RS61281B1 - Sintetički intermedijer koristan u pripremi triazolopiridinskih c-met inhibitora - Google Patents

Sintetički intermedijer koristan u pripremi triazolopiridinskih c-met inhibitora

Info

Publication number: RS61281B1
Authority: RS; Serbia
Prior art keywords: triazolopyridine; preparation; synthetic intermediate; intermediate useful; met inhibitors
Prior art date: 2009-12-31

Application number

RS20201567A

Other languages

English (en)

Inventor

Wei-Guo Su

Hong Jia

Guangxiu Dai

Original Assignee

Hutchison Medipharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-12-31

Filing date

2010-12-30

Publication date

2021-02-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44226181&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS61281(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-12-30 Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd

2021-02-26 Publication of RS61281B1 publication Critical patent/RS61281B1/sr

Links

239000003112 inhibitor Substances 0.000 title 1
OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

RS20201567A 2009-12-31 2010-12-30 Sintetički intermedijer koristan u pripremi triazolopiridinskih c-met inhibitora RS61281B1 (sr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CN2009076321		2009-12-31
EP19151824.0A EP3511330B1 (en)	2009-12-31	2010-12-30	Synthetic intermediate useful in the preparation of triazolopyridine c-met inhibitors

Publications (1)

Publication Number	Publication Date
RS61281B1 true RS61281B1 (sr)	2021-02-26

Family

ID=44226181

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
RS20201567A RS61281B1 (sr)	2009-12-31	2010-12-30	Sintetički intermedijer koristan u pripremi triazolopiridinskih c-met inhibitora
RS20220854A RS63612B1 (sr)	2009-12-31	2010-12-30	Neki triazolopirazini, njihove kompozicije i postupci njihovog korišćenja
RS20150584A RS54217B1 (sr)	2009-12-31	2010-12-30	Neki triazolopirazini, njihove kompozicije i postupci njihovog korišćenja

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
RS20220854A RS63612B1 (sr)	2009-12-31	2010-12-30	Neki triazolopirazini, njihove kompozicije i postupci njihovog korišćenja
RS20150584A RS54217B1 (sr)	2009-12-31	2010-12-30	Neki triazolopirazini, njihove kompozicije i postupci njihovog korišćenja

Country Status (38)

