PT3440062T - Processo para a preparação de compostos de isoxazolina enriquecidos enantiomericamente - solvato de tolueno de (s)-afoxolaner - Google Patents

Processo para a preparação de compostos de isoxazolina enriquecidos enantiomericamente - solvato de tolueno de (s)-afoxolaner

Info

Publication number: PT3440062T
Authority: PT; Portugal
Prior art keywords: afoxolaner; preparation; enantiomerically enriched; isoxazoline compounds; toluene solvate
Prior art date: 2016-04-06

Application number

PT177182862T

Other languages

English (en)

Original Assignee

Boehringer Ingelheim Animal Health Usa Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-04-06

Filing date

2017-04-05

Publication date

2021-12-24

2017-04-05 Application filed by Boehringer Ingelheim Animal Health Usa Inc filed Critical Boehringer Ingelheim Animal Health Usa Inc

2021-12-24 Publication of PT3440062T publication Critical patent/PT3440062T/pt

Links

YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 title 3
OXDDDHGGRFRLEE-QHCPKHFHSA-N esafoxolaner Chemical compound C1([C@]2(ON=C(C2)C2=CC=C(C3=CC=CC=C32)C(=O)NCC(=O)NCC(F)(F)F)C(F)(F)F)=CC(Cl)=CC(C(F)(F)F)=C1 OXDDDHGGRFRLEE-QHCPKHFHSA-N 0.000 title 1
150000002547 isoxazolines Chemical class 0.000 title 1
239000012453 solvate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Environmental Sciences (AREA)
Agronomy & Crop Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Dentistry (AREA)
Engineering & Computer Science (AREA)
Plant Pathology (AREA)
Pest Control & Pesticides (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Chemical Kinetics & Catalysis (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT177182862T 2016-04-06 2017-04-05 Processo para a preparação de compostos de isoxazolina enriquecidos enantiomericamente - solvato de tolueno de (s)-afoxolaner PT3440062T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201662319207P	2016-04-06	2016-04-06

Publications (1)

Publication Number	Publication Date
PT3440062T true PT3440062T (pt)	2021-12-24

Family

ID=58549312

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT177182862T PT3440062T (pt)	2016-04-06	2017-04-05	Processo para a preparação de compostos de isoxazolina enriquecidos enantiomericamente - solvato de tolueno de (s)-afoxolaner

Country Status (31)

