PT91099A - Processo de preparacao de peptidos de ligacao a proteases de retroviros, dos seus intermediarios e de composicoes farmaceuticas - Google Patents

Processo de preparacao de peptidos de ligacao a proteases de retroviros, dos seus intermediarios e de composicoes farmaceuticas

Info

Publication number
PT91099A
PT91099A PT91099A PT9109989A PT91099A PT 91099 A PT91099 A PT 91099A PT 91099 A PT91099 A PT 91099A PT 9109989 A PT9109989 A PT 9109989A PT 91099 A PT91099 A PT 91099A
Authority
PT
Portugal
Prior art keywords
retroviros
ligaction
intermediaries
proteases
peptides
Prior art date
Application number
PT91099A
Other languages
English (en)
Other versions
PT91099B (pt
Inventor
William Francis Huffman
Brian Walter Metcalf
Geoffrey Bainbridge Dreyer
Thomas Downing Meek
Michael Lee Moore
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PT91099A publication Critical patent/PT91099A/pt
Publication of PT91099B publication Critical patent/PT91099B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT91099A 1988-07-08 1989-07-07 Processo de preparacao de peptidos de ligacao a proteases de retroviros, dos seus intermediarios e de composicoes farmaceuticas PT91099B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21617888A 1988-07-08 1988-07-08
US32193789A 1989-03-10 1989-03-10

Publications (2)

Publication Number Publication Date
PT91099A true PT91099A (pt) 1990-02-08
PT91099B PT91099B (pt) 1995-01-31

Family

ID=26910737

Family Applications (1)

Application Number Title Priority Date Filing Date
PT91099A PT91099B (pt) 1988-07-08 1989-07-07 Processo de preparacao de peptidos de ligacao a proteases de retroviros, dos seus intermediarios e de composicoes farmaceuticas

Country Status (5)

Country Link
EP (1) EP0352000A3 (pt)
CN (1) CN1039596A (pt)
IL (1) IL90872A0 (pt)
PT (1) PT91099B (pt)
ZW (1) ZW8289A1 (pt)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614533A (en) * 1987-03-13 1997-03-25 Bio-Mega/Boehringer Ingelheim Research, Inc. Substituted pipecolinic acid derivatives as HIV protease inhibitors
EP0361341A3 (en) * 1988-09-28 1991-07-03 Miles Inc. Therapeutics for aids based on inhibitors of hiv protease
WO1990009191A1 (de) * 1989-02-10 1990-08-23 Wolfgang Schramm Mittel zur hemmung von symmetrischen proteinen, insbesondere von enzymen
US5674979A (en) * 1989-02-10 1997-10-07 Schramm; Wolfgang Agent for inhibiting symmetrical proteins, in particular enzymes
US5342922A (en) * 1989-03-08 1994-08-30 Washington University Inhibitors of retroviral protease
DE3915755A1 (de) * 1989-05-13 1990-11-29 Bayer Ag Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
JPH05503703A (ja) * 1990-01-09 1993-06-17 スミスクライン・ビーチャム・コーポレイション Ｈｉｖプロテアーゼ抑制剤
CA2036397C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
CA2036398C (en) * 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
CA2036413C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
DE4026614A1 (de) * 1990-08-23 1992-02-27 Bayer Ag Phosphonopyrrolidin- und piperidin-haltige pseudopeptide vom statintyp, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel gegen retroviren
CA2052892A1 (en) * 1990-10-11 1992-04-12 Suresh K. Balani Inhibitors of hiv protease
WO1992009297A1 (en) * 1990-11-30 1992-06-11 Smithkline Beecham Corporation Hiv protease inhibitors
US5559140A (en) * 1991-01-02 1996-09-24 Merrell Pharmaceuticals Inc. Difluoro statone analogs
NZ241099A (en) * 1991-01-02 1994-08-26 Merrell Dow Pharma Difluorostatone analogues and derivatives and pharmaceutical compositions
EP0575500A4 (en) * 1991-03-08 1994-06-01 Smithkline Beecham Corp Hiv protease inhibitors
DE4126485A1 (de) * 1991-08-10 1993-02-11 Bayer Ag Trifluormethyl-haltige pseudopeptide
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
DE69414279T2 (de) * 1993-02-09 1999-04-08 Bayer Corp., Pittsburgh, Pa. Sulfonamidaminomethylenderivate als Immunsuppressiva
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
AU680009B2 (en) 1993-07-08 1997-07-17 Aventisub Ii Inc. Difluoro statone analogs
AU683927B2 (en) * 1993-09-09 1997-11-27 Merrell Pharmaceuticals Inc. Difluoro statone antiviral analogs
KR0125117B1 (ko) 1994-06-15 1997-12-05 성재갑 항 에이즈(aids)효과를 갖는 신규한 인간 면역 결핍 바이러스(hiv)프로테아제 억제 화합물 및 그의 제조방법
AUPM769394A0 (en) * 1994-08-25 1994-09-15 Commonwealth Scientific And Industrial Research Organisation Assay for the detection of proteases
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US6114380A (en) * 1995-12-18 2000-09-05 Merrell Pharmaceuticals Inc. Difluoro statone analogs
US6218424B1 (en) 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
EP1085853A1 (en) 1998-06-03 2001-03-28 GPI NIL Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
EP0104041B1 (en) * 1982-09-15 1988-07-27 Aktiebolaget Hässle Enzyme inhibitors
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
FR2614533A1 (fr) * 1987-04-23 1988-11-04 Sandoz Sa Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CN1039596A (zh) 1990-02-14
ZW8289A1 (en) 1989-12-20
IL90872A0 (en) 1990-02-09
EP0352000A3 (en) 1991-07-17
PT91099B (pt) 1995-01-31
EP0352000A2 (en) 1990-01-24

