PT3500586T - Processo contínuo para reduzir a heterogeneidade da proteína terapêutica - Google Patents

Processo contínuo para reduzir a heterogeneidade da proteína terapêutica

Info

Publication number
PT3500586T
PT3500586T PT178046553T PT17804655T PT3500586T PT 3500586 T PT3500586 T PT 3500586T PT 178046553 T PT178046553 T PT 178046553T PT 17804655 T PT17804655 T PT 17804655T PT 3500586 T PT3500586 T PT 3500586T
Authority
PT
Portugal
Prior art keywords
continuous process
therapeutic protein
reducing heterogeneity
heterogeneity
reducing
Prior art date
Application number
PT178046553T
Other languages
English (en)
Original Assignee
Enzene Biosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzene Biosciences Ltd filed Critical Enzene Biosciences Ltd
Publication of PT3500586T publication Critical patent/PT3500586T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT178046553T 2016-10-17 2017-10-16 Processo contínuo para reduzir a heterogeneidade da proteína terapêutica PT3500586T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN201621035458 2016-10-17

Publications (1)

Publication Number Publication Date
PT3500586T true PT3500586T (pt) 2021-06-17

Family

ID=60473571

Family Applications (1)

Application Number Title Priority Date Filing Date
PT178046553T PT3500586T (pt) 2016-10-17 2017-10-16 Processo contínuo para reduzir a heterogeneidade da proteína terapêutica

Country Status (14)

Country Link
US (1) US11618768B2 (pt)
EP (1) EP3500586B1 (pt)
JP (1) JP6976343B2 (pt)
KR (1) KR102543033B1 (pt)
CN (1) CN109843904A (pt)
AU (1) AU2017345387A1 (pt)
DK (1) DK3500586T3 (pt)
EA (1) EA201990593A1 (pt)
ES (1) ES2876416T3 (pt)
HR (1) HRP20210830T1 (pt)
HU (1) HUE054420T2 (pt)
PL (1) PL3500586T3 (pt)
PT (1) PT3500586T (pt)
WO (1) WO2018073717A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202005694A (zh) * 2018-07-02 2020-02-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
MX2022003438A (es) * 2019-09-24 2022-04-19 Regeneron Pharma Sistemas y metodos para uso y regeneracion de cromatografia.
CN114929725A (zh) * 2020-01-08 2022-08-19 信达生物制药(苏州)有限公司 阿达木单抗纯化方法及其稳定组合物
EP4217383A1 (en) * 2020-09-22 2023-08-02 Bristol-Myers Squibb Company Methods for producing therapeutic proteins
CN115475258A (zh) * 2022-09-06 2022-12-16 江苏丰华生物制药有限公司 一种注射用替奈普酶纯化工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126250A (en) 1988-09-28 1992-06-30 Eli Lilly And Company Method for the reduction of heterogeneity of monoclonal antibodies
IL91778A (en) * 1988-09-28 1994-10-07 Lilly Co Eli A method for reducing the heterogeneity of monoclonal antibodies
PL2307441T3 (pl) * 2008-08-07 2016-09-30 Sposób otrzymywania związków insuliny
EP2450375A1 (en) 2010-11-09 2012-05-09 Sandoz Gmbh Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor
CN104024423B (zh) 2011-04-29 2017-03-15 拜康研究有限公司 用于降低抗体异质性的方法和产生其抗体的方法
AU2012347545A1 (en) * 2011-12-07 2014-06-12 Amgen Inc. IgG2 disulfide isoform separation
WO2013158273A1 (en) * 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US20150267237A1 (en) * 2012-04-24 2015-09-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
WO2014137903A2 (en) 2013-03-08 2014-09-12 Genzyme Corporation Integrated continuous manufacturing of therapeutic protein drug substances
CN105483193B (zh) * 2015-11-24 2019-03-29 上海联合赛尔生物工程有限公司 从含酶切位点的融合蛋白中纯化蛋白的方法及试剂盒

Also Published As

Publication number Publication date
JP2019533724A (ja) 2019-11-21
AU2017345387A1 (en) 2019-04-11
JP6976343B2 (ja) 2021-12-08
EP3500586B1 (en) 2021-02-24
ES2876416T3 (es) 2021-11-12
KR20190064591A (ko) 2019-06-10
CN109843904A (zh) 2019-06-04
EA201990593A1 (ru) 2019-10-31
HUE054420T2 (hu) 2021-09-28
DK3500586T3 (da) 2021-05-31
US11618768B2 (en) 2023-04-04
HRP20210830T1 (hr) 2021-08-20
WO2018073717A1 (en) 2018-04-26
PL3500586T3 (pl) 2021-09-27
US20190263855A1 (en) 2019-08-29
EP3500586A1 (en) 2019-06-26
KR102543033B1 (ko) 2023-06-12

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