Country	Link
US (3)	US10433552B2 (pt)
EP (2)	EP3440062B1 (pt)
KR (2)	KR102403531B1 (pt)
CN (2)	CN114805234A (pt)
AR (1)	AR108184A1 (pt)
AU (2)	AU2017246305B2 (pt)
BR (1)	BR112018070663A2 (pt)
CA (2)	CA3019947A1 (pt)
CL (2)	CL2018002838A1 (pt)
CO (3)	CO2019013841A2 (pt)
CY (1)	CY1124797T1 (pt)
DK (1)	DK3440062T3 (pt)
EA (1)	EA201892245A1 (pt)
ES (1)	ES2903286T3 (pt)
HR (1)	HRP20211979T1 (pt)
HU (1)	HUE056909T2 (pt)
IL (2)	IL262093B (pt)
LT (1)	LT3440062T (pt)
MD (2)	MD4846C1 (pt)
MX (2)	MX2018012184A (pt)
MY (1)	MY189534A (pt)
NZ (1)	NZ747676A (pt)
PL (1)	PL3440062T3 (pt)
PT (1)	PT3440062T (pt)
RS (1)	RS62755B1 (pt)
SG (1)	SG11201808756XA (pt)
SI (1)	SI3440062T1 (pt)
TW (1)	TWI753897B (pt)
UA (1)	UA127309C2 (pt)
UY (1)	UY37196A (pt)
WO (1)	WO2017176948A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY37665A (es)	2017-04-05	2018-10-31	Merial Inc	Formas cristalinas de (s)-afoxolaner
WO2019099669A1 (en)	2017-11-16	2019-05-23	Avista Pharma Solutions, Inc.	Single enantiomer antiparasitic compounds
BR112020012018A2 (pt)	2017-12-15	2020-11-24	Tarsus Pharmaceuticals, Inc.	formulações de parasiticida de isoxazolina e métodos para tratar blefarite
TWI812673B (zh) *	2018-02-12	2023-08-21	美商富曼西公司	用於防治無脊椎害蟲之萘異噁唑啉化合物
EP3873881A1 (en)	2018-10-29	2021-09-08	Basf Se	Process for preparation of optically enriched aldol compounds
WO2021254445A1 (zh) *	2020-06-19	2021-12-23	东莞市东阳光仿制药研发有限公司	一种gaba抑制剂的晶型及其制备方法
CN116194450A (zh)	2020-07-24	2023-05-30	礼蓝美国公司	用于制备异噁唑啉化合物及其中间体的工艺
CN112724095A (zh) *	2020-09-25	2021-04-30	安徽省公众检验研究院有限公司	氟雷拉钠晶型及其制备方法
AU2022300356A1 (en) *	2021-06-25	2023-11-30	In The Bowl Animal Health, Inc.	Oral feline feed and methods for controlling flea infestations in a feline
CA3224701A1 (en)	2021-08-11	2023-02-16	Jingdan Hu	Process for making diaryl isoxazoline derivative
CN115710185B (zh) *	2021-08-23	2024-05-03	中国石油化工股份有限公司	利用金属碳化物催化剂生产甲胺的方法
CN114113388B (zh) *	2021-11-24	2023-05-23	丽珠集团新北江制药股份有限公司	一种4-肟甲基-1-萘甲酸中有关物质的检测方法
CN116903488B (zh) *	2022-11-25	2023-12-15	济南久隆医药科技有限公司	一种阿福拉纳的合成方法
CN115959979A (zh) *	2022-12-29	2023-04-14	南京正荣医药化学有限公司	一种3-氯-4-氟-5-三氟甲基三氟苯乙酮的制备方法
CN116143652B (zh) *	2023-01-13	2024-06-28	四川青木制药有限公司	一种阿福拉纳中间体及其制备方法和应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3060084A (en)	1961-06-09	1962-10-23	Du Pont	Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en)	1964-06-01	1967-01-24	Olin Mathieson	Water soluble film containing agricultural chemicals
US4144050A (en)	1969-02-05	1979-03-13	Hoechst Aktiengesellschaft	Micro granules for pesticides and process for their manufacture
US3920442A (en)	1972-09-18	1975-11-18	Du Pont	Water-dispersible pesticide aggregates
US4172714A (en)	1976-12-20	1979-10-30	E. I. Du Pont De Nemours And Company	Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en)	1981-03-30	1984-10-24	Avon Packers Ltd	Formulation of agricultural chemicals
US5180587A (en)	1988-06-28	1993-01-19	E. I. Du Pont De Nemours And Company	Tablet formulations of pesticides
EP0415688B1 (en)	1989-08-30	1998-12-23	Aeci Ltd	Dosage device and use thereof
BR9106147A (pt)	1990-03-12	1993-03-09	Du Pont	Granulos de pesticidas dispersaveis em agua ou soluveis em agua feitos a partir de ligantes termo-ativados
ES2091878T3 (es)	1990-10-11	1996-11-16	Sumitomo Chemical Co	Composicion plaguicida.
DE4322211A1 (de)	1993-07-03	1995-01-12	Basf Ag	Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung
EA014881B1 (ru)	2004-03-05	2011-02-28	Ниссан Кемикал Индастриз, Лтд.	Производные замещенного алкилбензола
EP1932836B1 (en)	2005-09-02	2013-11-06	Nissan Chemical Industries, Ltd.	Isoxazoline-substituted benzamide compound and harmful organism-controlling agent
EP1965645A2 (en)	2005-12-14	2008-09-10	E.I. Du Pont De Nemours And Company	Isoxazolines for controlling invertebrate pests
TW200803740A (en)	2005-12-16	2008-01-16	Du Pont	5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh)	2005-12-30	2013-10-21	Du Pont	控制無脊椎害蟲之異唑啉
MX2008013307A (es)	2006-04-20	2008-10-27	Du Pont	Pirazolinas para controlar plagas de invertebrados.
JP2008044880A (ja)	2006-08-15	2008-02-28	Bayer Cropscience Ag	殺虫性イソオキサゾリン類
US8466150B2 (en)	2006-12-28	2013-06-18	Abbott Laboratories	Inhibitors of poly(ADP-ribose)polymerase
JP5256753B2 (ja)	2007-03-29	2013-08-07	住友化学株式会社	イソオキサゾリン化合物とその有害生物防除用途
WO2008122375A2 (en)	2007-04-10	2008-10-16	Bayer Cropscience Ag	Insecticidal aryl isoxazoline derivatives
BRPI0809770B8 (pt) *	2007-06-13	2022-12-06	Du Pont	Composto e composição para controlar uma praga de invertebrados
TWI430995B (zh)	2007-06-26	2014-03-21	Du Pont	萘異唑啉無脊椎有害動物控制劑
EP2172462A4 (en)	2007-06-27	2010-12-15	Nissan Chemical Ind Ltd	METHOD FOR PRODUCING A 3-HYDROXYPROPAN-1-ON COMPOUND, METHOD FOR PRODUCING A 2-PROPENE-1-ON COMPOUND, AND METHOD FOR PRODUCING AN ISOXAZOLINE COMPOUND
TWI649303B (zh)	2007-08-17	2019-02-01	杜邦股份有限公司	製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法
TWI556741B (zh)	2007-08-17	2016-11-11	英特威特國際股份有限公司	異唑啉組成物及其作為抗寄生蟲藥上的應用
WO2009045999A1 (en)	2007-10-03	2009-04-09	E. I. Du Pont De Nemours And Company	Naphthalene isoxazoline compounds for control of invertebrate pests
JP5365807B2 (ja)	2007-11-12	2013-12-11	日産化学工業株式会社	光学活性イソキサゾリン化合物の触媒的不斉合成方法
JP2011527307A (ja)	2008-07-09	2011-10-27	ビーエーエスエフソシエタス・ヨーロピア	イソオキサゾリン化合物ｉを含む殺有害生物活性混合物
NZ593135A (en)	2008-12-19	2013-04-26	Novartis Ag	Isoxazoline derivatives and their use as pesticide
TWI487486B (zh)	2009-12-01	2015-06-11	Syngenta Participations Ag	以異唑啉衍生物為主之殺蟲化合物
JP2013520456A (ja) *	2010-02-25	2013-06-06	シンジェンタパーティシペーションズアクチェンゲゼルシャフト	イソオキサゾリン誘導体の製造方法
US20130203591A1 (en)	2010-06-09	2013-08-08	Syngenta Crop Protection Llc	Pesticidal mixtures including isoxazoline derivatives
JP5806743B2 (ja)	2011-03-10	2015-11-10	ゾエティス・エルエルシー	抗寄生虫薬としてのスピロ環式イソオキサゾリン誘導体
JP6075563B2 (ja)	2011-11-08	2017-02-08	日産化学工業株式会社	光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物
EP2809667A1 (en)	2012-02-03	2014-12-10	Zoetis LLC	Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents
EP2922854B1 (en)	2012-11-21	2022-05-04	Zoetis Services LLC	Synthesis of spirocyclic isoxazoline derivatives
WO2014090918A1 (en) *	2012-12-13	2014-06-19	Novartis Ag	Process for the enantiomeric enrichment of diaryloxazoline derivatives
PL2950795T3 (pl) *	2013-01-31	2018-09-28	Merial, Inc.	Sposób leczenia i wyleczenia leiszmaniozy z zastosowaniem feksinidazolu
AR096022A1 (es) *	2013-04-11	2015-12-02	Basf Se	Compuestos de pirimidinio sustituido, útiles para combatir plagas de animales

