PT2351555T - Dispositivo para a administração transdérmica de opióides resistente ao abuso - Google Patents
Dispositivo para a administração transdérmica de opióides resistente ao abusoInfo
- Publication number
- PT2351555T PT2351555T PT100109222T PT10010922T PT2351555T PT 2351555 T PT2351555 T PT 2351555T PT 100109222 T PT100109222 T PT 100109222T PT 10010922 T PT10010922 T PT 10010922T PT 2351555 T PT2351555 T PT 2351555T
- Authority
- PT
- Portugal
- Prior art keywords
- transdermal delivery
- delivery device
- abuse resistance
- opioid transdermal
- resistance opioid
- Prior art date
Links
- 230000037317 transdermal delivery Effects 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000003402 opiate agonist Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
- B09B3/0075—Disposal of medical waste
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B2101/00—Type of solid waste
- B09B2101/65—Medical waste
- B09B2101/68—Transdermal patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Environmental & Geological Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54719604P | 2004-02-23 | 2004-02-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2351555T true PT2351555T (pt) | 2016-11-29 |
Family
ID=34910866
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT05713575T PT1718258E (pt) | 2004-02-23 | 2005-02-15 | Dispositivo de administração transdérmica de opióides com resistência ao abuso |
PT90041914T PT2074989E (pt) | 2004-02-23 | 2005-02-15 | Dispositivo de administração transdérmica de opióides com resistência ao abuso |
PT100109222T PT2351555T (pt) | 2004-02-23 | 2005-02-15 | Dispositivo para a administração transdérmica de opióides resistente ao abuso |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT05713575T PT1718258E (pt) | 2004-02-23 | 2005-02-15 | Dispositivo de administração transdérmica de opióides com resistência ao abuso |
PT90041914T PT2074989E (pt) | 2004-02-23 | 2005-02-15 | Dispositivo de administração transdérmica de opióides com resistência ao abuso |
Country Status (27)
Country | Link |
---|---|
US (2) | US20080233178A1 (pt) |
EP (3) | EP2074989B1 (pt) |
JP (2) | JP2007523167A (pt) |
KR (1) | KR100789227B1 (pt) |
CN (1) | CN1921814B (pt) |
AT (1) | ATE426399T1 (pt) |
AU (2) | AU2005216053B2 (pt) |
BR (1) | BRPI0507210A (pt) |
CA (1) | CA2556624C (pt) |
CY (3) | CY1109155T1 (pt) |
DE (1) | DE602005013490D1 (pt) |
DK (3) | DK1718258T3 (pt) |
ES (3) | ES2609688T3 (pt) |
HK (1) | HK1097177A1 (pt) |
HR (3) | HRP20090363T1 (pt) |
HU (1) | HUE030128T2 (pt) |
IL (1) | IL177452A (pt) |
LT (1) | LT2351555T (pt) |
ME (2) | ME01116B (pt) |
NO (1) | NO338647B1 (pt) |
NZ (1) | NZ549576A (pt) |
PL (3) | PL2351555T3 (pt) |
PT (3) | PT1718258E (pt) |
RS (3) | RS55297B1 (pt) |
SI (3) | SI2351555T1 (pt) |
WO (1) | WO2005081825A2 (pt) |
ZA (1) | ZA200606251B (pt) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
CA2557354C (en) * | 2004-03-03 | 2013-05-07 | Vital Health Sciences Pty Ltd. | Alkaloid formulations |
DE102004019916A1 (de) * | 2004-04-21 | 2005-11-17 | Grünenthal GmbH | Gegen Missbrauch gesichertes wirkstoffhaltiges Pflaster |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
EP2269650A3 (en) * | 2004-08-03 | 2012-05-16 | Vital Health Sciences Pty Ltd. | Carrier for enteral administration |
US7780981B2 (en) | 2004-09-13 | 2010-08-24 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US20090239827A1 (en) * | 2005-03-03 | 2009-09-24 | Esra Ogru | Compounds having lipid lowering properties |