Similar Documents

Publication Publication Date Title
PT91099A (pt) Processo de preparacao de peptidos de ligacao a proteases de retroviros, dos seus intermediarios e de composicoes farmaceuticas
PT91731A (pt) Processo para a preparacao de composicoes farmaceuticas contendo ciclosporinas
PT90637A (pt) Processo de preparacao de polianidridos
PT83608B (pt) Processo de preparacao de derivados da paroxetina
BR8704055A (pt) Produto abrasivo e seu processo de preparacao
PT93241A (pt) Processo de preparacao de derivados de piperidina e de composicoes farmaceuticas que os contem
PT92487A (pt) Processo para a preparacao de derivados de peptidos
BR8907085A (pt) Processo de preparacao de composicoes de betume-polimero
PT90523A (pt) Processo para a preparacao de adsorvatos de ranitidina
PT83643B (pt) Processo de preparacao de derivados de quinoleina
PT87190A (pt) Processo para a preparacao de composicoes farmaceuticas para a reducao dos efeitos indesejaveis das beta-lactaminas
PT84790B (pt) Processo de preparacao de derivados de amino-tiazol e de amino-oxazole e de composicoes farmaceuticas contendo-os
PT90748A (pt) Processo par a preparacao de 4-amino-3-carboxi-quinoleinas e - naftiridinas
PT92120A (pt) Processo para a preparacao de composicoes oftalmologicas contendo ciclosporina
BR9609420A (pt) Derivados de 4-fenilaminotiazol seu processo de preparação e as composições farmacêuticas contendo os mesmos
PT90138A (pt) Processo de preparacao de peptidos de factor de crescimento do nervo
PT89946A (pt) Processo de preparacao de sulfatos ciclicos
BR8902861A (pt) Processo de preparacao de copoliamidas amorfas e transparentes e sua aplicacao
PT91098A (pt) Processo de preparacao de derivados de (aza)naftalenossultame
PT89657A (pt) Processo de preparacao de derivados do imidazolo, dos seus intermediarios e de composicoes farmaceuticas contendo aqueles compostos
PT81029B (pt) Processo para a preparacao de derivados de flavanona com efeito antialergico e aplicacao dos mesmos para a preparacao de composicoes farmaceuticas com efeito antialergico
PT89616A (pt) Processo para a preparacao de composicoes artropodicidas contendo misturas sinergicas de derivados piretroides e butoxido de piperonilo
PT91870A (pt) Processo para apreparacao de novas quinoliloxazol-2-onas e de composicoes farmaceuticas que as contem
PT89956A (pt) Processo para a preparacao de acidos 1-ciclopropil-quinolonocarboxilicos e seus derivados
FI885692A0 (fi) Karboksimetyylisulfoetyyliselluloosa ja menetelmä sen valmistamiseksi

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940712

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960131