RS49738B - Kompleks platine, njegovo dobijanje i terapeutska primena - Google Patents
Kompleks platine, njegovo dobijanje i terapeutska primenaInfo
- Publication number
- RS49738B RS49738B YUP-719/00A YU71900A RS49738B RS 49738 B RS49738 B RS 49738B YU 71900 A YU71900 A YU 71900A RS 49738 B RS49738 B RS 49738B
- Authority
- RS
- Serbia
- Prior art keywords
- platinum complex
- preparation
- carbon atoms
- therapeutic application
- halogen atom
- Prior art date
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title abstract 4
- 229910052697 platinum Inorganic materials 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000007942 carboxylates Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Kompleks platine sa oksidacionim brojem IV formule (I): naznačen time, što je X, atom halogena, B je, nezavisno jedan od drugog, atom halogena, hidroksilna grupa ili karboksilatna grupa koja sadrži 1 do 6 atoma ugljenika, i A je –NH2-R grupa, gde je R triciklična ugljovodonična grupa koji sadrži 10 do 14 atoma ugljenika, koji mogu po potrebi da budu supstituisani na tricikličnom prstenu jednom ili dve alkil grupe od kojih svaka sadrži 1 do 4 atoma ugljenika. Prijava sadrži još 7 zahteva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ19981628A CZ288912B6 (cs) | 1998-05-27 | 1998-05-27 | Komplex platiny v oxidačním čísle IV, způsob přípravy tohoto komplexu, tento komplex jako léčivo a farmaceutická kompozice tento komplex obsahující |
Publications (2)
Publication Number | Publication Date |
---|---|
YU71900A YU71900A (sh) | 2002-10-18 |
RS49738B true RS49738B (sr) | 2008-04-04 |
Family
ID=5463562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-719/00A RS49738B (sr) | 1998-05-27 | 1999-05-24 | Kompleks platine, njegovo dobijanje i terapeutska primena |
Country Status (24)
Country | Link |
---|---|
US (1) | US6503943B1 (sr) |
EP (1) | EP1082330B1 (sr) |
JP (1) | JP3575686B2 (sr) |
CN (1) | CN1124279C (sr) |
AU (1) | AU741380B2 (sr) |
BG (1) | BG64599B1 (sr) |
BR (1) | BR9910669B1 (sr) |
CA (1) | CA2332054C (sr) |
CZ (1) | CZ288912B6 (sr) |
DE (1) | DE69901177T2 (sr) |
ES (1) | ES2175968T3 (sr) |
HR (1) | HRP20000791B1 (sr) |
HU (1) | HU224716B1 (sr) |
IL (1) | IL139529A (sr) |
MX (1) | MXPA00011621A (sr) |
NO (1) | NO328930B1 (sr) |
PL (1) | PL191132B1 (sr) |
PT (1) | PT1082330E (sr) |
RS (1) | RS49738B (sr) |
RU (1) | RU2200164C2 (sr) |
SI (1) | SI1082330T1 (sr) |
SK (1) | SK284436B6 (sr) |
UA (1) | UA56315C2 (sr) |
WO (1) | WO1999061451A1 (sr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0408805A (pt) * | 2003-03-31 | 2006-03-28 | Pliva Lachema As | composição farmacêutica contendo complexo de platina e método de fabricação da mesma |
CZ2004235A3 (cs) * | 2004-02-12 | 2005-08-17 | Pliva-Lachema A. S. | Farmaceutická kompozice obsahující jako účinnou látku platinový komplex a způsob výroby této kompozice |
CZ296045B6 (cs) * | 2003-03-31 | 2005-12-14 | Pliva-Lachema A. S. | Farmaceutická kompozice obsahující jako účinnou látku komplex čtyřmocné platiny a způsob její výroby |
EP2298292A3 (en) | 2004-06-18 | 2011-08-10 | Agennix USA Inc. | Kinase inhibitors for treating cancers |
WO2006019760A1 (en) * | 2004-07-14 | 2006-02-23 | Gpc Biotech Ag | Variable-dose packaging system |
CZ2004945A3 (cs) * | 2004-09-08 | 2006-01-11 | Pliva - Lachema A. S. | Farmaceutická kompozice pro rektální nebo vaginální podání, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
CZ296459B6 (cs) * | 2004-09-14 | 2006-03-15 | Pliva-Lachema A. S. | Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
US7977500B2 (en) * | 2004-11-10 | 2011-07-12 | University Of South Florida | Platinum complexes for targeted drug delivery |
WO2006090931A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の抗癌剤との新規併用 |
EP1792622A1 (en) | 2005-11-11 | 2007-06-06 | GPC Biotech AG | Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues |
CZ300120B6 (cs) * | 2006-06-20 | 2009-02-11 | Pliva - Lachema A. S. | Farmaceutická kompozice pro injekcní podání |
CZ300424B6 (cs) * | 2006-06-20 | 2009-05-13 | Pliva - Lachema A. S. | Farmaceutická kompozice pro perorální podání |
CZ300590B6 (cs) * | 2006-06-20 | 2009-06-24 | Pliva - Lachema A. S. | Farmaceutická kompozice pro injekcní podání |
