HUE054420T2 - Folyamatos eljárás terápiás fehérje heterogenitásának csökkentésére - Google Patents

Folyamatos eljárás terápiás fehérje heterogenitásának csökkentésére

Info

Publication number
HUE054420T2
HUE054420T2 HUE17804655A HUE17804655A HUE054420T2 HU E054420 T2 HUE054420 T2 HU E054420T2 HU E17804655 A HUE17804655 A HU E17804655A HU E17804655 A HUE17804655 A HU E17804655A HU E054420 T2 HUE054420 T2 HU E054420T2
Authority
HU
Hungary
Prior art keywords
continuous process
therapeutic protein
reducing heterogeneity
heterogeneity
reducing
Prior art date
Application number
HUE17804655A
Other languages
English (en)
Inventor
Himanshu Gadgil
Abir Banerjee
Gopal Dyaga
Ashvin Pankhania
Harshita Londhe
Deepika Rao
Original Assignee
Enzene Biosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzene Biosciences Ltd filed Critical Enzene Biosciences Ltd
Publication of HUE054420T2 publication Critical patent/HUE054420T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HUE17804655A 2016-10-17 2017-10-16 Folyamatos eljárás terápiás fehérje heterogenitásának csökkentésére HUE054420T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN201621035458 2016-10-17

Publications (1)

Publication Number Publication Date
HUE054420T2 true HUE054420T2 (hu) 2021-09-28

Family

ID=60473571

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17804655A HUE054420T2 (hu) 2016-10-17 2017-10-16 Folyamatos eljárás terápiás fehérje heterogenitásának csökkentésére

Country Status (14)

Country Link
US (1) US11618768B2 (hu)
EP (1) EP3500586B1 (hu)
JP (1) JP6976343B2 (hu)
KR (1) KR102543033B1 (hu)
CN (1) CN109843904A (hu)
AU (1) AU2017345387A1 (hu)
DK (1) DK3500586T3 (hu)
EA (1) EA201990593A1 (hu)
ES (1) ES2876416T3 (hu)
HR (1) HRP20210830T1 (hu)
HU (1) HUE054420T2 (hu)
PL (1) PL3500586T3 (hu)
PT (1) PT3500586T (hu)
WO (1) WO2018073717A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202005694A (zh) * 2018-07-02 2020-02-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
JP2022548394A (ja) * 2019-09-24 2022-11-18 リジェネロン・ファーマシューティカルズ・インコーポレイテッド クロマトグラフィーの使用および再生のためのシステムおよび方法
WO2021139720A1 (zh) * 2020-01-08 2021-07-15 信达生物制药(苏州)有限公司 阿达木单抗纯化方法及其稳定组合物
JP2023542924A (ja) * 2020-09-22 2023-10-12 ブリストル－マイヤーズ スクイブ カンパニー 治療タンパク質を生産するための方法
CN115475258A (zh) * 2022-09-06 2022-12-16 江苏丰华生物制药有限公司 一种注射用替奈普酶纯化工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126250A (en) 1988-09-28 1992-06-30 Eli Lilly And Company Method for the reduction of heterogeneity of monoclonal antibodies
RO105652B1 (ro) * 1988-09-28 1992-11-30 Lilly Co Eli Procedeu de reducere a heterogenitatii anticorpilor monoclonali
EP2307441B1 (en) * 2008-08-07 2016-03-23 Biocon Limited A process for preparation of insulin compounds
EP2450375A1 (en) 2010-11-09 2012-05-09 Sandoz Gmbh Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor
PL2702164T3 (pl) 2011-04-29 2016-06-30 Biocon Res Limited Sposób obniżania heterogeniczności przeciwciał i sposób ich wytwarzania
EP2788097A4 (en) * 2011-12-07 2015-09-09 Amgen Inc IGG2 DISULFIDE ISOFORMATION SEPARATION
US9181572B2 (en) * 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US20150267237A1 (en) * 2012-04-24 2015-09-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
RU2768003C2 (ru) * 2013-03-08 2022-03-22 Джензим Корпорейшн Интегрированное непрерывное производство терапевтических белковых лекарственных веществ
CN105483193B (zh) * 2015-11-24 2019-03-29 上海联合赛尔生物工程有限公司 从含酶切位点的融合蛋白中纯化蛋白的方法及试剂盒

Also Published As

Publication number Publication date
ES2876416T3 (es) 2021-11-12
EP3500586A1 (en) 2019-06-26
PL3500586T3 (pl) 2021-09-27
CN109843904A (zh) 2019-06-04
HRP20210830T1 (hr) 2021-08-20
US20190263855A1 (en) 2019-08-29
AU2017345387A1 (en) 2019-04-11
JP6976343B2 (ja) 2021-12-08
KR20190064591A (ko) 2019-06-10
WO2018073717A1 (en) 2018-04-26
EA201990593A1 (ru) 2019-10-31
KR102543033B1 (ko) 2023-06-12
US11618768B2 (en) 2023-04-04
PT3500586T (pt) 2021-06-17
DK3500586T3 (da) 2021-05-31
JP2019533724A (ja) 2019-11-21
EP3500586B1 (en) 2021-02-24

Similar Documents

Publication Publication Date Title
HK1245829A1 (zh) 受控消除治療性細胞的方法
HK1251614A1 (zh) 用於惡性腫瘤的治療的方法
IL247508A0 (en) A method for preparing human plasma proteins
HK1256795A1 (zh) 可用於治療自身免疫疾病的二吡唑基衍生物
SG10201801562PA (en) Combination method for treatment of cancer
HUE054420T2 (hu) Folyamatos eljárás terápiás fehérje heterogenitásának csökkentésére
PL3297975T3 (pl) Sposób kompleksowej utylizacji fosfogipsów
IL267622A (en) Method for modifying the therapeutic effects of drugs
HK1258994A1 (zh) 用於疾病治療的方法
IL254883A0 (en) A method for protein purification
HK1247818A1 (zh) 治療疾病的方法
GB201515558D0 (en) Method of sequencing
GB201515557D0 (en) Method of sequencing
HK1245671A1 (zh) 使用白細胞介素-10治療疾病和病症的方法
IL252712A0 (en) Method for protein production
GB201602802D0 (en) Method of treatment
HK1246679A1 (zh) 絲蟲病的治療
HK1243937A1 (zh) 治療疾病的方法
IL253077A0 (en) Process and intermediates for the preparation of Fermpanel
IL249610A (en) Chimeric proteins for cancer treatment
HK1256714A1 (zh) 製備治療性蛋白質的方法
IL256707B (en) A method for the production of recombinant proteins
IL256706B (en) A method for making recombinant proteins
GB201512139D0 (en) Methods of treatment
EP3368158A4 (en) THIRD SPACE PROCESSING METHOD