DE60321333D1 - Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivität - Google Patents

Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivität

Info

Publication number
DE60321333D1
DE60321333D1 DE60321333T DE60321333T DE60321333D1 DE 60321333 D1 DE60321333 D1 DE 60321333D1 DE 60321333 T DE60321333 T DE 60321333T DE 60321333 T DE60321333 T DE 60321333T DE 60321333 D1 DE60321333 D1 DE 60321333D1
Authority
DE
Germany
Prior art keywords
receptor activity
modulators
chemokin receptor
tetrahydropyranyl cyclopentyl
tetrahydropyranyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60321333T
Other languages
English (en)
Inventor
Richard Jiao
Gregori Morriello
Lihu Yang
Stephen D Goble
Sander G Mills
Alexander Pasternak
Changyou Zhou
Gabor Butora
Shankaran Kothandaraman
Deodialsingh Guiadeen
Cheng Tang
Christopher Moyes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck and Co Inc filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of DE60321333D1 publication Critical patent/DE60321333D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
DE60321333T 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivität Expired - Lifetime DE60321333D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37618002P 2002-04-29 2002-04-29
PCT/US2003/012929 WO2003092586A2 (en) 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
DE60321333D1 true DE60321333D1 (de) 2008-07-10

Family

ID=29401316

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60321333T Expired - Lifetime DE60321333D1 (de) 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivität

Country Status (15)

Country Link
US (1) US6812234B2 (de)
EP (1) EP1501507B1 (de)
JP (1) JP3780291B2 (de)
AT (1) ATE396993T1 (de)
AU (1) AU2003231114B8 (de)
CA (1) CA2483752C (de)
CY (1) CY1110399T1 (de)
DE (1) DE60321333D1 (de)
DK (1) DK1501507T3 (de)
ES (1) ES2306867T3 (de)
NZ (1) NZ536477A (de)
PT (1) PT1501507E (de)
SI (1) SI1501507T1 (de)
WO (1) WO2003092586A2 (de)
ZA (1) ZA200407940B (de)

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US20060205761A1 (en) * 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
RU2317295C1 (ru) * 2003-10-27 2008-02-20 Мерк Энд Ко., Инк. Соль антагониста ccr-2
AR045875A1 (es) * 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2
US7576089B2 (en) 2003-12-18 2009-08-18 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
EP1701724A4 (de) * 2004-01-02 2007-11-14 Merck & Co Inc Alkylamino-, arylamino- und sulfonamidocyclopentylamidmodulatoren der aktivität von chemokinrezeptoren
WO2005072361A2 (en) * 2004-01-28 2005-08-11 Merck & Co., Inc. Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
US7557124B2 (en) 2004-04-26 2009-07-07 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
WO2005110409A2 (en) * 2004-04-26 2005-11-24 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl 1-substituted and 1,1-disubstituted tetrahydroisoquinoline modulators of chemokine receptor activity
AU2005237500A1 (en) * 2004-04-28 2005-11-10 Merck Sharp & Dohme Corp. 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
GEP20084519B (en) * 2004-05-11 2008-10-27 Incyte Corp 3-(4-heteroarylcyclo-hexylamino) cyclopenta-necarboxamides as modulators of chemokine receptors
JP4116670B2 (ja) * 2004-06-28 2008-07-09 インサイト コーポレイション ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド
AU2005259983B2 (en) 2004-06-28 2011-07-28 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
AU2006204038A1 (en) * 2005-01-06 2006-07-13 Merck & Co., Inc. Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders
WO2006098959A1 (en) * 2005-03-11 2006-09-21 Merck & Co., Inc. Process for the preparation of (r)-4,4-dialkoxy-pyran-3-ols such as (r)-4,4-dimethoxy-pyran-3-ol
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
SI2370442T1 (sl) * 2008-11-26 2013-06-28 Pfizer Inc. 3-aminociklopentankarboksiamidi kot modulatorji kemokinskega receptorja
PE20120061A1 (es) 2008-12-19 2012-02-19 Boehringer Ingelheim Int Derivados de pirimidina como antagonistas del receptor ccr2
PT3091012T (pt) 2009-12-17 2018-06-27 Centrexion Therapeutics Corp Antagonistas do receptor ccr2 e suas utilizações
WO2011087712A2 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Tricyclic derivatives and their pharmaceutical use and compositions
US9040526B2 (en) 2010-02-09 2015-05-26 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
JP5636094B2 (ja) * 2010-05-25 2014-12-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２受容体アンタゴニスト
WO2012125663A2 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
CA2902785A1 (en) 2013-02-28 2014-09-04 Santen Pharmaceutical Co., Ltd. Prophylactic or therapeutic agent for posterior ocular disease containing tetrahydropyranylaminocyclopentylcarbonyl-tetrahydropyridopyridine derivative as effective ingredient
AU2016263579B2 (en) 2015-05-21 2020-12-03 Chemocentryx, Inc. CCR2 modulators
MX2017017177A (es) 2015-07-02 2018-11-09 Centrexion Therapeutics Corp Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidi n-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-piran-2-il)m etilamino)pirimidin-4il) metanona.
WO2018134731A1 (en) 2017-01-17 2018-07-26 Glaxosmithkline Intellectual Property Development Limited Non peptidic heterobivalent molecules for treating inflammatory diseases
CN111712242B (zh) 2017-09-25 2023-11-24 凯莫森特里克斯股份有限公司 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
WO2019136368A2 (en) 2018-01-08 2019-07-11 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists

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US2002A (en) * 1841-03-12 Tor and planter for plowing
US3647804A (en) * 1970-02-27 1972-03-07 Upjohn Co Cycloalkanecarboxamides
US3772308A (en) * 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
JPH09291034A (ja) * 1996-02-27 1997-11-11 Yoshitomi Pharmaceut Ind Ltd 縮合ピリジン化合物およびその医薬としての用途
GB9812037D0 (en) 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
AU5473400A (en) * 1999-06-11 2001-01-02 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
AU8334501A (en) * 2000-08-17 2002-02-25 Merck & Co Inc Cyclopentyl modulators of chemokine receptor activity
WO2002070523A1 (en) 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
TWI262077B (en) * 2002-04-29 2006-09-21 Merck & Co Inc Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Also Published As

Publication number Publication date
CA2483752C (en) 2011-03-29
JP3780291B2 (ja) 2006-05-31
PT1501507E (pt) 2008-08-12
DK1501507T3 (da) 2008-09-29
EP1501507A2 (de) 2005-02-02
ATE396993T1 (de) 2008-06-15
WO2003092586A3 (en) 2004-09-16
ES2306867T3 (es) 2008-11-16
AU2003231114B8 (en) 2008-08-14
US6812234B2 (en) 2004-11-02
JP2005523929A (ja) 2005-08-11
SI1501507T1 (sl) 2008-12-31
US20040167156A1 (en) 2004-08-26
CA2483752A1 (en) 2003-11-13
WO2003092586A2 (en) 2003-11-13
AU2003231114A1 (en) 2003-11-17
EP1501507B1 (de) 2008-05-28
CY1110399T1 (el) 2014-04-09
EP1501507A4 (de) 2006-05-17
ZA200407940B (en) 2006-06-28
NZ536477A (en) 2005-05-27
AU2003231114B2 (en) 2008-07-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US

Owner name: MERCK SHARP & DOHME LTD., HODDESDON, HERTFORDS, GB