NZ565049A (en) | 2005-06-17 | 2012-02-24 | Vital Health Sciences Pty Ltd | A carrier comprising one or more DI and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
WO2007070632A2 (en) * | 2005-12-13 | 2007-06-21 | Biodelivery Sciences International, Inc. | Abuse resistant transmucosal drug delivery device |
KR20140079441A (ko) * | 2006-06-19 | 2014-06-26 | 알파마 파머슈티컬스 엘엘씨 | 약제학적 조성물 |
NZ594545A (en) | 2006-07-21 | 2012-12-21 | Biodelivery Sciences Int Inc | Transmucosal delivery devices with enhanced uptake containing fentanyl or buprenorphine |
EP2073797A2 (en) * | 2006-10-11 | 2009-07-01 | Alpharma, Inc. | Pharmaceutical compositions |
DE102007021549A1 (de) * | 2007-05-08 | 2008-11-13 | Novosis Ag | Transdermales therapeutisches System enthaltend mindestens zwei Opioide |
CN101909651B (zh) * | 2007-11-22 | 2013-11-06 | 美德阿利克斯株式会社 | 包括基于脂肪酸的离子型液体作为活性成分的外用制剂组合物 |
WO2009092601A1 (en) | 2008-01-25 | 2009-07-30 | Grünenthal GmbH | Pharmaceutical dosage form |
CA2719605C (en) * | 2008-03-25 | 2016-07-12 | Teikoku Seiyaku Co., Ltd. | Transdermally absorbable preparation |
MX2010010512A (es) * | 2008-03-26 | 2010-11-09 | Alltranz Inc | Formulaciones transdermicas de agonistas y antagonistas-agonistas de opiato que impiden el abuso. |
WO2009139213A1 (ja) * | 2008-05-15 | 2009-11-19 | 日本臓器製薬株式会社 | プロクロルペラジン含有外用医薬組成物 |
EP2299990A1 (de) * | 2008-06-09 | 2011-03-30 | Boehringer Ingelheim International GmbH | Neue einbettungspartikel für die inhalation |
US20110200643A1 (en) * | 2008-06-09 | 2011-08-18 | Boehringer Ingelheim International Gmbh | Emulsions for producing medicinal products |
RU2567723C2 (ru) | 2009-07-22 | 2015-11-10 | Грюненталь Гмбх | Стабильная при окислении, прочная на излом лекарственная форма |
BR112012001547A2 (pt) | 2009-07-22 | 2016-03-08 | Gruenenthal Gmbh | forma de dosagem farmacêutica extrusada por fusão a quente |
EP2531047A4 (en) | 2010-02-05 | 2014-03-19 | Phosphagenics Ltd | CARRIER WITH AN UNINUTRALIZED TOCOPHERYL PHOSPHATE |
CA2794042A1 (en) * | 2010-03-23 | 2011-09-29 | Bioalliance Pharma | Fast dissolving drug delivery systems |
EP2552486B1 (en) | 2010-03-30 | 2020-08-12 | Phosphagenics Limited | Transdermal delivery patch |
WO2011120070A1 (en) * | 2010-03-30 | 2011-10-06 | Phosphagenics Limited | Transdermal delivery patch |
WO2011123866A1 (en) * | 2010-04-02 | 2011-10-06 | Alltranz Inc. | Abuse-deterrent transdermal formulations of opiate agonists and agonist-antagonists |
JP5686986B2 (ja) * | 2010-04-07 | 2015-03-18 | 久光製薬株式会社 | 経皮投与製剤 |
RU2604676C2 (ru) | 2010-09-02 | 2016-12-10 | Грюненталь Гмбх | Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль |
CA2815898C (en) | 2010-11-17 | 2018-12-18 | Hexal Ag | Transdermal therapeutic system comprising buprenorphine |
KR101424163B1 (ko) | 2010-12-24 | 2014-08-01 | 주식회사 삼양바이오팜 | 수난용성 약물 함유 서방성 마이크로입자 및 그 제조방법 |
US9561243B2 (en) | 2011-03-15 | 2017-02-07 | Phosphagenics Limited | Composition comprising non-neutralised tocol phosphate and a vitamin A compound |
EP2729148A4 (en) | 2011-07-06 | 2015-04-22 | Parkinson S Inst | COMPOSITIONS AND METHODS FOR TREATING SYMPTOMS IN PATIENTS WITH PARKINSON'S DISEASE |
CA2839123A1 (en) | 2011-07-29 | 2013-02-07 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
DK2736497T3 (da) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Stød-resistent tablet, der tilvejebringer en øjeblikkelig frigivelse af et lægemiddel. |
