PT1399468E - Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico - Google Patents

Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico

Info

Publication number
PT1399468E
PT1399468E PT02743128T PT02743128T PT1399468E PT 1399468 E PT1399468 E PT 1399468E PT 02743128 T PT02743128 T PT 02743128T PT 02743128 T PT02743128 T PT 02743128T PT 1399468 E PT1399468 E PT 1399468E
Authority
PT
Portugal
Prior art keywords
amino
aminoacyl
propionyl
alquilboronic
heteroaril
Prior art date
Application number
PT02743128T
Other languages
English (en)
Inventor
Pascal Furet
Guagnano Vito
Imbach Patricia
Marc Lang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0113096A external-priority patent/GB0113096D0/en
Priority claimed from GB0129394A external-priority patent/GB0129394D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1399468E publication Critical patent/PT1399468E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
PT02743128T 2001-05-30 2002-05-29 Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico PT1399468E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0113096A GB0113096D0 (en) 2001-05-30 2001-05-30 Organic compounds
GB0129394A GB0129394D0 (en) 2001-12-07 2001-12-07 Organic compounds

Publications (1)

Publication Number Publication Date
PT1399468E true PT1399468E (pt) 2006-05-31

Family

ID=26246132

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02743128T PT1399468E (pt) 2001-05-30 2002-05-29 Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico

Country Status (11)

Country Link
US (2) US6933290B2 (pt)
EP (1) EP1399468B1 (pt)
JP (1) JP4416501B2 (pt)
CN (1) CN100415770C (pt)
AT (1) ATE317850T1 (pt)
BR (1) BR0210112A (pt)
CA (1) CA2446282A1 (pt)
DE (1) DE60209227T2 (pt)
ES (1) ES2258149T3 (pt)
PT (1) PT1399468E (pt)
WO (1) WO2002096933A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE317850T1 (de) * 2001-05-30 2006-03-15 Novartis Pharma Gmbh 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate
JP4412586B2 (ja) 2002-01-08 2010-02-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 エポネマイシンおよびエポキソマイシン類似物およびそれらの用途
PL376993A1 (pl) * 2002-11-11 2006-01-23 Bayer Healthcare Ag Pochodne fenylo- lub heteroarylo-aminoalkanów jako antagoniści receptora IP
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
EP1940843A4 (en) 2005-08-11 2010-09-15 Ariad Pharma Inc UNSATURATED HETEROCYCLIC DERIVATIVES
EP2662082A1 (en) 2005-11-14 2013-11-13 Ariad Pharmaceuticals, Incorporated Administration of mTOR inhibitors
DK1973545T3 (da) 2005-12-23 2013-02-25 Ariad Pharma Inc Bicykliske heteroarylforbindelser
NZ582693A (en) 2007-08-06 2012-01-12 Millennium Pharm Inc Boron-containing proteasome inhibitors
LT2300013T (lt) 2008-05-21 2017-12-27 Ariad Pharmaceuticals, Inc. Fosforo dariniai kaip kinazių inhibitoriai
EP2733147A1 (en) 2008-06-17 2014-05-21 Millennium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
CA2743449C (en) 2008-11-12 2016-10-18 Ariad Pharmaceuticals, Inc. Pyrazinopyrazines and derivatives as kinase inhibitors
EP3021120A1 (en) 2009-02-20 2016-05-18 Michael P. Lisanti Diagnosis, prognosis, therapeutics and methods for treating neoplastic deiseases comprising determining the level of caveolin-1 in a stromal cell sample
NZ600786A (en) 2009-12-22 2013-12-20 Cephalon Inc Proteasome inhibitors and processes for their preparation, purification and use
CN102892417A (zh) * 2010-03-01 2013-01-23 欧尼斯治疗公司 用于免疫蛋白酶体抑制的化合物
EP2560647B1 (en) 2010-04-19 2016-04-13 Niiki Pharma Inc. Combination therapy with a proteasome inhibitor and a gallium complex
GB2523211B (en) 2012-01-27 2020-03-18 Univ Jefferson MCT protein inhibitor-related prognostic and therapeutic methods
CN103421032B (zh) * 2012-05-17 2016-01-20 上海创诺制药有限公司 一种硼替佐米中间体及其制备方法和应用
US10022372B2 (en) 2013-04-19 2018-07-17 Thomas Jefferson University Caveolin-1 related methods for treating glioblastoma with temozolomide
TWI746422B (zh) 2014-05-20 2021-11-21 美商千禧製藥公司 用於癌症治療的方法
MA40240B1 (fr) 2014-06-19 2019-03-29 Ariad Pharma Inc Composés hétéroaryle d'inhibition de la kinase
MA41505A (fr) 2015-02-11 2017-12-19 Millennium Pharm Inc Nouvelle forme cristalline d'un inhibiteur de protéasome
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
DK3472149T3 (da) 2016-06-21 2023-11-27 Orion Ophthalmology LLC Heterocykliske prolinamidderivater

