PT944715E - Entrega intracelular de moleculas ou microparticulas mediada pela pressao - Google Patents
Entrega intracelular de moleculas ou microparticulas mediada pela pressaoInfo
- Publication number
- PT944715E PT944715E PT97948268T PT97948268T PT944715E PT 944715 E PT944715 E PT 944715E PT 97948268 T PT97948268 T PT 97948268T PT 97948268 T PT97948268 T PT 97948268T PT 944715 E PT944715 E PT 944715E
- Authority
- PT
- Portugal
- Prior art keywords
- cell
- microparticles
- mediated
- molecules
- pressure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
- C12M3/04—Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Sustainable Development (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Mechanical Engineering (AREA)
- Vascular Medicine (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/745,023 US5922687A (en) | 1995-05-04 | 1996-11-07 | Intracellular delivery of nucleic acids using pressure |
Publications (1)
Publication Number | Publication Date |
---|---|
PT944715E true PT944715E (pt) | 2003-01-31 |
Family
ID=24994918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97948268T PT944715E (pt) | 1996-11-07 | 1997-11-07 | Entrega intracelular de moleculas ou microparticulas mediada pela pressao |
Country Status (16)
Country | Link |
---|---|
US (1) | US5922687A (pt) |
EP (2) | EP0944715B1 (pt) |
JP (3) | JP2001505419A (pt) |
KR (1) | KR100449330B1 (pt) |
CN (1) | CN1109749C (pt) |
AT (1) | ATE223967T1 (pt) |
AU (1) | AU736298B2 (pt) |
BR (1) | BR9713334A (pt) |
CA (1) | CA2271244C (pt) |
DE (1) | DE69715449T2 (pt) |
DK (1) | DK0944715T3 (pt) |
ES (1) | ES2183221T3 (pt) |
HK (1) | HK1022711A1 (pt) |
IL (1) | IL129808A (pt) |
PT (1) | PT944715E (pt) |
WO (1) | WO1998020109A1 (pt) |
Families Citing this family (132)
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WO2003040165A2 (en) | 2000-10-19 | 2003-05-15 | Epimmune Inc. | Hla class i and ii binding peptides and their uses |
US6627616B2 (en) * | 1995-12-13 | 2003-09-30 | Mirus Corporation | Intravascular delivery of non-viral nucleic acid |
US7803782B2 (en) * | 2003-05-28 | 2010-09-28 | Roche Madison Inc. | Intravenous delivery of polynucleotides to cells in mammalian limb |
US7507722B1 (en) | 1999-11-05 | 2009-03-24 | Roche Madison Inc. | Intravascular delivery of nucleic acid |
US6379966B2 (en) * | 1999-02-26 | 2002-04-30 | Mirus Corporation | Intravascular delivery of non-viral nucleic acid |
US20040259828A1 (en) * | 1995-12-13 | 2004-12-23 | Wolff Jon A. | Intravascular delivery of non-viral nucleic acid |
US20020001574A1 (en) * | 1995-12-13 | 2002-01-03 | Jon A. Woiff | Process of delivering a polynucleotide to a muscle cell via the vascular system |
US6676626B1 (en) | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
US6582392B1 (en) * | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
US7435723B2 (en) * | 1997-11-21 | 2008-10-14 | Mirus Bio Corporation | Process for delivery of polynucleotides to the prostate |
US6699231B1 (en) | 1997-12-31 | 2004-03-02 | Heartport, Inc. | Methods and apparatus for perfusion of isolated tissue structure |
US6722370B1 (en) * | 1998-07-17 | 2004-04-20 | Corgentech, Inc. | Delivery of a composition to the liver by utilizing the portal vein |
WO2000015285A1 (en) * | 1998-09-14 | 2000-03-23 | Mirus Corporation | A process for delivering nucleic acids to cardiac tissue |
EP1161547A4 (en) * | 1999-02-26 | 2002-10-02 | Mirus Corp | INTRAVASCULAR ADMINISTRATION OF A NON-VIRAL NUCLEIC ACID |
EP1196609A2 (en) * | 1999-06-28 | 2002-04-17 | Oklahoma Medical Research Foundation | Catalytically active recombinant memapsin and methods of use thereof |
US7642248B2 (en) * | 1999-11-05 | 2010-01-05 | Roche Madison Inc | Devices and processes for distribution of genetic material to mammalian limb |
EP1246649B1 (en) | 1999-11-05 | 2006-10-18 | Mirus Bio Corporation | Intravascular delivery of nucleic acid |
US7214369B2 (en) * | 2003-05-05 | 2007-05-08 | Mirus Bio Corporation | Devices and processes for distribution of genetic material to mammalian limb |
