sphincter augmentation media
US5866155A (en) 1996-11-20 1999-02-02 Allegheny Health, Education And Research Foundation Methods for using microsphere polymers in bone replacement matrices and composition produced thereby
US5945126A (en) 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
GB9704749D0 (en) 1997-03-07 1997-04-23 Univ London Tissue Implant
GB9713980D0 (en) 1997-07-03 1997-09-10 Danbiosyst Uk New conjugates
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
CA2221195A1 (en) 1997-11-14 1999-05-14 Chantal E. Holy Biodegradable polymer matrix
US6841617B2 (en) 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
WO2000033764A1 (en) 1998-12-04 2000-06-15 Pathak Chandrashekhar P Biocompatible crosslinked polymers
US8008283B2 (en) 1998-12-23 2011-08-30 Neurotherapeutics Pharma, Inc. Methods and compositions for the treatment of neuropsychiatric disorders
US20040258763A1 (en) 1999-02-03 2004-12-23 Bell Steve J.D. Methods of manufacture and use of calcium phosphate particles containing allergens
IN192012B (ru) 1999-03-19 2004-02-07 Vinod Chintamani Malshe
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
AU4977800A (en) 1999-04-26 2000-11-10 California Institute Of Technology (in situ) forming hydrogels
US6287588B1 (en) 1999-04-29 2001-09-11 Macromed, Inc. Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
SE9904344D0 (sv) 1999-12-01 1999-12-01 Ralf Goeran Andersson Method of producing porous spherical particles
US20020010203A1 (en) 1999-12-22 2002-01-24 Ken Lipson Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
NZ520640A (en) 2000-02-15 2005-04-29 Upjohn Co Pyrrole substituted 2-indolinone protein kinase inhibitors
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6589549B2 (en) 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US7115585B2 (en) * 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
ES2177415B1 (es) 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
EP2316490A3 (en) 2000-10-31 2012-02-01 PR Pharmaceuticals, Inc. Methods and compositions for enhanced delivery of bioactive molecules
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
GB2370839A (en) 2001-01-06 2002-07-10 Benedikt Timmerman Immunogenic complex useful for disease control
BR0102252B1 (pt) 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso
US20020183858A1 (en) 2001-06-05 2002-12-05 Contiliano Joseph H. Attachment of absorbable tissue scaffolds to scaffold fixation devices
EP1406593B1 (en) 2001-06-22 2010-08-25 Johns Hopkins University School of Medicine Biodegradable polymer compositions, compositions and uses related thereto
GB0122318D0 (en) 2001-09-14 2001-11-07 Novartis Ag Organic compounds
CA2467559A1 (en) 2001-11-19 2003-05-30 Control Delivery Systems, Inc. Topical delivery of codrugs
US20050164994A1 (en) 2001-12-10 2005-07-28 Control Deliver Systems, Inc. Treatment of genitourinary tract disorders
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
MXPA05002669A (es) 2002-09-13 2005-08-19 Ocular Sciences Inc Dispositivos y metodos para mejorar la vision.
WO2004028583A2 (en) 2002-09-26 2004-04-08 Angiotech International Ag Perivascular wraps
AU2003299722A1 (en) 2002-12-17 2004-07-14 Mdrna, Inc. Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity
US7060299B2 (en) 2002-12-31 2006-06-13 Battelle Memorial Institute Biodegradable microparticles that stabilize and control the release of proteins
TW200500067A (en) 2003-01-21 2005-01-01 Control Delivery Sys Inc Salts of codrugs and uses related thereto
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
WO2004112838A2 (en) 2003-05-21 2004-12-29 Control Delivery Systems, Inc. Codrugs of diclofenac
TWI367103B (en) 2003-06-26 2012-07-01 Psivida Inc Bioerodible sustained release drug delivery systems
