CY1117368T1 - Συζευγματα ολιγομερων - αγωνιστων οπιοειδων - Google Patents
Συζευγματα ολιγομερων - αγωνιστων οπιοειδωνInfo
- Publication number
- CY1117368T1 CY1117368T1 CY20151100323T CY151100323T CY1117368T1 CY 1117368 T1 CY1117368 T1 CY 1117368T1 CY 20151100323 T CY20151100323 T CY 20151100323T CY 151100323 T CY151100323 T CY 151100323T CY 1117368 T1 CY1117368 T1 CY 1117368T1
- Authority
- CY
- Cyprus
- Prior art keywords
- oligomers
- connectors
- optional operators
- compound
- operators
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Polyethers (AREA)
Abstract
Η εφεύρεση παρέχει ενώσεις που είναι χημικά τροποποιημένες μέσω ομοιοπολικής προσάρτησης ενός υδατοδιαλυτού ολιγομερούς. Μία ένωση της εφεύρεσης, όταν χορηγείται με οποιονδήποτε αριθμό οδών χορήγησης, παρουσιάζει χαρακτηριστικά που είναι διαφορετικά από εκείνα της ένωσης που δεν είναι προσαρτημένη στο υδατοδιαλυτό ολιγομερές.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90638707P | 2007-03-12 | 2007-03-12 | |
EP08742082.4A EP2134371B1 (en) | 2007-03-12 | 2008-03-12 | Oligomer-opioid agonist conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117368T1 true CY1117368T1 (el) | 2017-04-26 |
Family
ID=39590911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100323T CY1117368T1 (el) | 2007-03-12 | 2015-04-03 | Συζευγματα ολιγομερων - αγωνιστων οπιοειδων |
Country Status (18)
Country | Link |
---|---|
EP (4) | EP3222293B1 (el) |
JP (2) | JP5420427B2 (el) |
KR (1) | KR101568428B1 (el) |
CN (1) | CN101646464B (el) |
AU (1) | AU2008226822B2 (el) |
CA (1) | CA2679479C (el) |
CY (1) | CY1117368T1 (el) |
DK (1) | DK2134371T3 (el) |
ES (1) | ES2534741T3 (el) |
HR (1) | HRP20150315T1 (el) |
IL (1) | IL200845A (el) |
ME (1) | ME02176B (el) |
MX (1) | MX2009009851A (el) |
PL (1) | PL2134371T3 (el) |
PT (1) | PT2134371E (el) |
RS (1) | RS53937B1 (el) |
SI (1) | SI2134371T1 (el) |
WO (1) | WO2008112288A2 (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
US20110237614A1 (en) * | 2008-09-16 | 2011-09-29 | Nektar Therapeutics | Pegylated Opioids with Low Potential for Abuse |
CN105503889B (zh) * | 2009-07-21 | 2019-12-24 | 尼克塔治疗公司 | 低聚物-阿片样激动剂轭合物 |
CN102573918A (zh) * | 2009-07-21 | 2012-07-11 | 尼克塔治疗公司 | 低聚物-阿片样激动剂轭合物 |
US20130023553A1 (en) * | 2010-01-12 | 2013-01-24 | Nektar Therapeutics | Pegylated opioids with low potential for abuse and side effects |
US20130022669A1 (en) * | 2010-03-30 | 2013-01-24 | Spago Imaging Ab | Branched, compact polyethyleneglycol derivatives |
SG190113A1 (en) | 2010-11-30 | 2013-07-31 | Research In Motion Ltd | Cell re-selection in a cellular telecommunications network |
CA2854512A1 (en) | 2011-11-07 | 2013-05-16 | Nektar Therapeutics | Compositions, dosage forms, and co-administration of an opioid agonist compound and an analgesic compound |
US10525054B2 (en) | 2011-11-07 | 2020-01-07 | Inheris Biopharma, Inc. | Compositions, dosage forms, and co-administration of an opioid agonist compound and an analgesic compound |
PL2914599T3 (pl) * | 2012-10-30 | 2018-05-30 | Nektar Therapeutics | Stałe postacie soli alfa-6-MPEG6-O-hydroksykodonu jako agoniści opioidowi i ich zastosowania |
US9815824B2 (en) | 2013-06-28 | 2017-11-14 | Nektar Therapeutics | Kappa opioid agonists and uses thereof |
CN107019803B (zh) * | 2016-01-29 | 2020-09-15 | 北京键凯科技股份有限公司 | 具有低成瘾作用的聚乙二醇化阿片样物质 |
CN107033154B (zh) * | 2016-02-02 | 2020-02-04 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物及其应用 |
CN108210933B (zh) * | 2016-12-22 | 2021-05-04 | 北京键凯科技股份有限公司 | 一种地佐辛与聚乙二醇的结合物 |
JP2021505671A (ja) * | 2017-12-08 | 2021-02-18 | ザ ロックフェラー ユニバーシティThe Rockefeller University | 中毒症、掻痒症、疼痛および炎症治療用ピラノ[3,4−b]ピラジンカッパオピオイド受容体リガンド |
US11680137B2 (en) | 2018-03-29 | 2023-06-20 | Nof Corporation | Method for purifying trityl group-containing monodispersed polyethylene glycol |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2654756A (en) | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
US2628962A (en) | 1949-10-20 | 1953-02-17 | Mallinckrodt Chemical Works | Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone |
