RO86823A - Procedeu pentru prepararea unor cefalosporine - Google Patents

Procedeu pentru prepararea unor cefalosporine

Info

Publication number: RO86823A
Authority: RO; Romania
Prior art keywords: cefalosporine; preparation
Prior art date: 1980-09-25

Application number

RO81112111A

Other languages

English (en)

French (fr)

Other versions

RO86823B (ro

Inventor

Hiroshi Sadaki

Hirokazu Narita

Hiroyuki Imaizumi

Yoshinori Konishi

Takihiro Inab

Tatsuo Hirakawa

Hideo Taki

Nasaru Tai

Yasuo Watanabe

Isamu Saikawa

Original Assignee

Toyama Chemical Co Ltd,Jp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-25

Filing date

1981-09-25

Publication date

1985-05-20

1980-09-25 Priority claimed from JP55132253A external-priority patent/JPS5758689A/ja

1980-11-12 Priority claimed from JP55158184A external-priority patent/JPS5782393A/ja

1980-12-13 Priority claimed from JP55175263A external-priority patent/JPS6052755B2/ja

1981-09-25 Application filed by Toyama Chemical Co Ltd,Jp filed Critical Toyama Chemical Co Ltd,Jp

1985-05-20 Publication of RO86823A publication Critical patent/RO86823A/ro

1985-05-31 Publication of RO86823B publication Critical patent/RO86823B/ro

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

RO112111A 1980-09-25 1981-09-25 Procedeu pentru prepararea unor cefalosporine RO86823B (ro)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP55132253A JPS5758689A (en)	1980-09-25	1980-09-25	Novel preparation of 7-substituted or unsubstituted amino-3-substituted methylcephem carboxylic acids
JP55158184A JPS5782393A (en)	1980-11-12	1980-11-12	7-amino-3-(2-(1,2,3,4-tetrazolyl)methyl)cephem-4-carboxylic acid
JP55175263A JPS6052755B2 (ja)	1980-12-13	1980-12-13	新規セファロスポリン類

Publications (2)

Publication Number	Publication Date
RO86823A true RO86823A (ro)	1985-05-20
RO86823B RO86823B (ro)	1985-05-31

Family

ID=27316463

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
RO112113A RO86825B (ro)	1980-09-25	1981-09-25	Procedeu pentru prepararea unor acizi 7-amino-3-metil-substituit-delta3-cefem-4-carboxilici
RO112112A RO86824B (ro)	1980-09-25	1981-09-25	Procedeu pentru prepararea unor cefalosporine
RO81105405A RO82689A (ro)	1980-09-25	1981-09-25	Procedeu pentru prepararea unor cefalosporine
RO112111A RO86823B (ro)	1980-09-25	1981-09-25	Procedeu pentru prepararea unor cefalosporine

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
RO112113A RO86825B (ro)	1980-09-25	1981-09-25	Procedeu pentru prepararea unor acizi 7-amino-3-metil-substituit-delta3-cefem-4-carboxilici
RO112112A RO86824B (ro)	1980-09-25	1981-09-25	Procedeu pentru prepararea unor cefalosporine
RO81105405A RO82689A (ro)	1980-09-25	1981-09-25	Procedeu pentru prepararea unor cefalosporine

Country Status (27)