KR100829173B1 (ko) * | 2006-09-19 | 2008-05-13 | 광주과학기술원 | 물에 대한 용해도가 우수한 플라틴 복합체의 포접복합체 및그 제조방법 |
GB2457454B (en) * | 2008-02-12 | 2010-05-12 | Pliva Lachema As | Polymorphic crystalline form II of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV) |
GB2457453B (en) * | 2008-02-12 | 2010-05-12 | Pliva Lachema As | Polymorphic crystalline form III of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) ammine dichloroplatinum (IV) |
GB2457455B (en) * | 2008-02-12 | 2010-04-21 | Pliva Lachema As | Polymorphic crystalline form (I) of (OC-6-43)-Bis(Acetato)-1-(Tricyclo[3,3,1,1 (3,7)]Decylamine)Amminedichloroplatinum(IV) |
GB2457452B (en) * | 2008-02-12 | 2010-05-12 | Pliva Lachema As | Amorphous form of (OC-6-43)-bis(acetate)(1-tricyclo[3,3,1,13,7]decylamine) amminedichloroplatinum (IV) |
WO2010149666A1 (en) | 2009-06-22 | 2010-12-29 | Medexis S.A. | Methods for treating neoplasia |
US20120238488A1 (en) | 2009-09-08 | 2012-09-20 | Konstantinos Alevizopoulos | Compounds and methods for treating neoplasia |
EP2598513A1 (en) | 2010-07-30 | 2013-06-05 | Medexis S.A. | Compounds and methods for treating neoplasia |
CN106795189B (zh) * | 2014-09-03 | 2019-05-07 | Vuab制药股份有限公司 | 抗肿瘤功效提高的铂(iv)络合物 |
CN104984356A (zh) * | 2015-05-14 | 2015-10-21 | 昆明贵研药业有限公司 | 赛特铂的环糊精复合物及制备方法 |
RU2613513C2 (ru) * | 2015-07-17 | 2017-03-16 | Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) | Способ получения комплексов платины (IV) с аминонитроксильными радикалами |
RU2726826C2 (ru) * | 2016-12-27 | 2020-07-15 | Общество с ограниченной ответственностью "Плат-АН" (ООО "Плат-АН") | Композиция на основе аминонитроксильного комплекса платины и доксорубицина и способ лечения опухолей |
US20220289781A1 (en) * | 2019-09-05 | 2022-09-15 | Vuab Pharma A.S. | New platinum iv complexes with substantially increased antitumor efficacy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE113054T1 (de) * | 1988-02-02 | 1994-11-15 | Johnson Matthey Inc | Pt(iv) komplexe. |
FI905018A0 (fi) * | 1989-10-17 | 1990-10-12 | Bristol Myers Squibb Co | I vatten och loesningsmedel loesliga axiala hydroxi-och mono- och dikarboxylsyraderivat med stor tumoeraktivitet. |
GB9105037D0 (en) * | 1991-03-09 | 1991-04-24 | Johnson Matthey Plc | Improvements in chemical compounds |
JPH10265380A (ja) * | 1997-03-17 | 1998-10-06 | Bristol Myers Squibb Co | 抗ガン剤 |
-
1998
- 1998-05-27 CZ CZ19981628A patent/CZ288912B6/cs not_active IP Right Cessation
-
1999
- 1999-05-24 IL IL13952999A patent/IL139529A/en not_active IP Right Cessation
- 1999-05-24 PT PT99920541T patent/PT1082330E/pt unknown
- 1999-05-24 UA UA2000116684A patent/UA56315C2/uk unknown
- 1999-05-24 BR BRPI9910669-8A patent/BR9910669B1/pt not_active IP Right Cessation
- 1999-05-24 RS YUP-719/00A patent/RS49738B/sr unknown
- 1999-05-24 HU HU0102549A patent/HU224716B1/hu not_active IP Right Cessation
- 1999-05-24 CN CN99806649A patent/CN1124279C/zh not_active Expired - Fee Related
- 1999-05-24 DE DE69901177T patent/DE69901177T2/de not_active Expired - Lifetime
- 1999-05-24 ES ES99920541T patent/ES2175968T3/es not_active Expired - Lifetime
- 1999-05-24 WO PCT/CZ1999/000015 patent/WO1999061451A1/en active IP Right Grant
- 1999-05-24 SK SK1773-2000A patent/SK284436B6/sk not_active IP Right Cessation
- 1999-05-24 AU AU38093/99A patent/AU741380B2/en not_active Ceased
- 1999-05-24 JP JP2000550855A patent/JP3575686B2/ja not_active Expired - Fee Related
- 1999-05-24 RU RU2000128648/04A patent/RU2200164C2/ru not_active IP Right Cessation
- 1999-05-24 PL PL344346A patent/PL191132B1/pl not_active IP Right Cessation
- 1999-05-24 CA CA002332054A patent/CA2332054C/en not_active Expired - Fee Related
- 1999-05-24 MX MXPA00011621A patent/MXPA00011621A/es not_active IP Right Cessation
- 1999-05-24 US US09/700,514 patent/US6503943B1/en not_active Expired - Fee Related
- 1999-05-24 EP EP99920541A patent/EP1082330B1/en not_active Expired - Lifetime
- 1999-05-24 SI SI9930056T patent/SI1082330T1/xx unknown
-
2000
- 2000-11-17 HR HR20000791A patent/HRP20000791B1/xx not_active IP Right Cessation
- 2000-11-21 BG BG104972A patent/BG64599B1/bg unknown
- 2000-11-27 NO NO20005990A patent/NO328930B1/no not_active IP Right Cessation
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