RU2018128002A - EMULSION TYPE "WATER IN OIL" - Google Patents

EMULSION TYPE "WATER IN OIL" Download PDF

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RU2018128002A
RU2018128002A RU2018128002A RU2018128002A RU2018128002A RU 2018128002 A RU2018128002 A RU 2018128002A RU 2018128002 A RU2018128002 A RU 2018128002A RU 2018128002 A RU2018128002 A RU 2018128002A RU 2018128002 A RU2018128002 A RU 2018128002A
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emulsion
oil
skin
water
type
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RU2018128002A
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RU2018128002A3 (en
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Кристоф АБЕЛЬС
Ульрих КНИ
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Др.Аугуст Вольфф Гмбх Унд Ко.Кг - Арцнаймиттель
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Publication of RU2018128002A3 publication Critical patent/RU2018128002A3/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (19)

1. Эмульсия типа ʺвода в маслеʺ, содержащая1. An emulsion of the type "water in oil" containing a) дисперсную/внутреннюю водную фазу, содержащую α-гидрокси-C2-C6-карбоновую кислоту;a) a dispersed / internal aqueous phase containing α-hydroxy-C 2 -C 6 carboxylic acid; b) непрерывную/внешнюю масляную фазу иb) continuous / external oil phase and c) систему эмульгатора, содержащую полиглицерил-3-полирицинолеат, сорбитанолеат и полистеарат сахарозы,c) an emulsifier system comprising polyglyceryl-3-polyricinoleate, sorbitan oleate and sucrose polystearate, причем эмульсия имеет значение pH от 1 до 5.moreover, the emulsion has a pH value of from 1 to 5. 2. Эмульсия типа ʺвода в маслеʺ по п. 1, причем α-гидрокси-C2-C6-карбоновая кислота выбрана из группы, состоящей из гликолевой кислоты, молочной кислоты, винной кислоты, лимонной кислоты, аскорбиновой кислоты, яблочной кислоты и их смесей, предпочтительно из гликолевой кислоты.2. A water-in-oil emulsion according to claim 1, wherein the α-hydroxy-C 2 -C 6 carboxylic acid is selected from the group consisting of glycolic acid, lactic acid, tartaric acid, citric acid, ascorbic acid, malic acid, and their mixtures, preferably from glycolic acid. 3. Эмульсия типа ʺвода в маслеʺ по п. 1 и/или 2, причем эмульсия имеет значение pH от 2,5 до 4,5, предпочтительно от 3,5 до 4,5.3. An emulsion of the type "water in oil" according to claim 1 and / or 2, the emulsion having a pH value from 2.5 to 4.5, preferably from 3.5 to 4.5. 4. Эмульсия типа ʺвода в маслеʺ по одному из пп. 1-3, дополнительно содержащая основное средство для регулирования pH, предпочтительно гидроксид аммония.4. An emulsion of the type "water in oil" according to one of paragraphs. 1-3, further comprising a basic pH adjuster, preferably ammonium hydroxide. 5. Эмульсия типа ʺвода в маслеʺ по одному из пп. 1-4, причем масляная фаза содержит изогексадекан.5. An emulsion of the type "water in oil" according to one of paragraphs. 1-4, and the oil phase contains isohexadecane. 6. Эмульсия типа ʺвода в маслеʺ по одному из пп. 1-5, причем эмульсия содержит от 0,5 до 3,0 масс. %, предпочтительно от от 1,0 до 2,0 масс. %, α-гидрокси-C2-C6-карбоновой кислоты в расчете на совокупную массу эмульсии.6. An emulsion of the type "water in oil" according to one of paragraphs. 1-5, and the emulsion contains from 0.5 to 3.0 mass. %, preferably from 1.0 to 2.0 mass. %, α-hydroxy-C 2 -C 6 -carboxylic acid based on the total weight of the emulsion. 7. Эмульсия типа ʺвода в маслеʺ по одному из пп. 1-6, причем эмульсия содержит от 1,0 до 5,0 масс. % полиглицерил-3-полирицинолеата, от 2,0 до 10,0 масс. % сорбитанолеата и от 0,5 до 3,0 масс. % полистеарата сахарозы в расчете на совокупную массу эмульсии.7. An emulsion of the type "water in oil" according to one of paragraphs. 1-6, and the emulsion contains from 1.0 to 5.0 mass. % polyglyceryl-3-polyricinoleate, from 2.0 to 10.0 wt. % sorbitan oleate and from 0.5 to 3.0 mass. % sucrose polystearate based on the total weight of the emulsion. 8. Эмульсия типа ʺвода в маслеʺ по одному из пп. 1-7, причем эмульсия содержит от 1,0 до 2,0 масс. % полиглицерил-3-полирицинолеата, от 3,0 до 5,0 масс. % сорбитанолеата и от 1,0 до 1,5 масс. % полистеарата сахарозы в расчете на совокупную массу эмульсии.8. An emulsion of the type "water in oil" according to one of paragraphs. 