IS7803A - Ný aðferð við nýmyndun tetraestera 5-[bis(karboxýmetýl)amínó]-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru í iðnaði og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra - Google Patents

Ný aðferð við nýmyndun tetraestera 5-[bis(karboxýmetýl)amínó]-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru í iðnaði og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra

Info

Publication number: IS7803A
Authority: IS; Iceland
Prior art keywords: carboxymethyl; synthesis; acid; hydrates; cyano
Prior art date: 2002-09-24

Application number

IS7803A

Other languages

English (en)

Other versions

IS2728B (is

Inventor

Vaysse-Ludot Lucile

Lecouve Jean-Pierre

Langlois Pascal

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2005-04-18

Publication date

2005-04-18

2005-04-18 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2005-04-18 Publication of IS7803A publication Critical patent/IS7803A/is

2011-04-15 Publication of IS2728B publication Critical patent/IS2728B/is

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IS7803A 2002-09-24 2005-04-18 Ný aðferð til að nota í iðnaði til nýmyndunar á 5-bis(karboxýmetýl)amínó-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru tetraestera og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra IS2728B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0211765A FR2844797B1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
PCT/FR2003/002775 WO2004029034A1 (fr)	2002-09-24	2003-09-22	Synthese d’esters d’acide thiophenecarboxyliques pour la fabrication de sels de l’acide ranelique

Publications (2)

Publication Number	Publication Date
IS7803A true IS7803A (is)	2005-04-18
IS2728B IS2728B (is)	2011-04-15

Family

ID=29415191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7803A IS2728B (is)	2002-09-24	2005-04-18	Ný aðferð til að nota í iðnaði til nýmyndunar á 5-bis(karboxýmetýl)amínó-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru tetraestera og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra

Country Status (39)

