RO81115A - Procedeu pentru prepararea unor d-6-n-propilergoline - Google Patents

Procedeu pentru prepararea unor d-6-n-propilergoline

Info

Publication number: RO81115A
Authority: RO; Romania
Prior art keywords: propylergoline; preparing; procedure
Prior art date: 1979-10-01

Application number

RO80102217A

Other languages

English (en)

French (fr)

Other versions

RO81115B (ro

Inventor

Edmund C Kornfeld

Nicholas J Bach

Original Assignee

Eli Lilly And Co,Us

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-01

Filing date

1980-09-25

Publication date

1983-02-15

1980-09-25 Application filed by Eli Lilly And Co,Us filed Critical Eli Lilly And Co,Us

1983-02-15 Publication of RO81115A publication Critical patent/RO81115A/ro

1983-02-28 Publication of RO81115B publication Critical patent/RO81115B/ro

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

RO102217A 1979-10-01 1980-09-25 Procedeu pentru prepararea unor d-6-n-propilergoline RO81115B (ro)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/080,768 US4246265A (en)	1979-10-01	1979-10-01	6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds

Publications (2)

Publication Number	Publication Date
RO81115A true RO81115A (ro)	1983-02-15
RO81115B RO81115B (ro)	1983-02-28

Family

ID=22159504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RO102217A RO81115B (ro)	1979-10-01	1980-09-25	Procedeu pentru prepararea unor d-6-n-propilergoline

Country Status (32)

Country	Link
US (1)	US4246265A (ro)
EP (1)	EP0026671B1 (ro)
JP (1)	JPS5657787A (ro)
KR (1)	KR830003478A (ro)
AT (1)	AT373251B (ro)
AU (1)	AU529508B2 (ro)
BE (1)	BE885385A (ro)
BG (1)	BG34908A3 (ro)
CA (1)	CA1137079A (ro)
CH (1)	CH645642A5 (ro)
CS (1)	CS223834B2 (ro)
DD (1)	DD153372A5 (ro)
DE (1)	DE3069771D1 (ro)
DK (1)	DK413780A (ro)
EG (1)	EG14583A (ro)
ES (1)	ES8200697A1 (ro)
FI (1)	FI803025A (ro)
FR (1)	FR2466465A1 (ro)
GB (1)	GB2058790B (ro)
GR (1)	GR70067B (ro)
HU (1)	HU181766B (ro)
IE (1)	IE50429B1 (ro)
IL (1)	IL61143A0 (ro)
IT (1)	IT1133631B (ro)
NZ (1)	NZ195053A (ro)
PH (1)	PH15021A (ro)
PL (1)	PL226917A1 (ro)
PT (1)	PT71840B (ro)
RO (1)	RO81115B (ro)
SU (1)	SU976851A3 (ro)
YU (1)	YU247280A (ro)
ZA (1)	ZA805959B (ro)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH644606A5 (de) *	1980-09-23	1984-08-15	Sandoz Ag	Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3216870A1 (de) *	1982-05-03	1983-11-03	Schering AG, 1000 Berlin und 4709 Bergkamen	Pharmazeutische zubereitungen mit zytostatischer wirkung
US4675322A (en) *	1984-12-10	1987-06-23	Eli Lilly And Company	1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4683313A (en) *	1985-06-24	1987-07-28	Eli Lilly And Company	2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles
US4782152A (en) *	1985-08-16	1988-11-01	Eli Lilly And Company	Decyanation of pergolide intermediate
US4772709A (en) *	1985-10-01	1988-09-20	Eli Lilly And Company	Process of making ketoalkanol esters of dihydrolysergic acid
FR2589734B1 (fr) *	1985-11-13	1988-09-02	Roussel Uclaf	Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique
US5668155A (en) *	1988-05-10	1997-09-16	The General Hospital Corporation	Administration of pirenzepine, methyl scopolamine and other muscarinic receptor antagonists for treatment of lipid metabolism disorders
DE3913756A1 (de) *	1989-04-21	1990-10-25	Schering Ag	8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung
IT1307934B1 (it) *	1999-01-27	2001-11-29	Poli Ind Chimica Spa	Processo per la preparazione di derivati alchimercaptometilergolinici.
US6388079B1 (en) *	2000-08-29	2002-05-14	Scinopharm Singapore Pte Ltd.	Process for preparing pergolide
EP1485382B1 (en)	2002-03-15	2008-11-19	Antibioticos S.p.A.	Process for the synthesis of pergolide
US8821915B2 (en)	2002-08-09	2014-09-02	Veroscience, Llc	Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders
GB0409785D0 (en) *	2004-04-30	2004-06-09	Resolution Chemicals Ltd	Preparation of cabergoline
US7339060B2 (en)	2005-03-23	2008-03-04	Resolution Chemicals, Ltd.	Preparation of cabergoline
GB0505965D0 (en) *	2005-03-23	2005-04-27	Resolution Chemicals Ltd	Preparation of cabergoline
US20070197576A1 (en) *	2006-02-08	2007-08-23	Resolution Chemicals Limited	Production of Cabergoline and Novel Polymorphic Form Thereof
US20190374534A1 (en)	2018-06-08	2019-12-12	Boehringer Ingelheim Vetmedica Gmbh	Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3901894A (en) *	1974-06-06	1975-08-26	Lilly Co Eli	8-thiomethylergolines
DE2657771A1 (de) *	1976-01-02	1977-07-14	Sandoz Ag	Neue organische verbindungen, ihre verwendung und herstellung
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4202979A (en) *	1979-01-11	1980-05-13	Eli Lilly And Company	6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds