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
EP0315574A3 (de) 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren
US5106948A (en) * 1988-05-27 1992-04-21 Mao Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
GB9017694D0 (en) 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
US5384410A (en) 1993-03-24 1995-01-24 The Du Pont Merck Pharmaceutical Company Removal of boronic acid protecting groups by transesterification
IL109319A0 (en) 1993-04-27 1994-07-31 Du Pont Merck Pharma Amidino and guanidino substituted boronic acid compounds
US5658885A (en) 1993-04-27 1997-08-19 The Dupont Merck Pharmaceutical Company Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
FR2721611B1 (fr) * 1994-06-22 1996-09-27 Adir Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent .
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
US5550262A (en) 1994-11-14 1996-08-27 Cephalon, Inc. Multicatalytic protease inhibitors
KR20010033150A (ko) 1997-12-16 2001-04-25 세파론, 인코포레이티드 항종양제용 다촉매 프로테아제 억제제
ATE317850T1 (de) * 2001-05-30 2006-03-15 Novartis Pharma Gmbh 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate

Also Published As

Publication number Publication date
EP1399468B1 (en) 2006-02-15
JP4416501B2 (ja) 2010-02-17
CN100415770C (zh) 2008-09-03
ATE317850T1 (de) 2006-03-15
WO2002096933A1 (en) 2002-12-05
US20040167337A1 (en) 2004-08-26
DE60209227D1 (de) 2006-04-20
ES2258149T3 (es) 2006-08-16
DE60209227T2 (de) 2006-08-17
CN1512999A (zh) 2004-07-14
CA2446282A1 (en) 2002-12-05
EP1399468A1 (en) 2004-03-24
BR0210112A (pt) 2004-06-08
JP2005501005A (ja) 2005-01-13
US6933290B2 (en) 2005-08-23
US20050239716A1 (en) 2005-10-27

Similar Documents

Publication Publication Date Title
PT1399468E (pt) Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico
BR0113838A (pt) Derivados de n-fenil-2-pirimidina-amina
WO2003099771A3 (en) Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
NO20040547L (no) Amino-ftalazinonderivater aktive som kinaseinhibitorer, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende disse.
CY1110914T1 (el) Δικυκλο-πυραζολες δραστικες ως αναστολεις kinασων, διεργασια για την παρασκευη τους και φαρμακευτικες συνθεσεις που τις περιλαμβανουν
TNSN08276A1 (en) Pyrimidinyl aryl urea derivatives being fgf inhibitors
MY126862A (en) Purine derivatives inhibitors of tyrosine protein kinase syk
DK1200412T3 (da) Antiproliferative imidazolforbindelser
ATE442142T1 (de) Fredericamycin-derivate als arzneimittel zur tumorbehandlung
NO20040268L (no) Nye 2H-pyridazin-3-derivater, farmasoytiske preparater inneholdende slike og fremgangsmate for fremstilling av den aktive ingrediensen
BRPI0409227B8 (pt) "composto, composição farmacêutica, uso de um composto e processo para a preparação de um composto de fórmula (i)"
WO2004071400A3 (en) Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
RS41104A (en) Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
ATE307810T1 (de) Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
DE60315479D1 (de) Pyrimidinamid derivate und deren verwendung
BRPI0413094A (pt) derivados de quinolina e seu uso em terapia
DE59909607D1 (de) Tan-1057 derivate
IL162314A (en) Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides, processes for their preparation, pharmaceutical compositions comprising them and uses thereof
HUP0401773A3 (en) Use of [(2-amino-3,4-dioxo-1cyclobuten-1-yl)amino]alkanacid derivatives for the preparation pharmaceutical compositions usable for treatment of pain
NO20021337D0 (no) 4-benzylaminoquinolinkonjugater med gallesyre og deres heteroanaloger, fremgangsmåte for deres fremstilling, legemidlersom inneholder disse forbindelser og deres anvendelse
ATE325809T1 (de) Amidderivate der 2-amino-3-hydroxy-4-tert-leucyl- amino-5-phenyl-pentansäure
NO20020914D0 (no) Alkoksy-substituerte benzimidazolforbindelser, preparater inneholdende slike samt anvendelser derav
PT1232173E (pt) Derivados do acido fusidico
NO20032959L (no) Derivater av etoposid og analoger, samt farmasöytiske preparater inneholdende disse
ATE298239T1 (de) Immunomodulierende zusammensetzungen enthaltend harnstoff derivate zur behandlung von entzündungskrankheiten