RS51259B - Polimorf atorvastatin tert.-butilestra i korišćenje intermediata za dobijanje atorvastatina - Google Patents
Polimorf atorvastatin tert.-butilestra i korišćenje intermediata za dobijanje atorvastatinaInfo
- Publication number
- RS51259B RS51259B RSP-2010/0173A RSP20100173A RS51259B RS 51259 B RS51259 B RS 51259B RS P20100173 A RSP20100173 A RS P20100173A RS 51259 B RS51259 B RS 51259B
- Authority
- RS
- Serbia
- Prior art keywords
- preparation
- atorvastin
- butylester
- polymorphs
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Kristalni oblik 1 atorvastatin tert.-butil estra formule (II)naznačen time, što dijagram difrakcije X zrakova praha ima vrhove na: 6.10, 6.83, 10.77, 17.01, ± 0.1 stepena dva-teta.Prijava sadrži još 24 patentna zahteva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200400112A SI21745A (sl) | 2004-04-09 | 2004-04-09 | Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina |
PCT/EP2005/003733 WO2005097742A1 (en) | 2004-04-09 | 2005-04-08 | Polymorphs of atorvastatin tert.-butylester and use as intermediates for the preparation of atorvastatin |
Publications (1)
Publication Number | Publication Date |
---|---|
RS51259B true RS51259B (sr) | 2010-12-31 |
Family
ID=34963800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RSP-2010/0173A RS51259B (sr) | 2004-04-09 | 2005-04-08 | Polimorf atorvastatin tert.-butilestra i korišćenje intermediata za dobijanje atorvastatina |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1732886B1 (sr) |
CN (2) | CN1946687B (sr) |
AT (1) | ATE459602T1 (sr) |
DE (1) | DE602005019703D1 (sr) |
DK (1) | DK1732886T3 (sr) |
EA (1) | EA010166B1 (sr) |
ES (1) | ES2339570T3 (sr) |
HR (1) | HRP20100217T1 (sr) |
NO (1) | NO20065146L (sr) |
PL (1) | PL1732886T3 (sr) |
PT (1) | PT1732886E (sr) |
RS (1) | RS51259B (sr) |
SI (2) | SI21745A (sr) |
UA (1) | UA86059C2 (sr) |
WO (1) | WO2005097742A1 (sr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007054896A1 (en) * | 2005-11-08 | 2007-05-18 | Ranbaxy Laboratories Limited | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
US20100260851A1 (en) * | 2007-07-11 | 2010-10-14 | Actavis Group Ptc Ehf | Novel Polymorph of Atorvastatin Calcium and Use Thereof for the Preparation of Amorphous Atorvastatin Calcium |
US20090081801A1 (en) * | 2007-08-15 | 2009-03-26 | Vinod Kumar Kansal | Process for synthesis of pyrrole derivative, an intermediate for atorvastatin |
CN101560177B (zh) * | 2008-04-16 | 2012-10-03 | 北京万全阳光医学技术有限公司 | 一种阿托伐他汀钙的制备方法 |
SI2413911T1 (sl) | 2009-03-31 | 2014-04-30 | Krka, D.D., Novo Mesto | Progresivna emulzijska kristalizacija |
CN105693587A (zh) * | 2016-01-15 | 2016-06-22 | 安徽悦康凯悦制药有限公司 | 一种阿托伐他汀钙的生产工艺 |
CN109280024A (zh) * | 2018-10-09 | 2019-01-29 | 河南师范大学 | 一种高纯度阿托伐他汀叔丁酯的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
EP1341785B1 (en) * | 2000-11-16 | 2008-10-08 | Teva Pharmaceutical Industries Ltd. | Hydrolysis of r(r*,r*)-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide |
US6476235B2 (en) * | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
CN100430405C (zh) * | 2001-08-16 | 2008-11-05 | 特瓦制药工业有限公司 | 制备他汀类的钙盐形式的方法 |
-
2004
- 2004-04-09 SI SI200400112A patent/SI21745A/sl not_active IP Right Cessation
-
2005
- 2005-04-08 DK DK05729986.9T patent/DK1732886T3/da active
- 2005-04-08 PL PL05729986T patent/PL1732886T3/pl unknown
- 2005-04-08 CN CN200580012246XA patent/CN1946687B/zh not_active Expired - Fee Related
- 2005-04-08 ES ES05729986T patent/ES2339570T3/es active Active
- 2005-04-08 PT PT05729986T patent/PT1732886E/pt unknown
- 2005-04-08 DE DE602005019703T patent/DE602005019703D1/de active Active
- 2005-04-08 SI SI200531002T patent/SI1732886T1/sl unknown
- 2005-04-08 EP EP05729986A patent/EP1732886B1/en active Active
- 2005-04-08 AT AT05729986T patent/ATE459602T1/de active
- 2005-04-08 EA EA200601651A patent/EA010166B1/ru not_active IP Right Cessation
- 2005-04-08 WO PCT/EP2005/003733 patent/WO2005097742A1/en active Application Filing
- 2005-04-08 RS RSP-2010/0173A patent/RS51259B/sr unknown
- 2005-04-08 CN CN2009101368132A patent/CN101538238B/zh not_active Expired - Fee Related
- 2005-08-04 UA UAA200610957A patent/UA86059C2/ru unknown
-
2006
- 2006-11-08 NO NO20065146A patent/NO20065146L/no not_active Application Discontinuation
-
2010
- 2010-04-16 HR HR20100217T patent/HRP20100217T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
PT1732886E (pt) | 2010-03-12 |
EA200601651A1 (ru) | 2007-02-27 |
UA86059C2 (ru) | 2009-03-25 |
CN1946687B (zh) | 2011-09-28 |
CN101538238A (zh) | 2009-09-23 |
HRP20100217T1 (hr) | 2010-05-31 |
DK1732886T3 (da) | 2010-06-14 |
DE602005019703D1 (de) | 2010-04-15 |
CN1946687A (zh) | 2007-04-11 |
EP1732886A1 (en) | 2006-12-20 |
ATE459602T1 (de) | 2010-03-15 |
ES2339570T3 (es) | 2010-05-21 |
PL1732886T3 (pl) | 2010-08-31 |
WO2005097742A1 (en) | 2005-10-20 |
NO20065146L (no) | 2006-11-08 |
EP1732886B1 (en) | 2010-03-03 |
SI1732886T1 (sl) | 2010-06-30 |
SI21745A (sl) | 2005-10-31 |
EA010166B1 (ru) | 2008-06-30 |
CN101538238B (zh) | 2012-08-29 |
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