PT2134371E - Conjugados agonistas de opióide-oligómero - Google Patents
Conjugados agonistas de opióide-oligómero Download PDFInfo
- Publication number
- PT2134371E PT2134371E PT87420824T PT08742082T PT2134371E PT 2134371 E PT2134371 E PT 2134371E PT 87420824 T PT87420824 T PT 87420824T PT 08742082 T PT08742082 T PT 08742082T PT 2134371 E PT2134371 E PT 2134371E
- Authority
- PT
- Portugal
- Prior art keywords
- oligomer
- opioid agonist
- agonist conjugates
- conjugates
- opioid
- Prior art date
Links
- 0 *C(CC[C@]1(*)C23c4c(*)c(*)ccc4CC1N(*)CC2)[C@]3(*)C#C Chemical compound *C(CC[C@]1(*)C23c4c(*)c(*)ccc4CC1N(*)CC2)[C@]3(*)C#C 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Polyethers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90638707P | 2007-03-12 | 2007-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2134371E true PT2134371E (pt) | 2015-04-16 |
Family
ID=39590911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87420824T PT2134371E (pt) | 2007-03-12 | 2008-03-12 | Conjugados agonistas de opióide-oligómero |
Country Status (18)
| Country | Link |
|---|---|
| EP (4) | EP2134371B1 (pt) |
| JP (2) | JP5420427B2 (pt) |
| KR (1) | KR101568428B1 (pt) |
| CN (1) | CN101646464B (pt) |
| AU (1) | AU2008226822B2 (pt) |
| CA (1) | CA2679479C (pt) |
| CY (1) | CY1117368T1 (pt) |
| DK (1) | DK2134371T3 (pt) |
| ES (1) | ES2534741T3 (pt) |
| HR (1) | HRP20150315T1 (pt) |
| IL (1) | IL200845A (pt) |
| ME (1) | ME02176B (pt) |
| MX (1) | MX2009009851A (pt) |
| PL (1) | PL2134371T3 (pt) |
| PT (1) | PT2134371E (pt) |
| RS (1) | RS53937B1 (pt) |
| SI (1) | SI2134371T1 (pt) |
| WO (1) | WO2008112288A2 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| CA2734333A1 (en) * | 2008-09-16 | 2010-03-25 | Nektar Therapeutics | Pegylated opioids with low potential for abuse |
| AU2010276244B2 (en) * | 2009-07-21 | 2015-08-13 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| CN105503889B (zh) * | 2009-07-21 | 2019-12-24 | 尼克塔治疗公司 | 低聚物-阿片样激动剂轭合物 |
| WO2011088140A1 (en) * | 2010-01-12 | 2011-07-21 | Nektar Therapeutics | Pegylated opioids with low potential for abuse and side effects |
| BR112012024655A2 (pt) * | 2010-03-30 | 2018-05-15 | Spago Imaging Ab | derivado de polietilenoglicol ramificado, composição, método para produção de derivados de peg ramificado, uso de um derivado de peg ramificado e dispositivo médico ou dispositivo protético ou parafuso ou dispositivo através do qual fluídos corporais circulam e retornam para o corpo, ou implante ou implante de eletrodo com um revestimento de superfície |
| BR112013013379B1 (pt) | 2010-11-30 | 2021-02-23 | Blackberry Limited | método em um dispositivo de telecomunicações celulares sem fio alojado em uma célula servidora, dispositivo de telecomunicações celulares sem fio e mídia de armazenamento legível por computador |
| US10525054B2 (en) | 2011-11-07 | 2020-01-07 | Inheris Biopharma, Inc. | Compositions, dosage forms, and co-administration of an opioid agonist compound and an analgesic compound |
| MX348933B (es) | 2011-11-07 | 2017-07-03 | Nektar Therapeutics | Composiciones, formas de dosificacion y coadministracion de un compuesto agonista opioide y un compuesto analgesico. |
| PT2914599T (pt) * | 2012-10-30 | 2018-01-08 | Nektar Therapeutics | Forma de sal sólida de alfa-6-mpeg6-o-hidroxicodona como agonistas opioides e suas utilizações |
| EP3013812B1 (en) * | 2013-06-28 | 2019-10-16 | Nektar Therapeutics | Kappa opioid agonists and uses thereof |
| CN107019803B (zh) * | 2016-01-29 | 2020-09-15 | 北京键凯科技股份有限公司 | 具有低成瘾作用的聚乙二醇化阿片样物质 |
| CN107033154B (zh) * | 2016-02-02 | 2020-02-04 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物及其应用 |
| CN108210933B (zh) * | 2016-12-22 | 2021-05-04 | 北京键凯科技股份有限公司 | 一种地佐辛与聚乙二醇的结合物 |
| JP2021505671A (ja) * | 2017-12-08 | 2021-02-18 | ザ ロックフェラー ユニバーシティＴｈｅ Ｒｏｃｋｅｆｅｌｌｅｒ Ｕｎｉｖｅｒｓｉｔｙ | 中毒症、掻痒症、疼痛および炎症治療用ピラノ［３，４−ｂ］ピラジンカッパオピオイド受容体リガンド |
| US11680137B2 (en) | 2018-03-29 | 2023-06-20 | Nof Corporation | Method for purifying trityl group-containing monodispersed polyethylene glycol |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2654756A (en) | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
| US2628962A (en) | 1949-10-20 | 1953-02-17 | Mallinckrodt Chemical Works | Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone |
| US2649454A (en) | 1951-08-20 | 1953-08-18 | Univ California | Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone |
| US2806033A (en) | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
| US5475019A (en) * | 1993-02-08 | 1995-12-12 | East Carolina University | Method of treating anxiety-related disorders with 2-aminocycloaliphatic amide compounds |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| DK1436012T3 (en) * | 2001-10-18 | 2018-01-22 | Nektar Therapeutics | Polymer Conjugates of Opioid Antagonists |
| WO2003058367A1 (en) | 2002-01-11 | 2003-07-17 | Valquest Limited | Flow mixer shuttle |
| NZ534255A (en) * | 2002-02-22 | 2007-06-29 | Bayer Pharmaceuticals Corp | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders |
| US7084150B2 (en) * | 2002-10-25 | 2006-08-01 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
| MXPA05009757A (es) * | 2003-03-13 | 2005-12-05 | Controlled Chemicals Inc | Conjugados de oxicodona con menor potencial de abuso y duracion de accion extendida. |
| ES2733764T3 (es) * | 2003-12-16 | 2019-12-02 | Nektar Therapeutics | Método para la preparación de oligo etilenglicol monodisperso |
| CA2663515C (en) * | 2006-09-22 | 2015-09-01 | Alltranz Inc. | Transdermally deliverable buprenorphine prodrugs and abuse-resistant compositions thereof |
| JP2010509227A (ja) * | 2006-11-07 | 2010-03-25 | ネクター セラピューティックス エイエル，コーポレイション | オピオイド作動薬およびオピオイド拮抗薬の用量形態および同時投与 |
-
2008
- 2008-03-12 SI SI200831401T patent/SI2134371T1/sl unknown
- 2008-03-12 EP EP08742082.4A patent/EP2134371B1/en active Active
- 2008-03-12 ES ES08742082.4T patent/ES2534741T3/es active Active
- 2008-03-12 KR KR1020097018448A patent/KR101568428B1/ko active IP Right Grant
- 2008-03-12 JP JP2009553628A patent/JP5420427B2/ja not_active Expired - Fee Related
- 2008-03-12 PT PT87420824T patent/PT2134371E/pt unknown
- 2008-03-12 EP EP13155667.2A patent/EP2620163B1/en not_active Not-in-force
- 2008-03-12 CA CA2679479A patent/CA2679479C/en not_active Expired - Fee Related
- 2008-03-12 EP EP17151793.1A patent/EP3222293B1/en active Active
- 2008-03-12 ME MEP-2015-44A patent/ME02176B/me unknown
- 2008-03-12 AU AU2008226822A patent/AU2008226822B2/en not_active Ceased
- 2008-03-12 MX MX2009009851A patent/MX2009009851A/es active IP Right Grant
- 2008-03-12 EP EP13155670.6A patent/EP2623123A1/en not_active Withdrawn
- 2008-03-12 DK DK08742082T patent/DK2134371T3/en active
- 2008-03-12 CN CN200880007968XA patent/CN101646464B/zh not_active Expired - Fee Related
- 2008-03-12 WO PCT/US2008/003353 patent/WO2008112288A2/en active Application Filing
- 2008-03-12 RS RS20150207A patent/RS53937B1/en unknown
- 2008-03-12 PL PL08742082T patent/PL2134371T3/pl unknown
-
2009
- 2009-09-10 IL IL200845A patent/IL200845A/en active IP Right Grant
-
2013
- 2013-05-09 JP JP2013099473A patent/JP5877403B2/ja not_active Expired - Fee Related
-
2015
- 2015-03-19 HR HRP20150315TT patent/HRP20150315T1/hr unknown
- 2015-04-03 CY CY20151100323T patent/CY1117368T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5420427B2 (ja) | 2014-02-19 |
| AU2008226822A1 (en) | 2008-09-18 |
| IL200845A0 (en) | 2010-05-17 |
| RS53937B1 (en) | 2015-08-31 |
| PL2134371T3 (pl) | 2015-06-30 |
| CA2679479C (en) | 2015-10-06 |
| EP2620163B1 (en) | 2017-05-03 |
| AU2008226822B2 (en) | 2013-08-01 |
| CN101646464B (zh) | 2013-05-29 |
| EP2623123A1 (en) | 2013-08-07 |
| SI2134371T1 (sl) | 2015-04-30 |
| HRP20150315T1 (hr) | 2015-04-24 |
| JP2010521466A (ja) | 2010-06-24 |
| MX2009009851A (es) | 2009-09-24 |
| EP2134371B1 (en) | 2015-01-14 |
| JP5877403B2 (ja) | 2016-03-08 |
| KR101568428B1 (ko) | 2015-11-11 |
| JP2013151563A (ja) | 2013-08-08 |
| WO2008112288A3 (en) | 2008-12-24 |
| WO2008112288A2 (en) | 2008-09-18 |
| IL200845A (en) | 2015-08-31 |
| EP2620163A1 (en) | 2013-07-31 |
| DK2134371T3 (en) | 2015-04-27 |
| ME02176B (me) | 2015-10-20 |
| CY1117368T1 (el) | 2017-04-26 |
| CN101646464A (zh) | 2010-02-10 |
| CA2679479A1 (en) | 2008-09-18 |
| EP3222293B1 (en) | 2019-11-27 |
| EP3222293A1 (en) | 2017-09-27 |
| KR20090118952A (ko) | 2009-11-18 |
| EP2134371A2 (en) | 2009-12-23 |
| ES2534741T3 (es) | 2015-04-28 |
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