US2649454A (en) | 1951-08-20 | 1953-08-18 | Univ California | Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone |
US2806033A (en) | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
US5475019A (en) * | 1993-02-08 | 1995-12-12 | East Carolina University | Method of treating anxiety-related disorders with 2-aminocycloaliphatic amide compounds |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
PT1436012T (pt) * | 2001-10-18 | 2018-03-27 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opióides |
AU2003201643A1 (en) | 2002-01-11 | 2003-07-24 | Valquest Limited | Flow mixer shuttle |
AU2003213219B2 (en) * | 2002-02-22 | 2009-02-26 | Bayer Healthcare Llc | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders |
WO2004039317A2 (en) * | 2002-10-25 | 2004-05-13 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
CA2518834A1 (en) * | 2003-03-13 | 2004-09-30 | Controlled Chemicals, Inc. | Oxycodone conjugates with lower the abuse potential and extended duration of action |
WO2005058367A2 (en) | 2003-12-16 | 2005-06-30 | Nektar Therapeutics Al, Corporation | Pegylated small molecules |
ES2549115T3 (es) * | 2006-09-22 | 2015-10-23 | Zynerba Pharmaceuticals, Inc. | Profármacos de buprenorfina administrables por vía transdérmica y composiciones resistentes al consumo excesivo de los mismos |
CN101534827A (zh) * | 2006-11-07 | 2009-09-16 | 尼克塔治疗亚拉巴马公司 | 阿片样物质激动剂和阿片样物质拮抗剂的剂型和联合给药 |
-
2008
- 2008-03-12 PT PT87420824T patent/PT2134371E/pt unknown
- 2008-03-12 CN CN200880007968XA patent/CN101646464B/zh not_active Expired - Fee Related
- 2008-03-12 DK DK08742082T patent/DK2134371T3/en active
- 2008-03-12 WO PCT/US2008/003353 patent/WO2008112288A2/en active Application Filing
- 2008-03-12 EP EP17151793.1A patent/EP3222293B1/en active Active
- 2008-03-12 EP EP08742082.4A patent/EP2134371B1/en active Active
- 2008-03-12 RS RS20150207A patent/RS53937B1/en unknown
- 2008-03-12 EP EP13155670.6A patent/EP2623123A1/en not_active Withdrawn
- 2008-03-12 AU AU2008226822A patent/AU2008226822B2/en not_active Ceased
- 2008-03-12 ES ES08742082.4T patent/ES2534741T3/es active Active
- 2008-03-12 MX MX2009009851A patent/MX2009009851A/es active IP Right Grant
- 2008-03-12 SI SI200831401T patent/SI2134371T1/sl unknown
- 2008-03-12 JP JP2009553628A patent/JP5420427B2/ja not_active Expired - Fee Related
- 2008-03-12 CA CA2679479A patent/CA2679479C/en not_active Expired - Fee Related
- 2008-03-12 PL PL08742082T patent/PL2134371T3/pl unknown
- 2008-03-12 EP EP13155667.2A patent/EP2620163B1/en not_active Not-in-force
- 2008-03-12 ME MEP-2015-44A patent/ME02176B/me unknown
- 2008-03-12 KR KR1020097018448A patent/KR101568428B1/ko active IP Right Grant
-
2009
- 2009-09-10 IL IL200845A patent/IL200845A/en active IP Right Grant
-
2013
- 2013-05-09 JP JP2013099473A patent/JP5877403B2/ja not_active Expired - Fee Related
-
2015
- 2015-03-19 HR HRP20150315TT patent/HRP20150315T1/hr unknown
- 2015-04-03 CY CY20151100323T patent/CY1117368T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP2623123A1 (en) | 2013-08-07 |
EP2620163B1 (en) | 2017-05-03 |
AU2008226822A1 (en) | 2008-09-18 |
AU2008226822B2 (en) | 2013-08-01 |
ES2534741T3 (es) | 2015-04-28 |
SI2134371T1 (sl) | 2015-04-30 |
EP3222293B1 (en) | 2019-11-27 |
JP5877403B2 (ja) | 2016-03-08 |
CN101646464B (zh) | 2013-05-29 |
WO2008112288A2 (en) | 2008-09-18 |
EP3222293A1 (en) | 2017-09-27 |
MX2009009851A (es) | 2009-09-24 |
RS53937B1 (en) | 2015-08-31 |
KR101568428B1 (ko) | 2015-11-11 |
CN101646464A (zh) | 2010-02-10 |
IL200845A0 (en) | 2010-05-17 |
JP2010521466A (ja) | 2010-06-24 |
HRP20150315T1 (hr) | 2015-04-24 |
EP2134371A2 (en) | 2009-12-23 |
JP5420427B2 (ja) | 2014-02-19 |
PL2134371T3 (pl) | 2015-06-30 |
WO2008112288A3 (en) | 2008-12-24 |
IL200845A (en) | 2015-08-31 |
CA2679479C (en) | 2015-10-06 |
JP2013151563A (ja) | 2013-08-08 |
KR20090118952A (ko) | 2009-11-18 |
CA2679479A1 (en) | 2008-09-18 |
EP2134371B1 (en) | 2015-01-14 |
PT2134371E (pt) | 2015-04-16 |
ME02176B (me) | 2015-10-20 |
EP2620163A1 (en) | 2013-07-31 |
DK2134371T3 (en) | 2015-04-27 |
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