Country	Link
US (4)	US4489072A (ro)
KR (1)	KR860000932B1 (ro)
AR (1)	AR240645A1 (ro)
AT (4)	AT375082B (ro)
AU (3)	AU550330B2 (ro)
CA (2)	CA1204735A (ro)
CH (4)	CH652129A5 (ro)
DD (2)	DD208351A5 (ro)
DE (5)	DE3152934C2 (ro)
DK (1)	DK163877C (ro)
EG (1)	EG17373A (ro)
ES (4)	ES8301998A1 (ro)
FI (2)	FI75575C (ro)
FR (2)	FR2509310B1 (ro)
GB (3)	GB2089339B (ro)
HU (1)	HU185850B (ro)
IN (4)	IN155375B (ro)
IT (1)	IT1172201B (ro)
LU (1)	LU83650A1 (ro)
MX (1)	MX155025A (ro)
NL (1)	NL8104386A (ro)
NO (1)	NO161117C (ro)
NZ (1)	NZ198350A (ro)
PH (5)	PH18072A (ro)
PT (1)	PT73727B (ro)
RO (4)	RO86825B (ro)
SE (5)	SE453090B (ro)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4703046A (en) *	1978-09-08	1987-10-27	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds and processes for preparation thereof
NZ198350A (en) *	1980-09-25	1985-02-28	Toyama Chemical Co Ltd	Cephalosporins and intermediates;pharmaceutical compositions
EP0061234A3 (en) *	1981-03-05	1983-11-16	Beecham Group Plc	Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them
EP0081971A3 (en) *	1981-12-08	1984-09-26	Tanabe Seiyaku Co., Ltd.	Novel cephalosporin compound and process for preparing the same
DK521883A (da) *	1982-11-17	1984-05-18	Toyama Chemical Co Ltd	Cephalosporinderivater, fremgangsmaade til fremstilling heraf og fremgangsmaade til fremstilling af mellemprodukter herfor
US4618606A (en) *	1982-11-17	1986-10-21	Toyama Chemical Co., Ltd.	Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins
JPS6064986A (ja) *	1983-09-20	1985-04-13	Toyama Chem Co Ltd	セファロスポリン類の製造法
JPS60190783A (ja) *	1983-12-21	1985-09-28	Sumitomo Seiyaku Kk	セフエム系化合物
GB8406231D0 (en) *	1984-03-09	1984-04-11	Fujisawa Pharmaceutical Co	Cephem compounds
GB2161476B (en) *	1984-05-25	1988-01-27	Toyama Chemical Co Ltd	2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
AT397086B (de) *	1984-05-25	1994-01-25	Toyama Chemical Co Ltd	Verfahren zur herstellung von neuen 2-(2-aminothiazol-4-4yl)-2-(syn)-alkoxyimino- acetamiden
FI851934L (fi) *	1984-05-30	1985-12-01	Ici Plc	Kefalosporinderivat.
DE3539901A1 (de) *	1985-11-11	1987-05-14	Hoechst Ag	Cephalosporinderivate und verfahren zu ihrer herstellung
JPH064643B2 (ja) *	1985-12-20	1994-01-19	ファイザー製薬株式会社	セフアロスポリン化合物
US4692517A (en) *	1986-03-20	1987-09-08	American Home Products Corporation	C-3' acylaminooxy-7-[(2-aminothiazol-4-yl)-α-(substituted-oximino)acetyl]cephalosporin derivatives
EP0265185A3 (en) *	1986-10-21	1990-03-28	Beecham Group Plc	Cephalosporins, processes for their preparation and pharmaceutical compositions containing them
ZA877987B (en) *	1986-11-12	1988-08-31	Ici Pharma	Antibiotic compounds
EP0269298B1 (en) *	1986-11-21	1994-10-19	Ici Pharma	Cephalosporins, process for their preparation and pharmaceutical compositions
DE3750673T2 (de) *	1986-11-21	1995-03-16	Ici Pharma	Cephalosporine, Verfahren zu ihrer Herstellung und pharmazeutische Präparate.