1-7, and the emulsion contains from 1.0 to 2.0 mass. % polyglyceryl-3-polyricinoleate, from 3.0 to 5.0 wt. % sorbitan oleate and from 1.0 to 1.5 mass. % sucrose polystearate based on the total weight of the emulsion. 9. Эмульсия типа ʺвода в маслеʺ по одному из пп. 1-8, причем эмульсия содержит от 1,0 до 1,5 масс. % полиглицерил-3-полирицинолеата, от 3,0 до 3,5 масс. % сорбитанолеата и от 1,0 до 1,5 масс. % полистеарата сахарозы в расчете на совокупную массу эмульсии.9. An emulsion of the type "water in oil" according to one of paragraphs. 1-8, and the emulsion contains from 1.0 to 1.5 mass. % polyglyceryl-3-polyricinoleate, from 3.0 to 3.5 mass. % sorbitan oleate and from 1.0 to 1.5 mass. % sucrose polystearate based on the total weight of the emulsion. 10. Эмульсия типа ʺвода в маслеʺ по одному из пп. 1-8, причем в системе эмульгатора массовое соотношение полиглицерил-3-полирицинолеата: сорбитанолеата: полистеарата сахарозы предпочтительно составляет (от 1,0 до 1,5): (от 3,0 до 3,5): (от 1,0 до 1,5), предпочтительно 1,5: 3,5: 1,0.10. An emulsion of the type "water in oil" according to one of paragraphs. 1-8, moreover, in the emulsifier system, the mass ratio of polyglyceryl-3-polyricinoleate: sorbitan oleate: sucrose polystearate is preferably (1.0 to 1.5): (3.0 to 3.5): (1.0 to 3.5 1.5), preferably 1.5: 3.5: 1.0. 11. Эмульсия типа ʺвода в маслеʺ по одному из пп. 1-10 для применения в качестве лекарственного средства, предпочтительно в качестве дерматологического средства для восстановления физиологического значения pH кожи.11. An emulsion of the type "water in oil" according to one of paragraphs. 1-10 for use as a medicine, preferably as a dermatological agent, to restore the physiological pH of the skin. 12. Эмульсия типа ʺвода в маслеʺ для применения по п. 11 для терапевтического и/или профилактического лечения заболеваний кожи, выбранных из группы, состоящей из микробных инфекций кожи, воспалений кожи, шершавой кожи, сухой кожи, раздражений кожи, кожного зуда, зуда, аллергий, псориаза, псориатического артрита, экземы, склеродермы, атопического дерматита, контактного дерматита, системной красной волчанки, гнездной алопеции, угревой сыпи и восприимчивости к контактным аллергиям.12. A water-in-oil emulsion for use according to claim 11 for the therapeutic and / or prophylactic treatment of skin diseases selected from the group consisting of microbial infections of the skin, skin inflammations, rough skin, dry skin, skin irritations, itching, itching, allergies, psoriasis, psoriatic arthritis, eczema, scleroderma, atopic dermatitis, contact dermatitis, systemic lupus erythematosus, alopecia areata, acne and susceptibility to contact allergies. 13. Нетерапевтическое применение эмульсии типа ʺвода в маслеʺ по одному из пп. 1-10 в качестве косметического средства, предпочтительно для восстановления физиологического значения pH кожи.13. Non-therapeutic use of an emulsion of the type "water in oil" according to one of paragraphs. 1-10 as a cosmetic, preferably to restore the physiological pH of the skin. 14. Нетерапевтическое применение по п. 13 для улучшения эпидермальных барьерных функций и эпидермальной барьерной целостности, для улучшения внешнего вида кожи и/или для повышения влагосодержания кожи.14. The non-therapeutic use of claim 13 for improving epidermal barrier functions and epidermal barrier integrity, for improving the appearance of the skin, and / or for increasing the moisture content of the skin. 15. Нетерапевтическое применение по п. 13 и/или 14 для лечения косметических состояний кожи, выбранных из группы, состоящей из шершавой кожи, сухой кожи, раздражений кожи, кожного зуда и зуда, и для предотвращения кожных инфекций и восприимчивости к контактным аллергиям.15. The non-therapeutic use of Claim 13 and / or 14 for treating cosmetic skin conditions selected from the group consisting of rough skin, dry skin, skin irritations, skin itching and itching, and for preventing skin infections and susceptibility to contact allergies.
RU2018128002A 2016-01-15 2017-01-13 EMULSION TYPE "WATER IN OIL" RU2018128002A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16151515.0 2016-01-15
EP16151515 2016-01-15
PCT/EP2017/050619 WO2017121831A1 (en) 2016-01-15 2017-01-13 Water-in-oil emusion

