PT2513058T - Métodos de síntese de inibidores do fator xa - Google Patents

Métodos de síntese de inibidores do fator xa

Info

Publication number
PT2513058T
PT2513058T PT108014952T PT10801495T PT2513058T PT 2513058 T PT2513058 T PT 2513058T PT 108014952 T PT108014952 T PT 108014952T PT 10801495 T PT10801495 T PT 10801495T PT 2513058 T PT2513058 T PT 2513058T
Authority
PT
Portugal
Prior art keywords
inhibitors
methods
synthesizing factor
synthesizing
factor
Prior art date
Application number
PT108014952T
Other languages
English (en)
Inventor
Pandey Anjali
P T Leitao Emilia
Rato Jose
Jake Song Zhiguo
Original Assignee
Millennium Pharm Inc
Portola Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Portola Pharm Inc filed Critical Millennium Pharm Inc
Publication of PT2513058T publication Critical patent/PT2513058T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
PT108014952T 2009-12-17 2010-12-15 Métodos de síntese de inibidores do fator xa PT2513058T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28768009P 2009-12-17 2009-12-17

Publications (1)

Publication Number Publication Date
PT2513058T true PT2513058T (pt) 2017-01-26

Family

ID=43532100

Family Applications (1)

Application Number Title Priority Date Filing Date
PT108014952T PT2513058T (pt) 2009-12-17 2010-12-15 Métodos de síntese de inibidores do fator xa

Country Status (10)

Country Link
US (2) US8394964B2 (pt)
EP (1) EP2513058B1 (pt)
JP (2) JP5766204B2 (pt)
CN (2) CN104774176A (pt)
AR (1) AR079491A1 (pt)
CA (1) CA2784904C (pt)
ES (1) ES2610145T3 (pt)
PT (1) PT2513058T (pt)
TW (1) TW201144283A (pt)
WO (1) WO2011084519A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101595092B (zh) * 2006-11-02 2012-02-01 米伦纽姆医药公司 合成因子xa抑制剂的医药盐的方法
CN104774176A (zh) * 2009-12-17 2015-07-15 米伦纽姆医药公司 合成Xa因子抑制剂的方法
AR082804A1 (es) * 2010-09-01 2013-01-09 Portola Pharm Inc Formas cristalinas de un inhibidor del factor xa
WO2013033370A1 (en) * 2011-08-31 2013-03-07 Portola Pharmaceuticals, Inc. Prevention and treatment of thrombosis in medically ill patients
US9200268B2 (en) 2012-12-27 2015-12-01 Portola Pharmaceuticals, Inc. Compounds and methods for purification of serine proteases
US20140346397A1 (en) 2012-12-27 2014-11-27 Portola Pharmaceuticals, Inc. Compounds and methods for purification of serine proteases
CN104341343B (zh) * 2013-07-24 2018-09-28 四川海思科制药有限公司 贝曲西班的晶型及其制备方法和用途
CN105017078B (zh) * 2014-04-23 2017-02-15 中国科学院大连化学物理研究所 一种芳香醛催化转化制备亚胺酸酯的方法
CN105085387A (zh) * 2014-05-20 2015-11-25 四川海思科制药有限公司 贝曲西班盐及其制备方法和用途
TW201708197A (zh) * 2015-06-23 2017-03-01 科思創德意志股份有限公司 新穎之經取代三及其製造方法
WO2017091757A1 (en) 2015-11-24 2017-06-01 Portola Pharmaceuticals, Inc. Isotopically enriched betrixaban
CN106995405A (zh) * 2016-01-25 2017-08-01 重庆医药工业研究院有限责任公司 一种贝曲西班马来酸盐无定型物及其制备方法
CN107098853A (zh) * 2016-02-20 2017-08-29 天津科伦药物研究有限公司 贝曲西班马来酸盐的制备方法
CN105732490A (zh) * 2016-03-25 2016-07-06 重庆医科大学 一种贝曲西班的制备方法
US20190300483A1 (en) * 2016-06-02 2019-10-03 Dr. Reddy's Laboratories Limited POLYMORPHS OF BETRlXABAN & ITS MALEATE SALT
EP3254674A1 (en) 2016-06-08 2017-12-13 Sandoz Ag Pharmaceutical compositions of betrixaban maleate
WO2018042320A1 (en) * 2016-08-30 2018-03-08 Dr. Reddy’S Laboratories Limited Salts of betrixaban and processes for preparation thereof
CN107778223B (zh) * 2016-08-31 2020-05-15 鲁南制药集团股份有限公司 一种马来酸贝曲西班的制备方法
KR102031186B1 (ko) * 2017-01-11 2019-11-08 주식회사 엘지생활건강 단백질 강도 강화용 조성물
CN107868039A (zh) * 2017-11-27 2018-04-03 中国药科大学 一种贝曲沙班中间体n－（5－氯－2－吡啶基）－2－［（4－氰基苯甲酰基）氨基］－5－甲氧基苯甲酰胺的制备方法
EP3830097A1 (en) * 2018-07-27 2021-06-09 UMICORE AG & Co. KG Organometallic compounds for the manufacture of a semiconductor element or electronic memory