US4847373A (en) *	1987-02-26	1989-07-11	Bristol-Myers Company	Production of 3-allyl- and 3-butenyl-3-cephems
GB8816519D0 (en) *	1987-07-23	1988-08-17	Ici Plc	Antibiotic compounds
US5232918A (en) *	1987-07-23	1993-08-03	Imperial Chemical Industries Plc	Cephalosporin derivatives
GB8811056D0 (en) *	1988-05-10	1988-06-15	Ici Plc	Antibiotic compounds
JPH0699443B2 (ja) *	1989-09-29	1994-12-07	ファイザー製薬株式会社	セファロスポリン化合物
US6800756B2 (en) *	2002-05-03	2004-10-05	Orchid Chemicals And Pharmaceuticals, Ltd.	Method for the preparation of ceftiofur sodium and its intermediates
US7847093B2 (en) *	2003-04-16	2010-12-07	Sandoz Ag	Processes for the preparations of cefepime
ATE473986T1 (de) *	2003-04-16	2010-07-15	Sandoz Ag	Verfahren zur herstellung von cefepim
MXPA06011046A (es) *	2004-03-26	2007-03-21	Amphora Discovery Corp	Ciertos compuestos basados en triazol, composiciones, y usos de los mismos.
US8198434B2 (en) *	2008-05-07	2012-06-12	Idexx Laboratories, Inc.	Process for preparing cefsulodin sodium
WO2011103686A1 (en) *	2010-02-26	2011-09-01	Viswanatha , Sundaramma	CEPHALOSPORIN DERIVATIVES USEFUL AS β-LACTAMASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
CN102351886B (zh) *	2011-09-07	2013-10-16	山东罗欣药业股份有限公司	头孢特仑新戊酯晶体、其制备方法及含有该晶体的组合物片剂
KR102377635B1 (ko)	2013-07-17	2022-03-24	오츠카 세이야쿠 가부시키가이샤	시아노트리아졸 화합물
CN106046026B (zh) *	2016-06-30	2018-07-06	济南康和医药科技有限公司	一种头孢特仑新戊酯的制备方法
CN112645842B (zh) *	2020-12-25	2022-08-19	复旦大学	一种氰乙酸叔丁酯的连续流制备方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB912541A (en) *	1958-03-17	1962-12-12	Nat Res Dev	Cephalosporin c compounds
DE1795484U (de)	1959-04-21	1959-09-10	Richard Langer	Quertraeger fuer laengsdraehte zum abstuetzen von pflanzen, insbesondere weinreben.
GB1032641A (en) *	1962-02-16	1966-06-15	Edward Penley Abraham	Cephalosporins
GB1057883A (en) *	1962-07-11	1967-02-08	Glaxo Lab Ltd	Improvements in or relating to antibiotics
US3226384A (en) *	1963-01-25	1965-12-28	Nat Res Dev	Cephalosporin ca derivatives
BE634644A (ro) *	1963-07-10
US3821206A (en) *	1966-12-15	1974-06-28	Glaxo Lab Ltd	Cephalosporins having a polyazole substituent
GB1211694A (en) *	1966-12-15	1970-11-11	Glaxo Lab Ltd	Derivatives of 7-aminocephalosporanic acid
DE2132883A1 (de) *	1970-07-08	1972-01-13	Ciba Geigy Ag	Cephemverbindungen
US3932465A (en) *	1970-07-08	1976-01-13	Ciba-Geigy Corporation	3-R-methyl-7-amino-ceph-em-4-carboxylic acid compounds
GB1399086A (en) *	1971-05-14	1975-06-25	Glaxo Lab Ltd	Cephalosporin compounds
US4343937A (en) *	1971-06-02	1982-08-10	Merck & Co., Inc.	3-Substituted-7-methoxy-7-amino-3-cephem-4-carboxylic acids
SU589918A3 (ru) *	1971-07-14	1978-01-25	Мерк Энд Ко Инк (Фирма)	Способ получени сложного эфира 3-замещенной метил-7-ациломидо-7-метокси-2-цефем -4- карбоноаой кислоты
JPS5653557B2 (ro) *	1973-10-15	1981-12-19
CH605997A5 (ro) *	1974-08-30	1978-10-13	Ciba Geigy Ag
