CN107496185A - Bacteriostatic agent based on diazonium alkyl imidazole urea and its preparation method and application - Google Patents
Bacteriostatic agent based on diazonium alkyl imidazole urea and its preparation method and application Download PDFInfo
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- CN107496185A CN107496185A CN201710645027.XA CN201710645027A CN107496185A CN 107496185 A CN107496185 A CN 107496185A CN 201710645027 A CN201710645027 A CN 201710645027A CN 107496185 A CN107496185 A CN 107496185A
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- Prior art keywords
- alkyl imidazole
- bacteriostatic agent
- imidazole urea
- diazonium alkyl
- propane diols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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Abstract
The invention discloses a kind of bacteriostatic agent based on diazonium alkyl imidazole urea and its preparation method and application, the bacteriostatic agent is made up of diazonium alkyl imidazole urea, nipagin esters and propane diols；Wherein, the weight ratio of diazonium alkyl imidazole urea, nipagin esters and propane diols is 12 20：60‑70：20‑25.The bacteriostatic agent based on diazonium alkyl imidazole urea has an excellent antibacterial effect and gentle to skin and then so as to competent skin care item antiseptic, while the preparation method has process simple and raw material is easy to get effect.
Description
Technical field
The present invention relates to bacteriostatic agent, in particular it relates to a kind of bacteriostatic agent and its preparation side based on diazonium alkyl imidazole urea
Method and application.
Background technology
Skin care item, it is both the skin-protection product for protecting skin.With social economy continuous progress and material life it is abundant,
Skin care item, no longer it is there was only the thing risen of the rich just in the past.Nowadays skin care item have come into ordinary citizen house as the popular vehicles.It gives people
Spirit, image enhancing serve great effect.Skin care item species is various, and feature is different.By function graduation point, skin care item
There are the skin care item such as moisturizing, whitening, moisturizing, oil-control, anti-aging, sensitive skin, pore refining, blackhead of dispelling, nti-freckle, the fat that disappears.
Either which kind of skin care item is not that can once or twice use, and generally requires to store the long period,
It certainly will need to consider antiseptic effect in storing process, although existing preservative can have certain antiseptic effect, for
Skin has certain stimulation.
The content of the invention
, should it is an object of the invention to provide a kind of bacteriostatic agent based on diazonium alkyl imidazole urea and its preparation method and application
Bacteriostatic agent based on diazonium alkyl imidazole urea has excellent antibacterial effect and and then so as to competent shield gentle to skin
Skin product antiseptic, while the preparation method has process simple and raw material is easy to get effect.
To achieve these goals, the invention provides a kind of bacteriostatic agent based on diazonium alkyl imidazole urea, the bacteriostatic agent
It is made up of diazonium alkyl imidazole urea, nipagin esters and propane diols；Wherein, diazonium alkyl imidazole urea, nipagin esters and propane diols
Weight ratio is 12-20：60-70：20-25.
Present invention also offers a kind of preparation method of the bacteriostatic agent based on diazonium alkyl imidazole urea, the preparation method bag
Include：
1）Nipagin esters are dissolved in propane diols and form solution I；
2）Diazonium alkyl imidazole urea is dissolved in solution I the bacteriostatic agent based on diazonium alkyl imidazole urea is made；
Wherein, the weight ratio of diazonium alkyl imidazole urea, nipagin esters and propane diols is 12-20：60-70：20-25.
Invention further provides a kind of above-mentioned bacteriostatic agent based on diazonium alkyl imidazole urea in skin care item
Using.
In the above-mentioned technical solutions, the present invention passes through diazonium alkyl imidazole urea, nipagin esters and the collaboration of propane diols three
Act on and then cause obtained bacteriostatic agent that there is excellent antibacterial effect and and then so as to competent skin care gentle to skin
Product antiseptic, while the preparation method has process simple and raw material is easy to get effect.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Embodiment
The embodiment of the present invention is described in detail below.It is it should be appreciated that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to limit the invention.
The invention provides a kind of bacteriostatic agent based on diazonium alkyl imidazole urea, the bacteriostatic agent by diazonium alkyl imidazole urea,
Nipagin esters and propane diols composition；Wherein, the weight ratio of diazonium alkyl imidazole urea, nipagin esters and propane diols is 12-20：60-
70：20-25.
In the present invention, the specific species of nipagin esters can select in wide scope, but in order that obtained suppression
Microbial inoculum has more excellent antibacterial effect, it is preferable that nipagin esters are made up of methyl hydroxybenzoate and propylben.
