PT712862E - Acilacao selectiva de grupos epsilon-amino em ensulina - Google Patents

Acilacao selectiva de grupos epsilon-amino em ensulina

Info

Publication number
PT712862E
PT712862E PT95308167T PT95308167T PT712862E PT 712862 E PT712862 E PT 712862E PT 95308167 T PT95308167 T PT 95308167T PT 95308167 T PT95308167 T PT 95308167T PT 712862 E PT712862 E PT 712862E
Authority
PT
Portugal
Prior art keywords
ensulina
acilacation
epsilon
selective
amino groups
Prior art date
Application number
PT95308167T
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT712862E publication Critical patent/PT712862E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT95308167T 1994-11-17 1995-11-14 Acilacao selectiva de grupos epsilon-amino em ensulina PT712862E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
PT712862E true PT712862E (pt) 2006-08-31

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95308167T PT712862E (pt) 1994-11-17 1995-11-14 Acilacao selectiva de grupos epsilon-amino em ensulina

Country Status (28)

Country Link
US (2) US5646242A (pt)
EP (2) EP1227107A1 (pt)
JP (1) JP4312828B2 (pt)
CN (1) CN1171742A (pt)
AR (1) AR003915A1 (pt)
AT (1) ATE328902T1 (pt)
AU (2) AU691066B2 (pt)
BR (1) BR9509652A (pt)
CA (1) CA2205061A1 (pt)
CO (1) CO4520285A1 (pt)
CZ (1) CZ287731B6 (pt)
DE (1) DE69535031T2 (pt)
DK (1) DK0712862T3 (pt)
ES (1) ES2264124T3 (pt)
HK (1) HK1014007A1 (pt)
HU (2) HU9903007D0 (pt)
IL (1) IL115972A (pt)
IN (1) IN179820B (pt)
NO (1) NO972185D0 (pt)
NZ (1) NZ297256A (pt)
PL (1) PL320556A1 (pt)
PT (1) PT712862E (pt)
RU (1) RU2155773C2 (pt)
SI (1) SI0712862T1 (pt)
TR (1) TR199501421A2 (pt)
WO (1) WO1996015803A1 (pt)
YU (1) YU71495A (pt)
ZA (1) ZA959680B (pt)