AR044926A1 (es) 2003-06-26 2005-10-12 Control Delivery Sys Inc Sistema de suministro de farmacos gelificante in situ
ES2384568T3 (es) 2003-07-30 2012-07-09 Kyowa Hakko Kirin Co., Ltd. Derivados de indazol
US7314959B2 (en) 2003-08-07 2008-01-01 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
US20090148527A1 (en) 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US20050175709A1 (en) 2003-12-11 2005-08-11 Baty Ace M.Iii Therapeutic microparticles
US7211275B2 (en) 2004-01-16 2007-05-01 Massachusetts Institute Of Technology Composite materials for controlled release of water soluble products
EP1713514B1 (en) 2004-01-28 2021-11-24 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
ES2246694B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US20050244463A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US8163030B2 (en) 2004-05-06 2012-04-24 Degradable Solutions Ag Biocompatible bone implant compositions and methods for repairing a bone defect
WO2005116729A2 (en) 2004-05-20 2005-12-08 Coopervision, Inc., Corneal onlays and wavefront aberration correction to enhance vision
WO2006014626A2 (en) 2004-07-19 2006-02-09 Celator Pharmaceuticals, Inc. Partuculate constructs for release of active agents
US20060083781A1 (en) 2004-10-14 2006-04-20 Shastri V P Functionalized solid lipid nanoparticles and methods of making and using same
US20060135609A1 (en) 2004-10-21 2006-06-22 Duke University Ophthamological drugs
WO2006060723A2 (en) 2004-12-03 2006-06-08 Vical Incorporated Methods for producing block copolymer/amphiphilic particles
US20080306041A1 (en) 2005-01-21 2008-12-11 Garvey David S Cardiovascular Compounds Comprising Heterocyclic Nitric Oxide Donor Groups, Compositions and Methods of Use
US7691364B2 (en) 2005-01-28 2010-04-06 Bezwada Biomedical, Llc Functionalized drugs and polymers derived therefrom
JP2008535928A (ja) 2005-04-12 2008-09-04 シヴィダ・インコーポレイテッド HMGCoA還元酵素インヒビターの組合せ及びその使用
KR20080002995A (ko) 2005-04-22 2008-01-04 알자 코포레이션 Her2 세포 수용체를 표적하는 이뮤노리포좀 조성물
CA2604225A1 (en) 2005-04-27 2006-11-02 Baxter International Inc. Surface-modified microparticles and methods of forming and using the same
JP5388005B2 (ja) 2005-06-17 2014-01-15 オーストラリアン ニュークリア サイエンス アンド テクノロジー オーガニゼーション 放出可能なドーパントをその中に含有する粒子
ES2812250T3 (es) 2005-11-28 2021-03-16 Marinus Pharmaceuticals Inc Formulaciones de ganaxolona y procedimientos para la preparación y uso de las mismas
DE102005058979A1 (de) 2005-12-09 2007-06-21 Qiagen Gmbh Magnetische Polymerpartikel
US20090148487A1 (en) 2005-12-14 2009-06-11 Scil Technology Gmbh Moldable biomaterial for bone regeneration
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
JP2009521493A (ja) 2005-12-23 2009-06-04 アルコン,インコーポレイテッド 眼への受容体チロシンキナーゼ阻害(RTKi)化合物の送達のための医薬製剤
US8663674B2 (en) 2006-01-13 2014-03-04 Surmodics, Inc. Microparticle containing matrices for drug delivery
EP1981852A1 (en) 2006-02-06 2008-10-22 NicOx S.A. Nitrooxy-comprising derivatives of apraclonidine and brimodnidine as al pha2 -adrenergic receptor agonists
US7883520B2 (en) 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
US20080166411A1 (en) 2006-04-10 2008-07-10 Pfizer Inc Injectable Depot Formulations And Methods For Providing Sustained Release Of Poorly Soluble Drugs Comprising Nanoparticles
EP1891941A1 (en) 2006-08-11 2008-02-27 OctoPlus Technologies B.V. Aqueous gels comprising microspheres
ATE498393T1 (de) 2006-09-08 2011-03-15 Univ Johns Hopkins Zusammensetzungen zur transportintensivierung durch die schleimhaut
WO2008033426A1 (en) 2006-09-12 2008-03-20 Psivida Inc. Injector apparatus and method of use
GB0619869D0 (en) 2006-10-07 2006-11-15 Regentec Ltd Porous particles
BRPI0718696A2 (pt) 2006-11-09 2013-12-31 Alcon Res Ltd Matriz de polímero insolúvel em água para liberação de fármaco.