Country	Link
US (8)	US8987269B2 (sr)
EP (5)	EP3511330B1 (sr)
JP (5)	JP5337313B2 (sr)
KR (3)	KR101905350B1 (sr)
CN (3)	CN106432225B (sr)
AU (2)	AU2010338712B2 (sr)
BR (1)	BR112012016129B1 (sr)
CA (1)	CA2785749C (sr)
CL (1)	CL2012001752A1 (sr)
CO (1)	CO6612235A2 (sr)
CU (1)	CU24167B1 (sr)
CY (2)	CY1118250T1 (sr)
DK (3)	DK2719699T3 (sr)
DO (1)	DOP2012000188A (sr)
EA (2)	EA025466B1 (sr)
EC (1)	ECSP12012011A (sr)
ES (4)	ES2546635T3 (sr)
GT (1)	GT201200220A (sr)
HK (2)	HK1194071A1 (sr)
HR (3)	HRP20221090T1 (sr)
HU (3)	HUE059696T2 (sr)
IL (2)	IL220433B (sr)
LT (1)	LT3795573T (sr)
ME (1)	ME02211B (sr)
MX (1)	MX336996B (sr)
MY (1)	MY179933A (sr)
NI (1)	NI201200118A (sr)
NZ (1)	NZ601128A (sr)
PE (3)	PE20160588A1 (sr)
PL (3)	PL3795573T3 (sr)
PT (3)	PT3511330T (sr)
RS (3)	RS61281B1 (sr)
SG (1)	SG181781A1 (sr)
SI (2)	SI2719699T1 (sr)
SM (1)	SMT201500213B (sr)
UA (1)	UA107822C2 (sr)
WO (1)	WO2011079804A1 (sr)
ZA (1)	ZA201205730B (sr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106432225B (zh) *	2009-12-31	2019-02-19	和记黄埔医药（上海）有限公司	某些*并吡啶化合物和*并吡嗪化合物、其组合物和其使用方法
JP5960688B2 (ja) *	2010-05-17	2016-08-02	インコゼンセラピューティクスプライベートリミテッド	プロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物
CN103030654A (zh) *	2011-10-09	2013-04-10	济南赛文医药技术有限公司	一种小分子c-Met蛋白激酶抑制剂
CN102516046A (zh) *	2011-11-22	2012-06-27	太仓市运通化工厂	一种2-溴丙醛的合成方法
WO2013144737A2 (en) *	2012-03-30	2013-10-03	Rhizen Pharmaceuticals Sa	Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
CA2776178A1 (en) *	2012-04-05	2013-10-05	Hydro-Quebec	Ionic compounds
KR101745741B1 (ko)	2012-08-13	2017-06-12	한국화학연구원	신규한 트리아졸로 피라진 유도체 및 그의 용도
CN104903320B (zh) *	2013-01-11	2018-11-13	富士胶片株式会社	含氮杂环化合物或其盐
KR101645112B1 (ko)	2013-03-06	2016-08-02	아스트라제네카 아베	표피 성장 인자 수용체의 활성화 돌연변이체 형태의 퀴나졸린 억제제
CN103265468A (zh) *	2013-06-17	2013-08-28	连云港盛和生物科技有限公司	一种2,4-二甲基-3-吡咯甲酸乙酯的合成方法
EP2818471A1 (en) *	2013-06-27	2014-12-31	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5
US9403831B2 (en)	2013-09-30	2016-08-02	Korea Research Institute Of Chemical Technology	Triazolopyrazine derivative and use thereof
SG11201605207PA (en) *	2013-12-26	2016-07-28	Ignyta Inc	Pyrazolo[1,5-a]pyridine derivatives and methods of their use
JP2016048495A (ja) *	2014-08-28	2016-04-07	京セラ株式会社	携帯端末、レコメンドプログラム、レコメンドシステムおよびレコメンド方法
EP3340983B1 (en)	2015-08-26	2023-10-04	Achillion Pharmaceuticals, Inc.	Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
WO2017035405A1 (en)	2015-08-26	2017-03-02	Achillion Pharmaceuticals, Inc.	Amino compounds for treatment of immune and inflammatory disorders
WO2017035401A1 (en)	2015-08-26	2017-03-02	Achillion Pharmaceuticals, Inc.	Amide compounds for treatment of immune and inflammatory disorders
DK3398951T3 (da) *	2015-12-31	2021-07-12	Shanghai Pharmaceuticals Holding Co Ltd	Salt af quinolonforbindelse, polymorfer deraf, fremgangsmåde til fremstilling deraf, sammensætning og anvendelser
GB201616116D0 (en)	2016-09-22	2016-11-09	Astrazeneca Ab	Use of c-Met inhibitors to treat cancers harbouring MET mutations
KR20180092096A (ko)	2017-02-08	2018-08-17	에이비온 주식회사	트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법
