PT97300A - Processo para a preparacao de esteres de acidos 1,4-di-hidropiridinocarboxilicos n-alquilados e de medicamentos que os contem - Google Patents
Processo para a preparacao de esteres de acidos 1,4-di-hidropiridinocarboxilicos n-alquilados e de medicamentos que os contemInfo
- Publication number
- PT97300A PT97300A PT97300A PT9730091A PT97300A PT 97300 A PT97300 A PT 97300A PT 97300 A PT97300 A PT 97300A PT 9730091 A PT9730091 A PT 9730091A PT 97300 A PT97300 A PT 97300A
- Authority
- PT
- Portugal
- Prior art keywords
- alkylated
- preparation
- acid esters
- dihydropyridinocarboxyl
- medicines containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Lubricants (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4011695A DE4011695A1 (de) | 1990-04-11 | 1990-04-11 | Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
PT97300A true PT97300A (pt) | 1992-01-31 |
PT97300B PT97300B (pt) | 1998-10-30 |
Family
ID=6404197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97300A PT97300B (pt) | 1990-04-11 | 1991-04-09 | Processo para a preparacao de esteres de acidos 1,4-di-hidropiridinocarboxilicos n-alquilados e de medicamentos que os contem |
Country Status (18)
Country | Link |
---|---|
US (2) | US5234935A (pt) |
EP (1) | EP0451654B1 (pt) |
JP (1) | JP3012352B2 (pt) |
KR (1) | KR0180741B1 (pt) |
AT (1) | ATE111079T1 (pt) |
AU (1) | AU642992B2 (pt) |
CA (1) | CA2040062A1 (pt) |
DE (2) | DE4011695A1 (pt) |
DK (1) | DK0451654T3 (pt) |
ES (1) | ES2063998T3 (pt) |
FI (1) | FI101377B (pt) |
HU (2) | HUT59905A (pt) |
IE (1) | IE64452B1 (pt) |
IL (1) | IL97796A (pt) |
NZ (1) | NZ237722A (pt) |
PT (1) | PT97300B (pt) |
TW (1) | TW197423B (pt) |
ZA (1) | ZA912652B (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4342196A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Neue 4-Phenyl-substituierte 1,4-Dihydropyridine |
DE4125271A1 (de) * | 1991-07-31 | 1993-02-11 | Bayer Ag | Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester |
US5310917A (en) * | 1991-09-13 | 1994-05-10 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropydrines |
WO1993006082A1 (en) * | 1991-09-13 | 1993-04-01 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropyridines |
DE4133257A1 (de) * | 1991-10-08 | 1993-04-15 | Bayer Ag | N-methyl-nimodipin, verfahren zu seiner herstellung und seine verwendung als zerebraltherapeutikum |
DE4200714A1 (de) * | 1992-01-14 | 1993-07-15 | Bayer Ag | Spezieller 1,4-dihydropyridin-3,5-dicarbonsaeureester, verfahren zu seiner herstellung und seine pharmazeutische verwendung |
DE4223867A1 (de) * | 1992-07-20 | 1994-01-27 | Bayer Ag | Spezieller 1,4-Dihydropyridin-3,5-dicarbonsäureester, Verfahren zu seiner Herstellung und seine pharmazeutische Verwendung |
DE4313692A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313691A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2,6-Disubstituierte 4-Chinolyl-dihydropyridine |
DE4313697A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4328884A1 (de) * | 1993-08-27 | 1995-03-02 | Bayer Ag | Verwendung von N-alkylierten 1,4-Dihydropyridincarbonsäureestern als Arzneimittel |
EE03192B1 (et) * | 1993-12-10 | 1999-06-15 | Bayer Aktiengesellschaft | Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine |
DE59410255D1 (de) | 1993-12-10 | 2003-04-17 | Bayer Ag | Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität |
DE4430094A1 (de) * | 1994-08-25 | 1996-02-29 | Bayer Ag | Verwendung von 3,5-Dicarbonsäureester-1,4-Dihydropyridinen als Arzneimittel |
DE19638570A1 (de) * | 1996-09-20 | 1998-03-26 | Bayer Ag | Wirkstoffhaltige thermoplastische Polyurethane |
US7199136B2 (en) | 2001-12-20 | 2007-04-03 | Bayer Healthcare Ag | 1,4-dihydro-1,4-diphenylpyridine derivatives |
US8420790B2 (en) * | 2009-10-30 | 2013-04-16 | Reliable Biopharmaceutical Corporation | Efficient and scalable process for the manufacture of Fondaparinux sodium |