EP2097421A2 (en) 2006-12-15 2009-09-09 Nicox S.A. Carbonic anhydrase inhibitors derivatives
GB0701896D0 (en) 2007-02-01 2007-03-14 Regentec Ltd Composition
JP2010519183A (ja) 2007-02-06 2010-06-03 インセプト エルエルシー 生理溶液の溶出のためのタンパク質の沈殿を用いる重合
WO2008112287A1 (en) 2007-03-12 2008-09-18 Nektar Therapeutics Oligomer-beta blocker conjugates
WO2008157614A2 (en) 2007-06-21 2008-12-24 Yale University Sustained intraocular delivery of drugs from biodegradable polymeric microparticles
CN101081206A (zh) 2007-06-29 2007-12-05 济南康泉医药科技有限公司 一种含酪氨酸激酶抑制剂的抗癌药物组合物
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
WO2009030270A1 (en) 2007-09-03 2009-03-12 Novartis Ag Dihydroindole derivatives useful in parkinson's disease
WO2009035565A1 (en) 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Prostaglandin analogues for implant devices and methods
WO2009054006A2 (en) * 2007-10-26 2009-04-30 National Institute Of Immunology Biodegradable polymer scaffold and process for preparation thereof
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
WO2009088448A2 (en) 2008-01-03 2009-07-16 Forsight Labs, Llc Intraocular, accomodating lens and methods of use
WO2009089070A2 (en) 2008-01-10 2009-07-16 The Johns Hopkins University Compositions and methods for reducing particle penetration through mucus
WO2009100176A2 (en) 2008-02-07 2009-08-13 Abbott Laboratories Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor
US9114070B2 (en) 2008-02-29 2015-08-25 Nagoya Industrial Science Research Institute Liposome for delivery to posterior segment of eye and pharmaceutical composition for disease in posterior segment of eye
ITMI20080382A1 (it) 2008-03-07 2009-09-08 Ctg Pharma S R L Composizioni farmaceutiche oculari
WO2009121018A2 (en) 2008-03-27 2009-10-01 University Of Kentucky Research Foundation Opioid-nornicotine codrugs for pain management
WO2009131794A1 (en) 2008-03-27 2009-10-29 University Of Kentucky Research Foundation Opioid-ketamine and norketamine codrug combinations for pain management
US9125735B2 (en) 2008-04-04 2015-09-08 Forsight Labs, Llc Method of correcting vision using corneal onlays
CN102112118A (zh) 2008-04-25 2011-06-29 北卡罗来纳-查佩尔山大学 特别用于非湿润模型的颗粒复制的可降解化合物及其使用方法
US8993615B2 (en) 2008-08-08 2015-03-31 The Johns Hopkins University Compositions and methods for treatment of neurodegenerative disease
TW201019963A (en) 2008-09-10 2010-06-01 Abbott Lab Polyethylene glycol lipid conjugates and uses thereof
US9161903B2 (en) 2008-10-31 2015-10-20 Warsaw Orthopedic, Inc. Flowable composition that hardens on delivery to a target tissue site beneath the skin
US9095506B2 (en) 2008-11-17 2015-08-04 Allergan, Inc. Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
US20100143479A1 (en) 2008-12-04 2010-06-10 Oakwood Laboratories, Llc Method of making sustained release microparticles
US9669136B2 (en) 2009-01-12 2017-06-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Tissue regeneration membrane
MX2011007759A (es) 2009-01-22 2011-10-11 Neurotherapeutics Pharma Inc Analogos de bumetanida, furosemida, piretanida, azosemida y torsemida, composiciones y metodos de uso.
WO2010088548A1 (en) 2009-01-29 2010-08-05 Forsight Labs, Llc Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US20120052041A1 (en) 2009-02-04 2012-03-01 The Brigham And Women's Hospital, Inc. Polymeric nanoparticles with enhanced drug-loading and methods of use thereof
JP5969212B2 (ja) 2009-02-10 2016-08-17 シヴィダ・ユーエス・インコーポレイテッドPsivida Us,Inc. 眼用トロカール組立体
WO2010093873A2 (en) 2009-02-12 2010-08-19 Incept, Llc Drug delivery through hydrogel plugs
KR20160135372A (ko) 2009-03-03 2016-11-25 알콘 리서치, 리미티드 리셉터 티로신 키나제 저해(RTKi) 화합물을 눈에 전달하기 위한 약학 조성물
GB0903810D0 (en) 2009-03-05 2009-04-22 Regentec Ltd Delivery system
WO2010108211A1 (en) 2009-03-27 2010-09-30 Australian Nuclear Science And Technology Organisation Triggered release