OA05233A (fr) *	1975-02-04	1981-02-28	Fujisawa Pharmaceutical Co	Procédé de préparation d'acides (7-acétamido Disubstitue)-3- substitue-3- cephem-4-carboxyliques et nouveaux produits industriels.
GB1547165A (en) *	1975-08-15	1979-06-06	Beecham Group Ltd	3-carbamoylbenzyl and 3-(carbamoylpyridylmethyl)-cephems
GB1575803A (en) *	1976-03-09	1980-10-01	Fujisawa Pharmaceutical Co	3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
US4165430A (en) *	1976-03-19	1979-08-21	Glaxo Laboratories Limited	Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
JPS5946237B2 (ja) *	1976-04-02	1984-11-10	武田薬品工業株式会社	セフアロスポリン誘導体およびその製造法
DE2760484C2 (ro) *	1976-04-14	1992-12-03	Takeda Chemical Industries, Ltd., Osaka, Jp
GB1565941A (en) *	1977-02-08	1980-04-23	Toyama Chemical Co Ltd	Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids
ES467601A1 (es) *	1977-03-12	1979-06-16	Hoechst Ag	Procedimiento para la preparacion de derivados de cefem.
DE2714880A1 (de) *	1977-04-02	1978-10-26	Hoechst Ag	Cephemderivate und verfahren zu ihrer herstellung
US4148997A (en) *	1977-11-07	1979-04-10	Yeda Research And Development Co., Ltd.	7-[Sulfomethyl)phenyl]acetamidocephalosporin derivatives
AR229883A1 (es) *	1978-05-26	1983-12-30	Glaxo Group Ltd	Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
DE2822861A1 (de) *	1978-05-26	1979-11-29	Hoechst Ag	Cephemderivate und verfahren zu ihrer herstellung
JPS6027677B2 (ja) *	1978-07-06	1985-06-29	富山化学工業株式会社	７−置換又は非置換アミノ−３−置換チオメチルセフエムカルボン酸類の新規製造法
ES485441A1 (es) *	1978-10-27	1980-07-01	Glaxo Group Ltd	Un procedimiento para la preparacion de antibioticos de ce- falosporina
IE49207B1 (en) *	1978-11-15	1985-08-21	Glaxo Group Ltd	Cephalosporin antibiotics
NL8001087A (nl) *	1979-02-23	1980-08-26	Glaxo Group Ltd	Cefalosporine antibiotica.
JPS55139387A (en)	1979-04-19	1980-10-31	Yamanouchi Pharmaceut Co Ltd	Novel synthetic method of 7-amino-3-heterocyclic thiomethyl-delta3-carboxylic acids
JPS55153790A (en)	1979-05-17	1980-11-29	Yamanouchi Pharmaceut Co Ltd	Preparation of 7-amino-3-heterocyclic thiomethyl-delta3- cephem-4-carboxylic acid
FR2461713A1 (fr) *	1979-07-19	1981-02-06	Roussel Uclaf	Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
NZ198350A (en) *	1980-09-25	1985-02-28	Toyama Chemical Co Ltd	Cephalosporins and intermediates;pharmaceutical compositions
EP0061234A3 (en) *	1981-03-05	1983-11-16	Beecham Group Plc	Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them
DK163925C (da) *	1981-09-10	1992-09-14	Takeda Chemical Industries Ltd	Fremgangsmaade til fremstilling af cephalosporinforbindelser
JPS6064986A (ja) *	1983-09-20	1985-04-13	Toyama Chem Co Ltd	セファロスポリン類の製造法
GB2161476B (en) *	1984-05-25	1988-01-27	Toyama Chemical Co Ltd	2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
CA1293719C (en) *	1986-09-22	1991-12-31	Takao Takaya	Cephem compounds and processes for preparation thereof