In the present invention, the content of methyl hydroxybenzoate and propylben can select in wide scope, but in order to
Make obtained bacteriostatic agent that there is more excellent antibacterial effect, it is preferable that the weight of methyl hydroxybenzoate and propylben ratio is 1：
0.4-0.5。
In the present invention, diazonium alkyl imidazole urea, methyl hydroxybenzoate, propylben, propane diols proportioning can be in width
In the range of select, but in order that obtained bacteriostatic agent has more excellent antibacterial effect, it is preferable that diazonium alkyl imidazole
Urea, methyl hydroxybenzoate, propylben, the weight ratio of propane diols are 15-17：42-44：19-21：20-22.
Present invention also offers a kind of preparation method of the bacteriostatic agent based on diazonium alkyl imidazole urea, the preparation method bag
Include：
1）Nipagin esters are dissolved in propane diols and form solution I；
2）Diazonium alkyl imidazole urea is dissolved in solution I the bacteriostatic agent based on diazonium alkyl imidazole urea is made；
Wherein, the weight ratio of diazonium alkyl imidazole urea, nipagin esters and propane diols is 12-20：60-70：20-25.
In above-mentioned preparation method, the mode that nipagin esters are dissolved in propane diols can select in wide scope, but be
Make obtained bacteriostatic agent that there is more excellent antibacterial effect and stability, it is preferable that in step 1）In, nipagin esters pass through
The mode of ultrasonic vibration is dissolved in propane diols, and the condition of ultrasonic vibration is：Supersonic frequency is 40-50KHz, and concussion temperature is
55-70 DEG C, the concussion time is 40-60min.
In above-mentioned preparation method, the specific species and feeding sequence of nipagin esters can select in wide scope,
But in order that obtained bacteriostatic agent has more excellent antibacterial effect and stability, it is preferable that nipagin esters are by nipalgin
Methyl esters and propylben composition；And feeding sequence is：Methyl hydroxybenzoate before this, followed by propylben.
In above-mentioned preparation method, the dosage of methyl hydroxybenzoate and propylben can select in wide scope, but
It is in order that obtained bacteriostatic agent has more excellent antibacterial effect, it is preferable that the weight of methyl hydroxybenzoate and propylben
Than for 1：0.4-0.5.
In above-mentioned preparation method, diazonium alkyl imidazole urea, methyl hydroxybenzoate, propylben, propane diols dosage can
To be selected in wide scope, but in order that obtained bacteriostatic agent has more excellent antibacterial effect, it is preferable that diazonium alkyl
Imidazoles urea, methyl hydroxybenzoate, propylben, the weight ratio of propane diols are 15-17：42-44：19-21：20-22.
Invention further provides a kind of above-mentioned bacteriostatic agent based on diazonium alkyl imidazole urea in skin care item
Using.
The present invention will be described in detail by way of examples below.
Embodiment 1
1）Methyl hydroxybenzoate, propylben are added in propane diols successively, then carry out ultrasonic vibration（Supersonic frequency is
45KHz, concussion temperature is 60 DEG C, and the concussion time is 50min）Form solution I；
2）Diazonium alkyl imidazole urea is placed in solution I and the bacteriostatic agent A1 based on diazonium alkyl imidazole urea is made by stirring；
Wherein, diazonium alkyl imidazole urea, methyl hydroxybenzoate, propylben, the weight ratio of propane diols are 16：43：20：21.
Embodiment 2
Bacteriostatic agent A2 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 15：42：19：20.
Embodiment 3
Bacteriostatic agent A3 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 17：44：21：22.
Embodiment 4
Bacteriostatic agent A4 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 16：42：21：21.
Embodiment 5
Bacteriostatic agent A5 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 16：44：19：21.
Comparative example 1
Bacteriostatic agent B1 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 16：35：20：21.
Comparative example 2
Bacteriostatic agent B2 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 16：50：20：21.
Comparative example 3
Bacteriostatic agent B3 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 16：43：15：21.
Comparative example 4
Bacteriostatic agent B4 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 16：43：25：21.
Comparative example 5
Bacteriostatic agent B5 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 16：43：20：15.
Comparative example 6
Bacteriostatic agent B6 is carried out according to the method for embodiment 1, except that：Diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin
Propyl ester, the weight ratio of propane diols are 16：43：20：25.
Detect example 1
Above-mentioned bacteriostatic agent is added in vaseline and beeswax lipstick is made, then detect its performance by the following method, wherein,
Biocidal property parameter is by defending method prison hair [2002] the 229th《Disinfection technology standard》（Version in 2002）Specified in method measure；
Toxicological test parameter is by defending supervision hair [2007] 1《Cosmetics health specification》（Version in 2007）Specified in method measure；
Skin irritatin parameter is by defending supervision hair [2007] 1《Cosmetics health specification》（Version in 2007）Specified in method measure.
