RU2013133864A - Составы менингококковых вакцин - Google Patents
Составы менингококковых вакцин Download PDFInfo
- Publication number
- RU2013133864A RU2013133864A RU2013133864/10A RU2013133864A RU2013133864A RU 2013133864 A RU2013133864 A RU 2013133864A RU 2013133864/10 A RU2013133864/10 A RU 2013133864/10A RU 2013133864 A RU2013133864 A RU 2013133864A RU 2013133864 A RU2013133864 A RU 2013133864A
- Authority
- RU
- Russia
- Prior art keywords
- meningitidis
- composition
- lyophilized
- kit
- strain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
1. Лиофилизированная антигенная композиция, включающая (i) иммуноген для индукции иммунного ответа против Neisseria meningitidis серологической группы B и (ii) конъюгированный капсульный сахарид из Neisseria meningitidis одной или нескольких серологических групп A, C, W135 и/или Y.2. Композиция по п. 1, где лиофилизированная антигенная композиция содержит мембранные везикулы из штамма N. meningitidis серологической группы B.3. Композиция по п. 1, где лиофилизированная антигенная композиция содержит рекомбинантные белки штамма N. meningitidis серологической группы B.4. Композиция по п. 1, где лиофилизированная антигенная композиция содержит липоолигосахарид из штамма N. meningitidis серологической группы B.5. Композиция по п. 1, где лиофилизированная антигенная композиция по существу не содержит солей алюминия.6. Набор, содержащий два контейнера, где один контейнер включает жидкость для восстановления, и второй контейнер включает лиофилизированную композицию по любому из предыдущих пунктов.7. Набор по п. 6, где жидкость для восстановления включает жидкий адъювант.8. Набор по п. 7, где жидкий адъювант включает эмульсию типа масло-в-воде.
Claims (8)
1. Лиофилизированная антигенная композиция, включающая (i) иммуноген для индукции иммунного ответа против Neisseria meningitidis серологической группы B и (ii) конъюгированный капсульный сахарид из Neisseria meningitidis одной или нескольких серологических групп A, C, W135 и/или Y.
2. Композиция по п. 1, где лиофилизированная антигенная композиция содержит мембранные везикулы из штамма N. meningitidis серологической группы B.
3. Композиция по п. 1, где лиофилизированная антигенная композиция содержит рекомбинантные белки штамма N. meningitidis серологической группы B.
4. Композиция по п. 1, где лиофилизированная антигенная композиция содержит липоолигосахарид из штамма N. meningitidis серологической группы B.
5. Композиция по п. 1, где лиофилизированная антигенная композиция по существу не содержит солей алюминия.
6. Набор, содержащий два контейнера, где один контейнер включает жидкость для восстановления, и второй контейнер включает лиофилизированную композицию по любому из предыдущих пунктов.
7. Набор по п. 6, где жидкость для восстановления включает жидкий адъювант.
8. Набор по п. 7, где жидкий адъювант включает эмульсию типа масло-в-воде.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99959007P | 2007-10-19 | 2007-10-19 | |
| US60/999,590 | 2007-10-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010119947/10A Division RU2498815C2 (ru) | 2007-10-19 | 2008-10-17 | НАБОР ДЛЯ ПОЛУЧЕНИЯ ИММУНОГЕННОЙ КОМПОЗИЦИИ ПРОТИВ Neisseria meningitidis СЕРОЛОГИЧЕСКОЙ ГРУППЫ В |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013133864A true RU2013133864A (ru) | 2015-01-27 |
Family
ID=40428348
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010119947/10A RU2498815C2 (ru) | 2007-10-19 | 2008-10-17 | НАБОР ДЛЯ ПОЛУЧЕНИЯ ИММУНОГЕННОЙ КОМПОЗИЦИИ ПРОТИВ Neisseria meningitidis СЕРОЛОГИЧЕСКОЙ ГРУППЫ В |