2017
- 2017-04-05 WO PCT/US2017/026245 patent/WO2017176948A1/en active Application Filing
- 2017-04-05 EA EA201892245A patent/EA201892245A1/ru unknown
- 2017-04-05 CA CA3019947A patent/CA3019947A1/en active Pending
- 2017-04-05 MD MDA20180090A patent/MD4846C1/ro active IP Right Grant
- 2017-04-05 MD MDA20220052A patent/MD20220052A2/ro unknown
- 2017-04-05 CN CN202210256802.3A patent/CN114805234A/zh active Pending
- 2017-04-05 PT PT177182862T patent/PT3440062T/pt unknown
- 2017-04-05 HU HUE17718286A patent/HUE056909T2/hu unknown
- 2017-04-05 KR KR1020187032223A patent/KR102403531B1/ko active IP Right Grant
- 2017-04-05 MY MYPI2018001696A patent/MY189534A/en unknown
- 2017-04-05 BR BR112018070663A patent/BR112018070663A2/pt active IP Right Grant
- 2017-04-05 EP EP17718286.2A patent/EP3440062B1/en active Active
- 2017-04-05 SG SG11201808756XA patent/SG11201808756XA/en unknown
- 2017-04-05 AU AU2017246305A patent/AU2017246305B2/en active Active
- 2017-04-05 HR HRP20211979TT patent/HRP20211979T1/hr unknown
- 2017-04-05 MX MX2018012184A patent/MX2018012184A/es unknown
- 2017-04-05 LT LTEPPCT/US2017/026245T patent/LT3440062T/lt unknown
- 2017-04-05 DK DK17718286.2T patent/DK3440062T3/da active
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2018
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2019
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Also Published As

