RU2007107945A - Адгезивная композиция - Google Patents
Адгезивная композиция Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A61L15/585—Mixtures of macromolecular compounds
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J153/00—Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A61K9/7007—Drug-containing films, membranes or sheets
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J139/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Adhesives based on derivatives of such polymers
- C09J139/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C09J139/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J153/00—Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
- C09J153/02—Vinyl aromatic monomers and conjugated dienes
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- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J155/00—Adhesives based on homopolymers or copolymers, obtained by polymerisation reactions only involving carbon-to-carbon unsaturated bonds, not provided for in groups C09J123/00 - C09J153/00
- C09J155/02—ABS [Acrylonitrile-Butadiene-Styrene] polymers
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C08K3/34—Silicon-containing compounds
- C08K3/346—Clay
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- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
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- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
- C08L2666/24—Graft or block copolymers according to groups C08L51/00, C08L53/00 or C08L55/02; Derivatives thereof
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- C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L53/02—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers of vinyl-aromatic monomers and conjugated dienes
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- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
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Claims (35)
1. Адгезивная композиция, содержащая:
гидрофобный полимер;
высокоэластичный пластификатор;
повышающую клейкость смолу;
гидрофильный полимер;
дополнительный полимер, способный к образованию водородных связей с гидрофильным полимером;
и частицы глины.
2. Композиция по п.1, в которой гидрофобный полимер выбирают из полиизобутиленов, бутилкаучуков, адгезивов на основе натурального каучука, полимеров простого винилового эфира, полисилоксанов, полиизопренов, стирол-изопрен-стирольных блок-сополимеров, стирол-бутадиен-стирольных блок-сополимеров, изобутилен-изопреновых сополимеров, бутадиен-акрилонитрильного каучука, полихлоропренов, этилен-пропилен-диеновых терсополимеров, акрилатов и их комбинаций.
3. Композиция по п.2, в которой гидрофобный полимер выбирают из полиизопренов, бутилкаучука, стирол-изопрен-стирольных блок-сополимеров и стирол-бутадиен-стирольных блок-сополимеров.
4. Композиция по п.1, в которой высокоэластичный пластификатор выбирают из пластификаторов на основе стирола, полиизобутиленов с низкой молекулярной массой, полиизопреновых каучуков с низкой молекулярной массой и их комбинаций.
5. Композиция по п.4, в которой пластификатор на основе стирола выбирают из стирол-бутадиеновых блок-сополимеров, стирол-изопреновых блок-сополимеров и их комбинаций.
6. Композиция по п.1, в которой повышающая клейкость смола представляет собой повышающую клейкость смолу, выбранную из гидрогенизированных углеводородных смол, углеводородных смол и синтетических политерпеновых смол.
7. Композиция по п.1, в которой гидрофильный полимер выбирают из поли(N-виниллактамов), поли(N-виниламидов), поли(N-винилакриламидов), поли(N-алкилакриламидов), полиакриловой кислоты, полиметакриловой кислоты, поливинилового спирта, поливиниламина, производных целлюлозы, полисахаридов и их сополимеров и смесей.
8. Композиция по п.7, в которой гидрофильный полимер выбирают из поли(N-виниллактамов), поли(N-виниламидов), поли(N-алкилакриламидов) и их сополимеров и смесей.
9. Композиция по п.1, в которой дополнительный полимер представляет собой олигомер, выбранный из полиалкиленгликолей с низкой молекулярной массой, многоатомных спиртов с низкой молекулярной массой, мономерных и олигомерных алкиленгликолей, неполных эфиров многоатомных спиртов, дикарбоновых кислот и алкандиолов.
10. Композиция по п.9, в которой олигомер представляет собой полиалкиленгликоль с низкой молекулярной массой.
11. Композиция по п.1, в которой средний диаметр частиц глины составляет приблизительно <15 мкм.
12. Композиция по п.1, в которой частицы глины состоят из филлосиликата.
13. Композиция по п.12, в которой филлосиликат представляет собой монтмориллонит.
14. Композиция по п.1, которая содержит приблизительно 1-40 мас.% гидрофобного полимера; приблизительно 1-30 мас.% высокоэластичного пластификатора; приблизительно 1-30 мас.% повышающей клейкость смолы; приблизительно 1-50 мас.% гидрофильного полимера; приблизительно 1-30 мас.% дополнительного полимера; и приблизительно 1-30 мас.% частиц глины.