Country	Link
US (1)	US7091364B2 (is)
EP (1)	EP1403265B1 (is)
JP (1)	JP4136866B2 (is)
KR (1)	KR100551502B1 (is)
CN (1)	CN1280286C (is)
AP (1)	AP1972A (is)
AR (1)	AR041357A1 (is)
AT (1)	ATE449767T1 (is)
AU (2)	AU2003299095A1 (is)
BR (1)	BR0304203A (is)
CA (1)	CA2442881C (is)
CY (1)	CY1109831T1 (is)
DE (1)	DE60330213D1 (is)
DK (1)	DK1403265T3 (is)
EA (1)	EA007108B1 (is)
EC (1)	ECSP055743A (is)
ES (1)	ES2337348T3 (is)
FR (1)	FR2844797B1 (is)
GE (1)	GEP20074139B (is)
HK (1)	HK1061846A1 (is)
HR (1)	HRP20050361B1 (is)
IL (1)	IL167315A (is)
IS (1)	IS2728B (is)
MA (1)	MA26100A1 (is)
ME (1)	ME00453B (is)
MX (1)	MXPA03008647A (is)
MY (1)	MY134924A (is)
NO (1)	NO328626B1 (is)
NZ (1)	NZ528401A (is)
OA (1)	OA12932A (is)
PL (1)	PL215879B1 (is)
PT (1)	PT1403265E (is)
RS (1)	RS51551B (is)
SG (1)	SG110069A1 (is)
SI (1)	SI1403265T1 (is)
TN (1)	TNSN05088A1 (is)
UA (1)	UA79157C2 (is)
WO (1)	WO2004029034A1 (is)
ZA (1)	ZA200307411B (is)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
SI2266584T1 (sl) *	2003-05-07	2012-12-31	Osteologix A/S, Symbion	Sestavek s stroncijem in vitaminom D za profilakso in/ali zdravljenje patologij hrustanca in/ali kosti
PT1534305E (pt) *	2003-05-07	2007-02-28	Osteologix As	Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
KR101165614B1 (ko)	2004-02-26	2012-07-18	오스테올로지스 에이에스	괴사성 골 질환의 예방 또는 치료에 사용하기 위한스트론튬 함유 화합물
BRPI0512357A (pt)	2004-06-25	2008-03-04	Strontin Aps	composições compreendendo estrÈncio e vitamina d e usos destas
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100391955C (zh) *	2005-04-30	2008-06-04	河北医科大学	一种雷尼酸锶中间体的合成方法
US20070292535A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating arthritic and or osteoporitic conditions
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
FR2921367B1 (fr)	2007-09-26	2009-10-30	Servier Lab	Nouveau procede de synthese du ranelate de strontium et de ses hydrates
US20120123131A1 (en) *	2008-08-22	2012-05-17	Koilpillai Joseph Prabahar	Process for the preparation of strontium ranelate
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011124992A1 (en) *	2010-03-24	2011-10-13	Actavis Group Ptc Ehf	Substantially pure strontium ranelate
CN101812048B (zh) *	2010-04-06	2012-11-14	浙江东亚药业有限公司	雷尼酸锶及其水合物的合成方法
EP2602248A1 (en)	2011-12-05	2013-06-12	University Of Leicester	Novel pyrrole compounds
WO2013113319A1 (en)	2012-01-31	2013-08-08	Pharmathen S.A.	Process for the preparation of strontium ranelate, intermediate or hydrates thereof
EP2756841B1 (en)	2013-01-21	2015-05-13	Galenicum Health S.L.	Pharmaceutical compositions comprising an acid salt
GB201310126D0 (en) *	2013-06-06	2013-07-24	Univ Leicester	Novel pyrrole derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3624304A1 (de)	1986-07-18	1988-01-28	Bayer Ag	Fungizide verwendung von substituierten thienylaminen
GB8715925D0 (en) *	1987-07-07	1987-08-12	Shell Int Research	Thiapentanamide derivatives
FR2651497B1 (fr)	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE19528380A1 (de) *	1995-08-02	1997-02-06	Hoechst Ag	Heterogene Vinylacetat/Ethylen-Dispersion
FR2749759B1 (fr) *	1996-06-17	1999-11-26	Adir	Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
DE19650196A1 (de) *	1996-12-04	1998-06-10	Bayer Ag	Thienylsulfonylamino(thio)carbonylverbindungen
US6835745B2 (en) *	2002-01-15	2004-12-28	Wyeth	Phenyl substituted thiophenes as estrogenic agents

2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/en unknown
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Application Discontinuation
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active IP Right Cessation
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
2004
- 2004-07-05 HK HK04104809A patent/HK1061846A1/xx not_active IP Right Cessation
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-21 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown

Also Published As

Publication number	Publication date
EP1403265B1 (fr)	2009-11-25
PL362366A1 (en)	2004-04-05
NZ528401A (en)	2004-05-28
US20040059134A1 (en)	2004-03-25
RS20050241A (en)	2007-06-04
BR0304203A (pt)	2004-08-24
AR041357A1 (es)	2005-05-11
ZA200307411B (en)	2004-07-07
EA007108B1 (ru)	2006-06-30
CA2442881C (fr)	2010-06-29
AU2003299095A1 (en)	2004-04-19
NO328626B1 (no)	2010-04-12
WO2004029034A1 (fr)	2004-04-08
KR100551502B1 (ko)	2006-02-13
OA12932A (en)	2006-10-13
TNSN05088A1 (fr)	2007-05-14
EP1403265A1 (fr)	2004-03-31
DK1403265T3 (da)	2010-04-06
EA200300927A1 (ru)	2004-04-29
JP2004269496A (ja)	2004-09-30
PL215879B1 (pl)	2014-02-28
CN1500784A (zh)	2004-06-02
HRP20050361A2 (en)	2005-06-30
PT1403265E (pt)	2009-12-16
SI1403265T1 (sl)	2010-01-29
HRP20050361B1 (hr)	2014-03-14
IS2728B (is)	2011-04-15
UA79157C2 (en)	2007-05-25
NO20034236L (no)	2004-03-25
CY1109831T1 (el)	2014-09-10
MXPA03008647A (es)	2005-04-19
RS51551B (en)	2011-06-30
SG110069A1 (en)	2005-04-28
JP4136866B2 (ja)	2008-08-20
KR20040026626A (ko)	2004-03-31
ECSP055743A (es)	2005-07-06
MA26100A1 (fr)	2004-04-01
ES2337348T3 (es)	2010-04-23
GEP20074139B (en)	2007-06-25
DE60330213D1 (de)	2010-01-07
IL167315A (en)	2009-08-03
CA2442881A1 (fr)	2004-03-24
NO20034236D0 (no)	2003-09-23
ME00453B (me)	2011-10-10
HK1061846A1 (en)	2004-10-08
ATE449767T1 (de)	2009-12-15
US7091364B2 (en)	2006-08-15
MY134924A (en)	2008-01-31
FR2844797B1 (fr)	2004-10-22
AU2003248280A1 (en)	2004-04-08
AP2005003255A0 (en)	2005-03-31
AP1972A (en)	2009-03-12
FR2844797A1 (fr)	2004-03-26
CN1280286C (zh)	2006-10-18
AU2003248280B2 (en)	2009-01-08

