BRPI0508410B8 - composições e métodos para a aplicação tópica e liberação transdérmica de toxinas botulínicas - Google Patents

composições e métodos para a aplicação tópica e liberação transdérmica de toxinas botulínicas

Info

Publication number
BRPI0508410B8
BRPI0508410B8 BRPI0508410A BRPI0508410A BRPI0508410B8 BR PI0508410 B8 BRPI0508410 B8 BR PI0508410B8 BR PI0508410 A BRPI0508410 A BR PI0508410A BR PI0508410 A BRPI0508410 A BR PI0508410A BR PI0508410 B8 BRPI0508410 B8 BR PI0508410B8
Authority
BR
Brazil
Prior art keywords
botulinum toxin
methods
topical application
compositions
transdermal delivery
Prior art date
Application number
BRPI0508410A
Other languages
English (en)
Inventor
M Waugh Jacob
D Dake Michael
Original Assignee
Revance Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revance Therapeutics Inc filed Critical Revance Therapeutics Inc
Publication of BRPI0508410A publication Critical patent/BRPI0508410A/pt
Publication of BRPI0508410A8 publication Critical patent/BRPI0508410A8/pt
Publication of BRPI0508410B1 publication Critical patent/BRPI0508410B1/pt
Publication of BRPI0508410B8 publication Critical patent/BRPI0508410B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Urology & Nephrology (AREA)

Abstract

composições e métodos para a aplicação tópica e liberação transdérmica de toxinas botulínicas. a presente invenção refere-se a uma composição para a aplicação tópica de uma toxina botulínica (incluindo derivados de toxina botulínica), que compreende uma toxina botulínica e um veículo compreendendo uma cadeia princial polimérica que compreende um polipeptídeo de cadeia longa ou polímero de não peptidila tendo grupos de ramificação ou "eficiência" positivamente carregado ligados. a invenção também se refere a métodos para redução da paralisia muscular e outras condições que podem ser tratadas com uma toxina botulínica, particularmente paralisia dos músculos subcutâneos, e mais preferivelmente, faciais, mediante a aplicação tópica de uma quantidade eficaaz da toxina botulínica e veículo, em conjunto, na pele ou epitélio do indivíduo. kits para administração também são descritos.
BRPI0508410A 2004-03-03 2005-03-03 composições e métodos para a aplicação tópica e liberação transdérmica de toxinas botulínicas BRPI0508410B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55001504P 2004-03-03 2004-03-03
PCT/US2005/007524 WO2005084410A2 (en) 2004-03-03 2005-03-03 Compositions and methods for topical application and transdermal delivery of botulinum toxins

Publications (4)

Publication Number Publication Date
BRPI0508410A BRPI0508410A (pt) 2007-07-24
BRPI0508410A8 BRPI0508410A8 (pt) 2017-03-14
BRPI0508410B1 BRPI0508410B1 (pt) 2017-05-09
BRPI0508410B8 true BRPI0508410B8 (pt) 2021-05-25

Family

ID=34919562

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508410A BRPI0508410B8 (pt) 2004-03-03 2005-03-03 composições e métodos para a aplicação tópica e liberação transdérmica de toxinas botulínicas

Country Status (25)

Country Link
US (2) US8398997B2 (pt)
EP (3) EP1729821B1 (pt)
JP (1) JP5095388B2 (pt)
KR (3) KR101322433B1 (pt)
CN (2) CN102357062B (pt)
AU (1) AU2005218665A1 (pt)
BR (1) BRPI0508410B8 (pt)
CA (1) CA2558408C (pt)
CR (1) CR8602A (pt)
CY (1) CY1120816T1 (pt)
DK (3) DK1729821T3 (pt)
ES (3) ES2691498T3 (pt)
HK (4) HK1105774A1 (pt)
HU (1) HUE025656T2 (pt)
IL (4) IL177816A (pt)
LT (1) LT2985039T (pt)
MX (2) MX345724B (pt)
NO (1) NO20064490L (pt)
NZ (1) NZ592041A (pt)
PL (1) PL2985039T3 (pt)
PT (3) PT1729821E (pt)
SG (3) SG150568A1 (pt)
SI (3) SI2656859T1 (pt)
TR (1) TR201815364T4 (pt)
WO (1) WO2005084410A2 (pt)

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DK2656859T3 (en) 2016-01-11
HK1162952A1 (zh) 2012-09-07
IL177816A0 (en) 2006-12-31
KR101343411B1 (ko) 2013-12-19
KR101322433B1 (ko) 2013-10-28
NZ592041A (en) 2012-12-21
IL237386A (en) 2017-07-31
KR20070018047A (ko) 2007-02-13
IL237388A (en) 2017-07-31
CY1120816T1 (el) 2019-12-11
BRPI0508410A8 (pt) 2017-03-14
WO2005084410A3 (en) 2006-06-29
KR20130060360A (ko) 2013-06-07
ES2554821T3 (es) 2015-12-23
IL237388A0 (en) 2015-04-30
CN102357062B (zh) 2015-08-05
HK1221650A1 (zh) 2017-06-09
CN102357062A (zh) 2012-02-22

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