15. Композиция по п.14, которая содержит приблизительно 15-25 мас.% гидрофобного полимера; приблизительно 10-20 мас.% высокоэластичного пластификатора; приблизительно 13-20 мас.% повышающей клейкость смолы; приблизительно 20-30 мас.% гидрофильного полимера; приблизительно 8-18 мас.% дополнительного полимера; и приблизительно 8-15 мас.% частиц глины.
16. Композиция по п.1, которая дополнительно содержит активное вещество.
17. Композиция по п.16, в которой активное вещество выбрано из антибиотиков, противогрибковых веществ, противовоспалительных веществ, бактериостатических и бактерицидных соединений, прижигающих веществ, кератолитических веществ, болеутоляющих веществ, протеолитических ферментов, веществ, улучшающих заживление тканей, вазодилататоров, кожно-нарывных средств и их комбинаций и присутствует в терапевтически эффективном количестве.
18. Композиция по п.16, которая дополнительно содержит усилитель проницаемости.
19. Композиция по п.1, которая дополнительно содержит по меньшей мере один дополнительный компонент, выбранный из группы, состоящей из адгезивных веществ, антиоксидантов, перекрестно-сшивающих или вулканизирующих агентов, регуляторов рН, пигментов, красителей, отражающих частиц, проводящих частиц и противомикробных веществ.
20. Адгезивная композиция, содержащая
гидрофобный полимер, выбранный из полиизопренов, бутилкаучуков, стирол-изопрен-стирольных блок-сополимеров и стирол-бутадиен-стирольных блок-сополимеров;
высокоэластичный пластификатор, выбранный из пластификаторов на основе стирола, полиизобутиленов с низкой молекулярной массой, полиизопреновых каучуков с низкой молекулярной массой и их комбинаций;
повышающую клейкость смолу, выбранную из гидрогенизированных углеводородных смол, углеводородных смол и синтетических политерпеновых смол;
гидрофильный полимер, выбранный из поли(N-виниллактамов), поли(N-виниламидов), поли(N-винилакриламидов), поли(N-алкилакриламидов), полиакриловой кислоты, полиметакриловой кислоты, поливинилового спирта, поливиниламина, производных целлюлозы, полисахаридов и их сополимеров и смесей;
дополнительный полимер, выбранный из полиалкиленгликолей с низкой молекулярной массой, многоатомных спиртов с низкой молекулярной массой, мономерных и олигомерных алкиленгликолей, неполных эфиров многоатомных спиртов, дикарбоновых кислот и алкандиолов; и
частиц филлосиликата.
21. Композиция по п.20, в которой гидрофобный полимер представляет собой стирол-изопрен-стирольный блок-сополимер.
22. Композиция по п.20, в которой высокоэластичный пластификатор представляет собой полиизопреновый каучук с низкой молекулярной массой.
23. Композиция по п.20, в которой повышающая клейкость смола представляет собой гидрогенизированную углеводородную смолу.
24. Композиция по п.20, в которой гидрофильный полимер выбирают из поли(N-виниллактамов), поли(N-виниламидов), поли(N-алкилакриламидов) и их сополимеров и смесей.
25. Композиция по п.20, в которой дополнительный полимер представляет собой полиалкиленгликоль с низкой молекулярной массой.
26. Композиция по п.20, в которой филлосиликат представляет собой монтмориллонит.
27. Адгезивная подушка для прикладывания к коже, содержащая: контактирующий с кожей слой адгезивной композиции по п.1 и поддерживающий слой.
28. Раневая повязка, содержащая слоистый композит обращенного к телу слоя, имеющий контактирующую с телом поверхность, и обращенный кнаружи неокклюзивный поддерживающий слой, в которой по меньшей мере часть контактирующей с телом поверхности состоит из адгезивной композиции по п.1.
29. Устройство для чрескожной доставки лекарств, состоящее из резервуара для лекарства, содержащего терапевтически эффективное количество активного вещества, обращенный кнаружи поддерживающий слой и средства для фиксации устройства к поверхности тела, содержащие адгезивную композицию по п.1.
30. Медленно растворяющаяся пленка, содержащая
гидрофильный полимер, выбранный из поли(N-виниллактамов), поли(N-виниламидов), поли(N-винилакриламидов), поли(N-алкилакриламидов), полиакриловой кислоты, полиметакриловой кислоты, поливинилового спирта, поливиниламина, производных целлюлозы, полисахаридов и их сополимеров и смесей;
дополнительный полимер, выбранный из полиалкиленгликолей с низкой молекулярной массой, многоатомных спиртов с низкой молекулярной массой, мономерных и олигомерных алкиленгликолей, неполных эфиров многоатомных спиртов, дикарбоновых кислот и алкандиолов; и
частицы глины.