Publication number	Publication date
TWI753897B (zh)	2022-02-01
TW201739740A (zh)	2017-11-16
AU2017246305B2 (en)	2021-04-29
US10433552B2 (en)	2019-10-08
US20190133129A1 (en)	2019-05-09
KR102403531B1 (ko)	2022-05-27
IL262093A (en)	2018-11-29
MX2018012184A (es)	2019-02-07
KR102438541B1 (ko)	2022-08-30
EA201892245A1 (ru)	2019-07-31
UA127309C2 (uk)	2023-07-19
PL3440062T3 (pl)	2022-02-07
EP3440062B1 (en)	2021-10-06
KR20220003635A (ko)	2022-01-10
ES2903286T3 (es)	2022-03-31
CN114805234A (zh)	2022-07-29
CN109195955B (zh)	2022-10-18
BR112018070663A2 (pt)	2019-02-05
KR20180132834A (ko)	2018-12-12
CN109195955A (zh)	2019-01-11
MD20180090A2 (ro)	2019-02-28
MD4846C1 (ro)	2023-10-31
US10750744B2 (en)	2020-08-25
AU2021203129B2 (en)	2023-03-16
MY189534A (en)	2022-02-16
US11324220B2 (en)	2022-05-10
SI3440062T1 (sl)	2021-12-31
CO2019013500A2 (es)	2020-02-28
WO2017176948A1 (en)	2017-10-12
CA3019947A1 (en)	2017-10-12
US20170311601A1 (en)	2017-11-02
CL2019003235A1 (es)	2020-02-14
CO2018010719A2 (es)	2018-12-28
AU2021203129A1 (en)	2021-06-10
SG11201808756XA (en)	2018-11-29
RS62755B1 (sr)	2022-01-31
IL280679A (en)	2021-03-25
HUE056909T2 (hu)	2022-04-28
AR108184A1 (es)	2018-07-25
HRP20211979T1 (hr)	2022-04-01
EP3978483A1 (en)	2022-04-06
AU2017246305A1 (en)	2018-11-15
CL2018002838A1 (es)	2018-11-30
MX2020013754A (es)	2022-07-25
CA3214922A1 (en)	2017-10-12
UY37196A (es)	2017-10-31
CY1124797T1 (el)	2022-11-25
IL262093B (en)	2021-02-28
DK3440062T3 (da)	2022-01-03
LT3440062T (lt)	2021-12-10
EP3440062A1 (en)	2019-02-13
CO2019013841A2 (es)	2020-04-01
MD4846B1 (ro)	2023-02-28
IL280679B (en)	2021-12-01
MD20220052A2 (ro)	2023-05-31
NZ747676A (en)	2023-05-26
US20210022344A1 (en)	2021-01-28

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