EP2782573B1 (en) | 2011-11-24 | 2019-10-09 | Richter Gedeon Nyrt. | 1,4-dihydropyridine derivatives with hsp modulating activity |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1813436C3 (de) * | 1968-12-07 | 1979-01-11 | Bayer Ag, 5090 Leverkusen | N-Substituierte 2,6-Dimethyl-l,4dihydropyridine |
US3883543A (en) * | 1969-05-10 | 1975-05-13 | Bayer Ag | N-alkyl-1,4-dihydropyridines |
DE1923990C3 (de) * | 1969-05-10 | 1978-11-23 | Bayer Ag | Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern |
DE1963188A1 (de) * | 1969-12-17 | 1971-06-24 | Bayer Ag | Neue Cyanphenyl-1,4-dihydropyridinderivate |
CH550189A (de) * | 1971-01-08 | 1974-06-14 | Ciba Geigy Ag | Verfahren zur herstellung von neuen dibenzo (b,f) thiepincarbonsaeuren. |
DE2210667A1 (de) * | 1972-03-06 | 1973-09-20 | Bayer Ag | Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2210672C3 (de) * | 1972-03-06 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
DE2228377A1 (de) * | 1972-06-10 | 1974-01-03 | Bayer Ag | Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
CH569043A5 (pt) * | 1973-01-23 | 1975-11-14 | Ciba Geigy Ag | |
US3956341A (en) * | 1974-02-21 | 1976-05-11 | Smithkline Corporation | 1,3,5-Tricarbo-1,4-dihydropyridines |
SU798099A1 (ru) * | 1978-03-06 | 1981-01-23 | Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp | 1-Бензил-2,6-диметил-4-о-или-M-НиТРОфЕНил-3,5-диэТОКСиКАРбОНил- 1,4-дигидРОпиРидиНы, пРО Вл ющиЕКОРОНАРОдилАТиРующую АКТиВНОСТь |
ATE107284T1 (de) * | 1984-09-28 | 1994-07-15 | Byk Gulden Lomberg Chem Fab | Neue diarylverbindungen. |
US4975440A (en) * | 1984-09-28 | 1990-12-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Optically-active 1,4-dihydropyridine |
US4780538A (en) * | 1986-02-12 | 1988-10-25 | Merck & Co., Inc. | Process for 1,4-dihydropyridine compounds using a titanamine catalyst |
GB8616047D0 (en) * | 1986-07-01 | 1986-08-06 | Sandoz Ltd | A 1 4-dihydropyridine derivatives |
GR1002248B (en) * | 1988-03-08 | 1996-04-23 | Egyt Gyogyszervegyeszeti Gyar | 1,4-dihydropyridine derivatives preparation method |
-
1990
- 1990-04-11 DE DE4011695A patent/DE4011695A1/de not_active Withdrawn
-
1991
- 1991-03-30 DK DK91105115.9T patent/DK0451654T3/da active
- 1991-03-30 EP EP91105115A patent/EP0451654B1/de not_active Expired - Lifetime
- 1991-03-30 AT AT91105115T patent/ATE111079T1/de active
- 1991-03-30 DE DE59102788T patent/DE59102788D1/de not_active Expired - Fee Related
- 1991-03-30 ES ES91105115T patent/ES2063998T3/es not_active Expired - Lifetime
- 1991-04-04 US US07/680,454 patent/US5234935A/en not_active Expired - Fee Related
- 1991-04-08 CA CA002040062A patent/CA2040062A1/en not_active Abandoned
- 1991-04-08 IL IL9779691A patent/IL97796A/en not_active IP Right Cessation
- 1991-04-08 JP JP3101762A patent/JP3012352B2/ja not_active Expired - Lifetime
- 1991-04-08 NZ NZ237722A patent/NZ237722A/en unknown
- 1991-04-09 AU AU74253/91A patent/AU642992B2/en not_active Ceased
- 1991-04-09 FI FI911700A patent/FI101377B/fi active
- 1991-04-09 PT PT97300A patent/PT97300B/pt not_active IP Right Cessation
- 1991-04-10 ZA ZA912652A patent/ZA912652B/xx unknown
- 1991-04-10 IE IE120091A patent/IE64452B1/en not_active IP Right Cessation
- 1991-04-10 TW TW080102712A patent/TW197423B/zh active
- 1991-04-10 KR KR1019910005710A patent/KR0180741B1/ko not_active IP Right Cessation
- 1991-04-11 HU HU911184A patent/HUT59905A/hu unknown
-
1993
- 1993-05-21 US US08/065,503 patent/US5432185A/en not_active Expired - Fee Related
-
1995
- 1995-06-22 HU HU95P/P00334P patent/HU211313A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
KR910018025A (ko) | 1991-11-30 |
PT97300B (pt) | 1998-10-30 |
FI101377B1 (fi) | 1998-06-15 |
NZ237722A (en) | 1995-10-26 |
DE59102788D1 (de) | 1994-10-13 |
US5234935A (en) | 1993-08-10 |
JPH04234847A (ja) | 1992-08-24 |
IL97796A (en) | 1995-03-15 |
FI911700A0 (fi) | 1991-04-09 |
CA2040062A1 (en) | 1991-10-12 |
EP0451654A2 (de) | 1991-10-16 |
IL97796A0 (en) | 1992-06-21 |
EP0451654A3 (en) | 1992-07-08 |
JP3012352B2 (ja) | 2000-02-21 |
ATE111079T1 (de) | 1994-09-15 |
FI911700A (fi) | 1991-10-12 |
