PT2379600E - Anticorpos contra inibidor da via de fator tecidual - Google Patents

Anticorpos contra inibidor da via de fator tecidual Download PDF

Info

Publication number
PT2379600E
PT2379600E PT97935431T PT09793543T PT2379600E PT 2379600 E PT2379600 E PT 2379600E PT 97935431 T PT97935431 T PT 97935431T PT 09793543 T PT09793543 T PT 09793543T PT 2379600 E PT2379600 E PT 2379600E
Authority
PT
Portugal
Prior art keywords
antibodies against
tissue factor
pathway inhibitor
against tissue
factor pathway
Prior art date
Application number
PT97935431T
Other languages
English (en)
Inventor
Ida Hilden
Berit Olsen Krogh
Jes Thorn Clausen
Ole Hvilsted Olsen
Brian Lauritzen
Brit Binow Sørensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40639722&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2379600(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of PT2379600E publication Critical patent/PT2379600E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
PT97935431T 2008-12-22 2009-12-18 Anticorpos contra inibidor da via de fator tecidual PT2379600E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08172520 2008-12-22

Publications (1)

Publication Number Publication Date
PT2379600E true PT2379600E (pt) 2014-04-29

Family

ID=40639722

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97935431T PT2379600E (pt) 2008-12-22 2009-12-18 Anticorpos contra inibidor da via de fator tecidual

Country Status (19)