EA033256B1 (ru) | 2011-08-18 | 2019-09-30 | Байоделивери Сайенсиз Интернэшнл, Инк. | Не вызывающие зависимость двухслойные устройства для трансмукозальной доставки бупренорфина |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
ES2885523T3 (es) | 2011-11-23 | 2021-12-14 | Therapeuticsmd Inc | Formulaciones y terapias de reposición hormonal de combinación naturales |
TW201336529A (zh) * | 2011-12-09 | 2013-09-16 | Purdue Pharma Lp | 包含聚(ε-己內酯)和聚氧化乙烯之藥物劑量型 |
US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
US20130225697A1 (en) | 2012-02-28 | 2013-08-29 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
WO2013156453A1 (en) | 2012-04-18 | 2013-10-24 | Grünenthal GmbH | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
AR096438A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso |
CA2907950A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper-resistant dosage form containing one or more particles |
AU2014289187B2 (en) * | 2013-07-12 | 2019-07-11 | Grunenthal Gmbh | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
GB2521334B (en) * | 2013-08-21 | 2018-06-20 | Univ Swansea | Topical drug patch including microspheres |
MX371372B (es) | 2013-11-26 | 2020-01-28 | Gruenenthal Gmbh | Preparacion de una composicion farmaceutica en polvo por medio de criomolienda. |
KR102226652B1 (ko) | 2014-01-22 | 2021-03-12 | 4피 테라퓨틱스 | 남용 및 오용 저지 경피 시스템 |
EP3142646A1 (en) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
JP2017516789A (ja) | 2014-05-26 | 2017-06-22 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | エタノール過量放出に対して防護されている多粒子 |
US10238648B2 (en) | 2014-07-18 | 2019-03-26 | Buzzz Pharmaceuticals Ltd. | Abuse deterrent opioid/opioid-antagonist transdermal patch |
US10010543B1 (en) | 2014-12-23 | 2018-07-03 | Barr Laboratories, Inc. | Transdermal dosage form |
CA2974324A1 (en) | 2015-01-28 | 2016-08-04 | Zita S. Netzel | Drug delivery methods and systems |
JP2018511127A (ja) | 2015-03-12 | 2018-04-19 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | 渇望入力及び支援システム |
KR20170139158A (ko) | 2015-04-24 | 2017-12-18 | 그뤼넨탈 게엠베하 | 즉시 방출되고 용매 추출 방지된 변조 방지된 투여 형태 |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
CA2998259A1 (en) | 2015-09-10 | 2017-03-16 | Grunenthal Gmbh | Protecting oral overdose with abuse deterrent immediate release formulations |
CA2999509A1 (en) | 2015-09-24 | 2017-03-30 | Pain Therapeutics, Inc. | Crystalline salts of naloxone and naltrexone |
US11096936B2 (en) | 2015-09-24 | 2021-08-24 | Cassava Sciences, Inc. | Cocrystals of naloxone and naltrexone |
GB201520390D0 (en) * | 2015-11-19 | 2016-01-06 | Euro Celtique Sa | Composition |
JP6882321B2 (ja) | 2015-12-09 | 2021-06-02 | フォスファージニクス リミテッド | 医薬製剤 |
JP7003053B2 (ja) | 2016-03-28 | 2022-01-20 | コーメディクス・インコーポレーテッド | 野外殺菌装置及び血管コネクタキット |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
US20190231707A1 (en) * | 2016-09-28 | 2019-08-01 | Chrono Therapeutics Inc. | Transdermal drug delivery device for delivering opioids |
AU2017381395A1 (en) | 2016-12-21 | 2019-06-20 | Phosphagenics Limited | Process |
JP6865235B2 (ja) * | 2016-12-28 | 2021-04-28 | 久光製薬株式会社 | ブトルファノール含有貼付剤 |
WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
WO2019090125A2 (en) * | 2017-11-02 | 2019-05-09 | Chrono Therapeutics Inc. | Smart abuse-deterrent transdermal drug delivery system |
US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
MX2021004027A (es) * | 2018-10-15 | 2021-08-11 | Chong Kun Dang Pharmaceutical Corp | Composiciones de microparticulas inyectables de naltrexona de accion prolongada. |