EP3589287B1 (en)	2017-03-01	2022-09-14	Achillion Pharmaceuticals, Inc.	Macrocyclic compounds for treatment of medical disorders
WO2018160891A1 (en)	2017-03-01	2018-09-07	Achillion Pharmaceutical, Inc.	Pharmaceutical compounds for treatment of medical disorders
AU2018227849B2 (en)	2017-03-01	2022-04-28	Achillion Pharmaceuticals, Inc.	Aryl, heteroary, and heterocyclic pharmaceutical compounds for treatment of medical disorders
CN108570053A (zh) *	2017-03-13	2018-09-25	中国科学院上海药物研究所	五元并六元杂环化合物、制备方法、中间体、组合和应用
KR101924801B1 (ko)	2017-08-16	2018-12-04	한국원자력의학원	트리아졸로피리딘계 유도체를 유효성분으로 함유하는 암 예방 또는 치료용 조성물
HU231333B1 (hu)	2018-07-13	2023-01-28	Richter Gedeon Nyrt	Spirokromán származékok
WO2020051532A2 (en)	2018-09-06	2020-03-12	Achillion Pharmaceuticals, Inc.	Macrocyclic compounds for the treatment of medical disorders
KR20210057086A (ko)	2018-09-06	2021-05-20	아칠리온 파르마세우티칼스 인코포레이티드	다니코판의 형태체 형태
US20220048904A1 (en) *	2018-09-11	2022-02-17	Astrazeneca Ab	Improved Method for the Manufacture of 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine and polymorphic forms thereof
CN112996497A (zh)	2018-09-25	2021-06-18	艾其林医药公司	补体因子d抑制剂的形态形式
WO2020087170A1 (en) *	2018-10-30	2020-05-07	Repare Therapeutics Inc.	Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as atr kinase inhibitors
EA202191541A1 (ru)	2018-12-14	2022-01-21	Бета Фарма, Инк.	ЗАМЕЩЕННЫЕ ФОСФОРОРГАНИЧЕСКИМИ ГРУППАМИ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET И ИХ ТЕРАПЕВТИЧЕСКИЕ ПРИМЕНЕНИЯ
BR112022000431A2 (pt) *	2019-07-22	2022-03-03	Repare Therapeutics Inc	Derivados de 2-morfolinopiridina substituídos como inibidores da atr cinase
EP4107166A1 (en) *	2020-02-20	2022-12-28	Achillion Pharmaceuticals, Inc.	Heteroaryl compounds for treatment of complement factor d mediated disorders
WO2021229605A1 (en) *	2020-05-14	2021-11-18	Dr. Reddy's Laboratories Limited	Process for preparation of savolitinib and its intermediates
CN116209754A (zh) *	2020-09-28	2023-06-02	科德克希思公司	用于合成手性胺的工程化生物催化剂及方法
US20240076285A1 (en) *	2020-12-16	2024-03-07	Shankar Venkatraman	Compounds and compositions for treating conditions associated with sting activity
KR102659095B1 (ko)	2021-01-08	2024-04-19	에이비온 주식회사	트리아졸로피라진 유도체 화합물을 유효성분으로 하는 약학적 조성물의 태블릿정의 제조방법
CN113278019A (zh) *	2021-05-31	2021-08-20	河南偶联生物科技有限公司	一种咪唑并[1,2-a]吡啶类化合物的合成方法
WO2023205722A1 (en) *	2022-04-20	2023-10-26	Engrail Therapeutics, Inc.	Gabaa receptor modulator salts, particles, and uses thereof
WO2024008929A1 (en)	2022-07-08	2024-01-11	Astrazeneca Ab	Epidermal growth factor receptor tyrosine kinase inhibitors in combination with hgf-receptor inhibitors for the treatment of cancer
CN115611802B (zh) *	2022-12-02	2023-03-14	北京迪泰医药科技有限公司	一种3-乙酰基-2-氯吡啶的合成方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3989816A (en)	1975-06-19	1976-11-02	Nelson Research & Development Company	Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4444762A (en)	1980-04-04	1984-04-24	Nelson Research & Development Company	Vehicle composition containing 1-substituted azacyclopentan-2-ones
US5977134A (en) *	1996-12-05	1999-11-02	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
EP1615931A1 (en)	2003-04-09	2006-01-18	Biogen Idec MA Inc.	Triazolopyrazines and methods of making and using the same