WO2010114770A1 (en) 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
CN103494765A (zh) 2009-05-04 2014-01-08 普西维达公司 多孔硅药物洗脱颗粒
EP3960215A1 (en) 2009-12-15 2022-03-02 Incept, LLC Implants and biodegradable fiducial markers
US8889193B2 (en) * 2010-02-25 2014-11-18 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
US20130071349A1 (en) 2010-03-02 2013-03-21 Allergan, Inc. Biodegradable polymers for lowering intraocular pressure
EP2550263A4 (en) 2010-03-23 2013-07-24 Univ Johns Hopkins COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
AU2011270701B2 (en) 2010-06-24 2015-05-14 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
EP3861969A1 (en) 2010-08-05 2021-08-11 ForSight Vision4, Inc. Injector apparatus for drug delivery
US10307372B2 (en) 2010-09-10 2019-06-04 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US20150056300A1 (en) 2010-10-22 2015-02-26 Bind Therapeutics, Inc. Therapeutic nanoparticles with high molecular weight copolymers
US20120121718A1 (en) 2010-11-05 2012-05-17 The Johns Hopkins University Compositions and methods relating to reduced mucoadhesion
WO2012088529A1 (en) 2010-12-23 2012-06-28 Nektar Therapeutics Polymer-sunitinib conjugates
WO2012088522A1 (en) 2010-12-23 2012-06-28 Nektar Therapeutics Polymer-des-ethyl sunitinib conjugates
WO2012109363A2 (en) 2011-02-08 2012-08-16 The Johns Hopkins University Mucus penetrating gene carriers
WO2012112674A2 (en) 2011-02-15 2012-08-23 The Johns Hopkins University Compounds and methods of use thereof for treating neurodegenerative disorders
JP2014510022A (ja) 2011-04-07 2014-04-24 スキャンポ・アーゲー 眼精疲労の処置方法
US20120263803A1 (en) 2011-04-12 2012-10-18 R-Tech Ueno, Ltd. Aqueous ophthalmic composition
JP6522337B2 (ja) 2011-05-11 2019-05-29 アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. 細胞反応性、長時間作用型または標的化コンプスタチン類似体およびその使用
KR102071083B1 (ko) 2011-09-14 2020-01-29 포사이트 비젼5, 인크. 안내 삽입물 장치 및 방법
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
CA2858161C (en) 2011-12-05 2020-03-10 Incept, Llc Medical organogel processes and compositions
EP2790733B1 (en) 2011-12-14 2019-10-30 The Johns Hopkins University Nanoparticles with enhanced mucosal penetration or decreased inflammation
RU2598627C2 (ru) 2012-01-19 2016-09-27 Дзе Джонс Хопкинс Юниверсити Композиции на основе наночастиц с улучшенным проникновением через слизистые оболочки
WO2013112434A1 (en) 2012-01-23 2013-08-01 Allergan, Inc. Time released biodegradable or bioerodible microspheres or microparticles suspended in a solidifying depot-forming injectable drug formulation
AU2013232300B2 (en) 2012-03-16 2015-12-17 The Johns Hopkins University Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
CN104363924B (zh) 2012-03-16 2018-04-17 约翰霍普金斯大学 用于递送hif‑1抑制剂的控制释放调配物
US20140107025A1 (en) 2012-04-16 2014-04-17 Jade Therapeutics, Llc Ocular drug delivery system
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
EP4008355A1 (en) 2012-05-03 2022-06-08 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
WO2013166436A1 (en) 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US9533068B2 (en) 2012-05-04 2017-01-03 The Johns Hopkins University Drug loaded microfiber sutures for ophthalmic application
AU2013256008B2 (en) 2012-05-04 2016-02-25 The Johns Hopkins University Lipid-based drug carriers for rapid penetration through mucus linings
JP6267193B2 (ja) 2012-05-22 2018-01-24 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 置換ジピリジルアミン類及びそれらの使用
WO2013177367A2 (en) 2012-05-23 2013-11-28 The Johns Hopkins University Compounds and methods of use thereof for treating neurodegenerative disorders
EP2858628A1 (en) 2012-06-25 2015-04-15 Bayer HealthCare LLC Topical ophthalmological pharmaceutical composition containing sunitinib