1981
- 1981-09-14 NZ NZ198350A patent/NZ198350A/en unknown
- 1981-09-16 PH PH26215A patent/PH18072A/en unknown
- 1981-09-16 GB GB8128011A patent/GB2089339B/en not_active Expired
- 1981-09-16 CA CA000386066A patent/CA1204735A/en not_active Expired
- 1981-09-17 AU AU75438/81A patent/AU550330B2/en not_active Expired
- 1981-09-19 IN IN1045/CAL/81A patent/IN155375B/en unknown
- 1981-09-23 US US06/304,912 patent/US4489072A/en not_active Expired - Lifetime
- 1981-09-23 DE DE3152934A patent/DE3152934C2/de not_active Expired - Lifetime
- 1981-09-23 DE DE3152932A patent/DE3152932C2/de not_active Expired - Lifetime
- 1981-09-23 IT IT49348/81A patent/IT1172201B/it active
- 1981-09-23 DE DE3152935A patent/DE3152935C2/de not_active Expired - Lifetime
- 1981-09-23 DE DE19813137854 patent/DE3137854A1/de active Granted
- 1981-09-23 DE DE3152931A patent/DE3152931C2/de not_active Expired
- 1981-09-23 NL NL8104386A patent/NL8104386A/xx not_active Application Discontinuation
- 1981-09-24 NO NO813252A patent/NO161117C/no unknown
- 1981-09-24 LU LU83650A patent/LU83650A1/fr unknown
- 1981-09-24 AT AT0410981A patent/AT375082B/de not_active IP Right Cessation
- 1981-09-24 ES ES505760A patent/ES8301998A1/es not_active Expired
- 1981-09-24 MX MX7609A patent/MX155025A/es unknown
- 1981-09-24 SE SE8105658A patent/SE453090B/sv not_active IP Right Cessation
- 1981-09-24 HU HU812759A patent/HU185850B/hu unknown
- 1981-09-24 PT PT73727A patent/PT73727B/pt unknown
- 1981-09-24 FI FI812980A patent/FI75575C/fi not_active IP Right Cessation
- 1981-09-24 DK DK421881A patent/DK163877C/da active
- 1981-09-25 RO RO112113A patent/RO86825B/ro unknown
- 1981-09-25 DD DD81247292A patent/DD208351A5/de unknown
- 1981-09-25 RO RO112112A patent/RO86824B/ro unknown
- 1981-09-25 CH CH6202/81A patent/CH652129A5/de not_active IP Right Cessation
- 1981-09-25 CH CH4519/84A patent/CH651837A5/de not_active IP Right Cessation
- 1981-09-25 CH CH4521/84A patent/CH652128A5/de not_active IP Right Cessation
- 1981-09-25 RO RO81105405A patent/RO82689A/ro unknown
- 1981-09-25 FR FR8118156A patent/FR2509310B1/fr not_active Expired
- 1981-09-25 DD DD81233599A patent/DD202436A5/de unknown
- 1981-09-25 CH CH4520/84A patent/CH652130A5/de not_active IP Right Cessation
- 1981-09-25 RO RO112111A patent/RO86823B/ro unknown
- 1981-09-26 EG EG543/81A patent/EG17373A/xx active
1982
- 1982-08-02 ES ES514669A patent/ES514669A0/es active Granted
- 1982-08-02 ES ES514670A patent/ES514670A0/es active Granted
- 1982-08-02 ES ES514671A patent/ES514671A0/es active Granted
- 1982-09-22 FR FR8215992A patent/FR2511377B1/fr not_active Expired
1983
- 1983-01-07 AR AR29180883A patent/AR240645A1/es active
- 1983-02-18 AT AT0055683A patent/AT378193B/de not_active IP Right Cessation
- 1983-02-18 AT AT0055583A patent/AT378962B/de not_active IP Right Cessation
- 1983-02-18 AT AT0055483A patent/AT378961B/de not_active IP Right Cessation
- 1983-06-17 PH PH29075A patent/PH19251A/en unknown
- 1983-06-17 PH PH29078A patent/PH18484A/en unknown
- 1983-06-17 PH PH29077A patent/PH20221A/en unknown
- 1983-06-17 PH PH29076A patent/PH19147A/en unknown
- 1983-09-01 CA CA000435930A patent/CA1200541A/en not_active Expired
1984
- 1984-01-27 GB GB08402249A patent/GB2135304B/en not_active Expired
- 1984-01-27 GB GB08402250A patent/GB2136420B/en not_active Expired
- 1984-08-29 IN IN601/CAL/84A patent/IN158589B/en unknown
- 1984-08-29 IN IN603/CAL/84A patent/IN159126B/en unknown
- 1984-08-29 IN IN602/CAL/84A patent/IN158590B/en unknown
- 1984-09-26 US US06/654,681 patent/US4673738A/en not_active Expired - Lifetime
1985
- 1985-11-13 AU AU49861/85A patent/AU568033B2/en not_active Expired
