PT3135301T - Sistema de administração otimizado in vivo com agentes endossomolíticos para conjugados de ácidos nucleicos - Google Patents

Sistema de administração otimizado in vivo com agentes endossomolíticos para conjugados de ácidos nucleicos

Info

Publication number: PT3135301T
Authority: PT; Portugal
Prior art keywords: optimized; nucleic acid; delivery system; vivo delivery; acid conjugates
Prior art date: 2010-06-22

Application number

PT161834510T

Other languages

English (en)

Inventor

Sun Jian-Sheng

Dutreix Marie

Quanz-Schoeffel Maria

Original Assignee

Inst Curie

Centre Nat Rech Scient

Onxeo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-06-22

Filing date

2011-06-21

Publication date

2018-07-16

2011-06-21 Application filed by Inst Curie, Centre Nat Rech Scient, Onxeo filed Critical Inst Curie

2018-07-16 Publication of PT3135301T publication Critical patent/PT3135301T/pt

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Botany (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

PT161834510T 2010-06-22 2011-06-21 Sistema de administração otimizado in vivo com agentes endossomolíticos para conjugados de ácidos nucleicos PT3135301T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP10166936		2010-06-22

Publications (1)

Publication Number	Publication Date
PT3135301T true PT3135301T (pt)	2018-07-16

Family

ID=42727428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT161834510T PT3135301T (pt)	2010-06-22	2011-06-21	Sistema de administração otimizado in vivo com agentes endossomolíticos para conjugados de ácidos nucleicos

Country Status (20)

Country	Link
US (5)	US9205099B2 (pt)
EP (4)	EP3135301B1 (pt)
JP (1)	JP5860874B2 (pt)
CN (2)	CN103025356B (pt)
AU (1)	AU2011269041B2 (pt)
CA (1)	CA2802463C (pt)
CY (1)	CY1120560T1 (pt)
DK (2)	DK3372248T3 (pt)
EA (2)	EA032867B9 (pt)
ES (2)	ES2674412T3 (pt)
HR (1)	HRP20180934T1 (pt)
HU (1)	HUE037926T2 (pt)
IL (2)	IL223467A (pt)
LT (1)	LT3135301T (pt)
PL (1)	PL3135301T3 (pt)
PT (1)	PT3135301T (pt)
RS (1)	RS57439B1 (pt)
SI (1)	SI3135301T1 (pt)
TR (1)	TR201807294T4 (pt)
WO (1)	WO2011161075A1 (pt)

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PL3135301T3 (pl) *	2010-06-22	2018-11-30	Onxeo	Zoptymalizowany system dostarczania in vivo z czynnikami andosomolitycznymi koniugatów kwasów nukleinowych
EP2527440A1 (en) *	2011-05-27	2012-11-28	Institut Curie	Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
CN103550783A (zh) *	2013-04-27	2014-02-05	中国人民解放军军事医学科学院放射与辐射医学研究所	一种核酸类药物靶向递送***及其制备方法
DK3594343T3 (da)	2015-07-23	2021-06-28	Inst Curie	Anvendelse af en kombination af dbait-molekyle og parp-inhibitorer til behandling af kræft
WO2017053995A1 (en) *	2015-09-25	2017-03-30	Ionis Pharmaceuticals, Inc.	Conjugated antisense compounds and their use
KR102441432B1 (ko) *	2016-03-01	2022-09-07	옹쎄오	Ｄｂａｉｔ 분자의 전신 투여에 의한 암 치료법
WO2017186882A1 (en)	2016-04-29	2017-11-02	Onxeo	A method of predicting a response to an anti-tumor treatment by means of signal interfering dna molecules
JP7107503B2 (ja) *	2016-12-01	2022-07-27	国立大学法人埼玉大学	薬物送達系用エンドサイトーシス増強剤
WO2018134310A1 (en)	2017-01-19	2018-07-26	Universiteit Gent	Molecular adjuvants for enhanced cytosolic delivery of active agents
WO2018162439A1 (en)	2017-03-08	2018-09-13	Onxeo	New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
WO2018175445A1 (en) *	2017-03-20	2018-09-27	Northwestern University	Poly(lactic-co-glycolic acid) (plga) spherical nucleic acids
EP3461488A1 (en)	2017-09-27	2019-04-03	Onxeo	Combination of a dbait molecule and a hdac inhibitor for treating cancer
WO2019175132A1 (en)	2018-03-13	2019-09-19	Onxeo	A dbait molecule against acquired resistance in the treatment of cancer
KR20210087949A (ko) *	2018-11-01	2021-07-13	알파 타우 메디컬 리미티드	종양내 알파-방출체 방사선 및 세포내 병원체에 대한 세포질 센서의 활성화
KR20210109564A (ko) *	2018-12-21	2021-09-06	옹쎄오	신규의 컨쥬게이티드 핵산 분자 및 이의 용도
CA3131130A1 (en) *	2019-03-06	2020-09-10	Generation Bio Co.	Non-active lipid nanoparticles with non-viral, capsid free dna
BR112021018168B1 (pt)	2019-03-21	2023-11-28	Onxeo	Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
TW202210633A (zh)	2020-06-05	2022-03-16	法商昂席歐公司	用於治療癌症之dbait分子與kras抑制劑的組合
AR122644A1 (es)	2020-06-19	2022-09-28	Onxeo	Nuevas moléculas de ácido nucleico conjugado y sus usos
WO2023111203A1 (en)	2021-12-16	2023-06-22	Onxeo	New conjugated nucleic acid molecules and their uses