SG11201502008WA (en) 2012-09-17 2015-04-29 Bind Therapeutics Inc Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
CN103833998B (zh) 2012-11-26 2017-10-27 杨子剑 含有利尿酸结构的新化合物以及制备方法和用途
CN103897174A (zh) 2012-12-26 2014-07-02 杨子剑 含有利尿酸结构的新聚合物以及制备方法和用途
US9044319B2 (en) 2013-03-01 2015-06-02 Cormatrix Cardiovascular, Inc. Anchored cardiovascular valve
EP2968113B8 (en) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
CN104059054B (zh) 2013-03-19 2018-11-20 浙江导明医药科技有限公司 用于治疗癌症的三级环状胺alk激酶抑制剂
KR20150139899A (ko) 2013-04-01 2015-12-14 알러간, 인코포레이티드 지속적인 안구내 방출을 위한 마이크로스피어 약물 전달 시스템
RU2015147601A (ru) 2013-05-01 2017-06-05 Ф. Хоффманн-Ля Рош Аг С-связанные гетероциклоалкилзамещенные пиримидины и их применения
US9789198B2 (en) 2013-05-31 2017-10-17 Jenkem Technology Co., Ltd. (Tianjin) Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity
CN104208715B (zh) 2013-05-31 2016-12-28 天津键凯科技有限公司 具有提高的药物生物活性的低分子量聚乙二醇药物结合物
HUE052420T2 (hu) 2013-09-12 2021-04-28 Smartdyelivery Gmbh Sejt specifikus célbajuttatás nanostruktúrált hordozórendszerekkel
US20150099802A1 (en) 2013-10-03 2015-04-09 Sucampo Ag Selective tumor treatment
US9655862B2 (en) 2013-10-29 2017-05-23 Shaker A. Mousa Ocular nanoformulation and method of use in angiogenesis-mediated disorders
EP3071248B1 (en) 2013-11-19 2020-08-05 Cornell University Tissue scaffold materials for tissue regeneration and methods of making
CA2933900A1 (en) 2013-12-20 2015-06-25 Georgia Tech Research Corporation Formulations and methods for targeted ocular delivery of therapeutic agents
KR101564401B1 (ko) 2014-04-10 2015-11-02 한국화학연구원 브린졸아마이드의 제조방법
US10238581B2 (en) * 2014-05-09 2019-03-26 Yale University Hyperbranched polyglycerol-coated particles and methods of making and using thereof
EP3193827A1 (en) 2014-08-13 2017-07-26 The Johns Hopkins University Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization
US20160106587A1 (en) 2014-10-16 2016-04-21 Incept, Llc Ocular gels or hydrogels and microinjectors
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
CA2969716C (en) 2014-12-10 2023-12-19 Incept, Llc Hydrogel drug delivery implants
EP3233058A1 (en) 2014-12-15 2017-10-25 The Johns Hopkins University Sunitinib formulations and methods for use thereof in treatment of glaucoma
JP6479485B2 (ja) 2015-01-15 2019-03-06 大内新興化学工業株式会社 眼疾患治療用ナノ粒子製剤
WO2016118506A1 (en) 2015-01-20 2016-07-28 The Johns Hopkins University Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure
EP3291812B1 (en) 2015-05-05 2021-09-01 EyePoint Pharmaceuticals US, Inc. Injectable depot formulations
EP3294212B1 (en) 2015-05-12 2023-10-25 Incept, LLC Drug delivery from hydrogels
WO2017015591A1 (en) 2015-07-22 2017-01-26 Incept, Llc Coated punctal plug
BR112018005589A2 (pt) * 2015-09-22 2018-10-09 Graybug Vision Inc “composto, composição farmaceuticamente aceitável, e, uso de um composto”
EA038755B1 (ru) * 2015-11-12 2021-10-14 Грейбаг Вижн, Инк. Агрегирующие микрочастицы для обеспечения замедленного высвобождения терапевтического агента для внутриглазной доставки
BR112018010671A8 (pt) 2015-11-25 2019-02-26 Incept Llc dispositivos e métodos de distribuição de fármaco com mudança de forma
EP3600324A4 (en) 2017-03-23 2020-12-09 Graybug Vision, Inc. COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISORDERS
RU2020118178A (ru) 2017-12-14 2022-01-14 Грейбуг Вижн, Инк. Лекарственные средства и композиции для доставки в глаз
EP3784705A4 (en) 2018-04-23 2022-03-02 Graybug Vision, Inc. IMPROVED CONTINUOUS PRODUCTION OF MICROPARTICLES
WO2019210215A1 (en) 2018-04-26 2019-10-31 Graybug Vision, Inc. Drugs to treat ocular disorders
TW202035364A (zh) 2018-09-27 2020-10-01 美商灰色視覺公司 用於眼部遞送之化合物及組合物
EP3880182A4 (en) 2018-11-15 2022-08-10 Graybug Vision, Inc. ENHANCED AGGREGATED MICROPARTICLES

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