PT97049A - Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados - Google Patents

Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados

Info

Publication number
PT97049A
PT97049A PT97049A PT9704991A PT97049A PT 97049 A PT97049 A PT 97049A PT 97049 A PT97049 A PT 97049A PT 9704991 A PT9704991 A PT 9704991A PT 97049 A PT97049 A PT 97049A
Authority
PT
Portugal
Prior art keywords
alpha
methyl ester
derivatives
phenylenanin
aspartil
Prior art date
Application number
PT97049A
Other languages
English (en)
Other versions
PT97049B (pt
Inventor
John B Hill
Mark R Johnson
Tse-Lok Ho
Russell Klix
Gayle Webber
Robert A Erickson
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Publication of PT97049A publication Critical patent/PT97049A/pt
Publication of PT97049B publication Critical patent/PT97049B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT97049A 1990-03-15 1991-03-15 Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados PT97049B (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49824390A 1990-03-15 1990-03-15
US60665690A 1990-10-31 1990-10-31
US65878491A 1991-02-26 1991-02-26
US66480691A 1991-03-08 1991-03-08

Publications (2)

Publication Number Publication Date
PT97049A true PT97049A (pt) 1991-12-31
PT97049B PT97049B (pt) 1998-07-31

Family

ID=27504394

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97049A PT97049B (pt) 1990-03-15 1991-03-15 Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados

Country Status (16)

Country Link
EP (1) EP0478729B1 (pt)
CN (1) CN1057835A (pt)
AT (1) ATE141613T1 (pt)
AU (1) AU628257B2 (pt)
CA (1) CA2060515A1 (pt)
CS (1) CS70091A2 (pt)
DE (1) DE69121502T2 (pt)
DK (1) DK0478729T3 (pt)
ES (1) ES2091324T3 (pt)
GR (1) GR3020839T3 (pt)
HU (1) HUT60712A (pt)
IE (1) IE910896A1 (pt)
NO (1) NO920193L (pt)
NZ (1) NZ237469A (pt)
PT (1) PT97049B (pt)
WO (1) WO1991014378A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04234374A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc ジケトピペラジン誘導体の製造方法
JPH04234375A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物及びその製造法
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
US6465677B1 (en) * 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
DE10019879A1 (de) * 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
AU7931301A (en) 2000-08-04 2002-02-18 Dmi Biosciences Inc Method of using diketopiperazines and composition containing them
WO2002012201A1 (en) * 2000-08-04 2002-02-14 Dmi Biosciences, Inc. Method of synthesizing diketopiperazines
CA3050734A1 (en) 2003-05-15 2004-12-02 Ampio Pharmaceuticals, Inc. Treatment of t-cell mediated diseases
US8217047B2 (en) 2008-05-27 2012-07-10 Dmi Acquisition Corp. Therapeutic methods and compounds
WO2012033792A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
KR20140075772A (ko) 2011-10-10 2014-06-19 앰피오 파마슈티컬스 인코퍼레이티드 면역 내성을 증가시킨 이식 의료 장비, 및 그의 제조 및 이식 방법
US8980834B2 (en) 2011-10-10 2015-03-17 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
SG11201400283RA (en) 2011-10-28 2014-03-28 Ampio Pharmaceuticals Inc Treatment of rhinitis
MX2015010937A (es) 2013-03-15 2015-10-29 Ampio Pharmaceuticals Inc Composiciones para la movilizacion, autodireccion, expansion y diferenciacion de celulas madre y metodos para usar las mismas.
JP6723222B2 (ja) 2014-08-18 2020-07-15 アンピオ ファーマシューティカルズ，インコーポレイテッド 関節病態の治療
WO2016209969A1 (en) 2015-06-22 2016-12-29 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
EP3560345B1 (en) * 2016-12-21 2023-08-09 Suntory Holdings Limited Food and beverages containing cyclo(aspartyl-glycine), glucose, and maltose

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2038106A1 (de) * 1970-07-31 1972-02-10 Henkel & Cie Gmbh Aktivatoren fuer Perverbindungen
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
IT1197461B (it) * 1983-05-13 1988-11-30 Debi Derivati Biologici Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0647600B2 (ja) * 1985-06-04 1994-06-22 味の素株式会社 β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
US4677220A (en) * 1985-10-31 1987-06-30 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids

Also Published As

Publication number Publication date
WO1991014378A1 (en) 1991-10-03
PT97049B (pt) 1998-07-31
GR3020839T3 (en) 1996-11-30
ES2091324T3 (es) 1996-11-01
CN1057835A (zh) 1992-01-15
EP0478729A4 (en) 1993-06-16
AU7564891A (en) 1991-10-21
HUT60712A (en) 1992-10-28
EP0478729A1 (en) 1992-04-08
DE69121502T2 (de) 1997-01-16
IE910896A1 (en) 1991-09-25
NO920193D0 (no) 1992-01-15
CA2060515A1 (en) 1991-09-16
DE69121502D1 (de) 1996-09-26
AU628257B2 (en) 1992-09-10
NO920193L (no) 1992-01-15
ATE141613T1 (de) 1996-09-15
CS70091A2 (en) 1991-10-15
EP0478729B1 (en) 1996-08-21
DK0478729T3 (da) 1996-09-16
NZ237469A (en) 1993-08-26

Similar Documents

Publication Publication Date Title
PT97049A (pt) Processo para a preparacao de ester de 1-metilo de n-l alfa-aspartil-fenilalanina (aspartame) e de produtos intermediarios e de derivados
PT641343E (pt) Derivados de 4-mercaptoacetilamino-¬2|benzazapinona (3) e a sua utilizacao como inibidores de encefalinase
PT93903A (pt) Processo para a fabricacao de um produto analogo as crias de enguia
IT1217658B (it) Processo perfezionato per la produzione di perfluoropolieteri costituiti sostanzialmente da unita' perfludossietilenche e perfluoroossipropileniche
FI940769A (fi) Menetelmä 2-aminoatsolijohdannaisten valmistamiseksi
DE69207696D1 (de) Einschritt-Verfahren zur Herstellung von Dirithromycin
DE69305372D1 (de) Verfahren zur Herstellung von Hydrocarbyltrisulfide-Produkt
PT87503A (pt) Process for the preparation of new cathecolamine by products
ITMI940726A0 (it) Procedimento per la produzione di d-alfa-amminoacidi
BR8803675A (pt) Triazinas substituidas,processo para sua preparacao,composicoes herbicidas,aplicacao e processo para preparacao de composicoes
FI942581A (fi) Menetelmä 5-bromi-6-metoksi-1-naftoehappometyyliesterin valmistamiseksi
BR9303969A (pt) Processo para produção de ácidos 2-arilbenzimidazol-5-sulfônicos
ITTO930519A0 (it) Procedimento di sintesi di acidi cloroacetici.
MX9300026A (es) Procedimiento para la preparacion de benzoesteres y benzoacidos.
FI890678A (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten 1,3-dioksaanialkeenihappojohdannaisten valmistamiseksi
ITPD910141A1 (it) Procedimento perfezionato per la realizzazione di calzature
BR8804931A (pt) Processo para a producao de uma tetra-hidro-1,3,5-tiadiazin-4-ona,e,composicao inseticida
IT1137381B (it) Processo per la preparazione di derivati esterei di acidi ciclopropancarbossilici
IT1172237B (it) Derivati di amminoacidi particolarmente utili come medicammenti e procedimento per la loro preparazione
IT1226387B (it) Processo per la preparazione di acidi 1,4-diaril-3-pirazol-acetici
IT9019111A0 (it) Procedimento perfezionato per la produzione di vanadio areni
PT86666A (pt) Process for the preparation of pilocarpine by products
DE59402562D1 (de) Verfahren zur Herstellung chlorierter 4,5-Difluorbenzoesäuren, -benzoesäurederivate und -benzaldehyde
BR8805858A (pt) Processo para preparacao de acidos c12-c40-graxos alfa-ramificado
ITMI951297A0 (it) Processo per la preparazione di derivati dell'acido-metil-2- tiofeneacetico

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910909

FG3A Patent granted, date of granting

Effective date: 19980414

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991031