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EP2527440A1 (en) *	2011-05-27	2012-11-28	Institut Curie	Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia

2011
- 2011-06-21 PL PL16183451T patent/PL3135301T3/pl unknown
- 2011-06-21 AU AU2011269041A patent/AU2011269041B2/en active Active
- 2011-06-21 PT PT161834510T patent/PT3135301T/pt unknown
- 2011-06-21 DK DK18167760.0T patent/DK3372248T3/da active
- 2011-06-21 CN CN201180031310.4A patent/CN103025356B/zh active Active
- 2011-06-21 CN CN201510086529.4A patent/CN104788523B/zh active Active
- 2011-06-21 CA CA2802463A patent/CA2802463C/en active Active
- 2011-06-21 LT LTEP16183451.0T patent/LT3135301T/lt unknown
- 2011-06-21 TR TR2018/07294T patent/TR201807294T4/tr unknown
- 2011-06-21 EP EP16183451.0A patent/EP3135301B1/en active Active
- 2011-06-21 ES ES16183451.0T patent/ES2674412T3/es active Active
- 2011-06-21 EA EA201690782A patent/EA032867B9/ru not_active IP Right Cessation
- 2011-06-21 JP JP2013515845A patent/JP5860874B2/ja active Active
- 2011-06-21 DK DK16183451.0T patent/DK3135301T3/en active
- 2011-06-21 HU HUE16183451A patent/HUE037926T2/hu unknown
- 2011-06-21 RS RS20180764A patent/RS57439B1/sr unknown
- 2011-06-21 EP EP18167760.0A patent/EP3372248B1/en active Active
- 2011-06-21 SI SI201131507T patent/SI3135301T1/en unknown
- 2011-06-21 US US13/703,965 patent/US9205099B2/en not_active Expired - Fee Related
- 2011-06-21 EP EP11727679.0A patent/EP2585113A1/en not_active Withdrawn
- 2011-06-21 EA EA201300039A patent/EA023927B1/ru not_active IP Right Cessation
- 2011-06-21 WO PCT/EP2011/060280 patent/WO2011161075A1/en active Application Filing
- 2011-06-21 ES ES18167760T patent/ES2784793T3/es active Active
- 2011-06-21 EP EP20158381.2A patent/EP3689381A1/en active Pending
2012
- 2012-12-06 IL IL223467A patent/IL223467A/en active IP Right Grant
2015
- 2015-10-27 US US14/923,482 patent/US9428538B2/en active Active
2016
- 2016-08-10 US US15/232,844 patent/US9687557B2/en active Active
2017
- 2017-05-11 IL IL252241A patent/IL252241A0/en unknown
- 2017-06-26 US US15/632,951 patent/US10363317B2/en active Active
2018
- 2018-06-15 HR HRP20180934TT patent/HRP20180934T1/hr unknown
- 2018-06-27 CY CY20181100665T patent/CY1120560T1/el unknown
2019
- 2019-07-01 US US16/458,214 patent/US10765758B2/en active Active

Also Published As

Publication number	Publication date
US9205099B2 (en)	2015-12-08
AU2011269041B2 (en)	2015-05-07
US20190314511A1 (en)	2019-10-17
DK3135301T3 (en)	2018-06-25
CA2802463C (en)	2019-02-26
IL223467A (en)	2017-09-28
ES2784793T3 (es)	2020-09-30
CN103025356A (zh)	2013-04-03
US10765758B2 (en)	2020-09-08
EP3689381A1 (en)	2020-08-05
IL252241A0 (en)	2017-08-31
EP3135301A1 (en)	2017-03-01
EA032867B9 (ru)	2020-01-22
AU2011269041A2 (en)	2013-07-11
CA2802463A1 (en)	2011-12-29
SI3135301T1 (en)	2018-08-31
JP2013534521A (ja)	2013-09-05
DK3372248T3 (da)	2020-04-06
LT3135301T (lt)	2018-07-10
US9428538B2 (en)	2016-08-30
EA023927B1 (ru)	2016-07-29
HUE037926T2 (hu)	2018-09-28
CY1120560T1 (el)	2019-07-10
EA032867B1 (ru)	2019-07-31
RS57439B1 (sr)	2018-09-28
CN104788523A (zh)	2015-07-22
US20130131155A1 (en)	2013-05-23
CN103025356B (zh)	2015-02-18
JP5860874B2 (ja)	2016-02-16
HRP20180934T1 (hr)	2018-10-05
CN104788523B (zh)	2017-09-08
AU2011269041A1 (en)	2013-01-31
EA201690782A1 (ru)	2016-08-31
EP2585113A1 (en)	2013-05-01
EP3372248A1 (en)	2018-09-12
EP3135301B1 (en)	2018-05-02
EP3372248B1 (en)	2020-03-11
US20170298089A1 (en)	2017-10-19
US10363317B2 (en)	2019-07-30
US20160046662A1 (en)	2016-02-18
WO2011161075A1 (en)	2011-12-29
TR201807294T4 (tr)	2018-06-21
EA201300039A1 (ru)	2013-05-30
PL3135301T3 (pl)	2018-11-30
ES2674412T3 (es)	2018-06-29
US9687557B2 (en)	2017-06-27
US20160339107A1 (en)	2016-11-24

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