1979
- 1979-10-01 US US06/080,768 patent/US4246265A/en not_active Expired - Lifetime
1980
- 1980-09-25 NZ NZ195053A patent/NZ195053A/xx unknown
- 1980-09-25 GR GR62959A patent/GR70067B/el unknown
- 1980-09-25 ZA ZA00805959A patent/ZA805959B/xx unknown
- 1980-09-25 CA CA000361035A patent/CA1137079A/en not_active Expired
- 1980-09-25 RO RO102217A patent/RO81115B/ro unknown
- 1980-09-25 BE BE1/9966A patent/BE885385A/fr not_active IP Right Cessation
- 1980-09-25 PL PL22691780A patent/PL226917A1/xx unknown
- 1980-09-25 FI FI803025A patent/FI803025A/fi not_active Application Discontinuation
- 1980-09-25 FR FR8020639A patent/FR2466465A1/fr active Granted
- 1980-09-26 IL IL61143A patent/IL61143A0/xx unknown
- 1980-09-26 CS CS806515A patent/CS223834B2/cs unknown
- 1980-09-26 PT PT71840A patent/PT71840B/pt unknown
- 1980-09-27 EG EG80594A patent/EG14583A/xx active
- 1980-09-29 HU HU802373A patent/HU181766B/hu unknown
- 1980-09-29 BG BG8049173A patent/BG34908A3/xx unknown
- 1980-09-29 IT IT25004/80A patent/IT1133631B/it active
- 1980-09-29 YU YU02472/80A patent/YU247280A/xx unknown
- 1980-09-29 JP JP13668780A patent/JPS5657787A/ja active Pending
- 1980-09-30 GB GB8031440A patent/GB2058790B/en not_active Expired
- 1980-09-30 PH PH24648A patent/PH15021A/en unknown
- 1980-09-30 EP EP80303447A patent/EP0026671B1/en not_active Expired
- 1980-09-30 KR KR1019800003793A patent/KR830003478A/ko unknown
- 1980-09-30 DD DD80224224A patent/DD153372A5/de unknown
- 1980-09-30 IE IE2036/80A patent/IE50429B1/en unknown
- 1980-09-30 AU AU62807/80A patent/AU529508B2/en not_active Ceased
- 1980-09-30 AT AT0487480A patent/AT373251B/de not_active IP Right Cessation
- 1980-09-30 DK DK413780A patent/DK413780A/da not_active Application Discontinuation
- 1980-09-30 ES ES495520A patent/ES8200697A1/es not_active Expired
- 1980-09-30 DE DE8080303447T patent/DE3069771D1/de not_active Expired
- 1980-09-30 CH CH730780A patent/CH645642A5/fr not_active IP Right Cessation
- 1980-10-01 SU SU802984351A patent/SU976851A3/ru active

