RU2018105003A - Композиции, содержащие аморфный эмодепсид - Google Patents
Композиции, содержащие аморфный эмодепсид Download PDFInfo
- Publication number
- RU2018105003A RU2018105003A RU2018105003A RU2018105003A RU2018105003A RU 2018105003 A RU2018105003 A RU 2018105003A RU 2018105003 A RU2018105003 A RU 2018105003A RU 2018105003 A RU2018105003 A RU 2018105003A RU 2018105003 A RU2018105003 A RU 2018105003A
- Authority
- RU
- Russia
- Prior art keywords
- spp
- emodepside
- nematode
- amorphic
- compositions containing
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Claims (4)
1. Способ лечения или профилактики от эндопаразита, включающий введение нуждающемуся в этом человеку или животному эффективного количества фармацевтической композиции, содержащей эмодепсид в поливинилпирролидоновой матрице, причем по меньшей мере 50% эмодепсида находятся в аморфном состоянии.
2. Способ по п. 1, причем эндопаразит представляет собой гельминт, выбранный из нематоды.
3. Способ по п. 2, причем эндопаразит представляет собой нематоду, выбранную из отряда Trichinellida, Tylenchida, Rhabditina, Spirurida.
4. Способ no п. 3, причем нематода выбрана из Trichuris spp., Trichinella spp., Strongyloides spp., Ancylostoma spp., Enterobius spp., Ascaris spp., Toxascaris spp., Dracunculus spp., Loa spp., Brugia spp., Wuchereria spp., Onchocerca spp.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11194878.2 | 2011-12-21 | ||
EP11194878 | 2011-12-21 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2014129620A Division RU2651761C2 (ru) | 2011-12-21 | 2012-12-18 | Композиции, содержащие аморфный эмодепсид |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2018105003A true RU2018105003A (ru) | 2019-02-22 |
RU2018105003A3 RU2018105003A3 (ru) | 2021-06-11 |
RU2761529C2 RU2761529C2 (ru) | 2021-12-09 |
Family
ID=47358491
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2014129620A RU2651761C2 (ru) | 2011-12-21 | 2012-12-18 | Композиции, содержащие аморфный эмодепсид |
RU2018105003A RU2761529C2 (ru) | 2011-12-21 | 2012-12-18 | Композиции, содержащие аморфный эмодепсид |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2014129620A RU2651761C2 (ru) | 2011-12-21 | 2012-12-18 | Композиции, содержащие аморфный эмодепсид |
Country Status (24)
Country | Link |
---|---|
US (3) | US9539331B2 (ru) |
EP (1) | EP2793861B1 (ru) |
JP (1) | JP6185930B2 (ru) |
KR (2) | KR101978620B1 (ru) |
CN (2) | CN108187028A (ru) |
AU (2) | AU2012357848C1 (ru) |
BR (1) | BR112014014973A2 (ru) |
CA (1) | CA2859787C (ru) |
CL (1) | CL2014001637A1 (ru) |
CO (1) | CO6990713A2 (ru) |
CR (1) | CR20140293A (ru) |
DO (1) | DOP2014000140A (ru) |
EC (1) | ECSP14005917A (ru) |
ES (1) | ES2734352T3 (ru) |
HK (1) | HK1255536A1 (ru) |
IL (1) | IL233183B (ru) |
MX (2) | MX368209B (ru) |
MY (1) | MY175307A (ru) |
NI (1) | NI201400065A (ru) |
PH (2) | PH12014501438B1 (ru) |
RU (2) | RU2651761C2 (ru) |
UA (1) | UA115232C2 (ru) |
WO (1) | WO2013092558A1 (ru) |
ZA (1) | ZA201404529B (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX368209B (es) | 2011-12-21 | 2019-09-24 | Bayer Pharma Ag Star | Preparaciones que comprenden emodepsido amorfo. |
SG10202103403SA (en) | 2015-05-20 | 2021-05-28 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic depsipeptide compounds |
CN108699052B (zh) | 2015-12-28 | 2022-04-29 | 勃林格殷格翰动物保健美国公司 | 驱虫缩酚酸肽化合物 |
CA3044038A1 (en) | 2016-11-16 | 2018-05-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
CN114195732A (zh) * | 2022-01-04 | 2022-03-18 | 丽珠集团福州福兴医药有限公司 | 一种艾默德斯的单晶型iii及其制备方法 |
CN115444927B (zh) * | 2022-09-19 | 2023-06-02 | 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) | 艾默德斯在制备治疗三阴性乳腺癌的药物中的应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE211466T1 (de) * | 1992-03-17 | 2002-01-15 | Fujisawa Pharmaceutical Co | Depsipeptide, herstellung und anwendung |
DE19918325A1 (de) * | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