Country Link
US (5) US8361469B2 (pt)
EP (3) EP2746294A3 (pt)
JP (2) JP5714505B2 (pt)
KR (2) KR101600308B1 (pt)
CN (1) CN102325795B (pt)
AU (1) AU2009331570C1 (pt)
BR (1) BRPI0924058B1 (pt)
CA (1) CA2745317C (pt)
DK (1) DK2379600T4 (pt)
ES (1) ES2458665T5 (pt)
FR (1) FR24C1008I1 (pt)
IL (1) IL213356A (pt)
MX (1) MX2011006501A (pt)
PL (1) PL2379600T5 (pt)
PT (1) PT2379600E (pt)
RU (1) RU2562114C2 (pt)
TW (1) TWI476003B (pt)
WO (1) WO2010072691A1 (pt)
ZA (1) ZA201104599B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010000721A1 (en) 2008-06-30 2010-01-07 Novo Nordisk A/S Anti-human interleukin-20 antibodies
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
MX2011006501A (es) 2008-12-22 2011-07-12 Novo Nordisk As Anticuerpos contra inhibidor de la via de factor de tejido.
US8454956B2 (en) 2009-08-31 2013-06-04 National Cheng Kung University Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies
MX2012009755A (es) * 2010-02-26 2012-09-12 Novo Nordisk As Composiciones que contienen anticuerpo estable.
SG10201502587SA (en) 2010-03-01 2015-06-29 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
US20130136733A1 (en) * 2010-05-28 2013-05-30 Novo Nordisk A/S Stable Multi-Dose Compositions Comprising an Antibody and a Preservative
US9228022B2 (en) 2010-06-30 2016-01-05 Novo Nordisk A/S Antibodies that are capable of specifically binding tissue factor pathway inhibitor
CN103080135B (zh) * 2010-06-30 2017-06-13 诺沃—诺迪斯克有限公司 能够特异性结合组织因子途径抑制剂的抗体
AU2012236296A1 (en) * 2011-04-01 2013-10-24 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (TFPI)
US9221904B2 (en) 2012-07-19 2015-12-29 National Cheng Kung University Treatment of osteoarthritis using IL-20 antagonists
US8603470B1 (en) 2012-08-07 2013-12-10 National Cheng Kung University Use of IL-20 antagonists for treating liver diseases
US8852588B2 (en) 2012-08-07 2014-10-07 National Cheng Kung University Treating allergic airway disorders using anti-IL-20 receptor antibodies
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
PL2970497T3 (pl) 2013-03-15 2018-05-30 Bayer Healthcare Llc Warianty przeciwciał anty-TFPI z różnicowym wiązaniem w zakresie pH dla poprawy farmakokinetyki
EP2970498A4 (en) * 2013-03-15 2016-11-23 Bayer Healthcare Llc PRODUCT ANTIBODIES DIRECTED AGAINST THE INHIBITOR OF THE PATHWAY OF TISSUE FACTOR
CN105209497B (zh) * 2013-03-15 2021-09-07 诺和诺德股份有限公司 能够特异性结合组织因子途径抑制物上的两个表位的抗体
US10457743B2 (en) 2013-07-19 2019-10-29 Novo Nordisk A/S Antibodies recognizing the N-terminal part of tissue factor pathway inhibitor capable of eliciting pro-coagulant activity
CN106659909B (zh) 2013-08-21 2022-01-11 德克萨斯州大学***董事会 用于靶向连接蛋白半通道的组合物和方法
RS59480B1 (sr) * 2013-12-12 2019-12-31 Shanghai hengrui pharmaceutical co ltd Pd-1 antitelo, njegov fragment koji se vezuje na antigen, i njegova medicinska primena
EP3137502B1 (en) * 2014-04-27 2020-07-29 FameWave Ltd. Humanized antibodies against ceacam1
US11279771B2 (en) 2014-09-17 2022-03-22 Novo Nordisk A/S Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161)
CN112225812A (zh) * 2015-02-25 2021-01-15 财团法人牧岩生命科学研究所 结合tfpi的新型抗体以及包含所述抗体的组合物
PE20240142A1 (es) * 2015-08-19 2024-02-01 Pfizer Anticuerpos inhibidores via del factor tisular y usos de los mismos
AU2017224122B2 (en) 2016-02-26 2024-04-11 The Board Of Regents Of The University Of Texas System Connexin (Cx) 43 hemichannel-binding antibodies and uses thereof
AR110755A1 (es) * 2017-01-20 2019-05-02 Genzyme Corp Anticuerpos dirigidos a hueso
JP7094722B2 (ja) * 2018-02-28 2022-07-04 キヤノン株式会社 画像読取装置及び画像形成装置
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
EP3863664A1 (en) * 2018-10-11 2021-08-18 Pfizer Inc. Dosage regimen for tfpi antagonists
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体
WO2021094917A1 (en) * 2019-11-13 2021-05-20 Pfizer Inc. Stable aqueous anti-tfpi antibody formulation
CN117487017A (zh) * 2020-07-02 2024-02-02 北京拓界生物医药科技有限公司 抗FXI/FXIa抗体、其抗原结合片段及医药用途
US20230357432A1 (en) 2020-09-24 2023-11-09 Novo Nordisk Health A/S Pharmaceutical formulation of concizumab and method of production thereof
WO2023143559A1 (en) * 2022-01-30 2023-08-03 Westlake University Tfpi binding polypeptides and uses thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
DK261490D0 (da) 1990-10-31 1990-10-31 Novo Nordisk As New pharmaceutical compound
EP0539975A1 (en) † 1991-10-31 1993-05-05 Teijin Limited Method for immunological assay of free lipoprotein-associated coagulation inhibitor (LACI) and kit therefor
JPH06153985A (ja) * 1992-11-16 1994-06-03 Teijin Ltd モノクローナル抗体
JPH06153981A (ja) 1992-11-30 1994-06-03 Teijin Ltd Ｌａｃｉの免疫学的測定方法、それに用いるキット並びにモノクローナル抗体
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US5589359A (en) 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
JPH0875736A (ja) 1994-09-06 1996-03-22 Chemo Sero Therapeut Res Inst ヒト組織因子凝固系インヒビターの定量法
US5902582A (en) * 1995-09-05 1999-05-11 Chiron Corporation Use of TFPI inhibitor for treatment of cancer
JP3681206B2 (ja) 1995-12-26 2005-08-10 株式会社三菱化学ヤトロン 抗ファクターＸａ・ティシュファクターパスウェイインヒビター複合体モノクローナル抗体及びその使用
AU7266898A (en) 1997-04-30 1998-11-24 Enzon, Inc. Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
US6656467B2 (en) * 2000-01-27 2003-12-02 Medimmune, Inc. Ultra high affinity neutralizing antibodies
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
JP2007534631A (ja) 2003-10-28 2007-11-29 ノボ　ノルディスク　アクティーゼルスカブ ラミニン−５γ２結合性ペプチド、その関連組成物およびその使用
US7585842B2 (en) 2004-04-16 2009-09-08 The Reagents Of The University Of California Human kunitz-type inhibitor with enhanced antifibrinolytic activity
US7015746B1 (en) * 2004-05-06 2006-03-21 National Semiconductor Corporation Bootstrapped bias mixer with soft start POR
EP1869082B1 (en) † 2005-03-04 2011-04-13 The Board Of Trustees Of The University Of Illinois Coagulation and fibrinolytic cascades modulator
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
SI2379096T1 (sl) * 2008-12-19 2020-03-31 Baxalta GmbH Zaviralci TFPI in postopki uporabe
JP5791512B2 (ja) * 2008-12-22 2015-10-07 ノヴォ ノルディスク アー／エス 組織因子経路阻害因子（ｔｆｐｉ）に対する抗体
MX2011006501A (es) * 2008-12-22 2011-07-12 Novo Nordisk As Anticuerpos contra inhibidor de la via de factor de tejido.
US8965454B2 (en) 2009-03-04 2015-02-24 Andrew Llc Amplifier system for cell sites and other suitable applications
US8598327B2 (en) 2009-08-18 2013-12-03 Baxter International Inc. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
CA2770762A1 (en) 2009-08-18 2011-02-24 Baxter International Inc. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
SG10201502587SA (en) * 2010-03-01 2015-06-29 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
US8598008B2 (en) † 2010-10-20 2013-12-03 Texas Instruments Incorporated Stacked ESD clamp with reduced variation in clamp voltage
AU2012214148A1 (en) † 2011-02-11 2013-08-29 Baxter Healthcare S.A. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
AU2012236296A1 (en) † 2011-04-01 2013-10-24 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (TFPI)
US20130267584A1 (en) † 2012-03-22 2013-10-10 Baxter Healthcare S.A. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
CN105209497B (zh) 2013-03-15 2021-09-07 诺和诺德股份有限公司 能够特异性结合组织因子途径抑制物上的两个表位的抗体
CN112225812A (zh) † 2015-02-25 2021-01-15 财团法人牧岩生命科学研究所 结合tfpi的新型抗体以及包含所述抗体的组合物
PE20240142A1 (es) † 2015-08-19 2024-02-01 Pfizer Anticuerpos inhibidores via del factor tisular y usos de los mismos