Also Published As

Publication number	Publication date
GB2058790B (en)	1983-06-08
EP0026671A1 (en)	1981-04-08
CH645642A5 (fr)	1984-10-15
HU181766B (en)	1983-11-28
BE885385A (fr)	1981-03-25
YU247280A (en)	1983-02-28
FI803025A (fi)	1981-04-02
GB2058790A (en)	1981-04-15
EG14583A (en)	1985-03-31
NZ195053A (en)	1983-07-29
IE802036L (en)	1981-04-01
IT1133631B (it)	1986-07-09
RO81115B (ro)	1983-02-28
GR70067B (ro)	1982-07-26
CA1137079A (en)	1982-12-07
IE50429B1 (en)	1986-04-16
PL226917A1 (ro)	1981-06-05
CS223834B2 (en)	1983-11-25
DD153372A5 (de)	1982-01-06
ES495520A0 (es)	1981-11-16
SU976851A3 (ru)	1982-11-23
IT8025004A0 (it)	1980-09-29
PT71840B (en)	1981-06-09
FR2466465A1 (fr)	1981-04-10
EP0026671B1 (en)	1984-12-05
ATA487480A (de)	1983-05-15
KR830003478A (ko)	1983-06-20
JPS5657787A (en)	1981-05-20
DK413780A (da)	1981-04-02
ES8200697A1 (es)	1981-11-16
PT71840A (en)	1980-10-01
DE3069771D1 (en)	1985-01-17
AU529508B2 (en)	1983-06-09
ZA805959B (en)	1982-04-28
PH15021A (en)	1982-05-13
US4246265A (en)	1981-01-20
FR2466465B1 (ro)	1983-11-25
IL61143A0 (en)	1980-11-30
AU6280780A (en)	1981-04-09
BG34908A3 (en)	1983-12-15
AT373251B (de)	1984-01-10

Publication	Publication Date	Title
SE8100368L (sv)	1981-01-22	Forfarande for framstellning av immunogammaglobulin
RO76886A (ro)	1982-02-01	Procedeu pentru prepararea unor 9-iminodibenzopirani
RO79706A (ro)	1982-08-17	Procedeu pentru prepararea unor alchilamine heterociclice
ES490112A0 (es)	1981-01-16	Procedimiento de preparar oxazolidinationas
IT1101294B (it)	1985-09-28	Procedimento per preparare ntirodiarilammine
RO81652A (ro)	1983-04-29	Procedeu pentru pentru prepararea unor benzimidazoazepine
RO82214A (ro)	1983-07-07	Procedeu pentru prepararea unor pirimodone
RO80379A (ro)	1983-04-29	Procedeu pentru prepararea unor oentapeptide
NO800931L (no)	1980-10-03	Fremgangsmaate for fremstilling av merkapto-acyldipeptider
RO81115A (ro)	1983-02-15	Procedeu pentru prepararea unor d-6-n-propilergoline
RO80716A (ro)	1982-12-06	Procedeu de preparare a unor pirolidinilbenzamide
RO81048A (ro)	1983-02-01	Procedeu pentru prepararea unor derivati de piramona
IT1097295B (it)	1985-08-31	Procedimento per preparare p-benzochinone
RO79822A (ro)	1983-02-01	Procedeu pentru prepararea unor 9-aminoalchilfluoreni
RO76176A (ro)	1981-11-04	Procedeu pentru prepararea unor peptide
RO69940A (ro)	1981-04-30	Procedeu pentru prepararea unor poliizobutenilsuccinimidopropiletilendiamine
IT1092403B (it)	1985-07-12	Procedimento per preparare protocatecualdeide
IT1143925B (it)	1986-10-29	Procedimento per preparare d-alfaam minoacidi
RO79886A (ro)	1982-10-11	Procedeu pentru prepararea unor 1-oxadetiacefalosporine
ES496787A0 (es)	1981-11-01	Procedimiento de preparar compuestos triacinicos antialergi-cos
IT8048889A0 (it)	1980-06-05	Composti perfluoroalchilici e procedimento per prepararli
IT1089268B (it)	1985-06-18	Procedimento per preparare metil-isocianato
ES493569A0 (es)	1981-07-01	Procedimiento de preparar derivados isoquinolinicos
ES495819A0 (es)	1981-09-16	Procedimiento de preparar derivados 1,2,4-oxadiazolin-5-oni-cos
ES489115A0 (es)	1981-11-01	Procedimiento de preparacion de polieteres glicidicos de po-lifenoles