US6979505B2 (en) *	2003-06-09	2005-12-27	Utc Fuel Cells, Llc	Method and apparatus for removal of contaminants from a hydrogen processor feed stream, as in a fuel cell power plant
EP1643836A4 (en) *	2003-07-02	2006-12-06	Sugen Inc	ARYLMETHYL TRIAZOLO AND IMIDAZOPYRAZINE C-MET INHIBITORS
US7122548B2 (en)	2003-07-02	2006-10-17	Sugen, Inc.	Triazolotriazine compounds and uses thereof
WO2005028480A2 (en)	2003-09-03	2005-03-31	Neurogen Corporation	5-aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds
BRPI0513916A (pt)	2004-07-27	2008-05-20	Sgx Pharmaceuticals Inc	moduladores de pirrol-piridina cinase
WO2006018735A2 (en)	2004-08-18	2006-02-23	Pharmacia & Upjohn Company Llc	Triazolopyridine compounds
AU2006215394B2 (en) *	2005-02-16	2009-10-08	Astrazeneca Ab	Chemical compounds
CN101119996A (zh) *	2005-02-16	2008-02-06	阿斯利康(瑞典)有限公司	化学化合物
CA2630884A1 (en)	2005-11-30	2007-06-07	Vertex Pharmaceuticals Incorporated	Inhibitors of c-met and uses thereof
EA015754B1 (ru) *	2005-12-21	2011-12-30	Янссен Фармацевтика, Н.В.	Триазолопиридазины в качестве модуляторов тирозинкиназы
NL2000613C2 (nl) *	2006-05-11	2007-11-20	Pfizer Prod Inc	Triazoolpyrazinederivaten.
EP2032578A2 (en) *	2006-05-30	2009-03-11	Pfizer Products Incorporated	Triazolopyridazine derivatives
PE20080403A1 (es) *	2006-07-14	2008-04-25	Amgen Inc	Derivados heterociclicos fusionados y metodos de uso
US8217177B2 (en)	2006-07-14	2012-07-10	Amgen Inc.	Fused heterocyclic derivatives and methods of use
WO2008021781A1 (en)	2006-08-07	2008-02-21	Incyte Corporation	Triazolotriazines as kinase inhibitors
CA2663528A1 (en)	2006-09-18	2008-03-27	Vertex Pharmaceuticals Incorporated	Heterocyclic inhibitors of c-met and uses thereof
KR101083177B1 (ko) *	2006-10-23	2011-11-11	에스지엑스 파마슈티컬스, 인코포레이티드	트리아졸로-피리다진 단백질 키나제 조정제
PT2084162E (pt)	2006-10-23	2012-10-09	Sgx Pharmaceuticals Inc	Triazoles bicíclicos como moduladores de proteína quinase
ES2689444T3 (es)	2006-11-22	2018-11-14	Incyte Holdings Corporation	Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa
WO2008124848A1 (en)	2007-04-10	2008-10-16	Sgx Pharmaceuticals, Inc.	Fused ring heterocycle kinase modulators
US8148369B2 (en)	2007-05-10	2012-04-03	Janssen Pharmaceutica Nv	Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
PA8792501A1 (es)	2007-08-09	2009-04-23	Sanofi Aventis	Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.
KR20100128305A (ko)	2008-02-28	2010-12-07	노파르티스 아게	Ｃ-ｍｅｔ 티로신 키나제 매개 질환의 치료를 위한 이미다조[1,2-ｂ]피리다진 유도체
WO2009143477A1 (en)	2008-05-22	2009-11-26	Amgen Inc.	Heterocycles as protein kinase inhibitors
UY32049A (es)	2008-08-14	2010-03-26	Takeda Pharmaceutical	Inhibidores de cmet
DE102008037790A1 (de)	2008-08-14	2010-02-18	Merck Patent Gmbh	Bicyclische Triazolderivate
EA201200260A1 (ru) *	2009-08-12	2012-09-28	Новартис Аг	Гетероциклические гидразоны и их применение для лечения рака и воспаления
EA201200318A1 (ru) *	2009-08-20	2012-09-28	Новартис Аг	Гетероциклические оксимы
CN106432225B (zh)	2009-12-31	2019-02-19	和记黄埔医药（上海）有限公司	某些*并吡啶化合物和*并吡嗪化合物、其组合物和其使用方法
JP5960688B2 (ja)	2010-05-17	2016-08-02	インコゼンセラピューティクスプライベートリミテッド	プロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物