| RU2013133864/10A RU2013133864A (ru) | 2007-10-19 | 2013-07-19 | Составы менингококковых вакцин |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010119947/10A RU2498815C2 (ru) | 2007-10-19 | 2008-10-17 | НАБОР ДЛЯ ПОЛУЧЕНИЯ ИММУНОГЕННОЙ КОМПОЗИЦИИ ПРОТИВ Neisseria meningitidis СЕРОЛОГИЧЕСКОЙ ГРУППЫ В |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20100285069A1 (ru) |
| EP (2) | EP2200642B1 (ru) |
| JP (3) | JP5701058B2 (ru) |
| CN (1) | CN101951949B (ru) |
| AT (1) | ATE553774T1 (ru) |
| AU (1) | AU2008313424B2 (ru) |
| BR (2) | BR122016015627A2 (ru) |
| CA (2) | CA2702871A1 (ru) |
| CO (1) | CO6270339A2 (ru) |
| CY (1) | CY1112908T1 (ru) |
| DK (1) | DK2200642T3 (ru) |
| ES (1) | ES2383231T3 (ru) |
| HR (1) | HRP20120433T1 (ru) |
| MX (2) | MX2010004271A (ru) |
| NZ (1) | NZ584683A (ru) |
| PL (1) | PL2200642T3 (ru) |
| PT (1) | PT2200642E (ru) |
| RU (2) | RU2498815C2 (ru) |
| SI (1) | SI2200642T1 (ru) |
| WO (1) | WO2009050586A1 (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| CA2688268A1 (en) * | 2007-06-04 | 2008-12-11 | Novartis Ag | Formulation of meningitis vaccines |
| US20100189737A1 (en) * | 2008-12-17 | 2010-07-29 | Arico Beatrice | Meningococcal vaccines including hemoglobin receptor |
| AU2010290896B2 (en) | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
| RU2580620C2 (ru) * | 2010-08-23 | 2016-04-10 | ВАЙЕТ ЭлЭлСи | СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086 |
| ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
| PE20140173A1 (es) | 2010-09-10 | 2014-02-20 | Wyeth Llc | Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis |
| BR112013022397A2 (pt) | 2011-03-02 | 2017-09-26 | Derek OHagan | vacinas combinadas com doses menores de antígeno e/ou adjuvante |
| US9283270B2 (en) * | 2012-01-20 | 2016-03-15 | Serum Institute Of India Ltd. | Method for stabilization of biological molecules |
| PL2822947T3 (pl) | 2012-03-07 | 2017-01-31 | Glaxosmithkline Biologicals Sa | Sole argininowe agonisty TLR7 |
| AU2013229432A1 (en) | 2012-03-08 | 2014-10-16 | Novartis Ag | Adjuvanted formulations of booster vaccines |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| MY198910A (en) | 2012-03-09 | 2023-10-02 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| CN104736563A (zh) | 2012-07-27 | 2015-06-24 | 国家健康与医学研究院 | Cd147作为受体用于脑膜炎球菌至血管内皮的菌毛介导的粘附 |
| EP2964665B1 (en) | 2013-03-08 | 2018-08-01 | Pfizer Inc | Immunogenic fusion polypeptides |
| MX369534B (es) | 2013-09-08 | 2019-11-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos. |
| CN107249626A (zh) | 2015-02-19 | 2017-10-13 | 辉瑞大药厂 | 脑膜炎奈瑟球菌组合物及其方法 |
| MX2019002489A (es) | 2016-09-02 | 2019-10-21 | Sanofi Pasteur Inc | Vacuna contra neisseria meningitidis. |
| SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| CN111278458A (zh) * | 2017-10-25 | 2020-06-12 | 默沙东公司 | 佐剂疫苗 |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
| US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
| US4663160A (en) | 1983-03-14 | 1987-05-05 | Miles Laboratories, Inc. | Vaccines for gram-negative bacteria |
| US4761283A (en) | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| IT1187753B (it) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
| US5204098A (en) | 1988-02-16 | 1993-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-protein conjugates |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| NL8802046A (nl) | 1988-08-18 | 1990-03-16 | Gen Electric | Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen. |
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| CA2006700A1 (en) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
| JPH04506662A (ja) | 1989-07-14 | 1992-11-19 | アメリカン・サイアナミド・カンパニー | 接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| ATE128628T1 (de) | 1990-08-13 | 1995-10-15 | American Cyanamid Co | Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff. |
