PT3172212T - Inibidores de aldosterona sintase - Google Patents

Inibidores de aldosterona sintase

Info

Publication number
PT3172212T
PT3172212T PT15744459T PT15744459T PT3172212T PT 3172212 T PT3172212 T PT 3172212T PT 15744459 T PT15744459 T PT 15744459T PT 15744459 T PT15744459 T PT 15744459T PT 3172212 T PT3172212 T PT 3172212T
Authority
PT
Portugal
Prior art keywords
synthase inhibitors
aldosterone synthase
aldosterone
inhibitors
synthase
Prior art date
Application number
PT15744459T
Other languages
English (en)
Inventor
Lord John
Mckibben Bryan
Burke Jennifer
Cogan Derek
Richard Marshall Daniel
Yu Maolin
Zhang Yunlong
A Cerny Matthew
Fader Lee
S Frederick Kosea
Surprenant Simon
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PT3172212T publication Critical patent/PT3172212T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
PT15744459T 2014-07-24 2015-07-23 Inibidores de aldosterona sintase PT3172212T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462028556P 2014-07-24 2014-07-24

Publications (1)

Publication Number Publication Date
PT3172212T true PT3172212T (pt) 2018-10-08

Family

ID=53761616

Family Applications (1)

Application Number Title Priority Date Filing Date
PT15744459T PT3172212T (pt) 2014-07-24 2015-07-23 Inibidores de aldosterona sintase

Country Status (34)

Country Link
US (1) US9334285B2 (pt)
EP (1) EP3172212B1 (pt)
JP (1) JP6250862B2 (pt)
KR (1) KR102378648B1 (pt)
CN (1) CN106488921B (pt)
AP (1) AP2016009616A0 (pt)
AR (1) AR101290A1 (pt)
AU (1) AU2015292632B2 (pt)
BR (1) BR112017000584B1 (pt)
CA (1) CA2956118C (pt)
CL (1) CL2017000040A1 (pt)
CO (1) CO2017000443A2 (pt)
CY (1) CY1121063T1 (pt)
DK (1) DK3172212T3 (pt)
EA (1) EA031105B1 (pt)
ES (1) ES2684050T3 (pt)
HR (1) HRP20181441T1 (pt)
HU (1) HUE039981T2 (pt)
IL (1) IL249665B (pt)
LT (1) LT3172212T (pt)
MX (1) MX368093B (pt)
MY (1) MY191352A (pt)
NZ (1) NZ727188A (pt)
PE (1) PE20170294A1 (pt)
PH (1) PH12017500089B1 (pt)
PL (1) PL3172212T3 (pt)
PT (1) PT3172212T (pt)
RS (1) RS57570B1 (pt)
SG (1) SG11201700595RA (pt)
SI (1) SI3172212T1 (pt)
TW (1) TWI600658B (pt)
UA (1) UA118801C2 (pt)
UY (1) UY36228A (pt)
WO (1) WO2016014736A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX369025B (es) * 2014-10-15 2019-10-25 Boehringer Ingelheim Int Inhibidores de aldosterona sintasa.
WO2016089800A1 (en) * 2014-12-02 2016-06-09 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors
US10858342B2 (en) 2016-06-28 2020-12-08 Boehringer Ingelheim International Gmbh Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases
SG10201610038SA (en) * 2016-07-29 2017-12-28 Apple Inc Systems and methods for management of asymmetrical multi-tapped battery packs
US11958818B2 (en) 2019-05-01 2024-04-16 Boehringer Ingelheim International Gmbh (R)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate
WO2023114170A1 (en) 2021-12-14 2023-06-22 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors for treating chronic kidney disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100703068B1 (ko) * 2003-12-30 2007-04-05 에스케이케미칼주식회사 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
CN101410389A (zh) * 2006-03-29 2009-04-15 诺瓦提斯公司 有机化合物
TW200808813A (en) * 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
AR092289A1 (es) * 2011-11-14 2015-04-15 Sunshine Lake Pharma Co Ltd Derivados de aminoquinazolina y sus sales y metodos de uso
US8912341B2 (en) * 2013-01-16 2014-12-16 Northwestern University Enantioselective N-heterocyclic carbene-catalyzed annulation reactions with imidazolidinones

Also Published As

Publication number Publication date
PE20170294A1 (es) 2017-04-12
AR101290A1 (es) 2016-12-07
EA201790253A1 (ru) 2017-07-31
TW201619165A (zh) 2016-06-01
PL3172212T3 (pl) 2018-11-30
DK3172212T3 (en) 2018-08-27
JP2017521466A (ja) 2017-08-03
CN106488921A (zh) 2017-03-08
EA031105B1 (ru) 2018-11-30
AP2016009616A0 (en) 2016-12-31
WO2016014736A1 (en) 2016-01-28
BR112017000584B1 (pt) 2022-07-26
MY191352A (en) 2022-06-18
JP6250862B2 (ja) 2017-12-20
SI3172212T1 (sl) 2018-10-30
LT3172212T (lt) 2018-08-27
US20160024105A1 (en) 2016-01-28
KR20170032459A (ko) 2017-03-22
AU2015292632A1 (en) 2016-12-22
CN106488921B (zh) 2019-03-15
MX2017000929A (es) 2017-05-04
TWI600658B (zh) 2017-10-01
CO2017000443A2 (es) 2017-04-10
HUE039981T2 (hu) 2019-02-28
PH12017500089A1 (en) 2017-05-22
CY1121063T1 (el) 2019-12-11
BR112017000584A2 (pt) 2017-11-07
IL249665A0 (en) 2017-02-28
US9334285B2 (en) 2016-05-10
MX368093B (es) 2019-09-19
UY36228A (es) 2016-01-29
NZ727188A (en) 2020-01-31
CA2956118C (en) 2022-11-15
RS57570B1 (sr) 2018-10-31
SG11201700595RA (en) 2017-02-27
IL249665B (en) 2019-08-29
EP3172212A1 (en) 2017-05-31
KR102378648B1 (ko) 2022-03-28
CA2956118A1 (en) 2016-01-28
PH12017500089B1 (en) 2017-05-22
HRP20181441T1 (hr) 2018-11-02
CL2017000040A1 (es) 2017-07-07
ES2684050T3 (es) 2018-10-01
AU2015292632B2 (en) 2019-11-21
EP3172212B1 (en) 2018-06-13
UA118801C2 (uk) 2019-03-11

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