PT831837E - Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe - Google Patents

Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe

Info

Publication number: PT831837E
Authority: PT; Portugal
Prior art keywords: compounds; eschalamine; utilization; manufacture; medicinal product
Prior art date: 1995-06-07

Application number

PT96919096T

Other languages

English (en)

Inventor

Michael Zasloff

Original Assignee

Genaera Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-07

Publication date

2003-09-30

1996-06-07 Application filed by Genaera Corp filed Critical Genaera Corp

2003-09-30 Publication of PT831837E publication Critical patent/PT831837E/pt

Links

230000005764 inhibitory process Effects 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
239000003112 inhibitor Substances 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
238000001228 spectrum Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT96919096T 1995-06-07 1996-06-07 Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe PT831837E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/474,799 US5792635A (en)	1995-06-07	1995-06-07	Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine

Publications (1)

Publication Number	Publication Date
PT831837E true PT831837E (pt)	2003-09-30

Family

ID=23884982

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96919096T PT831837E (pt)	1995-06-07	1996-06-07	Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe

Country Status (12)

Country	Link
US (1)	US5792635A (pt)
EP (1)	EP0831837B1 (pt)
JP (1)	JP4077512B2 (pt)
AT (1)	ATE238800T1 (pt)
AU (1)	AU712436B2 (pt)
CA (1)	CA2223908C (pt)
DE (1)	DE69627853T2 (pt)
DK (1)	DK0831837T3 (pt)
ES (1)	ES2201187T3 (pt)
PT (1)	PT831837E (pt)
WO (1)	WO1996040151A1 (pt)
ZA (1)	ZA964819B (pt)

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US6596712B2 (en)	1996-04-26	2003-07-22	Genaera Corporation	Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
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US20050130948A1 (en) *	2002-03-27	2005-06-16	Daryl Rees	Therapeutic methods and uses of sapogenins and their derivatives
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JP2008539243A (ja)	2005-04-25	2008-11-13	ジェネーラ・コーポレーション	スクアラミンジラクテートの多形塩形態および無定形塩形態
WO2007124086A1 (en) *	2006-04-21	2007-11-01	Genaera Corporation	Induction of weight loss and the selective inhibition of ptp1b
WO2009032321A2 (en) *	2007-09-06	2009-03-12	Genaera Corporation	A method for treating diabetes
US20120088737A2 (en) *	2009-10-02	2012-04-12	Ajinomoto Co., Inc	Novel acyl guanidine derivatives
WO2011056650A2 (en)	2009-10-27	2011-05-12	Michael Zasloff	Methods and compositions for treating and preventing viral infections
US8623416B2 (en) *	2009-11-25	2014-01-07	Michael Zasloff	Formulations comprising aminosterols
PL2838907T3 (pl) *	2012-04-20	2019-12-31	Ohr Pharmaceutical, Inc.	Aminosteroidy do leczenia choroby związanej z PTP1B
AU2014243773B2 (en) *	2013-03-13	2018-12-13	Sage Therapeutics, Inc.	Neuroactive steroids and methods of use thereof
US10040817B2 (en) *	2013-10-03	2018-08-07	Enterin Laboratories, Inc.	Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same
SI3319612T1 (sl)	2015-07-06	2021-11-30	Sage Therapeutics, Inc.	Oksisteroli in postopki za uporabo le-teh
ES2921010T3 (es)	2016-04-01	2022-08-16	Sage Therapeutics Inc	Oxisteroles y procedimientos de uso de los mismos
US10752653B2 (en)	2016-05-06	2020-08-25	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
JP7149266B2 (ja)	2016-09-30	2022-10-06	セージセラピューティクス，インコーポレイテッド	Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
CN110267966B (zh)	2016-10-18	2022-07-08	萨奇治疗股份有限公司	氧甾醇及其使用方法
WO2019050903A1 (en)	2017-09-08	2019-03-14	Enterin Laboratories, Inc.	METHODS OF TREATING SLEEP DISORDERS, SLEEP DISTURBANCES AND ASSOCIATED SYMPTOMS USING AMINOSTEROL COMPOSITIONS

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AU723663C (en) *	1995-06-07	2001-11-01	Magainin Pharmaceuticals, Inc.	Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds

1995
- 1995-06-07 US US08/474,799 patent/US5792635A/en not_active Expired - Fee Related
1996
- 1996-06-07 ES ES96919096T patent/ES2201187T3/es not_active Expired - Lifetime
- 1996-06-07 ZA ZA9604819A patent/ZA964819B/xx unknown
- 1996-06-07 CA CA002223908A patent/CA2223908C/en not_active Expired - Lifetime
- 1996-06-07 DK DK96919096T patent/DK0831837T3/da active
- 1996-06-07 JP JP50139797A patent/JP4077512B2/ja not_active Expired - Fee Related
- 1996-06-07 EP EP96919096A patent/EP0831837B1/en not_active Expired - Lifetime
- 1996-06-07 WO PCT/US1996/008954 patent/WO1996040151A1/en active IP Right Grant
- 1996-06-07 DE DE69627853T patent/DE69627853T2/de not_active Expired - Fee Related
- 1996-06-07 AU AU61528/96A patent/AU712436B2/en not_active Ceased
- 1996-06-07 AT AT96919096T patent/ATE238800T1/de not_active IP Right Cessation
- 1996-06-07 PT PT96919096T patent/PT831837E/pt unknown

Also Published As

Publication number	Publication date
ZA964819B (en)	1998-02-09
DE69627853T2 (de)	2004-02-19
EP0831837A1 (en)	1998-04-01
CA2223908C (en)	2007-02-20
CA2223908A1 (en)	1996-12-19
JP4077512B2 (ja)	2008-04-16
AU6152896A (en)	1996-12-30
ES2201187T3 (es)	2004-03-16
DE69627853D1 (de)	2003-06-05
JPH11506775A (ja)	1999-06-15
AU712436B2 (en)	1999-11-04
ATE238800T1 (de)	2003-05-15
US5792635A (en)	1998-08-11
WO1996040151A1 (en)	1996-12-19
EP0831837B1 (en)	2003-05-02
DK0831837T3 (da)	2003-08-25

Publication	Publication Date	Title
PT831837E (pt)	2003-09-30	Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe
WO1996040728A3 (en)	1997-03-27	Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (nhe), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the nhe-inhibitory efficacy of compounds
SE9504661D0 (sv)	1995-12-22	New compounds
TR200001603T2 (tr)	2000-10-23	Yeni bileşikler
TR200102800T2 (tr)	2002-01-21	Yeni bileşikler.
NO20002787L (no)	2000-08-01	Nye forbindelser
GR3034204T3 (en)	2000-11-30	Lipopolyamines as transfection agents and pharmaceutical uses thereof
MY120235A (en)	2005-09-30	Aryloxyarylsulfonylamino hydroxamic acid derivatives
NO965516L (no)	1997-02-21	Sterolderivater anvendt til regulering av meiose
ATE172451T1 (de)	1998-11-15	Vitamin d analoge
TR200001012T2 (tr)	2000-09-21	Yeni ariloksi-alkil-dialkilaminler.
TR199900310T2 (xx)	1999-04-21	Trombin inhibit�rleri
DE69021501T2 (de)	1996-01-18	Anti-entzündende 4-aminophenol-derivate.
DE3583189D1 (de)	1991-07-18	Carbazole und ihre verwendung als photoinitiatoren von photopolymerisierbaren, ungesaettigten verbindungen.
SE9504662D0 (sv)	1995-12-22	New compounds
ES2128313T3 (es)	1999-05-16	Naftalimidas n-substituidas, su obtencion y empleo.
PT1001942E (pt)	2003-11-28	Poli-hidroxibutilpirazinas sua preparacao e medicamentos que as contem
NO990322L (no)	1999-03-24	Farmas°ytisk blanding inneholdende en 5HT2c-antagonist og en D2-antagonist
DE69635990D1 (de)	2006-05-18	Bromierte hexahydroxybiphenylderivate
IT8322486A0 (it)	1983-08-09	N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
MX9804068A (es)	1998-09-30	Nuevos derivados de quinoxalindiona, su preparacion y empleo en medicamentos.
TR199901543T2 (xx)	1999-09-21	Benzo $F] kinolinnonlar�n sentezi
PT1105388E (pt)	2003-09-30	Derivados de azabiciclo-heptano n-substituidos o seu fabrico e a sua utilizacao
ATE243695T1 (de)	2003-07-15	5-bicycloindolverbindungen
ES2179029T3 (es)	2003-01-16	Derivados de 14,15-alfa-metileno-equilenina, proceso para su preparacion y medicamentos que contienen los mismos.