HUT59905A (en) | 1992-07-28 |
IE64452B1 (en) | 1995-08-09 |
AU642992B2 (en) | 1993-11-04 |
AU7425391A (en) | 1991-10-17 |
EP0451654B1 (de) | 1994-09-07 |
DK0451654T3 (da) | 1995-02-13 |
ES2063998T3 (es) | 1995-01-16 |
US5432185A (en) | 1995-07-11 |
DE4011695A1 (de) | 1991-10-17 |
FI101377B (fi) | 1998-06-15 |
HU911184D0 (en) | 1991-10-28 |
IE911200A1 (en) | 1991-10-23 |
ZA912652B (en) | 1992-01-29 |
TW197423B (pt) | 1993-01-01 |
HU211313A9 (en) | 1995-11-28 |
KR0180741B1 (ko) | 1999-03-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT97300A (pt) | Processo para a preparacao de esteres de acidos 1,4-di-hidropiridinocarboxilicos n-alquilados e de medicamentos que os contem | |
ES2139132T3 (es) | Composiciones farmaceuticas activas en la terapia de desordenes del sueño. | |
BR9407720A (pt) | Composto composiçao farmacêutica e processo para a prevençao ou tratamento de pertubaçoes imunorreguladoras ou doenças que compreendem a administraçao do composto | |
BR0007743A (pt) | Epa etìlico altamente purificado e outrosderivados de epa para distúrbios psiquiátricos eneurológicos | |
KR960700742A (ko) | 아토피성질환 치료약(atopic disease remedy) | |
PT88985A (pt) | Processo para a preparacao de composicoes farmaceuticas nasais e ou oftalmicas contendo azelastina | |
BR0013540A (pt) | Formulações farmacêuticas e seu uso na prevenção de acidente vascular cerebral, diabetes e/ou falha de coração congestiva | |
FR2635265B1 (fr) | Composition pharmaceutique intraveineuse comprenant de la cyclosporine en tant que principe actif et procede pour sa preparation | |
RU92016463A (ru) | Применение производных цистина для изготовления лекарственных препаратов с иммуномоделирующим действием, фармацевтические композиции на их основе | |
RU93045145A (ru) | Замещенные производные циклогексана и их применение для лечения заболеваний, содержащее их лекарственное средство | |
MX163574B (es) | Procedimiento para preparar una composicion farmaceutica para inhalacion conteniendo un gangliosido | |
KR970032872A (ko) | 아세틸살리실산을 함유하는 피부 손상 처치용 약물 | |
DE59010302D1 (de) | R-(-)-1-(5-Hydroxyhexyl)-3-methyl-7-propylxanthin, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel | |
CO4750645A1 (es) | Metodo de preparacion de granulos que incorporan un medica- mento para uso farmaceutico | |
KR880002535A (ko) | 약제로서의 15-데옥시스퍼구알린의 용도 | |
KR960703572A (ko) | 기질-포집 비이드 제제(matrix-entrapped beadlet preparation) | |
FR2575158B1 (fr) | Arylalcoyloxymethyl-2 morpholines, leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central | |
FR2686515B1 (fr) | Utilisation des derives du niobium comme principe actif de medicaments utiles dans le traitement et/ou la prevention des desordres du metabolisme des glucides et/ou des lipides. | |
DE3674323D1 (de) | 4-methoxyisophthalsaeurederivat mit pharmakologischer wirksamkeit gegen thromboembolische erkrankung und verfahren zu dessen herstellung. | |
ATE12649T1 (de) | Optisch aktives dipeptide, seine pharmazeutisch vertraeglichen salze, verfahren zur herstellung und diese enthaltende pharmazeutische praeparate. | |
王小马 et al. | THE EFFECT OF ACUPUNCTURE IN 90 CASES OF SEQUELAE OF BRAIN CONCUSSION | |
KR890000089A (ko) | 신장 질환 치료제 | |
MX9304119A (es) | Esteres de los acidos 1,4-dihidropiridin-3,5-dicarboxilicos especiales, procedimiento para su obtencion, medicamentos que los contienen y procedimiento para la obtencion de tales medicamentos. | |
AR002736A1 (es) | Uso de ester 3-metil-5-etilico de acido 2,6-dimetil-4-(2,3-diclorofenil-1,4 -dihidropiridin-3,5-dicarboxilico (felodipina) para fabricar un medicamento ypreparacion farmaceutica para el tratamiento de la disfuncion cerebral. | |
RU93037428A (ru) | Лекарственное средство для лечения опухолевых заболеваний |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Laying open of patent application |
Effective date: 19910912 |
|
FG3A | Patent granted, date of granting |
Effective date: 19980723 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20000131 |