DE10000792A1 (de) * | 2000-01-11 | 2001-07-19 | Bernhard C Lippold | Formulierungen von Wirkstoffen in Form einer festen Dispersion |
DE10031044A1 (de) | 2000-06-26 | 2002-01-03 | Bayer Ag | Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere |
DE10358525A1 (de) * | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
DE102004055316A1 (de) * | 2004-11-16 | 2006-05-18 | Bayer Healthcare Ag | Verhinderung vertikaler Endoparasiten-Infektionen |
DE102005011779A1 (de) * | 2005-03-11 | 2006-09-14 | Bayer Healthcare Ag | Endoparasitizide Mittel |
US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
RU2315614C1 (ru) * | 2006-04-19 | 2008-01-27 | Бийтемир Ахмедович Султанбеков | Средство "грепол" и способ применения его при паразитарных заболеваниях |
RU2425825C2 (ru) * | 2007-02-09 | 2011-08-10 | Пфайзер Лимитед | Амидоацетонитрильные производные, содержащие их фармацевтические композиции и их применение в изготовлении лекарственного средства |
DE102008022520A1 (de) | 2008-05-07 | 2009-11-12 | Bayer Animal Health Gmbh | Feste Arzneimittelformulierung mit verzögerter Freisetzung |
EP2355802A1 (de) * | 2008-11-14 | 2011-08-17 | Ratiopharm GmbH | Intermediate und orale darreichungsformen enthaltend lenalidomid |
DE102009012423A1 (de) * | 2009-03-10 | 2010-09-16 | Bayer Animal Health Gmbh | Zubereitung auf Ölbasis |
MX368209B (es) | 2011-12-21 | 2019-09-24 | Bayer Pharma Ag Star | Preparaciones que comprenden emodepsido amorfo. |
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2012
- 2012-12-18 MX MX2018002095A patent/MX368209B/es unknown
- 2012-12-18 US US14/365,841 patent/US9539331B2/en active Active
- 2012-12-18 CA CA2859787A patent/CA2859787C/en active Active
- 2012-12-18 MY MYPI2014701644A patent/MY175307A/en unknown
- 2012-12-18 WO PCT/EP2012/075909 patent/WO2013092558A1/de active Application Filing
- 2012-12-18 RU RU2014129620A patent/RU2651761C2/ru active
- 2012-12-18 KR KR1020187019676A patent/KR101978620B1/ko active IP Right Grant
- 2012-12-18 MX MX2014007224A patent/MX356094B/es active IP Right Grant
- 2012-12-18 CN CN201810220829.0A patent/CN108187028A/zh active Pending
- 2012-12-18 UA UAA201408095A patent/UA115232C2/uk unknown
- 2012-12-18 CN CN201280064016.8A patent/CN104023710A/zh active Pending
- 2012-12-18 ES ES12801761T patent/ES2734352T3/es active Active
- 2012-12-18 BR BR112014014973A patent/BR112014014973A2/pt not_active Application Discontinuation
- 2012-12-18 KR KR1020147017003A patent/KR101979049B1/ko active IP Right Grant
- 2012-12-18 AU AU2012357848A patent/AU2012357848C1/en active Active
- 2012-12-18 RU RU2018105003A patent/RU2761529C2/ru active
- 2012-12-18 JP JP2014547910A patent/JP6185930B2/ja active Active
- 2012-12-18 EP EP12801761.3A patent/EP2793861B1/de active Active
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2014
- 2014-06-16 CO CO14129965A patent/CO6990713A2/es unknown
- 2014-06-17 DO DO2014000140A patent/DOP2014000140A/es unknown
- 2014-06-17 IL IL233183A patent/IL233183B/en active IP Right Grant
- 2014-06-19 CL CL2014001637A patent/CL2014001637A1/es unknown
- 2014-06-19 CR CR20140293A patent/CR20140293A/es unknown
- 2014-06-19 EC ECIEPI20145917A patent/ECSP14005917A/es unknown
- 2014-06-20 PH PH12014501438A patent/PH12014501438B1/en unknown
- 2014-06-20 NI NI201400065A patent/NI201400065A/es unknown
- 2014-06-20 ZA ZA2014/04529A patent/ZA201404529B/en unknown
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2017
- 2017-01-04 US US15/397,923 patent/US20170182118A1/en not_active Abandoned
- 2017-11-03 US US15/803,445 patent/US10251932B2/en active Active
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2018
- 2018-02-15 PH PH12018500368A patent/PH12018500368A1/en unknown
- 2018-04-04 AU AU2018202376A patent/AU2018202376B2/en active Active
- 2018-08-16 HK HK18110516.4A patent/HK1255536A1/zh unknown
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