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2324153A1 (en) * 1998-03-19 1999-09-23 Ajinomoto Co., Inc. Aminoisoquinoline derivatives
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
US7122557B2 (en) * 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
DE602004024910D1 (de) 2003-10-09 2010-02-11 Millennium Pharm Inc Thioethersubstituierte benzamide als inhibitoren von faktor xa
US7696352B2 (en) 2004-06-18 2010-04-13 Millennium Pharmaceuticals, Inc. Factor Xa inhibitors
EP1893572B1 (en) 2004-06-18 2016-12-14 Millennium Pharmaceuticals, Inc. Factor xa inhibitors
EP1948608B1 (en) 2005-11-08 2012-03-14 Millennium Pharmaceuticals, Inc. Pharmaceutical salts and polymorphs of n-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-benzamide , a factor xa inhibitor
TW200813017A (en) 2006-05-05 2008-03-16 Millennium Pharm Inc Factor XA inhibitors
CN101595092B (zh) 2006-11-02 2012-02-01 米伦纽姆医药公司 合成因子xa抑制剂的医药盐的方法
CA2913963A1 (en) 2006-12-08 2008-06-19 Millenium Pharmaceuticals, Inc. Unit dose formulations and methods of treating thrombosis with an oral factor xa inhibitor
EP2114930A2 (en) 2007-01-05 2009-11-11 Millennium Pharmaceuticals, Inc. Factor xa inhibitors
EP2591783A1 (en) 2007-04-13 2013-05-15 Millennium Pharmaceuticals, Inc. Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor
CN104774176A (zh) 2009-12-17 2015-07-15 米伦纽姆医药公司 合成Xa因子抑制剂的方法
EP2513094B1 (en) 2009-12-17 2015-12-16 Millennium Pharmaceuticals, Inc. Crystalline salts of a factor xa inhibitor
US20110160250A1 (en) 2009-12-17 2011-06-30 Millennium Pharmaceuticals, Inc. Crystalline forms of a factor xa inhibitor
WO2011075602A1 (en) 2009-12-17 2011-06-23 Millennium Pharmaceuticals, Inc. Methods of preparing factor xa inhibitors and salts thereof

Also Published As

Publication number Publication date
JP2013514380A (ja) 2013-04-25
CN104774176A (zh) 2015-07-15
JP2015091840A (ja) 2015-05-14
US8987463B2 (en) 2015-03-24
US8394964B2 (en) 2013-03-12
CA2784904A1 (en) 2011-07-14
TW201144283A (en) 2011-12-16
US20110319627A1 (en) 2011-12-29
CN102762538B (zh) 2015-11-25
CA2784904C (en) 2017-10-10
ES2610145T3 (es) 2017-04-26
AR079491A1 (es) 2012-02-01
WO2011084519A1 (en) 2011-07-14
JP5766204B2 (ja) 2015-08-19
CN102762538A (zh) 2012-10-31
EP2513058B1 (en) 2016-11-09
US20130211094A1 (en) 2013-08-15
EP2513058A1 (en) 2012-10-24

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