- 1985-11-13 AU AU49862/85A patent/AU558649B2/en not_active Expired
1986
- 1986-01-16 SE SE8600192A patent/SE468478B/sv not_active IP Right Cessation
- 1986-01-16 SE SE8600194A patent/SE468476B/sv not_active IP Right Cessation
- 1986-01-16 SE SE8600195A patent/SE468477B/sv not_active IP Right Cessation
- 1986-01-16 SE SE8600193A patent/SE468479B/sv not_active IP Right Cessation
- 1986-03-29 KR KR1019860002383A patent/KR860000932B1/ko not_active IP Right Cessation
1987
- 1987-01-15 FI FI870153A patent/FI80041C/fi not_active IP Right Cessation
- 1987-03-06 US US07/022,433 patent/US4879381A/en not_active Expired - Lifetime
1991
- 1991-05-24 US US07/707,221 patent/US5144027A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SE8600195D0 (sv)	1986-01-16
SE468479B (sv)	1993-01-25
AU7543881A (en)	1982-04-01
AT375082B (de)	1984-06-25
DD208351A5 (de)	1984-05-02
ATA55483A (de)	1985-03-15
DK163877B (da)	1992-04-13
IN155375B (ro)	1985-01-19
FI75575B (fi)	1988-03-31
ES8306155A1 (es)	1983-05-01
RO86825A (ro)	1985-05-20
US5144027A (en)	1992-09-01
DE3152931C2 (ro)	1989-10-05
MX155025A (es)	1988-01-20
SE468477B (sv)	1993-01-25
DE3137854A1 (de)	1982-04-15
CH652130A5 (de)	1985-10-31
FI870153A (fi)	1987-01-15
GB8402250D0 (en)	1984-02-29
ES8306157A1 (es)	1983-05-01
ES514669A0 (es)	1983-05-01
FI80041B (fi)	1989-12-29
DK163877C (da)	1992-09-14
GB2135304A (en)	1984-08-30
SE468478B (sv)	1993-01-25
FR2509310B1 (fr)	1985-08-02
PH18072A (en)	1985-03-18
SE8600195L (sv)	1986-01-16
SE8105658L (sv)	1982-05-05
RO86824B (ro)	1985-05-31
AU4986185A (en)	1986-03-20
CH651837A5 (de)	1985-10-15
ES505760A0 (es)	1983-01-01
FI812980L (fi)	1982-03-26
DE3152932C2 (ro)	1990-02-08
IN158590B (ro)	1986-12-13
RO86824A (ro)	1985-05-20
ATA410981A (de)	1983-11-15
RO82689A (ro)	1983-11-01
RO82689B (ro)	1983-10-30
CH652128A5 (de)	1985-10-31
SE8600192L (sv)	1986-01-16
GB2089339B (en)	1985-04-24
FR2511377B1 (fr)	1985-12-13
IT1172201B (it)	1987-06-18
GB2135304B (en)	1985-03-27
NO161117B (no)	1989-03-28
ATA55583A (de)	1985-03-15
ES8301998A1 (es)	1983-01-01
PH18484A (en)	1985-08-02
PH19147A (en)	1986-01-15
RO86823B (ro)	1985-05-31
NO161117C (no)	1989-07-05
DE3152934C2 (ro)	1990-01-18
IN158589B (ro)	1986-12-13
ES8306156A1 (es)	1983-05-01
AU558649B2 (en)	1987-02-05
IT8149348A0 (it)	1981-09-23
PT73727B (en)	1982-12-30
IN159126B (ro)	1987-03-28
AU4986285A (en)	1986-04-24
US4879381A (en)	1989-11-07
SE8600194D0 (sv)	1986-01-16
CA1204735A (en)	1986-05-20
DD202436A5 (de)	1983-09-14
CH652129A5 (de)	1985-10-31
US4489072A (en)	1984-12-18
FR2509310A1 (fr)	1983-01-14
FI870153A0 (fi)	1987-01-15
FR2511377A1 (fr)	1983-02-18
HU185850B (en)	1985-04-28
DE3137854C2 (ro)	1987-06-19
SE8600194L (sv)	1986-01-16
AU568033B2 (en)	1987-12-10
LU83650A1 (fr)	1982-01-21
NZ198350A (en)	1985-02-28
ATA55683A (de)	1984-11-15
GB2136420A (en)	1984-09-19
DE3152935C2 (ro)	1992-07-16
FI75575C (fi)	1988-07-11
GB2136420B (en)	1985-05-01
EG17373A (en)	1990-12-30
PH19251A (en)	1986-02-17
NL8104386A (nl)	1982-04-16
SE453090B (sv)	1988-01-11
FI80041C (fi)	1990-04-10
AT378962B (de)	1985-10-25
US4673738A (en)	1987-06-16
ES514670A0 (es)	1983-05-01
PH20221A (en)	1986-10-23
PT73727A (en)	1981-10-01
SE468476B (sv)	1993-01-25
KR860000932B1 (ko)	1986-07-19
AR240645A1 (es)	1990-07-31
GB8402249D0 (en)	1984-02-29
NO813252L (no)	1982-03-26
GB2089339A (en)	1982-06-23
AT378961B (de)	1985-10-25
SE8600192D0 (sv)	1986-01-16
SE8600193L (sv)	1986-01-16
RO86825B (ro)	1985-05-31
SE8600193D0 (sv)	1986-01-16
CA1200541A (en)	1986-02-11
ES514671A0 (es)	1983-05-01
DK421881A (da)	1982-04-15
AT378193B (de)	1985-06-25
AU550330B2 (en)	1986-03-20

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