RS20050241A - Synthesis of thiophenecarboxylic acid esters for the production of ranelic acid salts - Google Patents
Synthesis of thiophenecarboxylic acid esters for the production of ranelic acid saltsInfo
- Publication number
- RS20050241A RS20050241A YUP-2005/0241A YUP20050241A RS20050241A RS 20050241 A RS20050241 A RS 20050241A YU P20050241 A YUP20050241 A YU P20050241A RS 20050241 A RS20050241 A RS 20050241A
- Authority
- RS
- Serbia
- Prior art keywords
- synthesis
- production
- ranelic
- acid esters
- thiophenecarboxylic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Postupak industrijske sinteze jedinjenja predstavljenih formulom (I): u kojoj R i R', bilo da su isti ili različiti, svaki za sebe predstavlja linearnu ili račvastu (C1-C6) alkil grupu. Primena sinteze dvovalentnih soli ranelinske soli a naročito stroncijum ranelata i njenih hidrata.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211765A FR2844797B1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| PCT/FR2003/002775 WO2004029034A1 (fr) | 2002-09-24 | 2003-09-22 | Synthese d’esters d’acide thiophenecarboxyliques pour la fabrication de sels de l’acide ranelique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RS20050241A true RS20050241A (en) | 2007-06-04 |
| RS51551B RS51551B (sr) | 2011-06-30 |
Family
ID=29415191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-2005/0241A RS51551B (sr) | 2002-09-24 | 2003-09-22 | Sinteza estara tiofenkarboksilne kiseline za proizvodnju soli ranelinske kiseline |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US7091364B2 (sr) |
| EP (1) | EP1403265B1 (sr) |
| JP (1) | JP4136866B2 (sr) |
| KR (1) | KR100551502B1 (sr) |
| CN (1) | CN1280286C (sr) |
| AP (1) | AP1972A (sr) |
| AR (1) | AR041357A1 (sr) |
| AT (1) | ATE449767T1 (sr) |
| AU (2) | AU2003299095A1 (sr) |
| BR (1) | BR0304203A (sr) |
| CA (1) | CA2442881C (sr) |
| CY (1) | CY1109831T1 (sr) |
| DE (1) | DE60330213D1 (sr) |
| DK (1) | DK1403265T3 (sr) |
| EA (1) | EA007108B1 (sr) |
| EC (1) | ECSP055743A (sr) |
| ES (1) | ES2337348T3 (sr) |
| FR (1) | FR2844797B1 (sr) |
| GE (1) | GEP20074139B (sr) |
| HK (1) | HK1061846A1 (sr) |
| HR (1) | HRP20050361B1 (sr) |
| IL (1) | IL167315A (sr) |
| IS (1) | IS2728B (sr) |
| MA (1) | MA26100A1 (sr) |
| ME (1) | ME00453B (sr) |
| MX (1) | MXPA03008647A (sr) |
| MY (1) | MY134924A (sr) |
| NO (1) | NO328626B1 (sr) |
| NZ (1) | NZ528401A (sr) |
| OA (1) | OA12932A (sr) |
| PL (1) | PL215879B1 (sr) |
| PT (1) | PT1403265E (sr) |
| RS (1) | RS51551B (sr) |
| SG (1) | SG110069A1 (sr) |
| SI (1) | SI1403265T1 (sr) |
| TN (1) | TNSN05088A1 (sr) |
| UA (1) | UA79157C2 (sr) |
| WO (1) | WO2004029034A1 (sr) |
| ZA (1) | ZA200307411B (sr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2844795B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| EP1534305B9 (en) * | 2003-05-07 | 2007-03-07 | Osteologix A/S | Treating cartilage / bone conditions with water-soluble strontium salts |
| CA2524610C (en) * | 2003-05-07 | 2014-03-25 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| CA2557324C (en) | 2004-02-26 | 2012-10-16 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
| DK1768748T4 (da) | 2004-06-25 | 2019-06-11 | Mokwalo Spf S A | Sammensætninger omfattende strontium og vitamin D og anvendelser deraf |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| CN100391955C (zh) * | 2005-04-30 | 2008-06-04 | 河北医科大学 | 一种雷尼酸锶中间体的合成方法 |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| US20070292535A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating arthritic and or osteoporitic conditions |
| FR2921367B1 (fr) | 2007-09-26 | 2009-10-30 | Servier Lab | Nouveau procede de synthese du ranelate de strontium et de ses hydrates |
| US20120123131A1 (en) * | 2008-08-22 | 2012-05-17 | Koilpillai Joseph Prabahar | Process for the preparation of strontium ranelate |
| CN101665483B (zh) * | 2008-09-01 | 2013-01-23 | 河北医科大学 | 一种雷尼酸锶中间体化合物ⅱ的合成方法 |
