PT3612519T - Compostos de fenil-2-hidroxi-acetilamino-2-metil-fenilo - Google Patents

Compostos de fenil-2-hidroxi-acetilamino-2-metil-fenilo

Info

Publication number
PT3612519T
PT3612519T PT187185707T PT18718570T PT3612519T PT 3612519 T PT3612519 T PT 3612519T PT 187185707 T PT187185707 T PT 187185707T PT 18718570 T PT18718570 T PT 18718570T PT 3612519 T PT3612519 T PT 3612519T
Authority
PT
Portugal
Prior art keywords
phenyl
acetylamino
hydroxy
methyl
compounds
Prior art date
Application number
PT187185707T
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT3612519T publication Critical patent/PT3612519T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
PT187185707T 2017-04-18 2018-04-11 Compostos de fenil-2-hidroxi-acetilamino-2-metil-fenilo PT3612519T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17382207 2017-04-18

Publications (1)

Publication Number Publication Date
PT3612519T true PT3612519T (pt) 2022-02-22

Family

ID=58606227

Family Applications (1)

Application Number Title Priority Date Filing Date
PT187185707T PT3612519T (pt) 2017-04-18 2018-04-11 Compostos de fenil-2-hidroxi-acetilamino-2-metil-fenilo

Country Status (27)

Country Link
US (2) US11655214B2 (pt)
EP (2) EP3612519B1 (pt)
JP (2) JP7110232B2 (pt)
KR (2) KR20230129627A (pt)
CN (2) CN117510405A (pt)
AU (2) AU2018255191B2 (pt)
BR (1) BR112019021867A2 (pt)
CA (1) CA3060564A1 (pt)
CO (1) CO2019012767A2 (pt)
CR (1) CR20190519A (pt)
CY (1) CY1125150T1 (pt)
DK (1) DK3612519T3 (pt)
ES (1) ES2906847T3 (pt)
HR (1) HRP20220263T1 (pt)
HU (1) HUE057745T2 (pt)
IL (2) IL270005B (pt)
LT (1) LT3612519T (pt)
MX (2) MX2019012428A (pt)
PH (1) PH12019502363A1 (pt)
PL (1) PL3612519T3 (pt)
PT (1) PT3612519T (pt)
RS (1) RS62933B1 (pt)
SA (1) SA519410320B1 (pt)
SG (1) SG11201909680UA (pt)
SI (1) SI3612519T1 (pt)
WO (1) WO2018194885A1 (pt)
ZA (1) ZA201906811B (pt)

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KR20230129627A (ko) 2017-04-18 2023-09-08 일라이 릴리 앤드 캄파니 페닐-2-히드록시-아세틸아미노-2-메틸-페닐 화합물
BR112020019023A2 (pt) 2018-03-26 2020-12-29 Icahn School Of Medicine At Mount Sinai Métodos de tratamento do câncer residual mínimo
WO2021041973A1 (en) 2019-08-29 2021-03-04 Hibercell, Inc. Perk inhibiting compounds
US20220348584A1 (en) 2019-08-29 2022-11-03 Hibercell, Inc. Perk inhibiting indolinyl compounds
JP2022546414A (ja) 2019-08-29 2022-11-04 ヒベルセル, インコーポレイテッド Perk阻害ピロロピリミジン化合物
WO2021041970A1 (en) 2019-08-29 2021-03-04 Hibercell, Inc. Perk inhibiting imidazolopyrazine compounds
WO2021231788A1 (en) * 2020-05-13 2021-11-18 Hibercell, Inc. Perk inhibiting pyrrolopyrimidine compounds to treat viral infections
WO2021231782A1 (en) * 2020-05-13 2021-11-18 Hibercell, Inc. Perk inhibitors for treating viral infections
CN113234029B (zh) * 2021-05-25 2022-03-22 白银康寓信生物科技有限公司 一种2-氨基-3,5-二卤代吡嗪的合成方法

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NZ580384A (en) * 2003-07-23 2011-03-31 Bayer Pharmaceuticals Corp 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
PE20070335A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion
KR20080040027A (ko) * 2005-09-02 2008-05-07 아스테라스 세이야쿠 가부시키가이샤 Rock 억제제로서 아미드 유도체
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BR112012024380A2 (pt) 2010-03-25 2015-09-15 Glaxosmithkline Llc compostos químicos
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WO2016004254A1 (en) 2014-07-01 2016-01-07 The Regents Of The University Of California Combined modulation of ire1
CN107108631B (zh) 2014-11-14 2020-06-16 内尔维阿诺医学科学有限公司 作为蛋白激酶抑制剂的6-氨基-7-二环-7-脱氮-嘌呤衍生物
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Also Published As

Publication number Publication date
RU2019136694A (ru) 2021-05-18
CN117510405A (zh) 2024-02-06
CA3060564A1 (en) 2018-10-25
JP7331212B2 (ja) 2023-08-22
MX2019012428A (es) 2022-01-28
AU2018255191A1 (en) 2019-11-07
RU2019136694A3 (pt) 2021-05-19
CR20190519A (es) 2020-03-06
LT3612519T (lt) 2022-03-25
KR20190140966A (ko) 2019-12-20
ZA201906811B (en) 2021-01-27
SA519410320B1 (ar) 2022-05-08
EP4039675A1 (en) 2022-08-10
SI3612519T1 (sl) 2022-04-29
AU2022206702A1 (en) 2022-08-11
KR20230129627A (ko) 2023-09-08
CN110831927A (zh) 2020-02-21
EP3612519A1 (en) 2020-02-26
US20210114985A1 (en) 2021-04-22
IL288822A (en) 2022-02-01
ES2906847T3 (es) 2022-04-20
US20230373922A1 (en) 2023-11-23
EP3612519B1 (en) 2021-12-01
DK3612519T3 (da) 2022-03-07
JP2022141835A (ja) 2022-09-29
PH12019502363A1 (en) 2020-12-07
CY1125150T1 (el) 2023-06-09
PL3612519T3 (pl) 2022-05-02
CN110831927B (zh) 2023-07-14
BR112019021867A2 (pt) 2020-05-26
HRP20220263T1 (hr) 2022-04-29
HUE057745T2 (hu) 2022-06-28
AU2018255191B2 (en) 2022-04-21
JP2021517555A (ja) 2021-07-26
KR102575246B1 (ko) 2023-09-06
IL270005B (en) 2022-01-01
CO2019012767A2 (es) 2020-04-01
WO2018194885A1 (en) 2018-10-25
IL288822B2 (en) 2023-06-01
RS62933B1 (sr) 2022-03-31
AU2022206702B2 (en) 2024-04-11
JP7110232B2 (ja) 2022-08-01
SG11201909680UA (en) 2019-11-28
MX2022001310A (es) 2022-03-02
US11655214B2 (en) 2023-05-23

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