2010
- 2010-12-30 CN CN201610432059.7A patent/CN106432225B/zh active Active
- 2010-12-30 KR KR1020177022937A patent/KR101905350B1/ko active IP Right Grant
- 2010-12-30 KR KR1020147010967A patent/KR101771299B1/ko active IP Right Grant
- 2010-12-30 SG SG2012044830A patent/SG181781A1/en unknown
- 2010-12-30 RS RS20201567A patent/RS61281B1/sr unknown
- 2010-12-30 RS RS20220854A patent/RS63612B1/sr unknown
- 2010-12-30 PT PT191518240T patent/PT3511330T/pt unknown
- 2010-12-30 MY MYPI2012002974A patent/MY179933A/en unknown
- 2010-12-30 BR BR112012016129-6A patent/BR112012016129B1/pt active IP Right Grant
- 2010-12-30 ES ES13198224.1T patent/ES2546635T3/es active Active
- 2010-12-30 EP EP19151824.0A patent/EP3511330B1/en active Active
- 2010-12-30 CA CA2785749A patent/CA2785749C/en active Active
- 2010-12-30 HU HUE20199091A patent/HUE059696T2/hu unknown
- 2010-12-30 PL PL20199091.8T patent/PL3795573T3/pl unknown
- 2010-12-30 SI SI201031021T patent/SI2719699T1/sl unknown
- 2010-12-30 AU AU2010338712A patent/AU2010338712B2/en active Active
- 2010-12-30 HU HUE13198224A patent/HUE025504T2/en unknown
- 2010-12-30 PT PT201990918T patent/PT3795573T/pt unknown
- 2010-12-30 EA EA201200951A patent/EA025466B1/ru not_active IP Right Cessation
- 2010-12-30 ES ES20199091T patent/ES2927146T3/es active Active
- 2010-12-30 RS RS20150584A patent/RS54217B1/sr unknown
- 2010-12-30 US US13/501,222 patent/US8987269B2/en active Active
- 2010-12-30 PE PE2016000292A patent/PE20160588A1/es unknown
- 2010-12-30 HR HRP20221090TT patent/HRP20221090T1/hr unknown
- 2010-12-30 CU CU20120101A patent/CU24167B1/es active IP Right Grant
- 2010-12-30 EP EP13198224.1A patent/EP2719699B1/en active Active
- 2010-12-30 SI SI201032046T patent/SI3511330T1/sl unknown
- 2010-12-30 PL PL19151824T patent/PL3511330T3/pl unknown
- 2010-12-30 ME MEP-2015-150A patent/ME02211B/me unknown
- 2010-12-30 CN CN201610437304.3A patent/CN106117248B/zh active Active
- 2010-12-30 PE PE2012000903A patent/PE20130375A1/es not_active Application Discontinuation
- 2010-12-30 EP EP10840591.1A patent/EP2519524A4/en not_active Withdrawn
- 2010-12-30 DK DK13198224.1T patent/DK2719699T3/en active
- 2010-12-30 WO PCT/CN2010/080499 patent/WO2011079804A1/en active Application Filing
- 2010-12-30 HU HUE19151824A patent/HUE052828T2/hu unknown
- 2010-12-30 ES ES19151824T patent/ES2840454T3/es active Active
- 2010-12-30 DK DK20199091.8T patent/DK3795573T3/da active
- 2010-12-30 DK DK19151824.0T patent/DK3511330T3/da active
- 2010-12-30 PE PE2020001800A patent/PE20211094A1/es unknown
- 2010-12-30 MX MX2012007756A patent/MX336996B/es active IP Right Grant
- 2010-12-30 PL PL13198224T patent/PL2719699T3/pl unknown
- 2010-12-30 ES ES15170608T patent/ES2726152T3/es active Active
- 2010-12-30 EA EA201691461A patent/EA030141B1/ru not_active IP Right Cessation
- 2010-12-30 EP EP20199091.8A patent/EP3795573B1/en active Active
- 2010-12-30 NZ NZ601128A patent/NZ601128A/en unknown
- 2010-12-30 LT LTEP20199091.8T patent/LT3795573T/lt unknown
- 2010-12-30 UA UAA201208929A patent/UA107822C2/ru unknown
- 2010-12-30 PT PT131982241T patent/PT2719699E/pt unknown
- 2010-12-30 EP EP15170608.2A patent/EP2966075B1/en active Active
- 2010-12-30 JP JP2012546344A patent/JP5337313B2/ja active Active
- 2010-12-30 CN CN201080065014.1A patent/CN102906092B/zh active Active
- 2010-12-30 KR KR1020127019509A patent/KR101434766B1/ko active IP Right Grant
2012
- 2012-04-10 US US13/501,224 patent/US8507487B2/en active Active
- 2012-06-14 IL IL220433A patent/IL220433B/en active IP Right Grant
- 2012-06-26 CL CL2012001752A patent/CL2012001752A1/es unknown
- 2012-06-28 GT GT201200220A patent/GT201200220A/es unknown
- 2012-06-29 NI NI201200118A patent/NI201200118A/es unknown
- 2012-06-29 CO CO12109937A patent/CO6612235A2/es not_active Application Discontinuation
- 2012-06-29 DO DO2012000188A patent/DOP2012000188A/es unknown
- 2012-06-29 EC EC2012012011A patent/ECSP12012011A/es unknown
- 2012-07-30 ZA ZA2012/05730A patent/ZA201205730B/en unknown
2013
- 2013-06-11 JP JP2013122502A patent/JP2013209418A/ja active Pending
2014
- 2014-07-23 HK HK14107500.2A patent/HK1194071A1/xx unknown
2015
- 2015-01-21 US US14/601,674 patent/US20150368271A1/en not_active Abandoned
- 2015-06-23 AU AU2015203480A patent/AU2015203480B2/en active Active
- 2015-07-16 IL IL239997A patent/IL239997A/en active IP Right Grant
- 2015-09-08 HR HRP20150952TT patent/HRP20150952T1/hr unknown
- 2015-09-09 SM SM201500213T patent/SMT201500213B/xx unknown
- 2015-09-17 CY CY20151100816T patent/CY1118250T1/el unknown
2016
- 2016-04-04 JP JP2016074893A patent/JP6194046B2/ja active Active
- 2016-04-14 HK HK16104273.2A patent/HK1216880A1/zh unknown
- 2016-10-14 US US15/293,722 patent/US9956218B2/en active Active
2017
- 2017-08-10 JP JP2017155493A patent/JP6486999B2/ja active Active
2018
- 2018-04-04 US US15/945,324 patent/US10512645B2/en active Active
2019
- 2019-02-20 JP JP2019028197A patent/JP6647434B2/ja active Active
- 2019-11-08 US US16/678,091 patent/US10946014B2/en active Active
2020
- 2020-12-17 HR HRP20202017TT patent/HRP20202017T1/hr unknown
- 2020-12-21 CY CY20201101206T patent/CY1123777T1/el unknown
2021
- 2021-02-03 US US17/248,688 patent/US11896592B2/en active Active
2023
- 2023-12-13 US US18/538,151 patent/US20240139182A1/en active Pending

