RS51259B - Polimorf atorvastatin tert.-butilestra i korišćenje intermediata za dobijanje atorvastatina - Google Patents

Polimorf atorvastatin tert.-butilestra i korišćenje intermediata za dobijanje atorvastatina

Info

Publication number
RS51259B
RS51259B RSP-2010/0173A RSP20100173A RS51259B RS 51259 B RS51259 B RS 51259B RS P20100173 A RSP20100173 A RS P20100173A RS 51259 B RS51259 B RS 51259B
Authority
RS
Serbia
Prior art keywords
preparation
atorvastin
butylester
polymorphs
intermediates
Prior art date
Application number
RSP-2010/0173A
Other languages
English (en)
Inventor
Rok Zupet
Anton Štimac
Matej Smrkolj
Renata JAKŠE
Marija Grčman
Original Assignee
Krka Tovarna Zdravil D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil D.D. filed Critical Krka Tovarna Zdravil D.D.
Publication of RS51259B publication Critical patent/RS51259B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Kristalni oblik 1 atorvastatin tert.-butil estra formule (II)naznačen time, što dijagram difrakcije X zrakova praha ima vrhove na: 6.10, 6.83, 10.77, 17.01, ± 0.1 stepena dva-teta.Prijava sadrži još 24 patentna zahteva.
RSP-2010/0173A 2004-04-09 2005-04-08 Polimorf atorvastatin tert.-butilestra i korišćenje intermediata za dobijanje atorvastatina RS51259B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200400112A SI21745A (sl) 2004-04-09 2004-04-09 Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina
PCT/EP2005/003733 WO2005097742A1 (en) 2004-04-09 2005-04-08 Polymorphs of atorvastatin tert.-butylester and use as intermediates for the preparation of atorvastatin

Publications (1)

Publication Number Publication Date
RS51259B true RS51259B (sr) 2010-12-31

Family

ID=34963800

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2010/0173A RS51259B (sr) 2004-04-09 2005-04-08 Polimorf atorvastatin tert.-butilestra i korišćenje intermediata za dobijanje atorvastatina

Country Status (15)

Country Link
EP (1) EP1732886B1 (sr)
CN (2) CN1946687B (sr)
AT (1) ATE459602T1 (sr)
DE (1) DE602005019703D1 (sr)
DK (1) DK1732886T3 (sr)
EA (1) EA010166B1 (sr)
ES (1) ES2339570T3 (sr)
HR (1) HRP20100217T1 (sr)
NO (1) NO20065146L (sr)
PL (1) PL1732886T3 (sr)
PT (1) PT1732886E (sr)
RS (1) RS51259B (sr)
SI (2) SI21745A (sr)
UA (1) UA86059C2 (sr)
WO (1) WO2005097742A1 (sr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007054896A1 (en) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US20100260851A1 (en) * 2007-07-11 2010-10-14 Actavis Group Ptc Ehf Novel Polymorph of Atorvastatin Calcium and Use Thereof for the Preparation of Amorphous Atorvastatin Calcium
US20090081801A1 (en) * 2007-08-15 2009-03-26 Vinod Kumar Kansal Process for synthesis of pyrrole derivative, an intermediate for atorvastatin
CN101560177B (zh) * 2008-04-16 2012-10-03 北京万全阳光医学技术有限公司 一种阿托伐他汀钙的制备方法
SI2413911T1 (sl) 2009-03-31 2014-04-30 Krka, D.D., Novo Mesto Progresivna emulzijska kristalizacija
CN105693587A (zh) * 2016-01-15 2016-06-22 安徽悦康凯悦制药有限公司 一种阿托伐他汀钙的生产工艺
CN109280024A (zh) * 2018-10-09 2019-01-29 河南师范大学 一种高纯度阿托伐他汀叔丁酯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
EP1341785B1 (en) * 2000-11-16 2008-10-08 Teva Pharmaceutical Industries Ltd. Hydrolysis of r(r*,r*)-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide
US6476235B2 (en) * 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
CN100430405C (zh) * 2001-08-16 2008-11-05 特瓦制药工业有限公司 制备他汀类的钙盐形式的方法

Also Published As

Publication number Publication date
PT1732886E (pt) 2010-03-12
EA200601651A1 (ru) 2007-02-27
UA86059C2 (ru) 2009-03-25
CN1946687B (zh) 2011-09-28
CN101538238A (zh) 2009-09-23
HRP20100217T1 (hr) 2010-05-31
DK1732886T3 (da) 2010-06-14
DE602005019703D1 (de) 2010-04-15
CN1946687A (zh) 2007-04-11
EP1732886A1 (en) 2006-12-20
ATE459602T1 (de) 2010-03-15
ES2339570T3 (es) 2010-05-21
PL1732886T3 (pl) 2010-08-31
WO2005097742A1 (en) 2005-10-20
NO20065146L (no) 2006-11-08
EP1732886B1 (en) 2010-03-03
SI1732886T1 (sl) 2010-06-30
SI21745A (sl) 2005-10-31
EA010166B1 (ru) 2008-06-30
CN101538238B (zh) 2012-08-29

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