| IL101007A (en) | 1992-02-18 | 1997-08-14 | Pharmos Ltd | Dry stable compositions prepared by lyophilization |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| US5425946A (en) | 1992-08-31 | 1995-06-20 | North American Vaccine, Inc. | Vaccines against group C Neisseria meningitidis |
| PT658118E (pt) | 1992-08-31 | 2002-05-31 | Baxter Healthcare Sa | Vacinas contra neisseria meningitidis do grupo c |
| WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| GB9422096D0 (en) * | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| US6180111B1 (en) | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| AU7701098A (en) | 1997-05-28 | 1998-12-30 | Michael A. Apicella | Laft mutants of pathogenic gram-negative bacteria |
| GB9711964D0 (en) | 1997-06-09 | 1997-08-06 | Medical Res Council | Live attenuated vaccines |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| ATE384130T1 (de) | 1997-08-21 | 2008-02-15 | Nederlanden Staat | Neue mutanten der gram-negativen mukosalen bakterien und ihre verwendung als impfstoffe |
| AU9363798A (en) | 1997-11-06 | 1999-05-31 | Chiron S.P.A. | Neisserial antigens |
| CA2317815A1 (en) | 1998-01-14 | 1999-07-22 | Chiron S.P.A. | Neisseria meningitidis antigens |
| WO1999040188A2 (en) * | 1998-02-05 | 1999-08-12 | Smithkline Beecham Biologicals S.A. | Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccinations |
| US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| US6645503B1 (en) | 1998-03-10 | 2003-11-11 | Wyeth Holdings Corporation | Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria |
| ES2304065T3 (es) | 1998-05-01 | 2008-09-01 | Novartis Vaccines And Diagnostics, Inc. | Antigenos y composiciones de neisseria meningitidis. |
| ES2278446T3 (es) * | 1998-05-29 | 2007-08-01 | Novartis Vaccines And Diagnostics, Inc. | Vacunas combinadas b/c contra la meningitis. |
| EP1741443B1 (en) * | 1998-05-29 | 2014-05-21 | Novartis Vaccines and Diagnostics, Inc. | Combination meningitidis B/C vaccines |
| EP1109576B1 (en) | 1998-08-19 | 2009-10-21 | Baxter Healthcare SA | Immunogenic beta-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an n-acryloylated polysaccharide |
| AU1202200A (en) | 1998-10-09 | 2000-05-01 | Chiron Corporation | Neisseria genomic sequences and methods of their use |
| GB9823978D0 (en) | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| AU762369B2 (en) | 1998-11-03 | 2003-06-26 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur | LPS with reduced toxicity from genetically modified gram negative bacteria |
| AU1626199A (en) | 1998-12-04 | 2000-06-26 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | A vi-repa conjugate vaccine for immunization against salmonella typhi |
| EP1880735A3 (en) | 1999-03-19 | 2008-03-12 | GlaxoSmithKline Biologicals S.A. | Vaccine |
| JP2002541808A (ja) | 1999-04-09 | 2002-12-10 | テクラブ， インコーポレイテッド | ポリサッカリド結合体ワクチンのための組換えトキシンａタンパク質キャリア |
| GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| US6531131B1 (en) | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
| GB9925559D0 (en) | 1999-10-28 | 1999-12-29 | Smithkline Beecham Biolog | Novel method |
| AU1917501A (en) | 1999-11-12 | 2001-06-06 | University Of Iowa Research Foundation, The | Control of neisserial membrane synthesis |
| DK2289545T3 (en) | 2000-01-17 | 2016-09-05 | Glaxosmithkline Biologicals Sa | Supplemented OMV vaccine against meningococcus |
| CN100473663C (zh) | 2000-02-28 | 2009-04-01 | 启龙股份公司 | 奈瑟球菌蛋白质的异源表达 |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| CA2416137C (en) | 2000-07-27 | 2013-01-29 | Dan Granoff | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| JP2005504718A (ja) | 2001-01-23 | 2005-02-17 | アヴェンティス パストゥール | 多価髄膜炎菌多糖−タンパク質複合ワクチン |
| GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| AU2002309706A1 (en) | 2001-05-11 | 2002-11-25 | Aventis Pasteur, Inc. | Novel meningitis conjugate vaccine |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| MXPA04009339A (es) | 2002-03-26 | 2005-01-25 | Chiron Srl | Sacaridos modificados que tienen estabilidad mejorada en agua. |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| GB0213622D0 (en) | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| JP2006500963A (ja) | 2002-08-02 | 2006-01-12 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン組成物 |
| GB0218821D0 (en) * | 2002-08-13 | 2002-09-18 | Glaxosmithkline Biolog Sa | Novel compositions |
| GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| CA2823937A1 (en) * | 2002-10-07 | 2004-04-22 | Novartis Vaccines And Diagnostics, Inc. | Hiv vaccine formulations |
| AU2003274511B2 (en) | 2002-10-11 | 2009-06-04 | Glaxosmithkline Biologicals S.A. | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
| DK2279746T3 (da) * | 2002-11-15 | 2013-11-25 | Novartis Vaccines & Diagnostic | Overfladeproteiner i neisseria meningitidis |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| WO2004067030A2 (en) * | 2003-01-30 | 2004-08-12 | Chiron Srl | Injectable vaccines against multiple meningococcal serogroups |
| CA2521050A1 (en) * | 2003-04-02 | 2004-10-14 | Coley Pharmaceutical Group, Ltd. | Immunostimulatory nucleic acid oil-in-water formulations and related methods of use |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| ES2397923T3 (es) * | 2003-10-02 | 2013-03-12 | Novartis Ag | Vacunas líquidas para múltiples serogrupos meningocócicos |
| EP1706481A2 (en) * | 2003-12-23 | 2006-10-04 | GlaxoSmithKline Biologicals S.A. | Vaccine |
| KR20070008625A (ko) | 2004-04-05 | 2007-01-17 | 화이자 프로덕츠 인코포레이티드 | 미세유체화된 수중유 유화액 및 백신 조성물 |
| GB0409745D0 (en) * | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| WO2007013893A2 (en) * | 2004-11-15 | 2007-02-01 | Novartis Vaccines And Diagnostics Inc. | Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant |
| EP2682126B1 (en) | 2005-01-27 | 2016-11-23 | Children's Hospital & Research Center at Oakland | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| WO2006100111A1 (en) | 2005-03-23 | 2006-09-28 | Glaxosmithkline Biologicals S.A. | Composition |
| US20060228369A1 (en) | 2005-04-11 | 2006-10-12 | Program For Appropriate Technology In Health | Stabilization and preservation of temperature-sensitive vaccines |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| US8156755B2 (en) * | 2005-06-03 | 2012-04-17 | Intervet International B.V. | Refrigerator for storing vials and cartridge for use in the same |
| MX2007016403A (es) | 2005-06-27 | 2008-03-07 | Glaxosmithkline Biolog Sa | Composicion inmunogenica. |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| AR058592A1 (es) | 2005-12-22 | 2008-02-13 | Glaxosmithkline Biolog Sa | Vacuna |
| EP1991204A2 (en) * | 2006-02-24 | 2008-11-19 | Novartis AG | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| GB0700135D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Vaccine |
| CA2688268A1 (en) * | 2007-06-04 | 2008-12-11 | Novartis Ag | Formulation of meningitis vaccines |
-
2008
- 2008-10-17 PT PT08838605T patent/PT2200642E/pt unknown
- 2008-10-17 AU AU2008313424A patent/AU2008313424B2/en not_active Ceased
- 2008-10-17 EP EP08838605A patent/EP2200642B1/en not_active Not-in-force
- 2008-10-17 CN CN2008801213328A patent/CN101951949B/zh not_active Expired - Fee Related
- 2008-10-17 MX MX2010004271A patent/MX2010004271A/es active IP Right Grant
- 2008-10-17 CA CA2702871A patent/CA2702871A1/en not_active Abandoned
- 2008-10-17 PL PL08838605T patent/PL2200642T3/pl unknown
- 2008-10-17 RU RU2010119947/10A patent/RU2498815C2/ru not_active IP Right Cessation