Also Published As

Publication number	Publication date
HUE059696T2 (hu)	2022-12-28
KR20170098324A (ko)	2017-08-29
EP3795573B1 (en)	2022-07-06
SI2719699T1 (sl)	2015-12-31
BR112012016129B1 (pt)	2020-11-03
CN106432225B (zh)	2019-02-19
EP2519524A4 (en)	2013-07-03
ES2726152T3 (es)	2019-10-02
IL220433B (en)	2018-01-31
JP6194046B2 (ja)	2017-09-06
DK2719699T3 (en)	2015-08-24
JP6486999B2 (ja)	2019-03-20
CN102906092A (zh)	2013-01-30
CL2012001752A1 (es)	2013-01-25
LT3795573T (lt)	2022-11-10
PL2719699T3 (pl)	2016-01-29
MX336996B (es)	2016-02-09
KR101905350B1 (ko)	2018-11-30
KR20140059307A (ko)	2014-05-15
AU2010338712A1 (en)	2012-07-12
EP2966075B1 (en)	2019-02-27
JP2019108345A (ja)	2019-07-04
NI201200118A (es)	2013-01-24
PE20211094A1 (es)	2021-06-14
US20200179377A1 (en)	2020-06-11
EP3795573A1 (en)	2021-03-24
HK1194071A1 (en)	2014-10-10
DK3795573T3 (da)	2022-09-19
PL3511330T3 (pl)	2021-04-19
US8507487B2 (en)	2013-08-13
PL3795573T3 (pl)	2022-11-21
JP5337313B2 (ja)	2013-11-06
HK1216880A1 (zh)	2016-12-09
EA030141B1 (ru)	2018-06-29
EA201200951A1 (ru)	2013-09-30
US20240139182A1 (en)	2024-05-02
CN102906092B (zh)	2016-08-03
ES2546635T3 (es)	2015-09-25
JP2013516393A (ja)	2013-05-13
CA2785749C (en)	2017-11-28
HRP20202017T1 (hr)	2021-02-19
EP3511330B1 (en)	2020-09-30
NZ601128A (en)	2014-12-24
JP2016155848A (ja)	2016-09-01
ZA201205730B (en)	2016-01-27
SI3511330T1 (sl)	2021-01-29
MY179933A (en)	2020-11-19
GT201200220A (es)	2014-12-22
EP2719699A1 (en)	2014-04-16
DOP2012000188A (es)	2012-12-31
ES2840454T3 (es)	2021-07-06
AU2015203480B2 (en)	2017-10-26
US20170027934A1 (en)	2017-02-02
PT2719699E (pt)	2015-09-30
KR101771299B1 (ko)	2017-08-24
EA025466B1 (ru)	2016-12-30
JP2013209418A (ja)	2013-10-10
US9956218B2 (en)	2018-05-01
ES2927146T3 (es)	2022-11-02
JP6647434B2 (ja)	2020-02-14
IL239997A (en)	2017-11-30
US11896592B2 (en)	2024-02-13
US10512645B2 (en)	2019-12-24
AU2010338712B2 (en)	2015-04-02
KR20120125261A (ko)	2012-11-14
SMT201500213B (it)	2015-10-30
US10946014B2 (en)	2021-03-16
PT3511330T (pt)	2020-12-24
AU2015203480A1 (en)	2015-07-16
RS63612B1 (sr)	2022-10-31
CN106432225A (zh)	2017-02-22
DK3511330T3 (da)	2020-12-21
HUE052828T2 (hu)	2021-05-28
CU24167B1 (es)	2016-03-31
EP2519524A1 (en)	2012-11-07
EP3511330A1 (en)	2019-07-17
PE20160588A1 (es)	2016-07-09
US20120264739A1 (en)	2012-10-18
US8987269B2 (en)	2015-03-24
CO6612235A2 (es)	2013-02-01
PT3795573T (pt)	2022-09-15
EP2719699B1 (en)	2015-07-08
PE20130375A1 (es)	2013-04-10
US20150368271A1 (en)	2015-12-24
WO2011079804A1 (en)	2011-07-07
CN106117248B (zh)	2019-01-22
IL239997A0 (en)	2015-08-31
CU20120101A7 (es)	2012-10-15
BR112012016129A2 (pt)	2016-05-31
ECSP12012011A (es)	2012-10-30
RS54217B1 (sr)	2015-12-31
KR101434766B1 (ko)	2014-08-26
EA201691461A1 (ru)	2017-01-30
CY1118250T1 (el)	2017-06-28
ME02211B (me)	2016-02-20
CA2785749A1 (en)	2011-07-07
SG181781A1 (en)	2012-07-30
CN106117248A (zh)	2016-11-16
HRP20150952T1 (hr)	2015-10-09
MX2012007756A (es)	2012-11-06
US20120245178A1 (en)	2012-09-27
UA107822C2 (en)	2015-02-25
US20180263977A1 (en)	2018-09-20
JP2018009004A (ja)	2018-01-18
EP2966075A1 (en)	2016-01-13
US20210154192A1 (en)	2021-05-27
CY1123777T1 (el)	2022-03-24
HRP20221090T1 (hr)	2022-11-25
HUE025504T2 (en)	2016-02-29

