PT1401828E - Compostos de n-formil-hidroxilamina como inibidores de pdf - Google Patents

Compostos de n-formil-hidroxilamina como inibidores de pdf

Info

Publication number
PT1401828E
PT1401828E PT02754681T PT02754681T PT1401828E PT 1401828 E PT1401828 E PT 1401828E PT 02754681 T PT02754681 T PT 02754681T PT 02754681 T PT02754681 T PT 02754681T PT 1401828 E PT1401828 E PT 1401828E
Authority
PT
Portugal
Prior art keywords
formyl
hydroxylamine compounds
pdf inhibitors
pdf
inhibitors
Prior art date
Application number
PT02754681T
Other languages
English (en)
Inventor
Dinesh V Patel
Yuan Zhengyu
Rakesh K Jain
Garcia Alvarez Salvador
Jacobs Jeffrey
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of PT1401828E publication Critical patent/PT1401828E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
PT02754681T 2001-06-15 2002-06-14 Compostos de n-formil-hidroxilamina como inibidores de pdf PT1401828E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29841901P 2001-06-15 2001-06-15
US36031302P 2002-02-27 2002-02-27

Publications (1)

Publication Number Publication Date
PT1401828E true PT1401828E (pt) 2006-08-31

Family

ID=26970649

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02754681T PT1401828E (pt) 2001-06-15 2002-06-14 Compostos de n-formil-hidroxilamina como inibidores de pdf

Country Status (31)

Country Link
US (1) US7148242B2 (pt)
EP (1) EP1401828B1 (pt)
JP (1) JP4361365B2 (pt)
KR (2) KR20060014083A (pt)
CN (1) CN1511152A (pt)
AR (1) AR036053A1 (pt)
AT (1) ATE323081T1 (pt)
AU (1) AU2002321062B2 (pt)
BR (1) BR0210377A (pt)
CA (1) CA2448526A1 (pt)
CO (1) CO5640131A2 (pt)
CY (1) CY1105085T1 (pt)
CZ (1) CZ20033388A3 (pt)
DE (1) DE60210612T2 (pt)
DK (1) DK1401828T3 (pt)
ES (1) ES2262824T3 (pt)
HK (1) HK1064370A1 (pt)
HU (1) HUP0400208A3 (pt)
IL (1) IL158770A0 (pt)
MX (1) MXPA03011628A (pt)
MY (1) MY138619A (pt)
NO (1) NO327420B1 (pt)
NZ (1) NZ529489A (pt)
PE (1) PE20030100A1 (pt)
PL (1) PL364476A1 (pt)
PT (1) PT1401828E (pt)
RU (1) RU2325386C2 (pt)
SI (1) SI1401828T1 (pt)
SK (1) SK15242003A3 (pt)
WO (1) WO2002102790A1 (pt)
ZA (1) ZA200308379B (pt)

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DE60219630T2 (de) * 2001-06-15 2007-12-27 Vicuron Pharmaceuticals, Inc., Fremont Bicyclische pyrrolidinverbindungen
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
WO2004026824A1 (en) 2002-09-19 2004-04-01 Novartis Ag Process for preparing intermediates
AU2004216178B2 (en) * 2003-02-21 2008-07-03 Novartis Ag Chemical process for the preparation of intermediates to obtain N-formyl hydroxylamine compounds
TW200427458A (en) * 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
US20070060753A1 (en) * 2003-06-26 2007-03-15 Joel Slade Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines
KR100527624B1 (ko) * 2003-08-21 2005-11-22 한기종 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법
WO2006002896A1 (en) * 2004-06-30 2006-01-12 Novartis Ag Method for increasing the susceptibility of peptide deformylase inhibitors by using efflux pump inhibitors
US20080161249A1 (en) * 2004-11-17 2008-07-03 Smithkline Beecham Corporation Use of Novel Antibacterial Compounds
GT200600196A (es) 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
MX2007015421A (es) 2005-06-07 2008-02-21 Novartis Ag Inhibidores de desformilasa peptidica (pdf) 4.
DE102005026231A1 (de) * 2005-06-07 2006-12-14 Origenis Ag Peptid-Deformylase (PDF) Inhibitoren 3
SG133452A1 (en) * 2005-12-30 2007-07-30 Novartis Ag Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
MX2008011128A (es) * 2006-03-03 2008-09-08 Novartis Ag Compuestos de n-formil-hidroxilamina.
CN101328155B (zh) * 2007-06-20 2010-11-03 上海医药工业研究院 噁唑烷衍生物及其制备方法和应用
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
EP2473502A1 (en) * 2009-09-04 2012-07-11 Novartis AG Heteroaryl compounds as kinase inhibitors
NZ627520A (en) 2010-03-10 2015-10-30 Astrazeneca Ab 4-phenyl pyridine analogues as protein kinase inhibitors
JP5825086B2 (ja) 2011-12-19 2015-12-02 住友化学株式会社 α−置換−β−アミノ酸エステル誘導体不斉加水分解酵素
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
EP3280795B1 (en) 2015-04-07 2021-03-24 Novartis AG Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives
US10738028B2 (en) * 2016-05-11 2020-08-11 Rudong Ruien Pharmaceutical Technology Co. Ltd Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor

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US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
JPS6188884A (ja) * 1984-10-04 1986-05-07 Sankyo Co Ltd エンケフアリナ−ゼｂ阻害物質およびその製法
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DK77487A (da) 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
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Also Published As

Publication number Publication date
EP1401828A1 (en) 2004-03-31
SI1401828T1 (sl) 2006-10-31
WO2002102790A1 (en) 2002-12-27
AR036053A1 (es) 2004-08-04
CA2448526A1 (en) 2002-12-27
JP2005502606A (ja) 2005-01-27
CZ20033388A3 (en) 2004-03-17
BR0210377A (pt) 2004-08-10
ES2262824T3 (es) 2006-12-01
CO5640131A2 (es) 2006-05-31
MY138619A (en) 2009-07-31
HUP0400208A3 (en) 2008-10-28
US7148242B2 (en) 2006-12-12
RU2003137565A (ru) 2005-05-27
SK15242003A3 (sk) 2004-07-07
RU2325386C2 (ru) 2008-05-27
HK1064370A1 (en) 2005-01-28
ZA200308379B (en) 2004-05-21
NO20035571D0 (no) 2003-12-12
DE60210612T2 (de) 2006-09-21
AU2002321062B2 (en) 2006-02-02
KR100589544B1 (ko) 2006-06-15
EP1401828B1 (en) 2006-04-12
US20030045479A1 (en) 2003-03-06
KR20060014083A (ko) 2006-02-14
CN1511152A (zh) 2004-07-07
DE60210612D1 (de) 2006-05-24
PE20030100A1 (es) 2003-03-28
HUP0400208A2 (hu) 2004-06-28
CY1105085T1 (el) 2009-11-04
DK1401828T3 (da) 2006-07-31
NZ529489A (en) 2005-10-28
KR20040010721A (ko) 2004-01-31
NO20035571L (no) 2004-02-16
NO327420B1 (no) 2009-06-29
JP4361365B2 (ja) 2009-11-11
IL158770A0 (en) 2004-05-12
MXPA03011628A (es) 2005-03-07
PL364476A1 (en) 2004-12-13
ATE323081T1 (de) 2006-04-15

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