- 2008-10-17 EP EP12158035A patent/EP2462949A3/en not_active Withdrawn
- 2008-10-17 SI SI200830631T patent/SI2200642T1/sl unknown
- 2008-10-17 CA CA2925217A patent/CA2925217A1/en not_active Abandoned
- 2008-10-17 ES ES08838605T patent/ES2383231T3/es active Active
- 2008-10-17 AT AT08838605T patent/ATE553774T1/de active
- 2008-10-17 JP JP2010529472A patent/JP5701058B2/ja not_active Expired - Fee Related
- 2008-10-17 DK DK08838605.7T patent/DK2200642T3/da active
- 2008-10-17 NZ NZ584683A patent/NZ584683A/en not_active IP Right Cessation
- 2008-10-17 US US12/734,185 patent/US20100285069A1/en not_active Abandoned
- 2008-10-17 BR BR122016015627A patent/BR122016015627A2/pt not_active Application Discontinuation
- 2008-10-17 WO PCT/IB2008/003283 patent/WO2009050586A1/en active Application Filing
- 2008-10-17 BR BRPI0818545A patent/BRPI0818545A2/pt not_active IP Right Cessation
- 2008-10-17 MX MX2012007222A patent/MX340096B/es unknown
-
2010
- 2010-05-04 CO CO10052816A patent/CO6270339A2/es not_active Application Discontinuation
-
2012
- 2012-05-23 HR HRP20120433AT patent/HRP20120433T1/xx unknown
- 2012-07-12 CY CY20121100625T patent/CY1112908T1/el unknown
-
2013
- 2013-07-19 RU RU2013133864/10A patent/RU2013133864A/ru not_active Application Discontinuation
- 2013-07-30 JP JP2013157634A patent/JP5925736B2/ja not_active Expired - Fee Related
-
2015
- 2015-11-19 JP JP2015226282A patent/JP2016029108A/ja not_active Withdrawn
-
2016
- 2016-01-29 US US15/011,216 patent/US20160228529A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2013133864A (ru) | Составы менингококковых вакцин | |
| RU2006114677A (ru) | Жидкие вакцины для множественных серогрупп менингококков | |
| Saukkonen et al. | Comparative evaluation of potential components for group B meningococcal vaccine by passive protection in the infant rat and in vitro bactericidal assay | |
| Sanders et al. | Adjuvant properties of meningococcal outer membrane vesicles and the use of adjuvants in Neisseria meningitidis protein vaccines | |
| RU2009149359A (ru) | Состав вакцин против менингита | |
| ES2278446T3 (es) | Vacunas combinadas b/c contra la meningitis. | |
| JP2011500662A5 (ru) | ||
| MX348734B (es) | Vacunacion multiple que incluye meningococcus del serogrupo c. | |
| JP2014506916A5 (ru) | ||
| RU2010138815A (ru) | МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP | |
| JP2011042693A5 (ru) | ||
| DE602005015961D1 (de) | Kombinierte meningokokken-konjugate mit gemeinsamen trägerprotein | |
| RU2004136299A (ru) | Мукозальные вакцины с хитозановым адъювантом и/или антигенами менингококков | |
| JP2007516219A5 (ru) | ||
| RU2007102016A (ru) | Пространственный анализ конъюгатов сахаридов с помощью gpc и sec-mals | |
| RU2013144207A (ru) | Комбинированные вакцины с пониженными дозами антигена и/или адъюванта | |
| AR046840A1 (es) | Polisacaridos capsulares de neisseria meningitidis como inmunopotenciadores mucosales y formulaciones resultantes | |
| RU2015100889A (ru) | Вакцины для менингококка серогруппы х | |
| RU2494758C2 (ru) | Нейссериальные вакцинные композиции, содержащие комбинацию антигенов | |
| Beuvery | Immunisation against bacterial meningitis | |
| STANDARDIZATION | Response to Vaccine Antigens | |
| EP4249061A3 (en) | Immunogenic compositions against enteric diseases and methods for its preparation thereof | |
| AU2012200061B2 (en) | Multivalent meningococcal derivatized polysaccharide-protein conjugates and corresponding vaccines | |
| Petousis-Harris et al. | 2012 antigen review for the New Zealand national immunisation schedule: Meningococcal B and C | |
| Borrow et al. | The future of meningococcal vaccines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20171117 |