Publication	Publication Date	Title
SI3511330T1 (sl)	2021-01-29	Sintetična umetna spojina uporabna v pripravi triazolopiridinskih zaviralcev c-Met
LT3511330T (lt)	2021-03-25	Sintetinis tarpinis junginys, naudotinas triazolpiridino c-met inhibitorių paruošimui
HK1177462A1 (en)	2013-08-23	Triazolopyridine derivatives
IL220091A0 (en)	2012-09-24	Pcsk9 antagonists
PL2575504T3 (pl)	2019-05-31	Kompozycja odżywcza wykazująca właściwości immunologiczne
ZA201106503B (en)	2012-11-28	Antibody formulation
ZA201202906B (en)	2012-12-27	Novel naphthyridine derivatives and the use thereof as kinase inhibitors
IL219537A0 (en)	2012-06-28	Antibody formulation
ZA201107963B (en)	2015-12-23	Dentifrice composition
ZA201303811B (en)	2014-04-30	Triazolopyridine compounds
HK1168293A1 (en)	2012-12-28	Dentifrice composition
HK1198646A1 (en)	2015-05-22	Substituted imidazopyridines and the use thereof
HK1171941A1 (en)	2013-04-12	Dentifrice composition
EP2613344A4 (en)	2014-01-22	POLISHING COMPOSITION
ZA201004145B (en)	2011-02-23	Imiquimod formulation
ZA201303661B (en)	2018-12-19	Cleansing composition
GB0907003D0 (en)	2009-06-03	Formulation
EP2620160A4 (en)	2014-05-07	COMPOSITIONS FOR ORAL ADMINISTRATION
EP2612652A4 (en)	2014-09-03	DETERGENT COMPOSITION
HK1172251A1 (en)	2013-04-19	Dentifrice composition
IL219603A0 (en)	2012-07-31	Imidazopyridine derivatives
EP2413905A4 (en)	2012-10-31	COMPOSITION
EP2516649A4 (en)	2013-05-29	NOVEL PNEUMOVIRUS COMPOSITIONS AND METHODS OF USE
GB0911213D0 (en)	2009-08-12	Formulation
EP2312948A4 (en)	2012-03-21	5-CHINOLINONE AND IMIDAZOPYRIDINE COMPOUNDS AND THEIR USE