| WO2011124992A1 (en) * | 2010-03-24 | 2011-10-13 | Actavis Group Ptc Ehf | Substantially pure strontium ranelate |
| CN101812048B (zh) * | 2010-04-06 | 2012-11-14 | 浙江东亚药业有限公司 | 雷尼酸锶及其水合物的合成方法 |
| EP2602248A1 (en) | 2011-12-05 | 2013-06-12 | University Of Leicester | Novel pyrrole compounds |
| WO2013113319A1 (en) | 2012-01-31 | 2013-08-08 | Pharmathen S.A. | Process for the preparation of strontium ranelate, intermediate or hydrates thereof |
| ES2505716T3 (es) | 2013-01-21 | 2015-09-04 | Galenicum Health S.L. | Composiciones farmacéuticas que comprenden una sal de ácido |
| GB201310126D0 (en) * | 2013-06-06 | 2013-07-24 | Univ Leicester | Novel pyrrole derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3624304A1 (de) | 1986-07-18 | 1988-01-28 | Bayer Ag | Fungizide verwendung von substituierten thienylaminen |
| GB8715925D0 (en) * | 1987-07-07 | 1987-08-12 | Shell Int Research | Thiapentanamide derivatives |
| FR2651497B1 (fr) * | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| DE19528380A1 (de) * | 1995-08-02 | 1997-02-06 | Hoechst Ag | Heterogene Vinylacetat/Ethylen-Dispersion |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| DE19650196A1 (de) * | 1996-12-04 | 1998-06-10 | Bayer Ag | Thienylsulfonylamino(thio)carbonylverbindungen |
| US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
-
2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Application Discontinuation
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/sr unknown
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active IP Right Cessation
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
-
2004
- 2004-07-05 HK HK04104809A patent/HK1061846A1/xx not_active IP Right Cessation
-
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-21 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
-
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS20050241A (en) | Synthesis of thiophenecarboxylic acid esters for the production of ranelic acid salts | |
| HRPK20040255B3 (en) | Processes for preparing calcium salt forms of statins | |
| NI200500065A (es) | Nuevos procesos para la sintesis industrial del diester metilico del 5-amino-3-carboximetil-4-ciano-2-acido tiofenecarboxilico y aplicacion a la sintesis de sales bivalentes de acido ranelico y de sus hidratos. | |
| TW200734038A (en) | Novel dispersant and compositions thereof | |
| TW200635585A (en) | Monocyclic substituted methanones | |
| RS20050240A (en) | Novel method for the industrial synthesis of strontium ranelate and the hydrates thereof | |
| IN2012DN00758A (sr) | ||
| ID20564A (id) | Senyawa-senyawa heterosiklik yang mempunyai aktifitas anti-diabetes, pembuatannya dan penggunaannya (pecahan dari p-950588) | |
| GEP20074135B (en) | Process for the synthesis of (is)-4,5-dimethoxy-1-(methylaminomethyl)- benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | |
| EP1484327A4 (en) | NITROGENIC HETEROCYCLIC COMPOUND AND MEDICINES THEREOF | |
| UA89672C2 (en) | Sulfonylamino(thio)carbonyl compounds | |
| CA2418770A1 (en) | Acylacetonitrile compound, process for preparation thereof, and miticide containing the same | |
| TW200612931A (en) | Substituted biphenyl derivatives | |
| WO2007020527A3 (en) | Process for the preparation of strontium ranelate | |
| ES2195510T3 (es) | Derivados de imidazopiridina y procedimiento para prepararlos. | |
| UA97638C2 (ru) | Способ синтеза ранелата стронция и его гидратов | |
| WO2002062736A1 (fr) | Diphenol et procede de production de ce diphenol | |
| DE602004020667D1 (en) | Prostaglandinsynthese | |
| EP1378502A4 (en) | OLIGOLACTIC ACID ESTER WITH CHAIN | |
| MXPA05011183A (es) | Sintesis de 2-hidroxi-n, n-dimetil- 3-[[2-[1(r) -(5-metil -2-furanil) propil]amino]-3, 4-dioxo-1 -ciclobuten-1 -il]amino] benzamida. | |
| WO2010021000A3 (en) | A process for the preparation of strontium ranelate | |
| RS51467B (sr) | Prolekovi za ligande nmda receptora | |
| EP1403250A4 (en) | BIS DERIVATIVE (5-ARYL-2-PYRIDYL) |