PT3057934T - Ésteres halogenados de ácidos gordos insaturados ciclopropanados para uso no tratamento de doenças neurodegenerativas - Google Patents

Ésteres halogenados de ácidos gordos insaturados ciclopropanados para uso no tratamento de doenças neurodegenerativas

Info

Publication number
PT3057934T
PT3057934T PT14793391T PT14793391T PT3057934T PT 3057934 T PT3057934 T PT 3057934T PT 14793391 T PT14793391 T PT 14793391T PT 14793391 T PT14793391 T PT 14793391T PT 3057934 T PT3057934 T PT 3057934T
Authority
PT
Portugal
Prior art keywords
cyclopropanated
treatment
fatty acids
unsaturated fatty
neurodegenerative diseases
Prior art date
Application number
PT14793391T
Other languages
English (en)
Inventor
J Nelson Thomas
L Alkon Daniel
Original Assignee
Blanchette Rockefeller Neurosciences Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blanchette Rockefeller Neurosciences Inst filed Critical Blanchette Rockefeller Neurosciences Inst
Publication of PT3057934T publication Critical patent/PT3057934T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62Halogen-containing esters
    • C07C69/63Halogen-containing esters of saturated acids
    • C07C69/635Halogen-containing esters of saturated acids containing rings in the acid moiety
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT14793391T 2013-10-18 2014-10-20 Ésteres halogenados de ácidos gordos insaturados ciclopropanados para uso no tratamento de doenças neurodegenerativas PT3057934T (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361892727P 2013-10-18 2013-10-18
US201361896735P 2013-10-29 2013-10-29
US201461925449P 2014-01-09 2014-01-09
US201461925441P 2014-01-09 2014-01-09

Publications (1)

Publication Number Publication Date
PT3057934T true PT3057934T (pt) 2019-06-28

Family

ID=51846995

Family Applications (1)

Application Number Title Priority Date Filing Date
PT14793391T PT3057934T (pt) 2013-10-18 2014-10-20 Ésteres halogenados de ácidos gordos insaturados ciclopropanados para uso no tratamento de doenças neurodegenerativas

Country Status (9)

Country Link
US (3) US9962357B2 (pt)
EP (3) EP3567025B8 (pt)
JP (1) JP2016535012A (pt)
CA (1) CA2927675A1 (pt)
DK (1) DK3057934T3 (pt)
ES (2) ES2927760T3 (pt)
PL (1) PL3057934T3 (pt)
PT (1) PT3057934T (pt)
WO (1) WO2015058191A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180311209A1 (en) 2015-10-08 2018-11-01 Cognitive Research Enterprises, Inc. Dosing regimens of pkc activators

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY118354A (en) * 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
JPH10139735A (ja) * 1996-09-13 1998-05-26 Sumitomo Chem Co Ltd エステル化合物、それを有効成分とする有害生物防除剤およびその製造中間体
WO2001062740A1 (en) * 2000-02-25 2001-08-30 South Alabama Medical Science Foundation Mibefradil analogues and their use
WO2004050062A2 (en) 2002-12-03 2004-06-17 Blanchette Rockefeller Neurosciences Institute Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier
US7521447B2 (en) * 2003-03-03 2009-04-21 Array Biopharma Inc. P38 inhibitors and methods of use thereof
DE10351087A1 (de) * 2003-10-31 2005-05-25 Bayer Technology Services Gmbh Feste Wirkstoff-Formulierung
CN101223884B (zh) * 2007-01-15 2011-07-13 大日本除虫菊株式会社 杀虫防虫剂或害虫的摄食阻碍剂
US8163800B2 (en) 2008-07-28 2012-04-24 Blanchette Rockefeller Neurosciences Institute PKC-activating compounds for the treatment of neurodegenerative diseases
CN101608402B (zh) * 2009-07-14 2011-07-27 东华大学 植物油改性含氟拒水整理剂、制备方法及其应用
JP5934102B2 (ja) * 2009-10-30 2016-06-15 レトロトップ、 インコーポレイテッドRetrotope, Inc. Pufa誘導体による酸化ストレス障害の緩和
EP2693876B1 (en) * 2011-04-08 2020-01-15 Sphaera Pharma Pte. Ltd Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
US20120294924A1 (en) * 2011-04-29 2012-11-22 Thomas Tice Peptide-Lipid Conjugates And Uses Thereof
EP2780316B1 (en) 2011-11-13 2020-04-15 Blanchette Rockefeller Neurosciences Institute Esters of dcpla and methods of treatment using the same

Also Published As

Publication number Publication date
EP4101835A1 (en) 2022-12-14
US20180325856A1 (en) 2018-11-15
EP3057934B1 (en) 2019-03-27
WO2015058191A1 (en) 2015-04-23
ES2732153T3 (es) 2019-11-20
US20160256427A1 (en) 2016-09-08
PL3057934T3 (pl) 2019-09-30
EP3057934A1 (en) 2016-08-24
ES2927760T3 (es) 2022-11-10
EP3567025B8 (en) 2023-01-25
US9962357B2 (en) 2018-05-08
US20220151973A1 (en) 2022-05-19
DK3057934T3 (da) 2019-07-01
US20190192471A1 (en) 2019-06-27
ES2927760T8 (es) 2023-05-05
EP3567025A1 (en) 2019-11-13
EP3567025B1 (en) 2022-08-03
CA2927675A1 (en) 2015-04-23
US11273139B2 (en) 2022-03-15
JP2016535012A (ja) 2016-11-10

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