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RU2018128002A true RU2018128002A (en) 2020-02-18
RU2018128002A3 RU2018128002A3 (en) 2020-02-18

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US (1) US20190021961A1 (en)
EP (1) EP3402456A1 (en)
JP (1) JP2019501934A (en)
KR (1) KR20180101378A (en)
CN (1) CN108463206A (en)
CA (1) CA3010544A1 (en)
RU (1) RU2018128002A (en)
WO (1) WO2017121831A1 (en)

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EP3641725A1 (en) 2017-06-23 2020-04-29 The Procter and Gamble Company Composition and method for improving the appearance of skin
GB2560209B (en) * 2017-07-28 2020-02-19 Alchemy Ingredients Ltd High internal phase emulsions
JP7063703B2 (en) * 2018-04-20 2022-05-09 ミヨシ油脂株式会社 Emulsion stabilization method and emulsion and emulsion fuel using it
DE102018115270B4 (en) * 2018-06-26 2022-07-14 Vinederm GmbH Gel and patch preparation for topical treatment of skin and/or nail disorders
CA3102288A1 (en) 2018-07-03 2020-01-09 The Procter & Gamble Company Method of treating a skin condition
RU2714763C1 (en) * 2018-11-08 2020-02-19 Генетик Диагностикс Энд Терапи 21 Лтд Gene-therapeutic dna vector for targeted gene therapy, method for production thereof (embodiments), strain for production thereof, method for production thereof
KR102644391B1 (en) * 2018-11-29 2024-03-07 (주)아모레퍼시픽 Cosmetic composition of water-in-oil type having improved stability
EP4157206A1 (en) 2020-06-01 2023-04-05 The Procter & Gamble Company Method of improving penetration of a vitamin b3 compound into skin
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
WO2023056278A1 (en) * 2021-09-29 2023-04-06 Love Sun Body Ip Holdings Llc Facial and body sunscreen compositions
DE102022207466A1 (en) * 2022-07-21 2024-02-01 Beiersdorf Aktiengesellschaft Process for producing a cosmetic water-in-oil emulsion from a glycerin-in-oil emulsion
KR102627686B1 (en) 2023-08-17 2024-01-24 코스맥스 주식회사 Liquid crystal cream cosmetic composition that looks like snow particles with a gloss improving effect and manufacturing method thereof

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KR20180101378A (en) 2018-09-12
CA3010544A1 (en) 2017-07-20
US20190021961A1 (en) 2019-01-24
EP3402456A1 (en) 2018-11-21
WO2017121831A1 (en) 2017-07-20
RU2018128002A3 (en) 2020-02-18
CN108463206A (en) 2018-08-28

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