Publication	Publication Date	Title
IS7803A (is)	2005-04-18	Ný aðferð við nýmyndun tetraestera 5-[bis(karboxýmetýl)amínó]-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru í iðnaði og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra
IS7434A (is)	2004-09-02	N-amínóasetýl-pýrrólídín-2-karbónítríl og notkun þeirra sem DDP-IV tálma
SI1758905T1 (sl)	2009-10-31	8-(3-amino-piperidin-1-il)-ksantini, njihova priprava in njihova uporaba kot inhibitor DPP-IV
EG25655A (en)	2012-05-02	Benzamide derivatives useful as histone deacetylase inhibitors
IS7792A (is)	2005-04-11	Hýdantóínafleiður og notkun þeirra sem TACE hemla
HRP20050359A2 (en)	2005-06-30	Novel method for the industrial synthesis of strontium ranelate and the hydrates thereof
NO20050118D0 (no)	2005-01-10	Substituerte fenylsulfonamidinhibitorer av beta-amyolid produksjon
DE60035631D1 (de)	2007-09-06	Inhibitoren der Interleukin-4 Produktion
ITMI20021399A0 (it)	2002-06-25	Inibitori della cicloossigenasi 2
NO20040133L (no)	2004-01-12	Additiv og anvendelse derav som korrosjonsinhibitor
GB0413967D0 (en)	2004-07-28	Metabolites of (3-{[4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO]-METHYL}-PHENOXY)-ACE TIC ACID
DE60224548D1 (de)	2008-02-21	Zuführvorrichtung für ein klebeband zum verbinden von bahnen
SG110070A1 (en)	2005-04-28	New process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
PL1940818T3 (pl)	2012-01-31	Pochodne aminokwasów zawierające grupę disulfanylową jako mieszane inhibitory neprylizyny i aminopeptydazy n
DK1551814T3 (da)	2008-10-27	Chirale oxazol-arylpropionsyrederivater og anvendelse deraf som ppar-agnister
ATE411995T1 (de)	2008-11-15	Inhibitoren der alpha-l-beta-2- integrinvermittelten zelladhäsion
GEP20074257B (en)	2007-12-10	Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in the synthesis of perindopril
SI1616007T1 (sl)	2013-12-31	Inhibitor proteini proteaze in njih uporaba
ITUD20050156A1 (it)	2007-03-27	Bracciale per un'apparecchiatura elettronica portatile
TH77328EX (th)	2006-05-10	''หน้าปัดนาฬิกา''
MA25613A1 (fr)	2002-12-31	Alphabet-copieuse a ecrire
SE0201637D0 (sv)	2002-05-31	Method of coupling binding agents to a substrate surface
TH59363EX (th)	2003-11-14	ตลับเมตร (รุ่นฮวงจุ้ย)
SE0202115D0 (sv)	2002-07-08	Use of a composition
ITMI20020318V0 (it)	2002-06-18	Struttura perfezionata del gancio di estremita' di un metro a nastro