PT3717457T - Processo de preparação de enzalutamida utilizando um intermediário inovador - Google Patents
Processo de preparação de enzalutamida utilizando um intermediário inovadorInfo
- Publication number
- PT3717457T PT3717457T PT188830822T PT18883082T PT3717457T PT 3717457 T PT3717457 T PT 3717457T PT 188830822 T PT188830822 T PT 188830822T PT 18883082 T PT18883082 T PT 18883082T PT 3717457 T PT3717457 T PT 3717457T
- Authority
- PT
- Portugal
- Prior art keywords
- enzalutamide
- preparation
- novel intermediate
- novel
- Prior art date
Links
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 title 1
- 229960004671 enzalutamide Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/08—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201721042702 | 2017-11-28 | ||
IN201821028360 | 2018-07-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3717457T true PT3717457T (pt) | 2023-10-26 |
Family
ID=66664429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT188830822T PT3717457T (pt) | 2017-11-28 | 2018-11-27 | Processo de preparação de enzalutamida utilizando um intermediário inovador |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP3717457B1 (pt) |
CN (1) | CN111386257B (pt) |
ES (1) | ES2959954T3 (pt) |
HU (1) | HUE064356T2 (pt) |
PL (1) | PL3717457T4 (pt) |
PT (1) | PT3717457T (pt) |
SI (1) | SI3717457T1 (pt) |
WO (1) | WO2019106691A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210118816A (ko) | 2018-12-19 | 2021-10-01 | 셀진 코포레이션 | 치환된 3-((3-아미노페닐)아미노)피페리딘-2,6-디온 화합물, 이의 조성물, 및 이를 사용한 치료 방법 |
CN113473987A (zh) | 2018-12-19 | 2021-10-01 | 细胞基因公司 | 被取代的3-((3-氨基苯基)氨基)哌啶-2,6-二酮化合物、其组合物和使用其的治疗方法 |
CN110981812A (zh) * | 2019-11-25 | 2020-04-10 | 奥锐特药业股份有限公司 | 一种无定形恩杂鲁胺的制备方法 |
CN111303042A (zh) * | 2020-03-25 | 2020-06-19 | 北京赛思源生物医药技术有限公司 | 一种恩杂鲁胺的新晶型 |
CN114805327A (zh) * | 2021-01-29 | 2022-07-29 | 苏州开拓药业股份有限公司 | 一种硫代乙内酰脲药物用中间体及其制备方法与用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
EP3329775B1 (en) * | 2010-02-24 | 2021-04-21 | Medivation Prostate Therapeutics LLC | Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds |
JP2015534550A (ja) | 2012-09-11 | 2015-12-03 | ドクター レディズ ラボラトリーズ リミテッド | エンザルタミドの多形形態およびその調製 |
CN106543085A (zh) | 2013-10-14 | 2017-03-29 | 杭州普晒医药科技有限公司 | 恩杂鲁胺的固态形式及其制备方法和用途 |
US20160318875A1 (en) * | 2013-12-16 | 2016-11-03 | Sun Pharmaceutical Industries Limited | Processes and intermediates for the preparation of enzalutamide |
CN104803918B (zh) * | 2014-01-26 | 2017-11-10 | 上海医药工业研究院 | 恩杂鲁胺的制备方法 |
US9611225B2 (en) * | 2014-01-27 | 2017-04-04 | Cadila Healthcare Limited | Process for preparation of androgen receptor antagonist |
EP3166931A4 (en) | 2014-07-11 | 2018-05-09 | Shilpa Medicare Limited | An improved process for the preparation of enzalutamide |
CN104091434B (zh) | 2014-07-31 | 2018-07-20 | 国家电网公司 | 基于电力***的费控信息通信方法和*** |
CN104356068A (zh) * | 2014-10-30 | 2015-02-18 | 杭州新博思生物医药有限公司 | 恩杂鲁胺新晶型及其制备方法 |
CN104610111A (zh) * | 2014-12-26 | 2015-05-13 | 杭州和泽医药科技有限公司 | 一种4-异硫代氰酰基-2-(三氟甲基)苯甲腈的制备方法 |
-
2018
- 2018-11-27 SI SI201830989T patent/SI3717457T1/sl unknown
- 2018-11-27 WO PCT/IN2018/050789 patent/WO2019106691A1/en unknown
- 2018-11-27 PL PL18883082.2T patent/PL3717457T4/pl unknown
- 2018-11-27 EP EP18883082.2A patent/EP3717457B1/en active Active
- 2018-11-27 PT PT188830822T patent/PT3717457T/pt unknown
- 2018-11-27 CN CN201880076178.0A patent/CN111386257B/zh active Active
- 2018-11-27 HU HUE18883082A patent/HUE064356T2/hu unknown
- 2018-11-27 ES ES18883082T patent/ES2959954T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
HUE064356T2 (hu) | 2024-03-28 |
PL3717457T3 (pl) | 2024-02-12 |
CN111386257A (zh) | 2020-07-07 |
EP3717457B1 (en) | 2023-06-21 |
PL3717457T4 (pl) | 2024-02-12 |
EP3717457A1 (en) | 2020-10-07 |
SI3717457T1 (sl) | 2023-12-29 |
WO2019106691A1 (en) | 2019-06-06 |
CN111386257B (zh) | 2024-05-24 |
ES2959954T3 (es) | 2024-02-29 |
EP3717457A4 (en) | 2021-04-28 |
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