GR1009871B (el) * | 2019-07-30 | 2020-11-12 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα που περιλαμβανει μικροσφαιριδια ναλτρεξονης και μεθοδος παρασκευης αυτου |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3405070A (en) | 1961-01-30 | 1968-10-08 | Ibm | Process for preparation of microcapsules |
NL282895A (pt) | 1961-09-05 | |||
US3270100A (en) | 1962-08-01 | 1966-08-30 | Delvan Mfg Company | Method for making capsules by interfacial polymerization |
US3396117A (en) | 1965-09-07 | 1968-08-06 | Amp Inc | Encapsulation technique |
US3341466A (en) | 1966-10-31 | 1967-09-12 | Brynko Carl | Process for making capsules |
US3567650A (en) | 1969-02-14 | 1971-03-02 | Ncr Co | Method of making microscopic capsules |
US3875074A (en) | 1972-03-06 | 1975-04-01 | Champion Int Corp | Formation of microcapsules by interfacial cross-linking of emulsifier, and microcapsules produced thereby |
US3966940A (en) * | 1973-11-09 | 1976-06-29 | Bristol-Myers Company | Analgetic compositions |
US4145184A (en) | 1975-11-28 | 1979-03-20 | The Procter & Gamble Company | Detergent composition containing encapsulated perfume |
US4277364A (en) | 1975-12-22 | 1981-07-07 | The United States Of America As Represented By The Secretary Of Agriculture | Encapsulation by entrapment |
US4391909A (en) | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
US4457933A (en) * | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
FR2519985A1 (fr) * | 1982-01-15 | 1983-07-22 | Ugine Kuhlmann | Procede perfectionne de fabrication de l'e-caprolactone |
US4438253A (en) | 1982-11-12 | 1984-03-20 | American Cyanamid Company | Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4588580B2 (en) | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
US4626539A (en) | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
US4806341A (en) | 1985-02-25 | 1989-02-21 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration |
US5955109A (en) * | 1985-12-18 | 1999-09-21 | Advanced Polymer Systems, Inc. | Methods and compositions for topical delivery of retinoic acid |
US4780320A (en) * | 1986-04-29 | 1988-10-25 | Pharmetrix Corp. | Controlled release drug delivery system for the periodontal pocket |
JP2670680B2 (ja) * | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
US5236714A (en) * | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
US5026556A (en) | 1988-11-10 | 1991-06-25 | Norwich Eaton Pharmaceuticals, Inc. | Compositions for the transdermal delivery of pharmaceutical actives |
US5240711A (en) | 1989-11-29 | 1993-08-31 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Transdermal therapeutic system comprising as active component buprenorphine |
CA2062828C (en) | 1990-04-24 | 1996-04-16 | Osafumi Hidaka | Pharmaceutical plasters |
US5069909A (en) | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Kabivitrum Ab | Morphine prodrugs |
US5149538A (en) * | 1991-06-14 | 1992-09-22 | Warner-Lambert Company | Misuse-resistive transdermal opioid dosage form |
US5288502A (en) * | 1991-10-16 | 1994-02-22 | The University Of Texas System | Preparation and uses of multi-phase microspheres |
DE4446600A1 (de) | 1994-12-24 | 1996-06-27 | Lohmann Therapie Syst Lts | Transdermale Resorption von Wirkstoffen aus unterkühlten Schmelzen |
US5665428A (en) | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