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US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
JP2001521006A (ja) * 1997-10-24 2001-11-06 イーライ・リリー・アンド・カンパニー 不溶性インシュリン組成物
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US5985263A (en) * 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US5981709A (en) * 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
US7181349B1 (en) 1999-05-27 2007-02-20 Cecil Yip Identification of compounds for modulating dimeric receptors
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
JP2003532691A (ja) * 2000-05-05 2003-11-05 ノボ ノルディスク アクティーゼルスカブ 重症疾患神経障害
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US20030054015A1 (en) * 2000-12-25 2003-03-20 Shinichiro Haze Sympathetic-activating perfume composition
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
CN1558912A (zh) * 2001-07-24 2004-12-29 ŵ��Ų�ڿ˹�˾ 生产酰化多肽的方法
US20030082671A1 (en) 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
WO2003010185A2 (en) * 2001-07-24 2003-02-06 Novo Nordisk A/S Method for making acylated polypeptides
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
DE60234198D1 (de) 2001-09-07 2009-12-10 Biocon Ltd Verfahren zur synthese von insulinpolypeptid-oligomer-konjugaten und proinsulinpolypeptid-oligomer-konjugaten und verfahren zu deren synthese
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
CA2500123A1 (en) * 2002-09-25 2004-04-08 Novo Nordisk A/S Method for producing acylated peptides
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
EP2264065B1 (en) * 2003-08-05 2017-03-08 Novo Nordisk A/S Novel insulin derivatives
JP2007532096A (ja) 2003-11-14 2007-11-15 ノボ　ノルディスク　アクティーゼルスカブ アシル化されたインスリンの製造方法
CN101027318B (zh) 2004-07-19 2016-05-25 比奥孔有限公司 胰岛素-低聚物共轭物，制剂及其用途
CN102660614A (zh) 2005-08-16 2012-09-12 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
CN101389650B (zh) * 2005-12-28 2012-10-10 诺沃-诺迪斯克有限公司 包含酰化胰岛素和锌的组合物以及制备所述组合物的方法
DE602007009496D1 (de) * 2006-02-27 2010-11-11 Novo Nordisk As Insulinderivate
US8927015B2 (en) * 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
JP5864834B2 (ja) 2006-09-22 2016-02-17 ノボ・ノルデイスク・エー／エス プロテアーゼ耐性のインスリンアナログ
WO2008037735A1 (en) 2006-09-27 2008-04-03 Novo Nordisk A/S Method for making maturated insulin polypeptides
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
JP5552046B2 (ja) 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
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JP5762001B2 (ja) 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
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US9603904B2 (en) * 2008-10-30 2017-03-28 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
CA2751673A1 (en) * 2009-02-20 2010-08-26 Ipsen Pharma S.A.S Analogues of neuropeptide y having proline substitution at position 34
EP2504019A2 (en) 2009-11-25 2012-10-03 ArisGen SA Mucosal delivery composition comprising a peptide complexed with a crown compound and/or a counter ion
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
CA2870313A1 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
EP2991672A1 (en) 2013-04-30 2016-03-09 Novo Nordisk A/S Novel administration regime
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
CN109715793A (zh) 2016-05-05 2019-05-03 科德克希思公司 青霉素-g 酰化酶
JP7076442B2 (ja) 2016-11-07 2022-05-27 ノヴォ ノルディスク アー／エス Ｐｅｇ化合物のｄｃｈｂｓ活性エステル及びその使用
CN110087674B (zh) 2016-12-16 2023-01-03 诺和诺德股份有限公司 含胰岛素的药物组合物
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
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Also Published As

Publication number Publication date
CA2205061A1 (en) 1996-05-30
US5646242A (en) 1997-07-08
AR003915A1 (es) 1998-09-30
SI0712862T1 (sl) 2006-10-31
ATE328902T1 (de) 2006-06-15
IL115972A0 (en) 1996-01-31
IN179820B (pt) 1997-12-13
CZ145697A3 (en) 1997-12-17
AU7885498A (en) 1998-11-05
JPH10509176A (ja) 1998-09-08
HUT77737A (hu) 1998-07-28
NO972185L (no) 1997-05-13
USRE37971E1 (en) 2003-01-28
BR9509652A (pt) 1997-09-16
AU4237296A (en) 1996-06-17
DE69535031D1 (de) 2006-07-20
HU217585B (hu) 2000-02-28
CN1171742A (zh) 1998-01-28
DE69535031T2 (de) 2006-12-28
AU691066B2 (en) 1998-05-07
EP0712862A3 (en) 1998-03-04
EP1227107A1 (en) 2002-07-31
RU2155773C2 (ru) 2000-09-10
PL320556A1 (en) 1997-10-13
HK1014007A1 (en) 1999-09-17
EP0712862A2 (en) 1996-05-22
YU71495A (sh) 1998-09-18
NO972185D0 (no) 1997-05-13
TR199501421A2 (tr) 1996-06-21
NZ297256A (en) 2000-01-28
JP4312828B2 (ja) 2009-08-12
ZA959680B (en) 1997-05-14
CZ287731B6 (en) 2001-01-17
ES2264124T3 (es) 2006-12-16
DK0712862T3 (da) 2006-09-25
AU720820B2 (en) 2000-06-15
HU9903007D0 (en) 1999-11-29
IL115972A (en) 2000-09-28
EP0712862B1 (en) 2006-06-07
CO4520285A1 (es) 1997-10-15
WO1996015803A1 (en) 1996-05-30
MX9703506A (es) 1997-07-31

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