MX2009005460A - (s)-n-estereoisomeros de analogos de 7,8-saturados-4,5-epoxi-morfi nano. - Google Patents

(s)-n-estereoisomeros de analogos de 7,8-saturados-4,5-epoxi-morfi nano.

Info

Publication number
MX2009005460A
MX2009005460A MX2009005460A MX2009005460A MX2009005460A MX 2009005460 A MX2009005460 A MX 2009005460A MX 2009005460 A MX2009005460 A MX 2009005460A MX 2009005460 A MX2009005460 A MX 2009005460A MX 2009005460 A MX2009005460 A MX 2009005460A
Authority
MX
Mexico
Prior art keywords
stereoisomers
epoxy
saturated
analogs
morphinanium
Prior art date
Application number
MX2009005460A
Other languages
English (en)
Inventor
Amy Qi Han
Julio Perez
Yakov Rotshteyn
Original Assignee
Progenics Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenics Pharm Inc filed Critical Progenics Pharm Inc
Publication of MX2009005460A publication Critical patent/MX2009005460A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Se describen estereoisómeros (S)-N novedosos de los análogos de 7-8-saturado-4,5-epoxi-morfinano. También se describen composiciones farmacéuticas que contienen los estereoisómeros (S)-N de los análogos de 7,8-saturados-4,5-epoxi-morfinano y método para usos farmacéuticos. Tales análogos se describen como que son útiles para tratar, entre distintas afecciones, hipermotilidad del tracto gastrointestinal.
MX2009005460A 2006-11-22 2007-11-21 (s)-n-estereoisomeros de analogos de 7,8-saturados-4,5-epoxi-morfi nano. MX2009005460A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86710106P 2006-11-22 2006-11-22
US86739406P 2006-11-27 2006-11-27
PCT/US2007/085420 WO2008136865A2 (en) 2006-11-22 2007-11-21 (s)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs

Publications (1)

Publication Number Publication Date
MX2009005460A true MX2009005460A (es) 2009-08-28

Family

ID=39716616

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005460A MX2009005460A (es) 2006-11-22 2007-11-21 (s)-n-estereoisomeros de analogos de 7,8-saturados-4,5-epoxi-morfi nano.

Country Status (8)

Country Link
US (1) US20080207669A1 (es)
EP (1) EP2111108A2 (es)
JP (1) JP2010510325A (es)
AU (1) AU2007352557A1 (es)
BR (1) BRPI0719587A2 (es)
CA (1) CA2670303A1 (es)
MX (1) MX2009005460A (es)
WO (1) WO2008136865A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5784507B2 (ja) * 2009-02-23 2015-09-24 マリンクロッド エルエルシー （＋）−モルフィナニウム第四級塩およびその生成方法
EP2398807A1 (en) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010096790A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-morphinananium n-oxides and processes for their production
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
RU2014112493A (ru) 2011-09-08 2015-10-20 МАЛЛИНКРОДТ Эл-Эл-Си Получения алкалоидов без выделения промежуточных продуктов
GB2498865A (en) * 2012-10-08 2013-07-31 Wockhardt Ltd Diamorphine formulations for intranasal administration
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
WO2015023675A2 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
ES2784690T3 (es) 2013-12-05 2020-09-29 Univ Bath Nuevos compuestos opioides y sus usos
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015095644A1 (en) 2013-12-20 2015-06-25 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
WO2016010771A1 (en) 2014-07-17 2016-01-21 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
MX2021000908A (es) 2018-07-23 2021-06-08 Trevi Therapeutics Inc Tratamiento de la tos cronica, la dificultad respiratoria y la disnea.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
US6384043B1 (en) * 1993-02-01 2002-05-07 Gholam A. Peyman Methods of alleviating pain sensations of the denuded eye with opioid analgesics
AU6934400A (en) * 1999-08-25 2001-03-19 Barrett R. Cooper Compositions and methods for treating opiate intolerance
US7087604B2 (en) * 2002-03-08 2006-08-08 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
AU2003281182A1 (en) * 2002-07-11 2004-02-02 Taiho Pharmaceutical Co., Ltd. Composition for nasal absorption
PL2368553T3 (pl) * 2003-04-08 2015-05-29 Progenics Pharm Inc Preparaty farmaceutyczne zawierające metylonaltrekson
WO2005037949A2 (en) * 2003-10-07 2005-04-28 Chrysalis Technologies Incorporated Aerosol formulations of butalbital, lorazepam, ipratropium, baclofen, morphine and scopolamine
EP1845989A1 (en) * 2005-01-20 2007-10-24 Progenics Pharmaceuticals, Inc. Use of methylnaltrexone and related compounds to treat post-operative gastrointestinal dysfunction
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS

Also Published As

Publication number Publication date
WO2008136865A2 (en) 2008-11-13
BRPI0719587A2 (pt) 2013-12-17
US20080207669A1 (en) 2008-08-28
JP2010510325A (ja) 2010-04-02
WO2008136865A9 (en) 2009-01-15
EP2111108A2 (en) 2009-10-28
CA2670303A1 (en) 2008-11-13
WO2008136865A3 (en) 2009-02-26
AU2007352557A1 (en) 2008-11-13

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