RO81115B - Procedeu pentru prepararea unor d-6-n-propilergoline - Google Patents

Procedeu pentru prepararea unor d-6-n-propilergoline

Info

Publication number
RO81115B
RO81115B RO102217A RO10221780A RO81115B RO 81115 B RO81115 B RO 81115B RO 102217 A RO102217 A RO 102217A RO 10221780 A RO10221780 A RO 10221780A RO 81115 B RO81115 B RO 81115B
Authority
RO
Romania
Prior art keywords
propylengolins
preparing
sodium
propylglycines
methyloxymethylergoline
Prior art date
Application number
RO102217A
Other languages
English (en)
Other versions
RO81115A (ro
Inventor
Edmund Carl Kornfeld
Nicholas James Bach
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO81115A publication Critical patent/RO81115A/ro
Publication of RO81115B publication Critical patent/RO81115B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedeu pentru prepararea unor D-6-n-propilergoline cu formula generala I: (vezi formula) în care Y reprezinta oxigen sau sulf, caracterizat prin aceea ca se aduce în reactie D-6-n-propil-8-metiloximetilergolina cu metilmercaptanat de sodiu sau metilat de sodiu, la temepartura de 25...100 degree C, în solvent ales dintre dimetilformamida, metilacetamida si dimetilsulfoxid sub atmosfera de azot, apoi produsul de reactie este, eventual, trecut sub forma de sare acceptabila farmaceutic, în mod în sine cunoscut.
RO102217A 1979-10-01 1980-09-25 Procedeu pentru prepararea unor d-6-n-propilergoline RO81115B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/080,768 US4246265A (en) 1979-10-01 1979-10-01 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds

Publications (2)

Publication Number Publication Date
RO81115A RO81115A (ro) 1983-02-15
RO81115B true RO81115B (ro) 1983-02-28

Family

ID=22159504

Family Applications (1)

Application Number Title Priority Date Filing Date
RO102217A RO81115B (ro) 1979-10-01 1980-09-25 Procedeu pentru prepararea unor d-6-n-propilergoline

Country Status (32)

Country Link
US (1) US4246265A (ro)
EP (1) EP0026671B1 (ro)
JP (1) JPS5657787A (ro)
KR (1) KR830003478A (ro)
AT (1) AT373251B (ro)
AU (1) AU529508B2 (ro)
BE (1) BE885385A (ro)
BG (1) BG34908A3 (ro)
CA (1) CA1137079A (ro)
CH (1) CH645642A5 (ro)
CS (1) CS223834B2 (ro)
DD (1) DD153372A5 (ro)
DE (1) DE3069771D1 (ro)
DK (1) DK413780A (ro)
EG (1) EG14583A (ro)
ES (1) ES495520A0 (ro)
FI (1) FI803025A (ro)
FR (1) FR2466465A1 (ro)
GB (1) GB2058790B (ro)
GR (1) GR70067B (ro)
HU (1) HU181766B (ro)
IE (1) IE50429B1 (ro)
IL (1) IL61143A0 (ro)
IT (1) IT1133631B (ro)
NZ (1) NZ195053A (ro)
PH (1) PH15021A (ro)
PL (1) PL226917A1 (ro)
PT (1) PT71840B (ro)
RO (1) RO81115B (ro)
SU (1) SU976851A3 (ro)
YU (1) YU247280A (ro)
ZA (1) ZA805959B (ro)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4683313A (en) * 1985-06-24 1987-07-28 Eli Lilly And Company 2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate
US4772709A (en) * 1985-10-01 1988-09-20 Eli Lilly And Company Process of making ketoalkanol esters of dihydrolysergic acid
FR2589734B1 (fr) * 1985-11-13 1988-09-02 Roussel Uclaf Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique
US5668155A (en) * 1988-05-10 1997-09-16 The General Hospital Corporation Administration of pirenzepine, methyl scopolamine and other muscarinic receptor antagonists for treatment of lipid metabolism disorders
DE3913756A1 (de) * 1989-04-21 1990-10-25 Schering Ag 8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung
IT1307934B1 (it) 1999-01-27 2001-11-29 Poli Ind Chimica Spa Processo per la preparazione di derivati alchimercaptometilergolinici.
US6388079B1 (en) * 2000-08-29 2002-05-14 Scinopharm Singapore Pte Ltd. Process for preparing pergolide
EP1485382B1 (en) * 2002-03-15 2008-11-19 Antibioticos S.p.A. Process for the synthesis of pergolide
US8821915B2 (en) 2002-08-09 2014-09-02 Veroscience, Llc Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders
GB0409785D0 (en) * 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0505965D0 (en) * 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
US20070197576A1 (en) * 2006-02-08 2007-08-23 Resolution Chemicals Limited Production of Cabergoline and Novel Polymorphic Form Thereof
CA2956257C (en) 2014-09-25 2022-07-12 Boehringer Ingelheim Vetmedica Gmbh Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals
WO2019234069A1 (en) 2018-06-08 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
DE2657771A1 (de) * 1976-01-02 1977-07-14 Sandoz Ag Neue organische verbindungen, ihre verwendung und herstellung
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4202979A (en) * 1979-01-11 1980-05-13 Eli Lilly And Company 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds

Also Published As

Publication number Publication date
EG14583A (en) 1985-03-31
GB2058790B (en) 1983-06-08
EP0026671B1 (en) 1984-12-05
SU976851A3 (ru) 1982-11-23
PT71840B (en) 1981-06-09
DE3069771D1 (en) 1985-01-17
KR830003478A (ko) 1983-06-20
IT1133631B (it) 1986-07-09
CA1137079A (en) 1982-12-07
EP0026671A1 (en) 1981-04-08
IL61143A0 (en) 1980-11-30
ES8200697A1 (es) 1981-11-16
CH645642A5 (fr) 1984-10-15
HU181766B (en) 1983-11-28
PH15021A (en) 1982-05-13
RO81115A (ro) 1983-02-15
DK413780A (da) 1981-04-02
IE50429B1 (en) 1986-04-16
BE885385A (fr) 1981-03-25
ZA805959B (en) 1982-04-28
GB2058790A (en) 1981-04-15
IT8025004A0 (it) 1980-09-29
FR2466465A1 (fr) 1981-04-10
AU529508B2 (en) 1983-06-09
AT373251B (de) 1984-01-10
ATA487480A (de) 1983-05-15
GR70067B (ro) 1982-07-26
FR2466465B1 (ro) 1983-11-25
IE802036L (en) 1981-04-01
YU247280A (en) 1983-02-28
PT71840A (en) 1980-10-01
ES495520A0 (es) 1981-11-16
JPS5657787A (en) 1981-05-20
AU6280780A (en) 1981-04-09
CS223834B2 (en) 1983-11-25
PL226917A1 (ro) 1981-06-05
FI803025A (fi) 1981-04-02
US4246265A (en) 1981-01-20
BG34908A3 (en) 1983-12-15
DD153372A5 (de) 1982-01-06
NZ195053A (en) 1983-07-29

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