RU2007136616A - Композиция и способ для местного применения и чрескожного введения ботулинового токсина - Google Patents

Композиция и способ для местного применения и чрескожного введения ботулинового токсина Download PDF

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RU2007136616A
RU2007136616A RU2007136616/15A RU2007136616A RU2007136616A RU 2007136616 A RU2007136616 A RU 2007136616A RU 2007136616/15 A RU2007136616/15 A RU 2007136616/15A RU 2007136616 A RU2007136616 A RU 2007136616A RU 2007136616 A RU2007136616 A RU 2007136616A
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composition according
positively charged
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skin surface
agent
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Майкл Д. ДЭЙК (US)
Майкл Д. ДЭЙК
Джейкоб М. ВО (US)
Джейкоб М. ВО
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Риванс Терапьютикс, Инк. (Us)
Риванс Терапьютикс, Инк.
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin

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Abstract

1. Состав, включающий: ! ботулинический токсин, ! положительно заряженный носитель и, ! по меньшей мере, одно вещество, выбранное из группы, состоящей из распределяющего агента, олигомерного мостикового соединения и полианионного мостикового соединения, ! при этом ботулинический токсин входит в состав нековалентного комплекса с положительно заряженным носителем. ! 2. Состав по п.1, отличающийся тем, что положительно заряженный носитель содержит также боковые группы. ! 3. Состав по п.1 или 2, отличающийся тем, что положительно заряженный носитель имеет молекулярный вес менее 21 000. ! 4. Состав по п.3, отличающийся тем, что положительно заряженный носитель представляет собой полилизин или PEI. ! 5. Состав по п.2, отличающийся тем, что боковые группы представляют собой защищенный олигоаргинин или домены TAT. ! 6. Состав по п.1, отличающийся тем, что он содержит дополнительно агент, модифицирующий вязкость. ! 7. Состав по п.6, отличающийся тем, что агент, модифицирующий вязкость, представляет собой гидроксипропилцеллюлозу или Cetaphil. ! 8. Набор для трансдермальной доставки ботулинического токсина, содержащий состав по п.1. ! 9. Способ обработки морщин, включающий нанесение на поверхность кожи пациента состава по п.1 и возможное последующее нанесение агента окклюзии. ! 10. Способ лечения гипергидроза, включающий нанесение на поверхность кожи пациента состава по п.1 и возможное последующее нанесение агента окклюзии. ! 11. Способ по п.9, отличающийся тем, что поверхность кожи выбрана из группы, состоящей из поверхности лица, лба, шеи, рук и ног. ! 12. Способ по п.10, отличающийся тем, что поверхность кожи выбрана из группы, состоящей из поверхности подмышечн

Claims (12)

1. Состав, включающий:
ботулинический токсин,
положительно заряженный носитель и,
по меньшей мере, одно вещество, выбранное из группы, состоящей из распределяющего агента, олигомерного мостикового соединения и полианионного мостикового соединения,
при этом ботулинический токсин входит в состав нековалентного комплекса с положительно заряженным носителем.
2. Состав по п.1, отличающийся тем, что положительно заряженный носитель содержит также боковые группы.
3. Состав по п.1 или 2, отличающийся тем, что положительно заряженный носитель имеет молекулярный вес менее 21 000.
4. Состав по п.3, отличающийся тем, что положительно заряженный носитель представляет собой полилизин или PEI.
5. Состав по п.2, отличающийся тем, что боковые группы представляют собой защищенный олигоаргинин или домены TAT.
6. Состав по п.1, отличающийся тем, что он содержит дополнительно агент, модифицирующий вязкость.
7. Состав по п.6, отличающийся тем, что агент, модифицирующий вязкость, представляет собой гидроксипропилцеллюлозу или Cetaphil.
8. Набор для трансдермальной доставки ботулинического токсина, содержащий состав по п.1.
9. Способ обработки морщин, включающий нанесение на поверхность кожи пациента состава по п.1 и возможное последующее нанесение агента окклюзии.
10. Способ лечения гипергидроза, включающий нанесение на поверхность кожи пациента состава по п.1 и возможное последующее нанесение агента окклюзии.
11. Способ по п.9, отличающийся тем, что поверхность кожи выбрана из группы, состоящей из поверхности лица, лба, шеи, рук и ног.
12. Способ по п.10, отличающийся тем, что поверхность кожи выбрана из группы, состоящей из поверхности подмышечной ямки, лба, спины, груди, ладоней, дорсальной части руки, тыльной части стопы или подошвы ноги.
RU2007136616/15A 2005-03-03 2006-03-03 Композиция и способ для местного применения и чрескожного введения ботулинового токсина RU2007136616A (ru)

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RU2013114743/15A RU2013114743A (ru) 2005-03-03 2013-04-02 Композиции и способы для топического нанесения и трансдермальной доставки ботулинических токсинов

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EP (1) EP1861112A4 (ru)
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KR (2) KR101453963B1 (ru)
CN (3) CN102499981B (ru)
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US20070077259A1 (en) 2007-04-05
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US9314416B2 (en) 2016-04-19
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