EP2177534A3 (en) | 1999-11-18 | 2010-07-14 | Pharmexa Inc. | Heteroclitic analogs of class i epitopes |
US20040072785A1 (en) * | 1999-11-23 | 2004-04-15 | Wolff Jon A. | Intravascular delivery of non-viral nucleic acid |
US6346098B1 (en) | 2000-03-07 | 2002-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and kits for locally administering an active agent to an interstitial space of a host |
US7094408B2 (en) * | 2000-04-28 | 2006-08-22 | The United States Of America As Represented By The Department Of Health And Human Services | Immunogenicity using a combination of DNA and vaccinia virus vector vaccines |
EP1299727B1 (en) | 2000-07-12 | 2009-04-22 | Agensys, Inc. | Novel tumor antigen useful in diagnosis and therapy of bladder, ovary, lung and kidney cancers |
WO2002008448A2 (en) * | 2000-07-25 | 2002-01-31 | The Board Of Trustees Of The Leland Stanford Junior University | Non-viral linear dna vectors and methods for using the same |
AU8846601A (en) | 2000-08-28 | 2002-03-13 | Agensys Inc | Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer |
WO2002066611A2 (en) * | 2001-02-16 | 2002-08-29 | The Board Of Trustees Of The Leland Stanford Junior University | Minimal plasmid vectors that provide for persistent and high level gene expression and methods for using the same |
US6924358B2 (en) | 2001-03-05 | 2005-08-02 | Agensys, Inc. | 121P1F1: a tissue specific protein highly expressed in various cancers |
US7271240B2 (en) | 2001-03-14 | 2007-09-18 | Agensys, Inc. | 125P5C8: a tissue specific protein highly expressed in various cancers |
CA2443123A1 (en) | 2001-04-10 | 2002-10-24 | Agensys, Inc. | Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers |
US20030191073A1 (en) | 2001-11-07 | 2003-10-09 | Challita-Eid Pia M. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
PT2280070E (pt) * | 2001-07-23 | 2015-10-29 | Univ Leland Stanford Junior | Métodos e composições para inibição mediada por iarn da expressão génica em mamíferos |
US10590418B2 (en) * | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
JP2005505271A (ja) | 2001-09-06 | 2005-02-24 | アジェンシス, インコーポレイテッド | 癌の処置および検出において有用なsteap−1と名称が与えられる核酸および対応するタンパク質 |
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1996
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1997
- 1997-11-07 AT AT97948268T patent/ATE223967T1/de not_active IP Right Cessation
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- 1997-11-07 KR KR10-1999-7004103A patent/KR100449330B1/ko not_active IP Right Cessation
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- 1997-11-07 BR BR9713334-5A patent/BR9713334A/pt not_active Application Discontinuation
- 1997-11-07 EP EP02019889A patent/EP1279412A3/en not_active Withdrawn
- 1997-11-07 DK DK97948268T patent/DK0944715T3/da active
- 1997-11-07 ES ES97948268T patent/ES2183221T3/es not_active Expired - Lifetime
- 1997-11-07 DE DE69715449T patent/DE69715449T2/de not_active Expired - Fee Related
- 1997-11-07 CN CN97181265A patent/CN1109749C/zh not_active Expired - Fee Related
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CA2271244A1 (en) | 1998-05-14 |
KR100449330B1 (ko) | 2004-09-18 |
EP0944715B1 (en) | 2002-09-11 |
CA2271244C (en) | 2008-09-02 |
IL129808A (en) | 2004-06-20 |
HK1022711A1 (en) | 2000-08-18 |
EP0944715A1 (en) | 1999-09-29 |
KR20000053164A (ko) | 2000-08-25 |
ES2183221T3 (es) | 2003-03-16 |
EP1279412A2 (en) | 2003-01-29 |
BR9713334A (pt) | 2000-05-09 |
CN1109749C (zh) | 2003-05-28 |
CN1244213A (zh) | 2000-02-09 |
DE69715449D1 (de) | 2002-10-17 |
AU7002098A (en) | 1998-05-29 |
US5922687A (en) | 1999-07-13 |
IL129808A0 (en) | 2000-02-29 |
JP2001505419A (ja) | 2001-04-24 |
EP1279412A3 (en) | 2003-12-17 |
DK0944715T3 (da) | 2002-12-30 |
DE69715449T2 (de) | 2003-07-31 |
JP2008054681A (ja) | 2008-03-13 |
JP2008237221A (ja) | 2008-10-09 |
ATE223967T1 (de) | 2002-09-15 |
AU736298B2 (en) | 2001-07-26 |
EP0944715A4 (en) | 1999-12-22 |
WO1998020109A1 (en) | 1998-05-14 |
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