KR0162872B1 (ko) * | 1996-04-01 | 1998-12-01 | 김은영 | 용매추출법을 이용한 생분해성 고분자 미립구의 개선된 제조방법 및 이를 이용한 국소염증 질환 치료용 미립구의 제조방법 |
US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
US5919473A (en) * | 1997-05-12 | 1999-07-06 | Elkhoury; George F. | Methods and devices for delivering opioid analgesics to wounds via a subdermal implant |
US7011843B2 (en) * | 1997-10-01 | 2006-03-14 | Lts Lohmann-Therapie Systeme Ag | Method for protecting a human being against health impairment by ingestion of a transdermal therapeutic system |
CA2314893C (en) * | 1997-12-22 | 2005-09-13 | Euro-Celtique, S.A. | Opioid agonist/antagonist combinations |
US6287693B1 (en) | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
US6306425B1 (en) * | 1999-04-09 | 2001-10-23 | Southern Research Institute | Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol |
US6716449B2 (en) * | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
EP1299104B1 (en) * | 2000-02-08 | 2009-05-13 | Euro-Celtique S.A. | Tamper-resistant oral opioid agonist formulations |
EP2316439B1 (en) * | 2001-05-01 | 2015-06-17 | Euro-Celtique S.A. | Abuse resistant opioid containing transdermal systems |
US7125561B2 (en) * | 2001-05-22 | 2006-10-24 | Euro-Celtique S.A. | Compartmentalized dosage form |
US7332182B2 (en) * | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
US6913760B2 (en) * | 2001-08-06 | 2005-07-05 | New England Medical Hospitals, Inc. | Drug delivery composition |
JP2005526839A (ja) * | 2002-04-23 | 2005-09-08 | アルザ・コーポレーシヨン | 不正使用の可能性が低い経皮鎮痛薬システム |
EA007240B1 (ru) * | 2002-06-10 | 2006-08-25 | Еуро-Селтик С. А. | Системы дезактивации активного вещества в трансдермальном средстве |
AU2003283055A1 (en) * | 2002-08-09 | 2004-02-25 | Grunenthal Gmbh | Opioid-receptor antagonists in transdermal systems having buprenorphine |
US20040126323A1 (en) * | 2002-08-20 | 2004-07-01 | Ihor Shevchuk | Transdermal dosage form comprising an active agent and a salt and free-base form of an adverse agent |
US7524515B2 (en) * | 2003-01-10 | 2009-04-28 | Mutual Pharmaceuticals, Inc. | Pharmaceutical safety dosage forms |
US20040191301A1 (en) * | 2003-03-27 | 2004-09-30 | Van Duren Albert Philip | Transdermal device having a phase change material |
ME00276B (me) * | 2003-04-30 | 2011-05-10 | Purdue Pharma Lp | Transdermalni dozni oblik otporan na promjene koje sadrže komponentu aktivnog sredstva i komponentu suprotnog sredstva na mjestu koji je ispod sloja aktivnog sredstva |
US8790689B2 (en) * | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
-
2005
- 2005-02-15 PT PT05713575T patent/PT1718258E/pt unknown
- 2005-02-15 PL PL10010922T patent/PL2351555T3/pl unknown
- 2005-02-15 DK DK05713575T patent/DK1718258T3/da active
- 2005-02-15 DE DE602005013490T patent/DE602005013490D1/de active Active
- 2005-02-15 US US10/584,816 patent/US20080233178A1/en not_active Abandoned
- 2005-02-15 WO PCT/US2005/004741 patent/WO2005081825A2/en active Application Filing
- 2005-02-15 RS RS20161033A patent/RS55297B1/sr unknown
- 2005-02-15 NZ NZ549576A patent/NZ549576A/en unknown
- 2005-02-15 RS RSP-2009/0286A patent/RS50963B/sr unknown
- 2005-02-15 DK DK09004191.4T patent/DK2074989T3/da active
- 2005-02-15 CA CA2556624A patent/CA2556624C/en active Active
- 2005-02-15 LT LTEP10010922.2T patent/LT2351555T/lt unknown
- 2005-02-15 RS RS20140048A patent/RS53159B/en unknown
- 2005-02-15 PL PL05713575T patent/PL1718258T3/pl unknown
- 2005-02-15 DK DK10010922.2T patent/DK2351555T3/en active
