PT2794611T - Pirazolo[1,5-a]pirimidinas como agentes antivirais - Google Patents
Pirazolo[1,5-a]pirimidinas como agentes antiviraisInfo
- Publication number
- PT2794611T PT2794611T PT128140928T PT12814092T PT2794611T PT 2794611 T PT2794611 T PT 2794611T PT 128140928 T PT128140928 T PT 128140928T PT 12814092 T PT12814092 T PT 12814092T PT 2794611 T PT2794611 T PT 2794611T
- Authority
- PT
- Portugal
- Prior art keywords
- pyrazolo
- pyrimidines
- antiviral agents
- antiviral
- agents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579625P | 2011-12-22 | 2011-12-22 | |
| US201261618510P | 2012-03-30 | 2012-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2794611T true PT2794611T (pt) | 2017-12-06 |
Family
ID=47557523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT128140928T PT2794611T (pt) | 2011-12-22 | 2012-12-20 | Pirazolo[1,5-a]pirimidinas como agentes antivirais |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8946238B2 (pt) |
| EP (1) | EP2794611B1 (pt) |
| JP (2) | JP6122868B2 (pt) |
| AU (1) | AU2012358805B2 (pt) |
| CA (1) | CA2858096C (pt) |
| ES (1) | ES2647486T3 (pt) |
| PT (1) | PT2794611T (pt) |
| WO (1) | WO2013096681A1 (pt) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011270798B2 (en) | 2010-06-24 | 2015-03-19 | Gilead Sciences, Inc. | Pyrazolo [1, 5 -a] pyrimidines as antiviral agents |
| ES2647486T3 (es) | 2011-12-22 | 2017-12-21 | Gilead Sciences, Inc. | Pirazolo[1,5-a]pirimidinas como agentes antivirales |
| PT2838900T (pt) | 2012-04-17 | 2019-11-15 | Gilead Sciences Inc | Compostos e métodos para tratamento antiviral |
| CN114716426A (zh) | 2013-08-21 | 2022-07-08 | 詹森生物制药有限公司 | 抗病毒化合物 |
| JP2017523988A (ja) * | 2014-08-05 | 2017-08-24 | アリオス バイオファーマ インク． | パラミクソウイルスを治療するための併用療法 |
| JP2017537118A (ja) | 2014-12-08 | 2017-12-14 | ヤンセン・サイエンシズ・アイルランド・ユーシー | Ｒｓウイルス（ｒｓｖ）複製の阻害活性を有するピペリジン置換ピラゾロ［１，５−ａ］ピリミジン誘導体 |
| AU2015359562B2 (en) * | 2014-12-08 | 2020-01-16 | Janssen Sciences Ireland Uc | Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV) |
| CA2972259A1 (en) | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| JP2018076234A (ja) * | 2015-03-16 | 2018-05-17 | 大正製薬株式会社 | ピラゾロ［１，５−ａ］ピリミジン化合物 |
| US9957281B2 (en) | 2015-07-22 | 2018-05-01 | Enanta Pharmaceuticals, Inc. | Benzodiazepine derivatives as RSV inhibitors |
| US20170226129A1 (en) | 2016-01-15 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| EP3454862A4 (en) | 2016-05-10 | 2020-02-12 | C4 Therapeutics, Inc. | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| CN109153682B (zh) * | 2016-05-20 | 2021-05-25 | 豪夫迈·罗氏有限公司 | 用于治疗感染性疾病的具有氧、硫和氮连接基的新的吡嗪化合物 |
| NZ752894A (en) | 2016-10-06 | 2023-05-26 | Orbus Therapeutics Inc | Formulations for administration of eflornithine |
| EP3582784B1 (en) | 2017-02-16 | 2022-06-08 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| EP3684767B1 (en) | 2017-09-22 | 2024-04-24 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| JP7198811B2 (ja) | 2017-09-29 | 2023-01-04 | エナンタ ファーマシューティカルズ インコーポレイテッド | Ｒｓｖ阻害剤としての組み合わせ医薬剤 |
| CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
| WO2019087214A1 (en) | 2017-11-06 | 2019-05-09 | Jubilant Biosys Limited | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| IL274534B (en) | 2017-11-13 | 2022-07-01 | Enanta Pharm Inc | Processes for the separation of 2-one benzodiazepines and 2-one benzodiazepine derivatives |
| CN111542523B (zh) | 2017-11-24 | 2024-03-29 | 朱比连特埃皮斯科瑞有限责任公司 | 作为prmt5抑制剂的杂环化合物 |
| RU2020116571A (ru) | 2017-12-07 | 2021-11-22 | Эмори Юниверсити | N4-гидроксицитидин и производные и связанные с этим противовирусные применения |
| CA3087926A1 (en) | 2018-01-31 | 2019-08-08 | Janssen Sciences Ireland Unlimited Company | Cycloalkyl substituted pyrazolopyrimidines having activity against rsv |
| AU2019234185A1 (en) | 2018-03-13 | 2020-10-01 | Jubilant Prodel LLC. | Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation |
| CN112004815A (zh) | 2018-04-23 | 2020-11-27 | 爱尔兰詹森科学公司 | 具有针对rsv的活性的杂芳香族化合物 |
| MX2021006138A (es) * | 2018-11-26 | 2021-06-23 | Janssen Sciences Ireland Unlimited Co | Otros compuestos heteroaromaticos que tienen actividad contra el vrs. |
| WO2020138015A1 (ja) | 2018-12-27 | 2020-07-02 | 大正製薬株式会社 | ピラゾロ［１，５－ａ］ピリミジン大環状化合物 |