31. Композиция по п.30, в которой частицы глины состоят из филлосиликата.
32. Медленно растворяющаяся пленка, содержащая:
гидрофильный полимер, выбранный из поли(N-виниллактамов), поли(N-виниламидов), поли(N-винилакриламидов), поли(N-алкилакриламидов), полиакриловой кислоты, полиметакриловой кислоты, поливинилового спирта, поливиниламина, производных целлюлозы, полисахаридов и их сополимеров и смесей;
дополнительный полимер, выбранный из полиалкиленгликолей с низкой молекулярной массой, многоатомных спиртов с низкой молекулярной массой, мономерных и олигомерных алкиленгликолей, неполных эфиров многоатомных спиртов, дикарбоновых кислот и алкандиолов;
набухающий в воде водонерастворимый полимер; и
частицы глины.
33. Композиция по п.32, в которой частицы глины состоят из филлосиликата.
34. Продукт для ухода за полостью рта для прикладывания к зубам, содержащий: контактирующий с зубами слой адгезивной композиции по п.1 и поддерживающий слой.
35. Продукт для ухода за полостью рта для прикладывания к слизистой оболочке полости рта, содержащий контактирующий со слизистой оболочкой слой адгезивной композиции по п.1 и поддерживающий слой.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US59959304P | 2004-08-05 | 2004-08-05 | |
US60/599,593 | 2004-08-05 |
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RU2007107945A true RU2007107945A (ru) | 2008-09-10 |
RU2393877C2 RU2393877C2 (ru) | 2010-07-10 |
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RU2007107945/15A RU2393877C2 (ru) | 2004-08-05 | 2005-08-04 | Адгезивная композиция |
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US (1) | US9242021B2 (ru) |
EP (1) | EP1791575B1 (ru) |
JP (1) | JP5270158B2 (ru) |
KR (1) | KR20070048229A (ru) |
CN (2) | CN101039706A (ru) |
AU (1) | AU2005271259B2 (ru) |
CA (1) | CA2576158C (ru) |
ES (1) | ES2526700T3 (ru) |
MX (1) | MX2007001512A (ru) |
RU (1) | RU2393877C2 (ru) |
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WO (1) | WO2006017807A2 (ru) |
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-
2005
- 2005-08-04 EP EP05786086.8A patent/EP1791575B1/en active Active
- 2005-08-04 US US11/198,468 patent/US9242021B2/en active Active
- 2005-08-04 WO PCT/US2005/028063 patent/WO2006017807A2/en active Application Filing
- 2005-08-04 CA CA2576158A patent/CA2576158C/en active Active
- 2005-08-04 RU RU2007107945/15A patent/RU2393877C2/ru active IP Right Revival
- 2005-08-04 ES ES05786086.8T patent/ES2526700T3/es active Active
- 2005-08-04 MX MX2007001512A patent/MX2007001512A/es unknown
- 2005-08-04 CN CNA2005800301277A patent/CN101039706A/zh active Pending
- 2005-08-04 AU AU2005271259A patent/AU2005271259B2/en not_active Ceased
- 2005-08-04 KR KR1020077005134A patent/KR20070048229A/ko not_active Application Discontinuation
- 2005-08-04 CN CN201310239615.5A patent/CN103497713B/zh active Active
- 2005-08-04 JP JP2007525060A patent/JP5270158B2/ja not_active Expired - Fee Related
- 2005-08-08 TW TW094126736A patent/TW200621320A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
RU2393877C2 (ru) | 2010-07-10 |
KR20070048229A (ko) | 2007-05-08 |
US9242021B2 (en) | 2016-01-26 |
CN103497713A (zh) | 2014-01-08 |
ES2526700T3 (es) | 2015-01-14 |
AU2005271259B2 (en) | 2012-01-19 |
CA2576158C (en) | 2020-10-27 |
CA2576158A1 (en) | 2006-02-16 |
JP5270158B2 (ja) | 2013-08-21 |
CN103497713B (zh) | 2018-07-17 |
AU2005271259A1 (en) | 2006-02-16 |
MX2007001512A (es) | 2007-04-20 |
US20060034905A1 (en) | 2006-02-16 |
CN101039706A (zh) | 2007-09-19 |
WO2006017807A2 (en) | 2006-02-16 |
JP2008508954A (ja) | 2008-03-27 |
EP1791575A2 (en) | 2007-06-06 |
WO2006017807A3 (en) | 2006-08-10 |
EP1791575B1 (en) | 2014-10-08 |
TW200621320A (en) | 2006-07-01 |
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