- 2005-02-15 BR BRPI0507210-7A patent/BRPI0507210A/pt not_active Application Discontinuation
- 2005-02-15 EP EP09004191.4A patent/EP2074989B1/en not_active Revoked
- 2005-02-15 SI SI200532122A patent/SI2351555T1/sl unknown
- 2005-02-15 ME MEP-2009-234A patent/ME01116B/me unknown
- 2005-02-15 PT PT90041914T patent/PT2074989E/pt unknown
- 2005-02-15 AU AU2005216053A patent/AU2005216053B2/en active Active
- 2005-02-15 ES ES10010922.2T patent/ES2609688T3/es active Active
- 2005-02-15 ME MEP-2016-276A patent/ME02661B/me unknown
- 2005-02-15 EP EP05713575A patent/EP1718258B1/en active Active
- 2005-02-15 CN CN2005800057047A patent/CN1921814B/zh active Active
- 2005-02-15 SI SI200531823T patent/SI2074989T1/sl unknown
- 2005-02-15 AT AT05713575T patent/ATE426399T1/de active
- 2005-02-15 ES ES05713575T patent/ES2324719T3/es active Active
- 2005-02-15 EP EP10010922.2A patent/EP2351555B1/en active Active
- 2005-02-15 ES ES09004191.4T patent/ES2447547T3/es active Active
- 2005-02-15 PT PT100109222T patent/PT2351555T/pt unknown
- 2005-02-15 KR KR1020067019553A patent/KR100789227B1/ko active IP Right Grant
- 2005-02-15 JP JP2006554163A patent/JP2007523167A/ja active Pending
- 2005-02-15 HU HUE10010922A patent/HUE030128T2/en unknown
- 2005-02-15 SI SI200530703T patent/SI1718258T1/sl unknown
- 2005-02-15 PL PL09004191T patent/PL2074989T3/pl unknown
-
2006
- 2006-07-28 ZA ZA200606251A patent/ZA200606251B/en unknown
- 2006-08-10 IL IL177452A patent/IL177452A/en active IP Right Grant
- 2006-09-21 NO NO20064272A patent/NO338647B1/no unknown
-
2007
- 2007-04-23 HK HK07104247.6A patent/HK1097177A1/xx unknown
-
2009
- 2009-06-18 CY CY20091100639T patent/CY1109155T1/el unknown
- 2009-06-24 HR HR20090363T patent/HRP20090363T1/hr unknown
- 2009-07-02 AU AU2009202684A patent/AU2009202684B2/en active Active
-
2011
- 2011-06-24 JP JP2011140151A patent/JP2011225594A/ja active Pending
-
2014
- 2014-01-23 HR HRP20140076TT patent/HRP20140076T1/hr unknown
- 2014-02-05 CY CY20141100095T patent/CY1115057T1/el unknown
-
2016
- 2016-12-05 HR HRP20161643TT patent/HRP20161643T1/hr unknown
- 2016-12-19 US US15/383,465 patent/US20170157114A1/en not_active Abandoned
- 2016-12-28 CY CY20161101353T patent/CY1118392T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL177452A0 (en) | Abuse resistance opioid transdermal delivery device | |
IL174894A0 (en) | Transdermal drug delivery device | |
EP1737357A4 (en) | DEVICE FOR TRANSDERING | |
EP1807033A4 (en) | DEVICE FOR THE TRANSDERMAL ADMINISTRATION OF MEDICAMENTS, INCLUDING A PROTECTION SECURITY | |
EP1768583A4 (en) | ELECTROSTIMULATION AND MEDICAL DISTRIBUTION DEVICE | |
PL3437682T3 (pl) | Urządzenie do podawania leków | |
EP1781355A4 (en) | DEVICE FOR DELIVERY OF DRUGS | |
EP1790375A4 (en) | TRANSDERMAL MEDICINE ADMINISTRATION WITH MICRONADEL | |
AU2003265226A8 (en) | Transdermal drug delivery device, method and use | |
EP1680057A4 (en) | DEVICE AND METHOD FOR IMPROVING TRANSDERMAL DRUG DELIVERY | |
GB0313604D0 (en) | Delivery device for powdered medicament | |
EG24359A (en) | x-ray visible drug delivery device | |
AU2003230034A8 (en) | Transdermal delivery device for the administration of fentanyl | |
IL164189A0 (en) | Ionized drug delivery device | |
GB0229836D0 (en) | Transdermal delivery device for the administration of fentanyl | |
GB0405364D0 (en) | Disposable drug delivery device | |
GB2418367B (en) | Device for generating an alarm in an apparatus for the metering of volatile anaesthetic |