| KR20210138684A (ko) | 2019-03-18 | 2021-11-19 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 억제제로서의 벤조디아제핀 유도체 |
| CN114761016A (zh) | 2019-10-04 | 2022-07-15 | 英安塔制药有限公司 | 抗病毒杂环化合物 |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| AU2022227674A1 (en) | 2021-02-26 | 2023-09-21 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| CN117730079A (zh) * | 2021-06-25 | 2024-03-19 | 亚博思生物科技(第一)有限公司 | 作为rsv感染症的治疗及/或预防用医药的经杂环烷基取代的聚杂唑衍生物 |
| CN117658980A (zh) * | 2022-09-08 | 2024-03-08 | 郑州同源康医药有限公司 | 双环类prmt5抑制剂 |
| CN115710200A (zh) * | 2022-11-21 | 2023-02-24 | 重庆医科大学 | 苯甲酰氟类化合物、苯甲酸类化合物及其制备方法 |
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| US6342501B1 (en) | 1994-02-25 | 2002-01-29 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d] pyrimidines as antiviral agents |
| US5543413A (en) * | 1994-02-25 | 1996-08-06 | Regents Of The University Of Michigan | Heterocyclic thioamides and related analogs as antiviral agents with a unique mode of action |
| CZ382496A3 (en) | 1994-06-29 | 1997-12-17 | Smithkline Beecham Corp | Compounds representing antagonists of vitronectin receptors, process of their preparation, intermediates of such process, pharmaceutical composition containing the compounds and their use |
| ATE245641T1 (de) | 1998-02-17 | 2003-08-15 | Tularik Inc | Antivirale pyrimidinderivate |
| TWI225488B (en) | 1999-12-21 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivatives of homopiperidinyl substituted benzimidazole analogues |
| AU2003220190A1 (en) | 2002-03-13 | 2003-09-29 | Pharmacia & Upjohn Company Llc | Pyrazolo(1,5-a)pyridine derivatives as neurotransmitter modulators |
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| DE10247271A1 (de) | 2002-10-10 | 2004-08-26 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-a]pyridin-3-yle |
| RU2422444C2 (ru) | 2003-12-24 | 2011-06-27 | Байота Сайентифик Менеджмент Пти Лтд | Полициклические средства для лечения респираторно-синцитиальных вирусных инфекций |
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| JP2011513273A (ja) | 2008-02-26 | 2011-04-28 | ノバルティス アーゲー | Ｃｘｃｒ２の阻害剤としての複素環系化合物 |
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| KR101483834B1 (ko) * | 2009-12-23 | 2015-01-16 | 카트호리이케 유니버시타이트 로이펜 | 항바이러스 화합물 |
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| AU2011270798B2 (en) | 2010-06-24 | 2015-03-19 | Gilead Sciences, Inc. | Pyrazolo [1, 5 -a] pyrimidines as antiviral agents |
| KR101821680B1 (ko) | 2010-07-22 | 2018-01-24 | 길리애드 사이언시즈, 인코포레이티드 | 파라믹소비리대 바이러스 감염을 치료하기 위한 방법 및 화합물 |
| ES2647486T3 (es) | 2011-12-22 | 2017-12-21 | Gilead Sciences, Inc. | Pirazolo[1,5-a]pirimidinas como agentes antivirales |
| PT2838900T (pt) | 2012-04-17 | 2019-11-15 | Gilead Sciences Inc | Compostos e métodos para tratamento antiviral |
-
2012
- 2012-12-20 ES ES12814092.8T patent/ES2647486T3/es active Active
- 2012-12-20 AU AU2012358805A patent/AU2012358805B2/en active Active
- 2012-12-20 PT PT128140928T patent/PT2794611T/pt unknown
- 2012-12-20 EP EP12814092.8A patent/EP2794611B1/en active Active
- 2012-12-20 JP JP2014548913A patent/JP6122868B2/ja active Active
- 2012-12-20 US US13/722,962 patent/US8946238B2/en active Active
- 2012-12-20 CA CA2858096A patent/CA2858096C/en active Active
- 2012-12-20 WO PCT/US2012/071065 patent/WO2013096681A1/en active Application Filing
-
2014
- 2014-12-10 US US14/566,340 patent/US9278975B2/en active Active
-
2016
- 2016-01-19 US US15/000,821 patent/US20160235748A1/en not_active Abandoned
- 2016-11-18 JP JP2016224719A patent/JP2017036336A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20150166546A1 (en) | 2015-06-18 |
| US20160235748A1 (en) | 2016-08-18 |
| JP2015506348A (ja) | 2015-03-02 |
| JP6122868B2 (ja) | 2017-04-26 |
| ES2647486T3 (es) | 2017-12-21 |
| CA2858096C (en) | 2020-06-23 |
| CA2858096A1 (en) | 2013-06-27 |
| AU2012358805A1 (en) | 2014-06-19 |
| NZ625737A (en) | 2016-04-29 |
| JP2017036336A (ja) | 2017-02-16 |
| WO2013096681A1 (en) | 2013-06-27 |
| EP2794611B1 (en) | 2017-10-11 |
| AU2012358805B2 (en) | 2017-07-20 |
| US20130164280A1 (en) | 2013-06-27 |
| AU2012358805A8 (en) | 2014-06-26 |
| EP2794611A1 (en) | 2014-10-29 |
| US8946238B2 (en) | 2015-02-03 |
| US9278975B2 (en) | 2016-03-08 |
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