Also Published As

Publication number Publication date
EP2746294A2 (en) 2014-06-25
PL2379600T3 (pl) 2014-07-31
TWI476003B (zh) 2015-03-11
KR20160031028A (ko) 2016-03-21
CA2745317A1 (en) 2010-07-01
DK2379600T3 (da) 2014-04-28
CA2745317C (en) 2019-03-05
IL213356A0 (en) 2011-07-31
WO2010072691A1 (en) 2010-07-01
ZA201104599B (en) 2012-03-28
CN102325795B (zh) 2015-03-25
FR24C1008I1 (fr) 2024-04-19
US20110318356A1 (en) 2011-12-29
US8652471B2 (en) 2014-02-18
US8361469B2 (en) 2013-01-29
DK2379600T4 (da) 2021-01-04
EP2379600B2 (en) 2020-10-14
ES2458665T5 (es) 2021-06-30
JP2015178495A (ja) 2015-10-08
EP2379600B1 (en) 2014-01-22
AU2009331570B2 (en) 2013-10-17
PL2379600T5 (pl) 2021-03-08
US20130251721A1 (en) 2013-09-26
US9574011B2 (en) 2017-02-21
BRPI0924058B1 (pt) 2021-08-17
CN102325795A (zh) 2012-01-18
RU2562114C2 (ru) 2015-09-10
JP5714505B2 (ja) 2015-05-07
AU2009331570A1 (en) 2011-06-30
EP2379600A1 (en) 2011-10-26
KR20110103432A (ko) 2011-09-20
IL213356A (en) 2017-06-29
JP6114326B2 (ja) 2017-04-12
EP2746294A3 (en) 2015-01-07
MX2011006501A (es) 2011-07-12
EP3260466A1 (en) 2017-12-27
US20190211112A1 (en) 2019-07-11
AU2009331570C1 (en) 2024-04-18
ES2458665T3 (es) 2014-05-06
US20130251722A1 (en) 2013-09-26
TW201026330A (en) 2010-07-16
KR101600308B1 (ko) 2016-03-07
RU2011129068A (ru) 2013-01-27
JP2012513377A (ja) 2012-06-14
KR101745394B1 (ko) 2017-06-09
BRPI0924058A2 (pt) 2019-10-15
US20170114147A1 (en) 2017-04-27

Similar Documents

Publication Publication Date Title
IL282658A (en) Monoclonal antibodies against tissue factor pathway inhibitor (TFPI)
ZA201104599B (en) Antibodies against tissue factor pathway inhibitor
HK1176601A1 (zh) 抑制劑
EP2272817A4 (en) INHIBITOR OF PAI-1
EP2207803A4 (en) CD9-SPECIFIC HUMAN ANTIBODIES
ZA201100898B (en) Novel inhibitors
EP2344533A4 (en) SPECIFIC HUMAN ANTIBODY OF TMPRSS4
ZA201102837B (en) Phosphodiestarase inhibitors
EP2222662A4 (en) INHIBITORS OF KYNURENINE AMINO TRANSFERASE
EP2177529A4 (en) NEW DE-SECRETASE INHIBITOR
GB0820117D0 (en) Tourniquet
GB0714941D0 (en) Inhibitors
HRP20190159T1 (hr) Antitijela humanog anti-alfa-sinukleina
GB201019387D0 (en) Inhibitors
GB0809820D0 (en) Modified tissues
GB0713152D0 (en) Phosphodlesterase inhibitors
GB0816125D0 (en) Novel inhibitors
GB0720364D0 (en) Inhibitor
GB0804978D0 (en) Reflection
GB0707497D0 (en) Novel inhibitors
GB0707495D0 (en) Novel inhibitors
GB0707493D0 (en) Novel inhibitors
GB0707488D0 (en) Novel inhibitors
GB0704589D0 (en) Novel inhibitors
GB0707498D0 (en) Novel inhibitors