Specific testing result is shown in Table 1.
Table 1
Wherein, the radius of bacterium circle is smaller, illustrates that antibacterial effect is better.By above-described embodiment, comparative example and example is detected, this
The bacteriostatic agent that invention provides has excellent antibacterial effect, and non-stimulated for skin.
The preferred embodiment of the present invention described in detail above, still, the present invention are not limited in above-mentioned embodiment
Detail, in the range of the technology design of the present invention, a variety of simple variants can be carried out to technical scheme, this
A little simple variants belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should equally be considered as content disclosed in this invention.
Claims (10)
1. a kind of bacteriostatic agent based on diazonium alkyl imidazole urea, it is characterised in that the bacteriostatic agent is by diazonium alkyl imidazole urea, Buddhist nun
Moor golden ester and propane diols composition；Wherein, the weight ratio of the diazonium alkyl imidazole urea, nipagin esters and propane diols is 12-20：
60-70：20-25.
2. bacteriostatic agent according to claim 1, wherein, the nipagin esters are by methyl hydroxybenzoate and propylben group
Into.
3. bacteriostatic agent according to claim 2, wherein, the weight ratio of the methyl hydroxybenzoate and propylben is 1：
0.4-0.5。
4. bacteriostatic agent according to claim 3, wherein, the diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin third
Ester, the weight ratio of propane diols are 15-17：42-44：19-21：20-22.
5. a kind of preparation method of the bacteriostatic agent based on diazonium alkyl imidazole urea, it is characterised in that the preparation method includes：
1）Nipagin esters are dissolved in propane diols and form solution I；
2）Diazonium alkyl imidazole urea is dissolved in the solution I bacteriostatic agent based on diazonium alkyl imidazole urea is made；
Wherein, the weight ratio of the diazonium alkyl imidazole urea, nipagin esters and propane diols is 12-20：60-70：20-25.
6. preparation method according to claim 5, wherein, in step 1）In, the nipagin esters pass through ultrasonic vibration
Mode is dissolved in propane diols, and the condition of the ultrasonic vibration is：Supersonic frequency is 40-50KHz, and concussion temperature is 55-70
DEG C, the concussion time is 40-60min.
7. preparation method according to claim 5, wherein, the nipagin esters are by methyl hydroxybenzoate and propylben group
Into；And feeding sequence is：Methyl hydroxybenzoate before this, followed by propylben.
8. preparation method according to claim 7, wherein, the weight ratio of the methyl hydroxybenzoate and propylben is 1：
0.4-0.5。
9. preparation method according to claim 8, wherein, the diazonium alkyl imidazole urea, methyl hydroxybenzoate, nipalgin third
Ester, the weight ratio of propane diols are 15-17：42-44：19-21：20-22.
10. the bacteriostatic agent based on diazonium alkyl imidazole urea in a kind of 1-4 such as claim as described in any one is in skin care item
Application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710645027.XA CN107496185A (en) | 2017-08-01 | 2017-08-01 | Bacteriostatic agent based on diazonium alkyl imidazole urea and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710645027.XA CN107496185A (en) | 2017-08-01 | 2017-08-01 | Bacteriostatic agent based on diazonium alkyl imidazole urea and its preparation method and application |
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| Publication Number | Publication Date |
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| CN107496185A true CN107496185A (en) | 2017-12-22 |
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| CN201710645027.XA Pending CN107496185A (en) | 2017-08-01 | 2017-08-01 | Bacteriostatic agent based on diazonium alkyl imidazole urea and its preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114028320A (en) * | 2021-11-16 | 2022-02-11 | 广州市利伟保健品有限公司 | Plant bacteriostatic lotion for female private parts |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103535385A (en) * | 2013-10-25 | 2014-01-29 | 北京桑普生物化学技术有限公司 | Plant extract and synergist contained antimicrobial composition |
-
2017
- 2017-08-01 CN CN201710645027.XA patent/CN107496185A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103535385A (en) * | 2013-10-25 | 2014-01-29 | 北京桑普生物化学技术有限公司 | Plant extract and synergist contained antimicrobial composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114028320A (en) * | 2021-11-16 | 2022-02-11 | 广州市利伟保健品有限公司 | Plant bacteriostatic lotion for female private parts |
| CN114028320B (en) * | 2021-11-16 | 2024-04-26 | 广州市利伟保健品有限公司 | Plant antibacterial lotion for female private parts |
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Application publication date: 20171222 |